Introduction to Geriatric Pharmacotherapy Resource List Commission for Certification in Geriatric Pharmacy This document is online at: http://www.ccgp.org/documents/IntroGeriatricPharmCCGP.pdf Commission for Certification in Geriatric Pharmacy 1321 Duke Street Alexandria, VA 22314-3563 P: 703-535-3036 F: 703-739-1500 [email protected] www.ccgp.org
CCGP Geriatric Pharmacotherapy Resource List
Introduction to Geriatric Pharmacotherapy Resource List Commission for Certification in Geriatric Pharmacy
1. Introduction 2. Getting Started 3. General Geriatric Resources 4. Geriatric Journal List 5. Geriatric Primer Article Series in The Consultant Pharmacist 6. General Journal Articles 7. Live Meetings and Workshops 8. Adverse Drug Events in Older Adults 9. Clinical Practice Guidelines 10. Geriatric Syndromes 11. Potentially Inappropriate Medications in Older Adults 12. Prescribing Cascade 13. Adherence or Compliance with Drug Therapy 14. Population-Specific Activities
This list of resources and links is provided for information purposes
only. This list is not intended to specifically prepare pharmacists to take the Certified Geriatric Pharmacist examination. The content of the examination is developed by an independent committee of experts, and the resources listed here may or may not be applicable to the examination. 1. Introduction
With the aging of the United States population, it is increasingly important for pharmacists to understand how drug therapy principles for older adults may be different from those applied in younger adults. Just as medications can be metabolized and behave differently in children than in adults, so can medications act differently in older adults. This is especially the case in the frail elderly, those adults above the age of 85. Despite the importance of geriatrics, most health professional training programs, including those in pharmacy, lack adequate emphasis on geriatrics and the use of medications in older adults. The purpose of this Web page is to provide links to resources that may be helpful to pharmacists in learning basic information about geriatric pharmacotherapy.
CCGP Geriatric Pharmacotherapy Resource List Here is a link to an introductory article that describes some of the issues related to medication use in older adults: http://www.agingwellmag.com/archive/020110p8.shtml Citation: Clark, TR. Tough decisions about medications. Aging Well magazine, Winter 2010. 2. Getting Started
Two resources are especially useful to help provide a content outline of what geriatric pharmacotherapy is all about. These resources are: Geriatric Pharmacy Curriculum Guide, published by the American Society of Consultant Pharmacists (ASCP). This guide is available free and can be downloaded as a PDF file at: http://www.ascp.com/education/curriculumguide/index.cfm The candidate handbook for the Certified Geriatric Pharmacist examination also contains a content outline used for developing questions for the examination. The CGP candidate handbook can be downloaded at this link: http://www.ccgp.org/pharmacist/certification/request.htm A brief, 10-question quiz on geriatric pharmacotherapy can also be taken free at the Web site of the Commission for Certification in Geriatric Pharmacy (CCGP). The quiz is available here: http://www.ccgp.org/pharmacist/test.htm ASCP also has a sample 10-question quiz on geriatric pharmacotherapy. It is located here: http://www.ascp.com/resources/clinical/upload/TestYourGeriatricsIQ.pdf Pharmacists who desire to undertake a more comprehensive self-assessment of knowledge of geriatric drug therapy can purchase a self-assessment examination from CCGP. This examination can be taken online and scoring is provided as part of the process. More information is available at this link: http://www.ccgp.org/pharmacist/self.htm 3. General Geriatric Resources
Merck Manual of Geriatrics Online
Although no longer available in printed form, this resource continues to be available and periodically updated online. Access is free. The link is: http://www.merck.com/mkgr/mmg/home.jsp
CCGP Geriatric Pharmacotherapy Resource List ASCP Foundation Geriatric Clinical Newsletter
The American Society of Consultant Pharmacists Foundation launched Geriatric Clinical News, a bi-monthly electronic newsletter in February 2008. Since that time, topics covered in the newsletter include:
• Evidence-based medicine and older adults • Patient preferences and clinical practice guidelines • Update on the prescribing cascade
All past issues of the newsletter are archived and available in full text at this URL: http://www.ascpfoundation.org/newspress/geriatric_clinical_news.cfm ASCP List of Online Study Activities
The American Society of Consultant Pharmacists has a list of online continuing education programs, organized by topic. This list, with links to the programs, is available at: http://www.ascp.com/education/selfstudy/ Geriatric Pharmacy Review
The web site at www.GeriatricPharmacyReview.com has 50 hours of continuing education in 20 modules. A fee is required to access the modules, and a discount is available for ASCP members. This resource is provided by the American Society of Consultant Pharmacists. SCOUP.net
The Senior Care Online University for Professionals (SCOUP) provides online symposia on a variety of topics. Some are free and some charge a small fee for processing the continuing education credit. This Web site is provided by ASCP, and is available at: http://www.scoup.net Geriatrics At Your Fingertips
This handy resource is available as a pocket size print edition, or as an electronic edition for the PDA. It is produced by the American Geriatrics Society. Information is available at this link: http://www.americangeriatrics.org/products/ Geriatric Pharmacotherapy Listserver
ASCP maintains a listserver for discussion of issues related to geriatric drug therapy. Access to the listserver is free. Subscribe to the listserver at: http://www.ascp.com/consultnet/listservers.cfm
CCGP Geriatric Pharmacotherapy Resource List The Silver Book
A service of the Alliance for Aging Research, The Silver Book® is an almanac of more than 1,000 facts, statistics, graphs, and data from more than 200 agencies, organizations, and experts. It is an online searchable database that is constantly updated and expanded in order to highlight the latest research and data on the burden of chronic disease and the value of investing in medical research. This resource can be found at: http://www.silverbook.org 4. Geriatric Journal List
Age & Ageing (British Geriatrics Society) http://ageing.oxfordjournals.org/ American Journal of Geriatric Pharmacotherapy http://ajgeripharmacother.com/current.html Annals of Long-Term Care http://www.annalsoflongtermcare.com/ BMC Geriatrics (open access journal) http://www.biomedcentral.com/bmcgeriatr/ Clinical Geriatrics http://www.clinicalgeriatrics.com/ Clinics in Geriatric Medicine http://geriatric.theclinics.com/ The Consultant Pharmacist http://www.ascp.com/publications/tcp/ Drugs & Aging http://adisonline.com/aging/Pages/default.aspx Geriatrics http://www.modernmedicine.com/modernmedicine/Geriatrics/home/40131 Geriatrics & Aging (Canada) http://www.geriatricsandaging.ca/ The Gerontologist http://gerontologist.oxfordjournals.org/
CCGP Geriatric Pharmacotherapy Resource List Journal of the American Geriatrics Society http://www3.interscience.wiley.com/journal/117995531/toc?journal=jgs Journal of the American Medical Directors Association http://www.jamda.com/ Journals of Gerontology: Medical Sciences http://biomedgerontology.oxfordjournals.org/ 5. Geriatric Primer Articles in The Consultant Pharmacist
The Consultant Pharmacist, ASCP’s monthly journal, has published a series of articles in their “geriatric primer” series. These journal articles are available online and are free for ASCP members. The link to The Consultant Pharmacist Web page is: http://www.ascp.com/publications/tcp/
• Pharmacokinetic and Pharmacodynamic Alterations in the Geriatric
Patient (April 2008) - http://tinyurl.com/23n5o7z
• Evaluating Medication Regimens in the Elderly (July 2008) -
• Communicating with Seniors and their Caregivers (Sept. 2008) -
• The Senior Friendly Pharmacy (Dec. 2008) - http://tinyurl.com/y8nz9bf • Home is Where the Heart Is: Living Arrangements for Older Adults (Feb.
• Identifying, Preventing, and Reporting Elder Abuse (April 2009) -
• Common Geriatric Syndromes and Special Problems (June 2009) -
• Implications and Management of Decline for the Geriatric Patient (Aug.
6. General Journal Articles
Pharmaco-epistemology for the prescribing geriatrician
With the emphasis today on evidence-based prescribing, this excellent article helps the clinician caring for older adults to understand common mistakes that are made with interpretation and application of clinical trial evidence. Full text of this article is available free. D. Le Couteur and H. Kendig. Australasian Journal on Ageing 2008; 27(1):3-7. http://www3.interscience.wiley.com/journal/119419086/abstract
CCGP Geriatric Pharmacotherapy Resource List Clinical pharmacology in the geriatric patient
This article by Sarah Hilmer and colleagues is a good overview of medication use in older adults, and the full text is available online for free. The quality and accessibility of this article make it a good starting point for students or practitioners who need a good overview of the topic. Hilmer SN, McLachlan AJ, Le Couteur DG. Fundamental & Clinical Pharmacology 2007;21(3):217-230. Link to abstract (full text can be downloaded free in PDF or HTML): http://www3.interscience.wiley.com/journal/117978191/abstract Appropriate prescribing in elderly people
Spinewine A, Schmader KE, Barber N, Hughes C, Lapane K, Swine C, Hanlon JT. Appropriate prescribing in elderly people: How can it be measured and optimized? Lancet 2007;370:173-184. Link to abstract: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)61091- 5/abstract Pharmaceutical care
Although not specific to geriatrics, this classic article by Hepler and Strand introduced and defined “pharmaceutical care” and described the eight types of medication-related problems. Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm 1990;47:533-543. Full text of the article is available at: http://www.pharmacy.umn.edu/img/assets/10745/opps_and_responsibilities.pdf End of life care
Holmes, HM, Hayley, DC, Alexander, GC & Sachs, GA. Reconsidering medication appropriateness for patients late in life. Arch Intern Med 2006;166:605-609. Link to abstract: http://archinte.ama-assn.org/cgi/content/extract/166/6/605 Quality indicators for medication use in vulnerable elders
This article is one of a series from the Assessing Care of Vulnerable Elders (ACOVE) project. The entire collection of articles was published as a supplement to the Journal of the American Geriatrics Society.
CCGP Geriatric Pharmacotherapy Resource List Shrank WH, Polinski JM, Avorn J. Quality indicators for medication use in vulnerable elders. J Am Geriatr Soc. 2007;55 Suppl 2:S373-382. Link to abstract: http://www3.interscience.wiley.com/journal/117996005/abstract 7. Live Meetings and Workshops
ASCP Annual Meeting – The ASCP Annual Meeting is in the Fall of each year. The 2010 Annual Meeting is in Orlando, FL on November 10-13. Link for meeting information: http://www.ascpannual.com/ Clinical Update for the Geriatric Pharmacist Workshop – This workshop is held in conjunction with ASCP Annual and Midyear meetings, and also at some regional meetings. The 2010 presentations of this workshop are scheduled for:
• November 9 at the ASCP Annual Meeting
More details on these workshops are at: http://www.ascp.com/education/meetings/clinicalupdateworkshop.cfm Geriatric Assessment for the Senior Care Pharmacist Workshop – This workshop is held in conjunction with ASCP Annual and Midyear meetings. The next presentation of this workshop is scheduled for:
• November 12 and 13 at the ASCP Annual Meeting
More details about this workshop are at: http://www.ascp.com/education/meetings/geriatricassessment.cfm 8. Adverse Drug Events in Older Adults
A drug burden index to define the functional burden of medications in older people
Hilmer and colleagues developed a tool (drug burden index) to correlate medication use with decline in physical and cognitive performance. Medications with anticholinergic and sedative properties are associated with poorer function in community-dwelling older people. Full text is available free at: http://archinte.ama-assn.org/cgi/content/abstract/167/8/781 Hilmer SN, et al. Arch Intern Med. 2007;167:781-787.
CCGP Geriatric Pharmacotherapy Resource List Medication use leading to emergency department visits for adverse drug events in older adults
A nationally representative public health surveillance system tracked emergency department visits, and visits related to adverse drug events in older adults were analyzed. Three medications accounted for one-third of all emergency department visits for adverse drug events in older adults. Full text of the article is available free. Link: http://www.annals.org/cgi/content/abstract/147/11/755 Budnitz DS, Shehab N, Kegler SR, Richards CL. Ann Intern Med. 2007;147:755- 765. Adverse drug events among older persons in the ambulatory setting
Multiple methods were used to detect possible drug-related events in this cohort study of an ambulatory Medicare population, with over 30,000 person-years of observation. The overall rate of adverse drug events was 50.1 per 1000 person- years, with 38% categorized as serious, life-threatening, or fatal. Cardiovascular medications, diuretics, and nonopioid analgesics were the most common medication categories associated with preventable adverse drug events. The article provides more extensive information about other types of adverse drug events and strategies for prevention. The full text of the article is available at: http://jama.ama-assn.org/cgi/content/abstract/289/9/1107 Gurwitz JH, et al. JAMA. 2003;289:1107-1116. Adverse drug events in nursing homes
Handler, SM, Wright RM, Ruby CM, Hanlon JT. The epidemiology of medication- related adverse events in nursing homes. Am J Geriatr Pharmacother 2006:4:264-272. Link: http://tinyurl.com/2d52atd Handler SM, Hanlon JT. Detecting Adverse Drug Events Using a Nursing Home Specific Trigger Tool. Ann Long-Term Care 2010;18:17-22. Link: http://tinyurl.com/2vfbzud 9. Clinical Practice Guidelines
Clinical practice guidelines and older adults
CCGP Geriatric Pharmacotherapy Resource List Boyd and colleagues reviewed clinical practice guidelines (CPGs) for diseases common in older adults, and evaluated implications of applying recommendations from these CPGs to older adults with multiple morbidities. Their review suggests that adhering to current CPGs in caring for an older person with several co-morbidities may have undesirable effects. Basing standards for quality of care and pay for performance on existing CPGs could lead to inappropriate judgment of the care provided to older individuals with complex co- morbidities and could create perverse incentives that emphasize the wrong aspects of care for this population and diminish the quality of their care. Link to abstract: http://jama.ama-assn.org/cgi/content/abstract/294/6/716 Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716-724. Patient Preferences and Clinical Practice Guidelines
This article is from the August 2008 issue of the ASCP Foundation Geriatric Clinical News. The link is: http://content.enewslettersonline.com/12293/17378.html National Guideline Clearinghouse
This compilation of clinical practice guidelines is made available by the Agency for Healthcare Research and Quality. The link is: http://www.guideline.gov/ AHRQ Effective Health Care Program
The Agency for Healthcare Research and Quality maintains a Web site with a variety of useful resources, including guidelines, literature reviews and comparative effectiveness reviews. Link to Web site: http://effectivehealthcare.ahrq.gov/ Adult Immunization Schedule for 2010 The link to the schedule on the CDC Web site is: http://www.cdc.gov/vaccines/recs/schedules/adult-schedule.htm Practice guideline for the treatment of patients with Alzheimer's disease and other dementias This guideline from the American Psychiatric Association was updated in 2007:
CCGP Geriatric Pharmacotherapy Resource List http://www.guideline.gov/summary/summary.aspx?doc_id=11533&nbr=005974 Antithrombotic and thrombolytic therapy-CHEST Guidelines, 2008 http://chestjournal.chestpubs.org/content/133/6_suppl Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Link to full text: http://www.journals.uchicago.edu/doi/full/10.1086/651706 COPD Guidelines—GOLD http://www.goldcopd.org/Guidelineitem.asp?l1=2&l2=1&intId=2180 Diabetes—Standards of medical care in diabetes-January 2010, American Diabetes Association. Link to full text guidelines: http://care.diabetesjournals.org/content/33/Supplement_1/S11.full.pdf+html HIV/AIDS—Use of antiretrovirals in adults with HIV infection, from the International AIDS Society-USA; full text of guidelines are available free on the JAMA Web site at: http://jama.ama-assn.org/cgi/content/full/304/3/321 Osteoporosis—Management of osteoporosis in postmenopausal women: 2010 position statement of the North American Menopause Society. Download at: http://www.menopause.org/aboutmeno/consensus.aspx Pharmacological Management of Persistent Pain in Older Persons
This 2009 guideline is available free from the American Geriatrics Society: http://www.americangeriatrics.org/education/pharm_management.shtml Urinary Tract Infection, Catheter-associated The Infectious Diseases Society of America has released 2010 guidelines on diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults, including those who are institutionalized. The full text of these guidelines is available free at: http://www.journals.uchicago.edu/doi/abs/10.1086/650482 10. Geriatric Syndromes
Geriatric Conditions and Disability: The Health and Retirement Study
Of adults age 65 years or older, 50% have one or more geriatric conditions (or geriatric syndromes). These include cognitive impairment, falls, low body mass index, incontinence, dizziness, vision impairment, and hearing impairment. These conditions may be as strongly associated with disability as chronic
CCGP Geriatric Pharmacotherapy Resource List diseases, and should be addressed in the care of older adults. Full text of this article is available at: http://www.annals.org/cgi/content/abstract/147/3/156 Cigolle CT, et al. Ann Intern Med. 2007;147(3):156-164. Common Geriatric Syndromes and Special Problems
Link to abstract (full text free to subscribers and ASCP members): http://tinyurl.com/y8zpwr6 Sleeper RB. Consult Pharm 2009;24(6):447-462. Delirium: Diagnosis, Prevention, and Management.
From the National Institute for Health and Clinical Excellence (NICE) in the UK. A quick reference guide is also available. July 2010. Full text online: http://www.nice.org.uk/CG103 Falls and medication use
Woolcott JC, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952-1960. Link to abstract: http://archinte.ama-assn.org/cgi/content/abstract/169/21/1952 11. Potentially Inappropriate Medications in the Elderly
Updating the Beers criteria for potentially inappropriate medication use in older adults
The Beers criteria are well known as a list of medications that are considered to be potentially inappropriate in the elderly. The original list of Beers criteria medications was published in 1991 and the most recent version is from 2003. The full text of the 2003 update is available from this link: http://archinte.ama-assn.org/cgi/content/abstract/163/22/2716 Fick DM, et al. Arch Intern Med. 2003;163:2716-2724. Zhan criteria for potentially inappropriate medication use in the elderly
The best known criteria for potentially inappropriate medication use in the elderly are the Beers criteria. Zhan modified the Beers criteria for a study of potentially
CCGP Geriatric Pharmacotherapy Resource List inappropriate medication use in community-dwelling elderly and reported the results. The full text of the article is available free online. Here is a link to the abstract, which also includes a long list of articles that have referenced this study: http://jama.ama-assn.org/cgi/content/abstract/286/22/2823 Zhan C, Sangl J, Bierman AS; et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA. 2001;286(22):2823-2829. STOPP and START Criteria
The STOPP and START criteria have been attracting interest among geriatric clinicians because they are more recent than the Beers criteria and they address undertreatment among older adults along with use of medications that are potentially inappropriate. This article by the ASCP Foundation provides an overview and references: http://content.enewslettersonline.com/12293/20682.html Developing Explicit Positive Beers Criteria for Preferred Central Nervous System Medications in Older Adults This study identified 13 preferred medications for use in older adults with four central nervous system conditions: dementia, depression, Parkinson’s disease, and psychosis. Link to article: http://www.ascp.com/resources/clinical/BeersCriteriaArticle.cfm Stefanacci RG, Cavallero E, Beers MH, et al. Consult Pharm 2009;24:601-10. ASCP-AMDA Joint Position Statement on Beers criteria
ASCP and the American Medical Directors Association developed a Joint Position Statement on the Beers List of Potentially Inappropriate Medications in Older Adults. The link to the policy statement is: http://www.ascp.com/resources/policy/upload/Sta04-ASCP-AMDA-Beers.pdf 12. Prescribing Cascade
Increased incidence of levodopa therapy following metoclopramide use
In one of the early articles about the prescribing cascade, Avorn and colleagues used the New Jersey Medicaid database to determine whether there was an increase in use of anti-parkinsonian therapy in older persons (65 years and over)
CCGP Geriatric Pharmacotherapy Resource List taking metoclopramide hydrochloride. They found that metoclopramide users were three times more likely to begin use of a levodopa-containing medication compared with nonusers. Link to abstract: http://jama.ama-assn.org/cgi/content/abstract/274/22/1780 Avorn A, Gurwitz JH, Bohn RL, et al. JAMA. 1995;274(22):1780-1782. Update on the prescribing cascade
Clark, TR. Geriatric Clinical News, October 2008. http://content.enewslettersonline.com/12293/18770.html 13. Adherence or Compliance with Drug Therapy
Medication Use Safety Training (MUST for Seniors)
This Web site is sponsored by the National Council on Patient Information and Education (NCPIE), and is available at: http://www.mustforseniors.org Adult Meducation
Sponsored by the American Society of Consultant Pharmacists Foundation, the focus of this Web site is on improving medication adherence in older adults. The link is: http://www.adultmeducation.com/ Center for Connected Health
The Center for Connected Health has resources on medication adherence at: http://www.connected-health.org/programs/medication-adherence.aspx 14. Population-Specific Activities
Shown below is a list of resources that have been recommended by Certified Geriatric Pharmacists. These resources may have applicability to Domain #3 of the content outline for the Certified Geriatric Pharmacist examination, “Population Specific Activities.” Full text journal articles
Below is a series of six articles from the Canadian Medical Association Journal that provide an overview of statistics and literature evaluation. The full text of the articles is available free online.
CCGP Geriatric Pharmacotherapy Resource List Wyer PC, et al. Tips for learning and teaching evidence-based medicine: introduction to the series. CMAJ. Aug. 17, 2004. 171(4):347-348. http://www.cmaj.ca/cgi/reprint/171/4/347 Barratt A, Wyer PC, Hatala R, et al. Tips for learners of evidence-based medicine, Part 1: relative risk reduction, absolute risk reduction, and number needed to treat. CMAJ. Aug. 17, 2004. 171(4):353-358. http://www.cmaj.ca/cgi/reprint/171/4/353 Montori VM, Kleinbart J, Newman TB, et al. Tips for learners of evidence-based medicine, Part 2: measures of precision (confidence intervals). CMAJ. Sept. 14, 2004. 171(6):611-615. http://www.cmaj.ca/cgi/reprint/171/6/611 McGinn T, Wyer PC, Newman TB, et al. Tips for learners of evidence-based medicine, Part 3: measures of observer variability (kappa statistic). CMAJ. Nov. 23, 2004. 171(11):1369-1373. http://www.cmaj.ca/cgi/reprint/171/11/1369 Hatala R, Keitz S, Wyer P, et al. Tips for learners of evidence-based medicine, Part 4: assessing heterogeneity of primary studies in systematic reviews and whether to combine their results. CMAJ. March 1, 2005. 172(5):661-665. http://www.cmaj.ca/cgi/reprint/172/5/661 Montori VM, Wyer P, Newman TB, et al. Tips for learners of evidence-based medicine, Part 5: the effect of spectrum of disease on the performance of diagnostic tests. CMAJ. Aug. 16, 2005. 173(4):385-390. http://www.cmaj.ca/cgi/reprint/173/4/385 Books
Woloshin S, Schwartz LM, Welch HG. Know Your Chances: Understanding Health Statistics. 2008. This inexpensive paperback book was written for lay audiences and is very readable. Link to Amazon.com: http://tinyurl.com/29s42d2 Malone P, Kier K, Stanovich J. Drug Information: A Guide for Pharmacists. 2006. Has a chapter on “clinical application of statistical analysis,” which is reportedly very good. The book costs over $50 though. Link to Amazon.com: http://tinyurl.com/2g8app6 Online Continuing Education
A Primer on Interpreting Published Studies, 1-hour continuing education. Cost = $10. Available at: http://www.theceinstitute.org/
CCGP Geriatric Pharmacotherapy Resource List Module #19 at www.GeriatricPharmacyReview.com is 1 hour of continuing education on “Evaluation and Use of Clinical Information to Improve Patient Care.” Access to this module can be purchased for $14 for ASCP members and $35 for non-members. ##
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MUSCLE The purpose of this practical session is to demonstrate muscular tissue. Study each muscle type according to the following scheme: (i) (vii) Number and position of the blood vessels and connective tissue Smooth muscle This is a cross section through the umbilical cord. The three large blood vessels are used as examples of smooth muscle. Identify: The orientation of the bloo