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Medek.co.uk
Active Ingredient ManufacturerLaridek How does it work? Laridek® tablets contain two active ingredients, artemether and lumefantrine. These are
Malaria is caused by a protozoal parasite called Plasmodium, which is carried by
mosquitoes. During a bite from an infected mosquito, the parasite passes into the body.
Once inside, it lives and reproduces, resulting in the disease known as malaria.
The malaria parasites have various stages in their lifecycle within the body. After entering
the bloodstream during a bite from an infected mosquito, they are carried to the liver where
they reproduce. They are then released back into the bloodstream where they infect red
In the red blood cells, the malaria parasites digest haemoglobin, the red protein within red
blood cells that is responsible for carrying oxygen. When this happens, the haemoglobin is
divided into two parts; haem and globin. Haem is toxic to the malaria parasites. They
protect themselves from it by producing a substance that converts the toxic haem into a
compound called haemozoin, which is not toxic to the parasites.
Artemether and lumefantrine both work by interfering with the ability of the malaria
parasites to convert haem into haemozoin. This causes levels of the toxic haem to rise,
which kills the blood stages of the malaria parasites and stops the infection from
Laridek® tablets are given to treat malaria caused by Plasmodium falciparum parasites
(falciparum malaria or malignant malaria).
What is it used for?
Treatment of uncomplicated Plasmodium falciparum malaria in adults, children
Warning!
Laridek tablets should be taken with or after food. If the patient can't tolerate food
the tablets should still be taken, but they may be less effective. The tablets can be
If you are sick within one hour of taking a dose of this medicine you should
consult your doctor or pharmacist, as you may need to take another dose.
It is very important that you complete the prescribed course of this medicine,
unless otherwise directed by your doctor, as the medicine may not be fully
Unless your doctor or pharmacist tells you otherwise, you should avoid drinking
grapefruit juice while taking this medicine, as it may affect the level of this
This medicine may cause fatigue and dizziness. You should take care when
performing potentially hazardous activites, such as driving or operating
machinery, until you know how this medicine affects you and are sure you can
If you have kidney, liver or heart problems you should be regularly monitored
while you are taking this medicine, to check the level of potassium in your blood
(blood test), and your heart function (ECG).
Laridek® is a Medek Pharmaceuticals brand
Use with caution in Not to be used in
Complicated cases of malaria, eg affecting the brain, or causing pulmonary
Family history of an abnormal heart rhythm, present from birth, seen on a heart
monitoring trace (ECG) as a 'prolonged QT interval'
People with diseases or conditions that can cause an abnormal heart rhythm, seen
on a heart monitoring trace (ECG) as a 'prolonged QT interval' (your doctor will
know), or people taking medicines that can cause this (see end of factsheet)
History of irregular heartbeats (arrhythmias)
Disturbances in the levels of salts (electrolytes) in the blood, eg low blood
potassium level (hypokalaemia) or low blood magnesium level
This medicine should not be used if you are allergic to one or any of its ingredients. Please
inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform
your doctor or pharmacist immediately. Pregnancy and Breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other
medicines may be safely used in pregnancy or breastfeeding providing the benefits to the
mother outweigh the risks to the unborn baby. Always inform your doctor if you are
pregnant or planning a pregnancy, before using any medicine.
The safety of this medicine for use during pregnancy has not been established. It
should therefore be used with caution during pregnancy, and only if the expected
benefits to the mother outweigh any risks to the foetus. Seek medical advice from
It is not known if this medicine passes into breast milk. Women who need to take
this medicine should not breastfeed during treatment, and for at least a week
following their last dose. Seek further medical advice from your doctor. Label warnings
Take this medication with or after food.
Laridek® is a Medek Pharmaceuticals brand
Side effects Medicines and their possible side effects can affect individual people in different ways. The
following are some of the side effects that are known to be associated with this medicine.
Because a side effect is stated here, it does not mean that all people using this medicine
will experience that or any side effect.
Disturbances of the gut such as nausea, vomiting, diarrhoea or abdominal pain
Awareness of your heartbeat (palpitations)
The side effects listed above may not include all of the side effects reported by the drug's
For more information about any other possible risks associated with this medicine, please
read the information provided with the medicine or consult your doctor or pharmacist. How can this medicine affect other medicines? It is important to tell your doctor or pharmacist what medicines you are already taking,
including those bought without a prescription and herbal medicines, before you start
treatment with this medicine. Similarly, check with your doctor or pharmacist before taking
any new medicines while taking this one, to ensure that the combination is safe.
The manufacturer states that this medicine must not be taken in combination with the
following medicines, because they may increase the amount of this medicine in the blood
and therefore increase the risk of its side effects:
azole antifungals, eg ketoconazole, itraconazole, miconazole or voriconazole
macrolide antibiotics, eg clarithromycin or erythromycin
protease inhibitors for HIV infection, eg ritonavir, nelfinavir, lopinavir, indinavir.
The manufacturer states that this medicine must not be taken in combination with the
following medicines, because it may increase the amount of these medicines in the blood
and increase the chance of their side effects:
Laridek® is a Medek Pharmaceuticals brand
The manufacturer states that this medicine must not be taken with any of the following
medicines, because the combination may increase the risk of abnormal heart rhythms:
certain medicines for irregular heart rhythms (antiarrhythmics), eg mexiletine,
propafenone, procainamide, disopyramide, amiodarone, quinidine, sotalol
antidepressant medicines, eg amitriptyline, maprotiline, fluoxetine
antipsychotic medicines, eg chlorpromazine, thioridazine, haloperidol
other antimalarials, eg quinine, halofantrine (patients previously treated with
halofantrine should not receive this medicine until at least one month after their
the antihistamines astemizole or terfenadine
certain anti-infectives, eg erythromycin, clarithromycin, ketoconazole,
moxifloxacin, pentamidine, voriconazole.
Laridek® is a Medek Pharmaceuticals brand
SIHM / ISHM SEULE, UNE PARTIE DES ARTICLES PRESENTES AU CONGRES INTERNATIONAL DE GALVESTON SERA INCLUSE DANS LES ACTES, PROCHAINEMENT PUBLIES MAIS L'INTEGRALITE DES RESUMES CORRESPONDANT AUX PRESENTATIONS ONLY A PORTION OF THE PAPERS PRESENTED AT THE INTERNATIONAL CONGRESS OF GALVESTON WILL BE INCLUDED IN THE PUBLISHED PROCEEDINGS BUT ALL THE ABSTRACTS OF THE ORAL PRESENTATIONS HAVE BEEN S
Miraculous Powers of Shri Guru Granth Sahib Ji are expressed in third person as I-NESS or EGO of the humble Experienced by Swami Anand Om Parkash Swami has completely vanished. The understanding, explanation & Truth is not formed or constructed through our research. views on the hymns (shabds) quoted from the sacred Shri Guru What research does is to bring it within the realm of our