Microsoft word - 2007 list english sept 16 final 20-9-06.doc
The official text of the Prohibited List
shall be maintained by WADA
and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail.
This List shall come into effect on 1 January 2007
THE 2007 PROHIBITED LIST
WORLD ANTI-DOPING CODE
Valid 1 January 2007
The use of any drug should be limited to medically justified
SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES
(IN- AND OUT-OF-COMPETITION)
S1. ANABOLIC AGENTS
Anabolic agents are prohibited. 1. Anabolic Androgenic Steroids (AAS)
a. Exogenous* AAS, including:
(5α-androst-1-ene-3β,17β-diol ); 1-androstendione
17β-ol); drostanolone; ethylestrenol
fluoxymesterone; formebolone; furazabol
androstano[2,3-c]-furazan); gestrinone; 4-hydroxytestosterone
dihydroxyandrost-4-en-3-one); mestanolone; mesterolone; metenolone;
methyltestosterone; mibolerone; nandrolone; 19-norandrostenedione
(estr-4-ene-3,17-dione); norboletone; norclostebol; norethandrolone;
oxabolone; oxandrolone; oxymesterone; oxymetholone; prostanozol
stanozolol; stenbolone; 1-testosterone
and other substances with a similar chemical structure or similar
b. Endogenous** AAS:
(dehydroepiandrosterone, DHEA); testosterone
and the following metabolites and isomers: 5α-androstane-3α,17α-diol; 5α-androstane-3α,17β-diol; 5α-androstane-
3β,17α-diol; 5α-androstane-3β,17β-diol; androst-4-ene-3α,17α-diol;
androst-4-ene-3α,17β-diol; androst-4-ene-3β,17α-diol; androst-5-ene-
3α,17α-diol; androst-5-ene-3α,17β-diol; androst-5-ene-3β,17α-diol;
ene-3,17-dione); epi-dihydrotestosterone; 3α-hydroxy-5α-androstan-17-
one; 3β-hydroxy-5α-androstan-17-one; 19-norandrosterone; 19-
Where an anabolic androgenic steroid is capable of being produced endogenously,
will be deemed to contain such Prohibited Substance
where the concentration of such Prohibited Substance
or its metabolites or markers and/or any other relevant ratio(s) in the Athlete
so deviates from the range of values normally found in humans that it is unlikely to be consistent with normal endogenous production. A Sample
shall not be deemed to contain a Prohibited
in any such case where an Athlete
proves that the concentration of the Prohibited Substance
or its metabolites or markers and/or the relevant ratio(s) in the Athlete
is attributable to a physiological or pathological condition. In all cases, and at any concentration, the Athlete
’s sample will be deemed to contain a Prohibited Substance
and the laboratory will report an Adverse
if, based on any reliable analytical method (e.g. IRMS), the laboratory can show that the Prohibited Substance
is of exogenous origin. In such case, no further investigation is necessary. If a value in the range of levels normally found in humans is reported and the reliable analytical method (e.g. IRMS) has not determined the exogenous origin of
the substance, but if there are indications, such as a comparison to endogenous reference steroid profiles, of a possible Use
of a Prohibited Substance,
further investigation shall be conducted by the relevant Anti-Doping Organization
by reviewing the results of any previous test(s) or by conducting subsequent test(s), in order to determine whether the result is due to a physiological or pathological condition, or has occurred as a consequence of the exogenous origin of a
When a laboratory has reported a T/E ratio greater than four (4) to one (1) and any reliable analytical method (e.g. IRMS) applied has not determined the exogenous origin of the substance, further investigation may be conducted by a
review of previous tests or by conducting subsequent test(s), in order to determine whether the result is due to a physiological or pathological condition, or has occurred as a consequence of the exogenous origin of a Prohibited Substance
. If a laboratory reports, using an additional reliable analytical method (e.g. IRMS), that the Prohibited Substance
is of exogenous origin, no further investigation is
necessary and the Sample
will be deemed to contain such Prohibited Substance
. When an additional reliable analytical method (e.g. IRMS) has not been applied and a minimum of three previous test results are not available, a longitudinal profile of the Athlete
shall be established by performing a minimum of three no advance notice tests in a period of three months by the relevant Anti-Doping Organization
. If the longitudinal profile of the Athlete
established by the
subsequent tests is not physiologically normal, the result shall be reported as an Adverse Analytical Finding
. In extremely rare individual cases, boldenone of endogenous origin can be consistently found at very low nanograms per milliliter (ng/mL) levels in urine.
When such a very low concentration of boldenone is reported by a laboratory and the application of any reliable analytical method (e.g. IRMS) has not determined the exogenous origin of the substance, further investigation may be conducted by subsequent tests. When an additional reliable analytical method (e.g. IRMS) has not been applied, a longitudinal profile of the athlete shall be established by
performing a minimum of three no advance notice tests in a period of three months by the relevant Anti-Doping Organization
. If the longitudinal profile of the Athlete
established by the subsequent tests is not physiologically normal, the result shall be reported as an Adverse Analytical Finding
. For 19-norandrosterone, an Adverse Analytical Finding
reported by a laboratory is
considered to be scientific and valid proof of exogenous origin of the Prohibited
. In such case, no further investigation is necessary.
Should an Athlete
fail to cooperate in the investigations, the Athlete
shall be deemed to contain a Prohibited Substance
2. Other Anabolic Agents, including but not limited to:
Clenbuterol, tibolone, zeranol, zilpaterol.
For purposes of this section:
* “exogenous” refers to a substance which is not ordinarily capable of being produced by the body naturally.
** “endogenous” refers to a substance which is capable of being produced by the body naturally.
S2. HORMONES AND RELATED SUBSTANCES
The following substances, including other substances with a similar chemical structure or similar biological effect(s), and their releasing factors, are prohibited:
1. Erythropoietin (EPO);
2. Growth Hormone (hGH), Insulin-like Growth Factors (
Mechano Growth Factors (MGFs);
3. Gonadotrophins (LH, hCG),
prohibited in males only; 4. Insulin;
Unless the Athlete
can demonstrate that the concentration was due to a physiological or pathological condition, a Sample
will be deemed to contain a Prohibited Substance
(as listed above) where the concentration of the Prohibited
or its metabolites and/or relevant ratios or markers in the Athlete
so exceeds the range of values normally found in humans that it is unlikely to be consistent with normal endogenous production. If a laboratory reports, using a reliable analytical method, that the Prohibited
is of exogenous origin, the Sample
will be deemed to contain a Prohibited Substance
and shall be reported as an Adverse Analytical Finding
. The presence of other substances with a similar chemical structure or similar biological effect(s), diagnostic marker(s) or releasing factors of a hormone listed above or of any other finding which indicate(s) that the substance detected is of
exogenous origin, will be deemed to reflect the use of a Prohibited Substance
shall be reported as an Adverse Analytical Finding
. S3. BETA-2 AGONISTS
All beta-2 agonists including their D- and L-isomers are prohibited.
As an exception, formoterol, salbutamol, salmeterol and terbutaline when administered by inhalation, require an abbreviated Therapeutic Use Exemption. Despite the granting of any form of Therapeutic Use Exemption, a concentration of salbutamol (free plus glucuronide) greater than 1000 ng/mL will be considered
an Adverse Analytical Finding
unless the Athlete
proves that the abnormal result was the consequence of the therapeutic use of inhaled salbutamol.
S4. AGENTS WITH ANTI-ESTROGENIC ACTIVITY
The following classes of anti-estrogenic substances are prohibited:
1. Aromatase inhibitors including, but not limited to, anastrozole,
letrozole, aminoglutethimide, exemestane, formestane, testolactone.
2. Selective Estrogen Receptor Modulators (SERMs) including, but not
limited to, raloxifene, tamoxifen, toremifene.
3. Other anti-estrogenic substances including, but not limited to,
clomiphene, cyclofenil, fulvestrant.
S5. DIURETICS AND OTHER MASKING AGENTS
Masking agents are prohibited. They include:
Diuretics*, epitestosterone, probenecid, alpha-reductase inhibitors (
finasteride, dutasteride), plasma expanders (
e.g. albumin, dextran,
and other substances with similar biological effect(s).
acetazolamide, amiloride, bumetanide, canrenone, chlorthalidone,
etacrynic acid, furosemide, indapamide, metolazone, spironolactone,
e.g. bendroflumethiazide, chlorothiazide, hydrochlorothiazide),
, and other substances with a similar chemical structure or similar
biological effect(s) (except for drosperinone, which is not prohibited).
* A Therapeutic Use Exemption is not valid if an Athlete
’s urine contains a diuretic
in association with threshold or sub-threshold levels of a Prohibited Substance
M1. ENHANCEMENT OF OXYGEN TRANSFER
The following are prohibited:
1. Blood doping, including the use of autologous, homologous or heterologous
blood or red blood cell products of any origin.
2. Artificially enhancing the uptake, transport or delivery of oxygen, including
but not limited to perfluorochemicals, efaproxiral (RSR13) and modified haemoglobin products (e.g. haemoglobin-based blood substitutes, microencapsulated haemoglobin products).
M2. CHEMICAL AND PHYSICAL MANIPULATION
or attempting to tamper, in order to alter the integrity and
validity of Samples
collected during Doping Controls
is prohibited. These include but are not limited to catheterisation, urine substitution and/or alteration.
Intravenous infusions are prohibited, except as a legitimate medical
M3. GENE DOPING
The non-therapeutic use of cells, genes, genetic elements, or of the modulation of gene expression, having the capacity to enhance athletic performance, is
SUBSTANCES AND METHODS
In addition to the categories S1 to S5 and M1 to M3 defined above,
the following categories are prohibited in competition:
All stimulants (including both their (D- & L-) optical isomers where relevant) are
prohibited, except imidazole derivatives for topical use and those stimulants
included in the 2007 Monitoring Program*.
Stimulants include: Adrafinil, adrenaline**, amfepramone, amiphenazole, amphetamine,
amphetaminil, benzphetamine, benzylpiperazine, bromantan, cathine***,
clobenzorex, cocaine, cropropamide, crotetamide, cyclazodone,
****, etamivan, etilamphetamine,
etilefrine, famprofazone, fenbutrazate, fencamfamin, fencamine,
fenetylline, fenfluramine, fenproporex, furfenorex, heptaminol,
isometheptene, levmethamfetamine, meclofenoxate, mefenorex,
mephentermine, mesocarb, methamphetamine (D-),
methylenedioxyamphetamine, methylenedioxymethamphetamine, p-
****, methylphenidate, modafinil,
nikethamide, norfenefrine, norfenfluramine, octopamine, ortetamine,
oxilofrine, parahydroxyamphetamine, pemoline, pentetrazol,
phendimetrazine, phenmetrazine, phenpromethamine, phentermine, 4-
phenylpiracetam (carphedon), prolintane, propylhexedrine, selegiline
and other substances with a similar
chemical structure or similar biological effect(s).
* The following substances included in the 2007 Monitoring Program (bupropion,
caffeine, phenylephrine, phenylpropanolamine, pipradol, pseudoephedrine,
synephrine) are not considered as Prohibited Substances
** Adrenaline associated with local anaesthetic agents or by local administration (e.g. nasal, ophthalmologic) is not prohibited.
is prohibited when its concentration in urine is greater than 5
micrograms per milliliter.
**** Each of ephedrine
is prohibited when its
concentration in urine is greater than 10 micrograms per milliliter.
A stimulant not expressly mentioned as an example under this section should be considered as a Specified Substance only if the Athlete
can establish that the substance is particularly susceptible to unintentional anti-doping rule violations
because of its general availability in medicinal products or is less likely to be
successfully abused as a doping agent.
The following narcotics are prohibited:
buprenorphine, dextromoramide, diamorphine (heroin), fentanyl and its
derivatives, hydromorphone, methadone, morphine, oxycodone,
oxymorphone, pentazocine, pethidine.
Cannabinoids (e.g. hashish, marijuana) are prohibited.
All glucocorticosteroids are prohibited when administered orally, rectally,
intravenously or intramuscularly. Their use requires a Therapeutic Use Exemption
Other routes of administration (intraarticular /periarticular/ peritendinous/
epidural/ intradermal injections and inhalation) require an Abbreviated
Therapeutic Use Exemption except as noted below.
Topical preparations when used for dermatological (including
iontophoresis/phonophoresis), auricular, nasal, ophthalmic, buccal, gingival and perianal disorders are not prohibited and do not require any form of Therapeutic Use Exemption.
SUBSTANCES PROHIBITED IN PARTICULAR
Alcohol (ethanol) is prohibited in-competition
only, in the following sports. Detection will be conducted by analysis of breath and/or blood. The doping violation threshold (haematological values) for each Federation is reported in
Unless otherwise specified, beta-blockers are prohibited in-competition
the following sports. • Aeronautic (FAI)
• Archery (FITA, IPC) (also prohibited
Beta-blockers include, but are not limited to, the following:
acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol,
carvedilol, celiprolol, esmolol, labetalol, levobunolol, metipranolol,
metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol.
“Specified Substances”* are listed below:
• All inhaled Beta-2 Agonists, except salbutamol (free plus glucuronide)
greater than 1000 ng/mL and clenbuterol;
• Cathine, cropropamide, crotetamide, ephedrine, etamivan, famprofazone,
heptaminol, isometheptene, levmethamfetamine, meclofenoxate, p-methylamphetamine, methylephedrine, nikethamide, norfenefrine, octopamine, ortetamine, oxilofrine, phenpromethamine, propylhexedrine,
selegiline, sibutramine, tuaminoheptane, and any other stimulant not expressly listed under section S6 for which the Athlete establishes that it fulfils the conditions described in section S6;
* “The Prohibited List may identify specified substances which are particularly susceptible to unintentional anti-doping rule violations because of their general availability in medicinal products or which are less likely to be successfully abused as doping agents.”
A doping violation involving such substances may result in a
reduced sanction provided that the “…Athlete can establish that the Use of such a specified substance was not intended to enhance sport performance…”
Current Medicinal Chemistry, 2011, 18, 1509-1514 1509 Exploring Old Drugs for the Treatment of Hematological Malignancies F. Gan#,1,2, B. Cao#,1, D. Wu1, Z. Chen1, T. Hou*,3 and X. Mao*,1,4 1Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, China 2Department of Pharmacy, The First Hospital, Xianning Universit
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