Medical treatment of dvt and pe
CHAPTER 7
MEDICAL TREATMENT OF DEEP VEIN THROMBOSIS AND
PULMONARY EMBOLUS
Original authors: Russell D. Hull, Graham F. Pineo, and Thomas W. Wakefield
Abstracted by Kellie R. Brown
Introduction
Once the diagnosis of
deep vein thrombosis (DVT) or
pulmonary embolus (PE) is
made, treatment of the condition must be undertaken. While new therapies are on the
horizon, this chapter will discuss currently accepted therapies.
Goals of Treatment (Why treat a DVT or PE)?
• To prevent a
pulmonary embolism (if not already present)
• To prevent death from
pulmonary embolism
• To prevent a recurrent
DVT
• To prevent the
post-phlebitic syndrome
How is a DVT or PE treated? (See Table 1)
DVT and
PE are treated essentially the same, with a few exceptions. Once the condition
is diagnosed,
heparin (a
blood thinner injected into a
vein or directly into the fatty
tissues of the body) is given. There are two types of
heparin that can be used. One is
called
unfractionated heparin, and this is the one that is runs directly into the
vein by
way of an intravenous line. One is called
Low Molecular Weight Heparin (LMWH),
and this is the one that is injected directly through the skin into the fatty tissues of the
body. Either can be used, but
LMWH is generally preferred, unless the patient has
kidney failure.
Once the
heparin has thinned the blood enough (as determined by blood tests), an oral
blood thinner can be started. This is called
warfarin (commonly known as
Coumadin). The
heparin is continued until the
warfarin has reached an effective level,
as determined by a blood test called the
INR (which stands for
international normalized
ratio). The
INR should be about 2 to 3 in most cases. At this point the
heparin can be
stopped.
The
warfarin is continued for various amounts of time, depending on the clinical
situation. In most uncomplicated cases of a first time
DVT or
PE, the
warfarin is
continued for 3-6 months. In certain cases, when the
DVT or
PE is recurrent, or when
the risk factors for
DVT or
PE are not temporary (such as a blood clotting disorder),
warfarin may be maintained for life.
Provided by the American Venous Forum: veinforum.org
What if blood thinners can’t be used?
If
heparin or
warfarin can’t be used, either because the patient can’t tolerate it or they
have a high risk of bleeding from it, then a
vena cava filter can be used.
A vena cava
filter is a mesh “umbrella” device that is inserted into the large
vein in the abdomen
using a catheter inserted in the groin. This catches any
clot that may break off from the
clot in the leg, and prevents it from traveling to the lung and becoming a
PE.
Surgery to remove the
clot, either from the leg (as in a
DVT) or from the lung (as in a
PE) is rarely done. If the symptoms from the
DVT or
PE are very severe and life or limb
threatening, then
thrombolysis (
clot dissolving drugs) can be considered.
Some patients with a
pulmonary embolus are very ill. If a patient with a
PE has a very
low blood pressure, or is having a lot of trouble keeping enough oxygen in the blood,
then a more aggressive treatment may be done. One option for more aggressive
treatment is an injection of a medication to break up clot. This is called
thrombolysis.
This can break up the clot in the lung arteries, but it could also break up clot in other
places in the body, so it can cause bleeding. The most dreaded complication of this
treatment is to bleed into the brain. Because of the risk of this,
thrombolysis is used only
if the patient is not able to keep up their blood pressure or oxygen level.
Another aggressive treatment that could be tried is to remove the clot from the artery that
has the
PE in it. This can be done using a catheter placed from the groin and passed up
into the lungs, or it can be done with surgery. This is only done in patients who are likely
to die without this treatment.
Is there anything else that can be done to help the symptoms?
In addition to medication or a
vena cava filter, patients who have a
DVT should wear
elastic compression stockings for 2 years after the DVT is diagnosed. This will help
prevent the
post-thrombotic syndrome; long-term
swelling, lower leg
skin changes, or
even skin breakdown (
ulcers). Also, patients who have a
DVT can walk around as usual.
Bed rest is not encouraged. Leg elevation when at rest is helpful.
What if the DVT is in the arm?
Most
DVTs are located in the legs. However,
DVT can occur in the arm. If it does, it
should be treated just as lower extremity
DVT’s are treated. Most
DVTs in the arm are
caused by placement of central venous catheters (which are large IVs that are placed in
the large
veins of the arm and neck.) If one of these catheters is present in a
vein that has
clot in it, it should be removed and blood thinners should be started just as in the case of
a leg
DVT.
If the
clot is thought to be due to
thoracic outlet syndrome (a condition where the
opening from the chest into the arm isn’t large enough, and the vein gets compressed with
arm movement), then
thrombolysis is often used, followed usually by surgery to make
the
thoracic outlet larger.
Provided by the American Venous Forum: veinforum.org
Conclusion
DVT and
PE are treated essentially the same. Initial treatment usually consists of
LMWH, followed by
warfarin. Once the
warfarin levels are appropriate, the
LMWH is stopped. The
warfarin is continued for 3-6 months in most cases of a first time
DVT or
PE. In the case of a recurrent event,
warfarin may be continued for life. If
blood
thinners aren’t able to be used, a
filter can be placed to prevent the
clot from travelling
to the lungs. If symptoms are very severe, removal of the
clot from the
vein, usually by
thrombolysis, can be undertaken.
Table 1: DVT and PE Treatment Summary
Initial Treatment of DVT or PE
• Low molecular weight heparin (LMWH) or IV heparin should be started.
• This should be continued for at least 5 days. • Warfarin (an oral blood thinner) can be started once the heparin is at appropriate
• Heparin can be stopped once the Warfarin is at an appropriate level (INR of 2-3).
Additional Treatments
• Thrombolysis can be considered if the clot is severely symptomatic, or if it life or
• Vena Cava Filter can be used if blood thinners cannot be used, or if they fail.
• Surgery to remove the clot is not routinely used. It may be considered in very
Length of Warfarin Therapy
• For patients with a first time DVT or PE due to a reversible risk factor, treatment
with Warfarin is recommended for at least 3 months.
• For patients with a first time DVT or PE who have no identifiable risk factors,
treatment should continue for at least 6 to 12 months.
• Patients with a DVT or PE who have no identifiable risk factors should consider
• For patients with a first time DVT or PE who have a known clotting disorder should
be treated for at least 12 months, and possibly indefinitely.
• For patients with more than one known DVT or PE episode, warfarin therapy should
Post-thrombotic Syndrome
• An elastic compression stocking with a pressure of 30-40mmHg at the ankle (high
grade compression) should be used for 2 years after an episode of DVT. This helps to prevent long-term symptoms.
Provided by the American Venous Forum: veinforum.org
Source: http://www.veinforum.org/uploadDocs/1/Chapter-7---Medical-Treatment-of-Deep-Vein-Thrombosis-and-Pulmonary-Embolism.pdf
Prof.ssa Stefania Stefani Titolo di studio First class Degree In Biological Sciences (1980) Carriera accademica : Post .doc in Microbiology and Virology, 1989; Associate Professor 1991- 2001; Ful Professor in Microbiology from 2001; Attuale Posizione accademica : Ful Professor of Microbiology Settore scientifico-disciplinare : BIO/19 Principali insegnamenti tenuti
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