Microsoft word - evidence for acupuncture relevant to primary care.doc
The latest evidence for acupuncture – updated 28/02/11 Compiled by Mike Cummings, Medical Director of the British Medical Acupuncture Society
Contact: Allyson Brown, Support Manager to MD BMAS, 02077139437, [email protected]
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Acupuncture - A Western Scientific Approach.
1st ed. Edinburgh: Churchill Livingstone; 1998. p. 69-82.
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Oxford Textbook of Palliative Medicine.
Oxford: Oxford University Press; 2004. p. 410-24.
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editors. Soft Tissue Rheumatology.
Cambridge: Oxford University Press; 2004. p. 275-82.
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McMahon S, Koltzenburg M editors. Wall and Melzack's Textbook of Pain
. 5th ed. Philadelphia: Churchill Livingstone; 2005. p. 583-90.
o Lundeberg T. Effect of sensory stimulation (acupuncture) on circulatory and immune
systems. In: Ernst E, White A, editors. Acupuncture - A Scientific Appraisal.
1 ed. Oxford: Butterworth Heinemann; 1999. p. 93-106.
o White A, Cummings M, Filshie J. An Introduction to Western Medical Acupuncture
Acupuncture in experimental pain
o Han JS, Terenius L. Neurochemical basis of acupuncture analgesia. Annu Rev Pharmacol
o White A. Electroacupuncture and acupuncture analgesia. In: Filshie J, White A, editors.
Medical Acupuncture - A Western Scientific Approach.
Edinburgh: Churchill Livingstone; 1998. p. 153-76.
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o Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol
Evidence for acupuncture relevant to primary care
Chronic low back pain
A Cochrane review by Furlan et al of acupuncture and dry needling for low back pain, which
included 35 RCTs, concluded that ‘for chronic low back pain, acupuncture is more effective for
pain relief and functional improvement than no treatment or sham treatment immediately after
treatment and in the short term only’.1 A systematic review published in the same year by
Manheimer et al also found acupuncture to be significantly more effective than sham acupuncture in
chronic low back pain.2 More recent systematic reviews have not included meta-analysis. The
Cochrane review (including meta-analysis) is being updated and will be published soon.
Since these reviews there have been several relevant studies published. The ART (A
rial) study (n=298) from the Charite University Medical Center in Berlin of
acupuncture for chronic low back pain shows a trend in favour of verum over minimal (superficial
non-point) acupuncture, but a significant difference between verum and the no (additional)
treatment control group.3 The standard deviation in the primary outcome measure in this trial
exceeded the estimate in the sample size calculation by 50%, which reduced the intended statistical
power of the trial considerably.
Thomas et al reported positive results in their pragmatic trial of acupuncture in chronic low back
pain in primary care (n=241). They demonstrated effectiveness and cost-utility at 24 months – the cost per additional QALY was £4241.4 5 The primary outcome for additional acupuncture over
routine GP care was significant at 24 months but not at 12 months. This is a surprising result following a short course of acupuncture, since the systematic reviews demonstrate a short term effect only.1 2
The results of the very large pragmatic ARC (A
cupuncture in R
are) study on chronic
low back pain (n=3093 randomised; 11 630 total cohort) confirm effectiveness and cost effectiveness of acupuncture, with the cost per additional QALY of €10 526.6
The GERAC (Ger
upuncture trial) trial on low back pain (n=1162)7 found acupuncture
and minimal (sham) acupuncture to be superior to guideline-based standard treatment, however, acupuncture was not statistically superior to minimal (superficial non-point) acupuncture. On the basis of this, the German health authorities have decided that acupuncture will be included in routine reimbursement by social health insurance funds for the treatment of low back pain. One of the key findings in this trial was that the minimal (sham) acupuncture (often viewed as a ‘placebo’ control) was superior to guideline-based standard care (twice as good in the primary outcome measure). This calls into question the validity of making judgements about the clinical relevance of the difference between acupuncture and minimal (sham or ‘placebo’ control) acupuncture.
A large (n=638), four-arm sham controlled and comparative trial performed in the US
demonstrated no difference between individualised acupuncture, standardised acupuncture or simulated acupuncture (using blunted cocktail sticks) on mechanical low back pain, but all three groups were more than twice as effective as usual care alone.8
The NICE guidelines for the early management of persistent non-specific low back pain
(between 6 months and 1 year) include consideration of 12 sessions of acupuncture over 3 months.9 Chronic headache
The first Cochrane review on acupuncture for idiopathic headache was tentatively positive.10
Vickers and Wonderling show definitive effectiveness (not efficacy) and cost effectiveness – the
cost per additional QALY was £9180.11 12
Efficacy is still in some doubt following the results of the German ART studies in migraine and
TTH.13 14 Responder rates were good for needling but the rates in the minimal (sham) needling groups were also high. Responder rates were confirmed in a large epidemiological study (n=2022).15 The ARC study on headache confirmed effectiveness compared with usual care alone (n=3182 randomised; 15 056 total cohort),16 and confirmed cost effectiveness (n=2682), with the cost per additional QALY of €11 590.17
The GERAC trial on migraine (n=960) showed that outcomes do not differ between acupuncture,
minimal (sham) needling, and standard therapy (1st beta-blocker; 2nd flunarizine; 3rd valproic acid).18 The responder rates at 26 weeks after randomisation were 47%, 39% and 40% respectively.
Recently the Cochrane review has been updated and split into acupuncture for migraine
prophylaxis,19 and acupuncture for tension-type headache.20 The authors’ conclusions are as follows:
Acupuncture for migraine prophylaxis19 In the previous version of this review, evidence in support of acupuncture for migraine
prophylaxis was considered promising but insufficient. Now, with 12 additional trials, there is consistent evidence that acupuncture provides additional benefit to treatment of acute migraine attacks only or to routine care. There is no evidence for an effect of 'true' acupuncture over sham interventions, though this is difficult to interpret, as exact point location could be of limited importance. Available studies suggest that acupuncture is at least as effective as, or possibly more effective than, prophylactic drug treatment, and has fewer adverse effects. Acupuncture should be considered a treatment option for patients willing to undergo this treatment.
Acupuncture for tension-type headache20 In the previous version of this review, evidence in support of acupuncture for tension-type
headache was considered insufficient. Now, with six additional trials, the authors conclude that acupuncture could be a valuable non-pharmacological tool in patients with frequent episodic or chronic tension-type headaches.
Knee osteoarthritis (OA knee)
The largest sham controlled trial to date is the GERAC OA knee trial (n=1007).21 This trial used
off-point superficial acupuncture in the sham, and a third arm of conservative treatment only
(physiotherapy and NSAIDs). Both acupuncture groups (traditional Chinese acupuncture and sham
acupuncture) were significantly better than conservative treatment alone. The improvement in
WOMAC index in the real acupuncture group was very similar to that in the ART OA knee trial
(around 20% reduction at 26 weeks).22 The key difference between ART and GERAC appears to be
the effect size in the minimal acupuncture group (it was markedly higher in the GERAC trial than in
the ART trial).
An SR by White et al included 13 RCTs.23 The results from the five high quality trials (n=1334)
were pooled in meta-analysis for the primary outcome, and demonstrated a significant effect of acupuncture versus sham in short term pain. A subsequent SR by Manheimer et al found very similar results in their meta-analysis,24 although their interpretation differed in terms of clinical relevance.
The pragmatic ARC study on acupuncture for OA in the hip and knee (n=712 randomised; 3633
total cohort) has demonstrated marked clinical improvement, which is maintained at six months, from a 15 session course of treatment.25 The economic analysis performed alongside the ARC study (n=421) demonstrated cost effectiveness of €17 845 per additional QALY.26
The most recent Cochrane review of acupuncture for peripheral joint OA (lead by Manheimer)27
included 16 trials and 3498 participants. Twelve trials were on OA knee, three on OA hip and one included both. The authors concluded:
Sham-controlled trials show statistically significant benefits; however, these benefits are small,
do not meet our pre-defined thresholds for clinical relevance, and are probably due at least partially to placebo effects from incomplete blinding. Waiting list-controlled trials of acupuncture for peripheral joint osteoarthritis suggest statistically significant and clinically relevant benefits, much of which may be due to expectation or placebo effects.
We (White & Cummings)28 argue that you can only test the biological plausibility of
acupuncture against sham acupuncture, not its clinical relevance. Neck pain
The first SR of acupuncture for neck pain was neutral,29 but this was based on relatively small trials
with methodological drawbacks. The ARC study on neck pain (n=3766 randomised; 14 161 total
cohort) clearly demonstrates effectiveness,30 and combined with confirmed efficacy over sham for
acupuncture in chronic low back pain [see above], it seems reasonable to postulate that there is also
specific efficacy for acupuncture in neck pain. The economic analysis that formed part of the ARC
study found the cost per additional QALY of acupuncture in chronic neck pain was €12 469.31
A Cochrane review has been published recently,32 although this does not include the ARC study
above. It found moderate evidence that acupuncture relieves pain in chronic mechanical neck disorders. Interestingly the 10 trials included had a total of only 661 subjects.
The Cochrane review on acupuncture for shoulder pain in 2005 was inconclusive but suggested that
there may be a short term benefit on pain and function.33 Since then there have been two interesting
trials. Vas et al demonstrated the advantage of manual acupuncture to a single point (ST38) versus
sham (mock TENS) along with physical therapy rehabilitation for shoulder pain in 425 subjects.34
More recently the GRASP trial (G
cupuncture trial for chronic S
tested acupuncture against a distant superficial off-point sham and conventional orthopaedic care in
424 subjects with chronic shoulder pain.35 Acupuncture proved to be superior to sham and
conventional orthopaedic care, although the dropout rate in the sham group was rather high at 45%.
An SR in 1999 suggested some effect,36 but was based on one high quality trial.37 There have been
three trials of acupuncture in fibromyalgia since.37-40 Two high quality trials using EA have been
positive.37 41 Another study indicated a dose effect in terms of treatment frequency, but the same
study failed to show any effect of correct stimulation or location (in TCM terms).39 One RCT
showed no effect of acupuncture over pooled results in three control groups; two of the three control
groups used needling, and the study was under powered.38 Nausea & vomiting
This was the first area with a positive SR.42 The best evidence is for PONV, in which the NNT is 4
to 5 for early PONV.43 Not so relevant for primary care, but even Bandolier said it was probably
worth using! http://www.jr2.ox.ac.uk/bandolier/band71/b71-9.html
The latest Cochrane review on the subject concludes:44 P6 acupoint stimulation prevented PONV. There was no reliable evidence for differences in risks
of postoperative nausea or vomiting after P6 acupoint stimulation compared to antiemetic drugs.
A trial of electroacupuncture to SP6, referred to by urologists as PTNS (percutaneous tibial nerve
stimulation), has demonstrated efficacy of this intervention compared with sham (including the
Streitberger needle) in 220 subjects with overactive bladder symptoms.45 Other studies suggest that
the technique compares favourably to tolterodine,46 and that it is a viable long term therapy.47 Audits in primary care
These are small print, but Juliette Ross’s audit shows dramatic reductions in referral rates.48-50 Key to abbreviations
ARC – acupuncture in routine care (large cohort studies, some with randomised elements; also part
of the German Health Insurance Modellvorhaben; Berlin group)
ART – acupuncture randomised trial (part of the German Health Insurance Modellvorhaben – trial
phases; Berlin group)
GERAC – German acupuncture trial (part of the German Health Insurance Modellvorhaben;
GRASP – German randomized acupuncture trial for chronic shoulder pain
NNT – number needed to treat
OA – osteoarthritis
PONV – postoperative nausea and vomiting
QALY – quality adjusted life year (parameter used in economic analysis of healthcare
SR – systematic review
TENS – transcutaneous electrical nerve stimulation
1. Furlan AD, van Tulder MW, Cherkin DC, Tsukayama H, Lao L, Koes BW et al
. Acupuncture and dry-needling for
low back pain. Cochrane Database Syst Rev
2. Manheimer E, White A, Berman B, Forys K, Ernst E. Meta-analysis: acupuncture for low back pain. Ann Intern
3. Brinkhaus B, Witt CM, Jena S, Linde K, Streng A, Wagenpfeil S et al
. Acupuncture in patients with chronic low
back pain: a randomized controlled trial. Arch Intern Med
4. Thomas KJ, MacPherson H, Thorpe L, Brazier J, Fitter M, Campbell MJ et al
. Randomised controlled trial of a
short course of traditional acupuncture compared with usual care for persistent non-specific low back pain. BMJ
5. Ratcliffe J, Thomas KJ, MacPherson H, Brazier J. A randomised controlled trial of acupuncture care for persistent
low back pain: cost effectiveness analysis. BMJ
6. Witt CM, Jena S, Selim D, Brinkhaus B, Reinhold T, Wruck K et al
. Pragmatic randomized trial evaluating the
clinical and economic effectiveness of acupuncture for chronic low back pain. Am J Epidemiol
7. Haake M, Muller HH, Schade-Brittinger C, Basler HD, Schafer H, Maier C et al
. German Acupuncture Trials
(GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups. Arch Intern Med
8. Cherkin DC, Sherman KJ, Avins AL, Erro JH, Ichikawa L, Barlow WE et al
. A randomized trial comparing
acupuncture, simulated acupuncture, and usual care for chronic low back pain. Arch Intern Med
9. NICE guideline on low back pain: early management of persistent non-specific low back pain
. 13 May 2009.
Available from http://guidance.nice.org.uk/CG88 (accessed on 13 May 2009).
10. Melchart D, Linde K, Fischer P, Berman B, White A, Vickers A et al
. Acupuncture for idiopathic headache.
Cochrane Database Syst Rev
11. Vickers AJ, Rees RW, Zollman CE, McCarney R, Smith CM, Ellis N et al
. Acupuncture for chronic headache in
primary care: large, pragmatic, randomised trial. BMJ
12. Wonderling D, Vickers AJ, Grieve R, McCarney R. Cost effectiveness analysis of a randomised trial of
acupuncture for chronic headache in primary care. BMJ
13. Linde K, Streng A, Jurgens S, Hoppe A, Brinkhaus B, Witt C et al
. Acupuncture for patients with migraine: a
randomized controlled trial. JAMA
14. Melchart D, Streng A, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S et al
. Acupuncture in patients with tension-
type headache: randomised controlled trial. BMJ
15. Melchart D, Weidenhammer W, Streng A, Hoppe A, Pfaffenrath V, Linde K. Acupuncture for chronic headaches--
an epidemiological study. Headache
16. Jena S, Witt CM, Brinkhaus B, Wegscheider K, Willich SN. Acupuncture in patients with headache. Cephalalgia
17. Witt CM, Reinhold T, Jena S, Brinkhaus B, Willich SN. Cost-effectiveness of acupuncture treatment in patients
with headache. Cephalalgia
18. Diener HC, Kronfeld K, Boewing G, Lungenhausen M, Maier C, Molsberger A et al
. Efficacy of acupuncture for
the prophylaxis of migraine: a multicentre randomised controlled clinical trial. Lancet Neurol
19. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for migraine prophylaxis.
Cochrane Database Syst Rev
20. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for tension-type headache.
Cochrane Database Syst Rev
21. Scharf HP, Mansmann U, Streitberger K, Witte S, Kramer J, Maier C et al
. Acupuncture and knee osteoarthritis: a
three-armed randomized trial. Ann Intern Med
22. Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S et al
. Acupuncture in patients with osteoarthritis of
the knee: a randomised trial. Lancet
23. White A, Foster NE, Cummings M, Barlas P. Acupuncture treatment for chronic knee pain: a systematic review.
24. Manheimer E, Linde K, Lao L, Bouter LM, Berman BM. Meta-analysis: acupuncture for osteoarthritis of the knee.
Ann Intern Med
25. Witt CM, Jena S, Brinkhaus B, Liecker B, Wegscheider K, Willich SN. Acupuncture in patients with osteoarthritis
of the knee or hip: A randomized, controlled trial with an additional nonrandomized arm. Arthritis Rheum
26. Reinhold T, Witt CM, Jena S, Brinkhaus B, Willich SN. Quality of life and cost-effectiveness of acupuncture
treatment in patients with osteoarthritis pain. Eur J Health Econ
27. Manheimer E, Cheng K, Linde K, Lao L, Yoo J, Wieland S et al
. Acupuncture for peripheral joint osteoarthritis.
Cochrane Database Syst Rev
28. White A, Cummings M. Does acupuncture relieve pain? BMJ
2009;338:a2760. PM:19174437 29. White AR, Ernst E. A systematic review of randomized controlled trials of acupuncture for neck pain.
30. Witt CM, Jena S, Brinkhaus B, Liecker B, Wegscheider K, Willich SN. Acupuncture for patients with chronic neck
31. Willich SN, Reinhold T, Selim D, Jena S, Brinkhaus B, Witt CM. Cost-effectiveness of acupuncture treatment in
patients with chronic neck pain. Pain
32. Trinh KV, Graham N, Gross AR, Goldsmith CH, Wang E, Cameron ID et al
. Acupuncture for neck disorders.
Cochrane Database Syst Rev
33. Green S, Buchbinder R, Hetrick S. Acupuncture for shoulder pain. Cochrane Database Syst Rev
34. Vas J, Ortega C, Olmo V, Perez-Fernandez F, Hernandez L, Medina I et al
. Single-point acupuncture and
physiotherapy for the treatment of painful shoulder: a multicentre randomized controlled trial. Rheumatology (Oxford)
35. Molsberger AF, Schneider T, Gotthardt H, Drabik A. German Randomized Acupuncture Trial for chronic shoulder
pain (GRASP) - a pragmatic, controlled, patient-blinded, multi-centre trial in an outpatient care environment. Pain
36. Berman BM, Ezzo J, Hadhazy V, Swyers JP. Is acupuncture effective in the treatment of fibromyalgia? J Fam
37. Deluze C, Bosia L, Zirbs A, Chantraine A, Vischer TL. Electroacupuncture in fibromyalgia: Results of a controlled
38. Assefi NP, Sherman KJ, Jacobsen C, Goldberg J, Smith WR, Buchwald D. A randomized clinical trial of
acupuncture compared with sham acupuncture in fibromyalgia. Ann Intern Med
39. Harris RE, Tian X, Williams DA, Tian TX, Cupps TR, Petzke F et al
. Treatment of fibromyalgia with formula
acupuncture: investigation of needle placement, needle stimulation, and treatment frequency. J Altern Complement Med
40. Martin DP, Sletten CD, Williams BA, Berger IH. Improvement in fibromyalgia symptoms with acupuncture:
results of a randomized controlled trial. Mayo Clin Proc
41. Martin DP, Sletten CD, Williams BA, Berger IH. Improvement in fibromyalgia symptoms with acupuncture:
results of a randomized controlled trial. Mayo Clin Proc
42. Vickers AJ. Can acupuncture have specific effects on health? A systematic review of acupuncture antiemesis trials.
J R Soc Med
43. Lee A, Done ML. The use of nonpharmacologic techniques to prevent postoperative nausea and vomiting: a meta-
analysis. Anesth Analg
44. Lee A, Fan LT. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting.
Cochrane Database Syst Rev
45. Peters KM, Carrico DJ, Perez-Marrero RA, Khan AU, Wooldridge LS, Davis GL et al
. Randomized trial of
percutaneous tibial nerve stimulation versus Sham efficacy in the treatment of overactive bladder syndrome: results from the SUmiT trial. J Urol
46. Peters KM, Macdiarmid SA, Wooldridge LS, Leong FC, Shobeiri SA, Rovner ES et al
. Randomized trial of
percutaneous tibial nerve stimulation versus extended-release tolterodine: results from the overactive bladder innovative therapy trial. J Urol
47. Macdiarmid SA, Peters KM, Shobeiri SA, Wooldridge LS, Rovner ES, Leong FC et al
. Long-term durability of
percutaneous tibial nerve stimulation for the treatment of overactive bladder. J Urol
48. Lindall S. Is acupuncture for pain relief in general practice cost-effective? Acupunct Med
1999;17(2):97-100 49. Ross J. An audit of the impact of introducing microacupuncture into primary care. Acupunct Med
50. Myers CP. Acupuncture in General Practice: Effect on Drug Expenditure. Acupunct Med
Chronobiology International, 28(1): 76–80, (2011)Copyright © Informa Healthcare USA, Inc. ISSN 0742-0528 print/1525-6073 onlineDOI: 10.3109/07420528.2010.531490Does the Modern Urbanized Sleeping Habitat Pose a Breast Cancer Risk?Itai Kloog,1,4 Boris A. Portnov,1 Hedy S. Rennert,2 and Abraham Haim31Department of Natural Resources and Environmental Management, Graduate School of Management,
Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics Doxycycline Minocycline Doxycycline monohydrate Minocycline hydrochloride Tablets: 50 mg, 75 mg, 100 mg, 150 mg Tablets: 50 mg, 75 mg, 100 mg Capsules: 50 mg, 100 mg, 150 mg Doxycycline hyclate Solodyn extended release tablets: 55 mg, Capsules: 50 mg, 100 mg Injection: 100 mg Doxycycline Ca