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Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics
Doxycycline
Minocycline
Doxycycline monohydrate
Minocycline hydrochloride
Tablets: 50 mg, 75 mg, 100 mg, 150 mg Tablets: 50 mg, 75 mg, 100 mg Capsules: 50 mg, 100 mg, 150 mg
Doxycycline hyclate
Solodyn extended release tablets: 55 mg,
Capsules: 50 mg, 100 mg
Injection: 100 mg
Doxycycline Calcium
Syrup: 50 mg/5 mL
Minocycline is 5 times more lipophilic than
doxycycline. Minocycline achieves highest penetration into saliva and cerebrospinal fluid compared to doxycycline and tetracycline.
hypersensitivity reactions than doxycycline.
• Gastrointestinal distress (dyspepsia,
• Gastrointestinal distress (dyspepsia,
and that is for doxycycline 40 mg daily.
The following reactions occurred at >
• Photosensitivity • Vaginal candidiasis
Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics
Doxycycline
Minocycline
• Pseudomembranous colitis • Hyperpigmentation
• Tooth discoloration in forming teeth
• Tooth discoloration in forming teeth
• Photosensitivity – dependent on dose, • Decrease dose in renal impairment
• Photosensitivity – dependent on dose,
• CNS effects like vertigo, dizziness or
• Potential overgrowth of nonsusceptible
• Pseudomembranous colitis and
C.
• Autoimmune syndromes – minocycline is
associated with drug induced lupus like syndrome, autoimmune hepatitis and vasculitis.
• Hypersensitivity reactions including
• Tissue hyperpigmentation • Development of drug resistant bacteria
• In patients with penicillin allergy,
• In patients with penicillin allergy,
treatment of
Neisseria gonorrhoeae,
from
Neisseria gonorrhoeae, Syphilis
Syphilis from
Treponema pallidum, Yaws
from
Treponema pallidum, Yaws from
from
Treponema pertenue, Listeriosis
Treponema pertenue, Listeriosis from
from
Listeria monocytogenes, Vincent’s
Listeria monocytogenes, Vincent’s
infection from
Fusobacterium fusiforme,
Actinomycosis from
Actinomyces Israelii,
and infections from
Clostridium species
Actinomyces Israelii, and infections
• Adjunct treatment of amebic dysentery
• Bacterial infection caused by:
Chlamydia
• Anthrax due to
Bacillus anthracis,
trachomatis, Chlamydia psittaci, Borrelia
recurrentis, Haemophilus ducreyi,
Yersinia pestis, Francisella tularensis,
Chlamydia trachomatis,
C. psittaci,
Vibrio cholerae, Campylobacter fetus,
Borrelia recurrentis, Haemophilus
Brucella species
, Bartonella bacilliformis,
ducreyi, Yersinia pestis, Francisella
aerogenes, Shigella species
,
species,
Bartonella bacilliformis,
• Skin and skin structure infections from
S.
Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics
Doxycycline
Minocycline
aerogenes, Shigella species,
aureus. However, not drug of choice for
• Treatment of asymptomatic carriers of
• Respiratory tract infection caused by
• Respiratory tract infection caused by
Mycoplasma pneumoniae, Streptococcus
• Treatment of rosacea in adult patients
pneumoniae, Haemophilus influenzae
• Skin and skin structure infections from • Uncomplicated
Ureaplasma urealyticum
• Urinary tract infection from
Klebsiella
urealyticum infection (non-gonococcal)
• Urinary tract infection from
Klebsiella
• Prophylaxis of
Plasmodium falciparum
Source: http://www.ashp.org/DocLibrary/Policy/DrugShortages/Doxycycline-oral-current-table.pdf
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