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Table. Comparison of Doxycycline and Minocycline 18-20,37-44
Characteristics
Doxycycline
Minocycline
Doxycycline monohydrate
Minocycline hydrochloride
Tablets: 50 mg, 75 mg, 100 mg, 150 mg Tablets: 50 mg, 75 mg, 100 mg Capsules: 50 mg, 100 mg, 150 mg Doxycycline hyclate
Solodyn extended release tablets: 55 mg, Capsules: 50 mg, 100 mg
Injection: 100 mg
Doxycycline Calcium
Syrup: 50 mg/5 mL
Minocycline is 5 times more lipophilic than doxycycline. Minocycline achieves highest penetration into saliva and cerebrospinal fluid compared to doxycycline and tetracycline. hypersensitivity reactions than doxycycline. • Gastrointestinal distress (dyspepsia, • Gastrointestinal distress (dyspepsia, and that is for doxycycline 40 mg daily. The following reactions occurred at > • Photosensitivity • Vaginal candidiasis Table. Comparison of Doxycycline and Minocycline 18-20,37-44
Characteristics
Doxycycline
Minocycline
• Pseudomembranous colitis • Hyperpigmentation • Tooth discoloration in forming teeth • Tooth discoloration in forming teeth • Photosensitivity – dependent on dose, • Decrease dose in renal impairment • Photosensitivity – dependent on dose, • CNS effects like vertigo, dizziness or • Potential overgrowth of nonsusceptible • Pseudomembranous colitis and C. • Autoimmune syndromes – minocycline is associated with drug induced lupus like syndrome, autoimmune hepatitis and vasculitis. • Hypersensitivity reactions including • Tissue hyperpigmentation • Development of drug resistant bacteria • In patients with penicillin allergy, • In patients with penicillin allergy, treatment of Neisseria gonorrhoeae, from Neisseria gonorrhoeae, Syphilis Syphilis from Treponema pallidum, Yaws from Treponema pallidum, Yaws from from Treponema pertenue, Listeriosis Treponema pertenue, Listeriosis from from Listeria monocytogenes, Vincent’s Listeria monocytogenes, Vincent’s infection from Fusobacterium fusiforme, Actinomycosis from Actinomyces Israelii, and infections from Clostridium species Actinomyces Israelii, and infections • Adjunct treatment of amebic dysentery • Bacterial infection caused by: Chlamydia • Anthrax due to Bacillus anthracis, trachomatis, Chlamydia psittaci, Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Chlamydia trachomatis, C. psittaci, Vibrio cholerae, Campylobacter fetus, Borrelia recurrentis, Haemophilus Brucella species, Bartonella bacilliformis, ducreyi, Yersinia pestis, Francisella aerogenes, Shigella species, species, Bartonella bacilliformis, • Skin and skin structure infections from S. Table. Comparison of Doxycycline and Minocycline 18-20,37-44
Characteristics
Doxycycline
Minocycline
aerogenes, Shigella species, aureus. However, not drug of choice for • Treatment of asymptomatic carriers of • Respiratory tract infection caused by • Respiratory tract infection caused by Mycoplasma pneumoniae, Streptococcus • Treatment of rosacea in adult patients pneumoniae, Haemophilus influenzae • Skin and skin structure infections from • Uncomplicated Ureaplasma urealyticum • Urinary tract infection from Klebsiella urealyticum infection (non-gonococcal) • Urinary tract infection from Klebsiella • Prophylaxis of Plasmodium falciparum

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