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Doi:10.1016/s0736-4679(03)00197-5

The Journal of Emergency Medicine, Vol. 25, No. 3, pp. 245–249, 2003 doi:10.1016/S0736-4679(03)00197-5
Original
Contributions

RIZATRIPTAN RPD FOR SEVERE MIGRAINE IN THE EMERGENCY
DEPARTMENT—A MULTICENTER STUDY
Emile Hay, MD,* Joseph Rodrig, MD,† Amer Hussain, MD,‡ Hashmonai Derazon, MD,* Giorgio Kopelovitch, MD,† Ella Dashkovsky, MD,‡ Natalia Bokish, MD,* Michael Kafka, MD,‡ Irina Shtibelman, RN,* and Shoshana Nassimyan, RN* *Department of Emergency Medicine of the Barzilai Medical Center, Ashkelon, Israel, †Sanz Medical Center, Laniado Hospital, Netanya, Israel, and ‡Bnei Zion Hospital, Haifa, Israel Reprint Address: Emile Hay, MD, Head of Emergency Department, Barzilai Medical Center, Ashkelon 78306, Israel e Abstract—Many patients with severe migraine come to
INTRODUCTION
the Emergency Department (ED) due to failure of different
drug regimens to stop their headache. We treated 98 pa-

Migraine affects 13 to 18% of women and 3 to 6% of tients with severe migraine who were seen in three different
men, with peak prevalence between 35 and 45 years of EDs. We used rizatriptan RPD wafers 10 mg and observed
age Although there is considerable variation in the the patients for 2 h. We found that at 2 h, 92.9% (91/98) of
severity and frequency of migraine attacks among pa- the patients had pain relief, and 73.5% were pain free. The
tients and within individuals, more than half of all pa- mean time to pain relief was 26.9 ؎ 29.6 min with a median
tients with migraines have restricted their work and their of 15 min, and the time to pain free was 70.2 ؎ 47.3 min
with a median of 75 min. Eighty-five percent of the patients

social life significantly The exact pathophysiology of were free of associated symptoms, such as nausea and
migraine remains poorly understood, but numerous stud- vomiting, at 2 h with a mean time to symptom free of 55 ؎
ies support the neurovascular theory and the role of the 47.5 min and a median of 45 min. Rizatriptan was reported
to be much better than other drugs by 74.4% of the pa-
tients. Side effects were minor and transient. Recurrence of
Until the last decade, migraine patients had a rather migraine occurred part of the day in 17.1% of the patients
limited choice of antimigraine drugs. Traditional thera- and all day or almost all day in 8.6% of the patients only.
pies included simple analgesics such as acetaminophen The results were consistent in all three EDs. We conclude
and salicylates, nonsteroidal anti-inflammatory drugs, er- that rizatriptan RPD is very effective and reliable as a
gotamine, and antiemetic drugs The revolution in first-line therapy for acute migraine in the ED. It dis-
migraine therapy began with the discovery of the triptan solves immediately in the mouth without the inconve-
drugs, which activate the serotonin receptor 5-HT nience of an injection. It works fast and has few side
effects and low headache recurrence.
2003 Elsevier
and relieve the headache Several triptan drugs are being marketed, including sumatriptan, naratriptan,zolmitriptan, and rizatriptan (Rizalt௡). Other new e Keywords—migraine; rizatriptan; rizatriptan in ED;
triptans are under investigations. These drugs differ in migraine in ED
their bioavailability, onset of action, duration of action, RECEIVED: 15 February 2002; FINAL SUBMISSION RECEIVED: 4 December 2002;ACCEPTED: 7 January 2003 adverse reactions, their capability to penetrate the blood Table 1. Exclusion Criteria
brain barrier (BBB), and activation of 5-HT receptors which easily penetrates the BBB, is rapidly absorbed, and has a rapid onset of action Studies with Unstable angina pectoris.
Basilar migraine.
rizatriptan in two different doses, 5 and 10 mg, and in two forms, conventional tablets and rapidly dissolving Use of other triptans less than 24 h before beginning the freeze-dried (RPD) wafers 10 mg, showed that it is effective and well tolerated with low side effects and better quality of life after treatment The RPD Patients taking ergot derivatives, propranolol, SSRI and MAO wafer dissolves immediately in the mouth and thus has the advantage of eliminating the need for drinking water.
This form is best tolerated by the vomiting patient Patients with severe migraine attack often seek help in severe to the degree that they refrained from any physical the Emergency Department (ED). Drugs usually used to or social activity. Only patients who had at least one treat acute migraine in the ED include parenteral opioids migraine attack per month during the last 6 months and and phenothiazines These drugs, although ef- graded their headache as severe were enrolled in the fective, are nonspecific and have many side effects, in- study. For all the patients, it was the first time that they cluding severe hypotension Sumatriptan subcu- ever took rizatriptan in any form for their migraine, but taneous injections have been used to treat acute migraine not necessarily their first experience with other triptans.
in the ED with good results, with the inconvenience of Exclusion criteria are described in Eligible administering an injection. Hay reported a pain relief rate patients were treated with RzRPD 10 mg wafer and of 80% within 20 to 30 min, and pain free rate of 75% observed for 2 h. Nonresponders, patients who had no within 90 min Akpunonu et al. reported a pain relief improvement of their headache, and partial responders, rate of 75% within 34 min, and 70% of the patients had patients who had pain relief but were not pain free, received other analgesics. During the 2-h observation period, we evaluated the following parameters every 15 (RzRPD) would be superior due to its ease of adminis- min: time to cessation of associated symptoms; nausea tration, its rapid onset of action, and its specific antimi- and vomiting; photophobia and phonophobia; time to graine effect. For this reason, we conducted the follow- pain relief; time to pain free; and adverse reactions.
ing prospective unblinded study to examine the efficacy, Patients were discharged home or admitted to the hospi- tolerability, and quality of life after Rizatriptan RPD tal if their headache remained as severe as before.
wafer (RzRPD) administration as a first-line therapy for Two nurses conducted telephone interviews with each acute migraine in the ED. The study was conducted patient 24 h after discharge from the ED. Patients were simultaneously in three different Emergency Depart- asked to answer a quality-of-life questionnaire to evalu- ments. The Institutional Board for Research in Human ate the rate of migraine recurrence and associated symp- Beings did not approve the use of placebo for double- toms, and any disability that interfered with the quality of blind study. The members of the Board thought it was life after discharge Interference with quality of not ethical to give placebo to patients with severe head- life was evaluated by the persistence of nervousness, ache in the ED. We could not obtain the agreement of restriction of social and work activities, disturbed con- other companies to conduct a double-drug double-blind centration, sleep disturbance, and disturbed mood.
This study was approved by the Institutional Board The study was supported financially by Merck Sharp and Dome Pharmaceutical Co. None of the authors hasany association with the company.
MATERIALS AND METHODS
A total of 98 patients were enrolled in the study, 87.8%of them were women. The mean age was 40.39 Ϯ 9.95, Patients over 18 years of age with known migraine [the range 18 – 63 years. summarizes the presence of International Headache Society (IHS) definition of mi- associated symptoms among the patients, before and graine who came to the ED for acute migraine after RzRPD treatment. At 2 h, 90.6% of the patients attack were considered eligible for the study. Patients were free of nausea, 100% stopped vomiting, 89% were were asked to grade their headache as mild, moderate, or free of phonophobia, and 90% were free of photophobia.
Table 2. Associated Symptoms Among Patients (N ؍ 98)
Table 4. Side Effects During the 2-Hour Observation
Ninety-one patients out of 98 (92.9%) had pain reliefwithin 2 h and 73.5% of the patients were pain free by DISCUSSION
2 h. The mean time to pain relief was 26.9 Ϯ 29.6 minwith a median of 15 min, and the mean time to pain free Our study demonstrates better efficacy of rizatriptan in was 70.2 Ϯ 47.3 min with a median of 75 min achieving pain relief and pain free end points at 2 h than Eighty-five percent (85%) of the patients were free of in previous studies. The majority of our patients, 92.9%, associated symptoms within 2 h, with a mean time to had pain relief with a median time to relief of 15 min vs.
symptom free of 55 Ϯ 47.5 min and a median of 45 min.
67– 80% found in other studies, and 73.5% were pain Rizatriptan was reported to be much better than other free by 2 h with a median of 75 min vs. 40 – 49% of the drugs ever used by 74.4% of the patients, 18.9% reported it as slightly better, and only 6.7% of the patients re- same is true for the percentage of symptom-free patients ported that it was similar to other drugs. None reported at 2 h: 85% in our study with a median time of 45 min vs.
that it was worse than other therapies. The results of the 22–75% in the same studies cited We believe three EDs were not significantly different, emphasizing that these significant differences originate from the dif- the consistency of the effect of RzRPD.
ferent design of the studies. Our patients were examined Only a few patients reported side effects during the in the EDs, and it was the emergency physician who 2-h treatment schedule. The side effects are presented in decided whether that headache was consistent with the Side effects included: weakness in 4 patients definition of the IHS of migraine. It should be remem- and dizziness in 5 patients. Two patients experienced bered that a migraine patient may also have a tension euphoria. All these side effects were transient and not headache severe enough to be confused with acute mi- necessarily related to rizatriptan RPD. Three patients graine, and this patient will not respond properly to were hospitalized for 24 h for continuous pain and their rizatriptan, meaning failure of treatment. Only those se- course was uneventful. Two of them were diagnosed lected patients with acute migraine were treated with with tension headache and the third with upper respira- rizatriptan. One may conclude that the more specific the diagnosis of the attack, the better the response will be.
The results of the quality of life survey 24 h after Our results are also better than those achieved with discharge from the ED are presented in Most ofthe patients (74.3%) had hardly any headache, 17.1% hadheadache part of the day, and 8.6% continued to expe-rience headache all day or almost all day. More than half Table 5. Quality of Life 24 Hours After Release From the
of the patients had restriction of normal activities and mood disturbances. About 40% of the patients had dif- ficulties in concentration and interference with sleep.
Table 3. Time to Pain Relief, Symptom Free and Pain Free
Figure 1. Present study results compared to average results of previous studies.
sumatriptan injection, and without the inconvenience of that the patients ignored the side effects, or perhaps they thought that side effects were part of the migraine. In- Regarding recurrence of migraine among rizatriptan terestingly, two patients reported euphoria, a side effect 10 mg responders, it is reported to range between 35% that we did not find in other studies. A possible expla- and 47% In our study, the rate of recurrence nation is the activation of serotonin receptors by this was much lower: 74.3% of the patients reported they had hardly any headache during the 24 h after discharge;17.1% of the patients experienced headache part of theday and only 8.6% reported headache for the whole day.
CONCLUSIONS
Again, these differences in the results might originatefrom the rigid selection of patients and from the different We find rizatriptan RPD wafer 10 mg to be very effective method of follow-up. In our study, two nurses conducted as a first-line therapy for acute migraine attack diagnosed the telephone interviews and contacted every patient who by physicians in the ED. Most patients left the ED was enrolled in the study. The nurses explained all the without pain and without the need for additional analge- questions to the patients and the questionnaires were sics. The immediate side effects were minimal and most of the patients found it to be much better than any other Rizatriptan also showed good results in the rest of the drug. We strongly recommend the use of rizatriptan RPD parameters of quality of life except for restriction of 10 mg wafers for the treatment of acute migraine in theED.
normal life activities, disturbed concentration, and dis-turbed mood. About half of the patients reported thesedisturbances all day or part of the day.
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