DEP (DermoElectroPoration® System) is the new Non Invasive, Stand
alone powered drug-delivery system carrying Dermoelectroporation®
FDA cleared as alternative to injections.
Technology to deliver Ionic drug solution into the body for medicalpurposes. As result of more than five years researches, Mattioli
Dermoelectroporation®, technology is consolidated to be an incredi-
ble procedure that allows the transdermal delivery of whatever sub-stance operators want, which are otherwise not absorbed into the
skin because of the typology and dimension of their own molecules.
Current delivery perception protected.
Dermoelectroporation® infact, increases the skin’s permeability just using some skin's water based channels opened by a particular
Control on homogeneous drug delivery. controlled current delivered to the patient and allowing the sub-
100% drug protection against external agents. stances to absobed till hypodermis and muscle membranes. The system has been FDA approved for the “local administration of
Real time skin impedance measurement feature. ionic drug solutions into the body for medical purposes and can be
Real time transdermal delivery monitoring. used as an alternative to injections”.DEP SYSTEM IS MADE OF THE FOLLOWING DEVICES:
to be delivered and time of treatment.
• DEP Transdermal delivery handpiece with
of ionic drug solution of macromolecules
• Super Precision Liquid Dispenser - Super PLD.
deliverable by traditional Ionthophore-sis are now successfully deliverabledue to the new Dermoelectroporation®
• Hyperhidrosys• Skin Rejuvenation treatments
DEP SYSTEM FEATURES:
• Pre and post plastic surgery sessions
of product with 100% protection against external agents
DEP System ensures speed of action, easier regulation of either current deliv-
Operators will enjoy the accuracy provided by the DEP System
Handpiece for any skin condition and for any length of treatment.
Patients will enjoy treatments with DEP System due to the very high
comfortable sessions. Vibration feature makes electrical pulses deliv-
• No irritations, burnings or inflammations
ery perception to decrease significantly and the handpice won’t allow
TECHNICAL SPECIFICATIONS POWER SUPPLY: 9 V DC, 1A max, external AVERAGE PULSE CURRENT: +/-1 mA, 2 mA, 3 mA, 4 mA, 5 mA, user selectable, ± 20% LOAD IMPEDANCE: 0 -15 KOhm PULSE FREQUENCY: 2200 Hz BURST TIME: 10 msec. BURST FREQUENCY: 50 Hz. Before After 1.700.000 dalton Hyaluronic acid delivery through the dermis to hypodermis using Transderm® Ionto System (B&A and biopsy courtesy of Dr. Jaggy Rao, MD, Univ. of Edmonton, Alberta, Canada)
DERMOELECTROPORATION® is a new named and patented proprietary tech-nology of Mattioli Engineering Labs of Florence, Italy. As result of more than fiveyears researches, Mattioli DERMOELECTROPORATION®, technology is consoli-dated to be an incredible procedure that allows the transdermal delivery of what-
ever substance operators want, which are otherwise not absorbed into the skin
because of the typology and dimension of their own molecules. DERMOELEC-
TROPORATION® infact, increases the skin’s permeability just using some skin's
water based channels opened by a particular controlled current delivered to the patient and allowing the substances to absobed till hypodermis and muscle membranes. DERMOELECTROPORATION® allows ionic dug solutions to penetrate down till Hypodermis and it is faster than traditional Ionthophoresis. MATTIOLI ENGINEERING
With DERMOELECTROPORATION® micro and macro-molecules (greater than
800 Kdalton in size, such as Hyaluronic, Vitamins, Amino acids, Heparin,
Antinflammatories etc) are safely delivered into the body without either modifica-
tion of the ionic drug solutions pH and Electrolysis effect of the ionic solution
itself. This was not possible with traditional Ionthophoresis systems before.
DEP SYSTEM Data sheet 55003030 Mattioli Engineering Copyright - All rights reserved.
Geel – 23 juli 2011 ANTWERPEN Aanvang : 12u00 Terrein : Sas 7, Brijloopsedijk, Geel ten Aard DE FOKKERSVERENIGING “HET BELGISCH WARMBLOEDPAARD” ORGANISEERT: PRIJSKAMP VOOR HET BELGISCH WARMBLOEDPAARD OPTIE DRESSUUR Geel – 23 juli 2011 ANTWERPEN Aanvang : 12u00 Terrein : Sas 7, Brijloopsedijk, Geel ten Aard Programma : A. Vanaf 12
CANDIDA QUESTIONNAIRE For each “Yes” in section A, make a note of the point score indicated, then add these together to obtain the total for that section. Do the same for sections B and C. At the end of the questionnaire add these three figures together to obtain the Grand Total. SECTION A: MEDICAL HISTORY 1. Have you taken tetracyclines or other antibiotics for acne for one mon