Uzma Yaqub***, Shazia Akbar*, Amran Waheed*, M. Saleem****, and Nasir-ud- ABSTRACT
Egyptians papyrus, Mesopotamian clay tabletscontained Aloe as an active ingredient used in curing This research shows the vital significance and infections, treating skin problems and as a laxative importance of Aloe Vera. It is a descriptive research. Aloe Vera is a vitally important plant that has been The word Aloe vera appears to be derived from Arabic used for different oilments i.e. geotron testinal, gont word “Alloeh”, which means “a shining bitter boils, etc. It has several other properties or substance.” We still refer to “bitter Aloes” describing charactertics incluidng antibacterial, anti-inflamatory the laxative drug still listed in U.S. pharmacopoeia and antiseptic attributes. Easy growth, maintenance today. There are many romantic tales about Aloe, and multiple uses of aloe plant’s constituents have suggesting that Egyptian queens, Nerfertiti and promoted several elaborated investigations in public Cleopatra, used it as part of their regular beauty regimen [5]. Supposedly Alexander the Great in 333 B.Coccupied the island of Socotra in the Indian ocean for Key words: Aloe vera, Glycoproteins, Aloein, Aloe-
its famed Aloe supplies, needed to treat his wounded soldiers [3,6]. Aloe was used by Hippocrates and Arabphysicians, and was introduced to Western INTRODUCTION
Herbs have been used for different remedies in all Aloe is also common in both traditional Chinese and cultures. In Asia, plant products and plant-derived drugs Ayurvedic medicine. The Chinese describe Aloe’s skin have been used therapeutically for centuries. More and the inner lining of its leaves as a cold, bitter remedy recently, people have become more interested and which is downward draining and used to cure better informed about the use of herbs [1]. The use of constipation due to accumulation of heat [7], the gel herbal remedies reached its zenith in late 1800s and is considered cool and moist. In Ayurvedic medicine, early 1900s [2]. In early part of 20th century a dramatic the traditional medicine of India, Aloe has multiple uses decline in use of herbal remedies began in USA, due inclusive of laxative, antihelminthic, hemorrhoid to isolation and chemical synthesis of structural remedy, and uterine stimulant. It is used topically, often analogs and so herbal remedies disappeared from in combination with licorice root, to treat eczema or pharmacy shelves. Fifty years later, trend towards psoriasis. In Arabian medicine, the fresh gel is used herbal remedies reverted and pharmacy shelves started on the forehead as a headache remedy or rubbed on to fill again. A survey in 1997 showed that nearly sixty the body to cool it in case of fever, as well as being million people were using herbs and a 75% increase used for wound-healing, conjunctivitis, and as a in sales occurred over the past years [2]. In fact, herbal disinfectant and laxative [4]. The aloe gel has been medicines played an important role in treating and extensively used in gastrointestinal disorders, preventing people from debilitating diseases since including peptic ulcer, and its clinical efficacy has been long. The role of plant-derived medicine in treating diseases will ever increase. Thousands of plants havebeen claimed to possess medicinal properties.
In recent times, Aloe vera gel has been used as an Throughout the world, today, extensive investments active ingredient in hundreds of skin lotions, sun have occurred for the therapeutic applications of herbal blocks and cosmetics [13]. The gel’s use in cosmetics plant-resources, which are of unlimited abundance has been increased by claims that it has anti-aging around us, to improve the quality of life. Aloe vera is a effects similar to vitamin A derivatives [13]. Aloe gained vitally important plant that has been used in folklore popularity in the United States in the 1930’s with reports for different purposes, such as for healing boils, wounds, of its success in treating X-ray burns [14]. Recently, burns and treatment of different ailments. Ancient Aloe extracts have been used to treat canker sores * PCSIR Laboratories Complex, Lahore. **IMMBS, The University of Lahore, Lahore. *** Lady Willingdon Hospital, Lahore.
**** Department of Botany, Govt. College, Lahore.
Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
Aloe Vera: A Plant of Vital Significance
Table - 1: Significant Clinical Developments in the Use of Aloe vera
Clinical Applications
50 B.C. Celsius, a Greek physician introduced Aloe Sap as laxative [20].
41-68 A.D. Aloe vera plant described in the book
Sap as healing agent. Additionally, induces sleep, "Greek Herbal" of Dioscorides. cleanses stomach, treatment for boils, ulcerated genitals, stops hair loss, heals tonsil, diseases of mouth and eyes [20]. 200 A.D. Galen, Antyllus, Aretaces, and many other
For different clinical purposes [20].
Southern European physicians used Aloe as medicine.
700-800 A.D. For the first time Chinese used Aloe vera.
For the of treatment of sinus, fever and Convulsions in children by Aloe [20].
Aloe (dried sap) was introduced to English For the treatment of external wounds and diseases 1700-1900
Carl Von Linne, 1720, described the plant As purgative and skin protectant [20]. For the treatment as Aloe Vera. In 1820 Aloe vera was officially for radiation injuries, ulcers, burns, dermatitis and listed in United States pharmacopoeia other skin injuries and diseases [20].
(U.S.P.) [20]. Aloin, The sap prepared as a purified product for commercial use. 1950 A.D.
A Russian scientist discovered the utility of For the treatment of parasitic diseases and several Aloe vera juice for various diseases.
1975 A.D.
Robert discovered that the plant has other For ringworm, skin allergies, abscess, hot spots, multiple applications in animals [20].
Suzuki et al., (1979) isolated two lectins from Hemagglutinating and mitogenic activity [21].
leaves. of Aloe arborescence Miller [21].
Bland discovered Aloe vera juice as a Helps digestive processes, controls infections and 1987 A.D. Burn described that the disease shingles
Aloe vera as remedy for shingles [20].
(Herpes Zoster) is caused by the same virus that also causes chicken pox and common herpes.
1991 A.D.
The Aloe extract acts as modulator-system towards wounds, inflammation and is valuable for managing Davis et al., described mannose 6- It improves wound healing and inhibits inflammation A glycoprotein was isolated from Aloe The glycoprotein promoted cell growth [25] and proliferation of human normal dermal cells and baby hamster kidney cells. 2000 A.D.
Pecere and co-workers [27] reported Aloe Emodin (hydroxyanthraquinones) from Aloe vera leaves has antineuroectodermal tumor activity both in vitro and vivo.
Wound-healing via cell proliferation and migration Choi et al. [29] isolated beta- sitosterol from Beta-sitosterol has an angiogenic effect in Aloe Vera. Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
M.A. Saeed, Ishtiaq Ahmad, Uzma Yaqub, Shazia Akbar, Amran Waheed, M. Saleem, and Nasir-ud-Din [15,16], stomach ulcers [10] etc. Many homes keep is genus of shrubby, scattered, succulent plant of the a plant handy in the kitchen where it readily thrives in Lily family (Liliaceae). There are over 250 species of bright sunlight with little care. In case of a minor burn, Aloe grown around the world and are native to Africa.
a fresh leaf can be cut and the gel of the inner leaf Most of them have rosette of leaves at the stem, but applied directly to the burn immediately after the injury.
no stem. Several species are cultivated as ornamentals The inner leaf lining of the plant is often used as a due to their sharp pointed spiny leaves and colorful natural laxative. In a quite recent survey (1990) of clusters of yellow or red flowers. Today two species members of a health-maintenance organization, Aloe are grown commercially, namely Aloe barbadensis vera was used by 64%; of these, 91% believed it had Miller, also called Aloe vera, and Aloe arborescence been helpful [17]. Aloe is also an ingredient in [51]. Tubular yellow flowers are produced annually in the spring. The Aloe plant is grown in warm tropicalareas and cannot survive freezing temperature. Mature Although, Aloe has remained stalwart over the aeons plant grows as tall as two and a half inches to four of time since the Biblical era to the 20th century, but it feet, with the average being around 28-36 inches in has never achieved a true notoriety as other products length. Each plant has 12-16 leaves that, when mature, i.e. foxglove, digitalis, cinchona (quinine), or willow bark may weigh up to 3 pounds. The plant can be harvested (acetyl salicylic acid). This position of “poor relative” every 6 to 8 weeks by removing 3 to 4 leaves per plant.
across the tracks has been the fate of Aloe, partially The Aloe barbadensis and Aloe arborescence are grown because of the failure of industry to fund scientific in the United States in the Rio Grande valley of South investigations and because of the slow progress of Texas, Florida and Southern California. Internationally science in developing models to test Aloe. The first the plants can be found in Mexico, the Pacific rim real investigation, which provided scientific countries, India, South America, the Caribbean, enlightenment concerning Aloe’s therapeutic efficacy started early in twentieth century [19]. That was theage when the medicinal chemists traveled extensively Chemistry of Aloe
and bought back plants, reputed for medicalapplications including cathartics, in order to isolate There are more than 200 compounds found in Aloe and characterize active substances using the barbadensis, about 75 of which have biological activity chemistry of the day. The significant clinical [46, 47, 50, 52-58]. The prominent components are developments in the applications of Aloe vera are listed anthraquinones [35-38], Aloin [44], Aloe emodine polysaccharides [48-53], enzymes [46,47], reducingsugars [39], organic acids, metallic cations [34]. The The precise and comprehensive isolation and analytical Aloe gel or fillet, which is stored in the inner portion of techniques have made it relatively easier to provide the leave, contains 99.5% water and 0.5% solid matter.
more information about the active principles of this Table-2 shows the chemical constituents of Aloe vera wondrous and magical Aloe plant [30,31]. Thus a large number of chemical substances have been identified, Biochemistry
which act as cathartic, emollients, accelerator ofwound-healing [28] and modulator of immune response The solid ingredients in Aloe gel are divided into large [32,33]. These include inorganic ions ( Na, K, Ca, Mg, molecules (0.1 %) and small molecules (0.4 %). Large Zn, etc.) [34] and small and large organic chemicals molecules are polysaccharides and the minor of quinone family [35-38], free sugars [39], constituents include a mixture of proteins carbohydrates (polysaccharides) [40-45], enzymes (glycoproteins), and compounds of lower molecular [46,47], lectins [48,49], proteins and the products of weights, such as sterols, terpenes and other their breakdowns i.e. peptides and amino acids), Aloe vera: Potentially Active Chemical
Aloe (urdu name ghigwar, local name kawar gandal), • High molecular-weight constituents e.g.
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Aloe Vera: A Plant of Vital Significance
Table 2: Constituents of Aloe vera and their Activity
Number Identified
Twenty amino acids required by humans have Component of proteins that are required for the been found, including 7 of the 8 essential functional proteins, such as muscle tissues, Anthraquinones Aloe vera provides 12 Anthraquinones, In small quantities, anthraquinones act as potent including aloe emodin, aloetic acid, aloin, antimicrobial [59] and antiviral 60 ] agents. In high concentration, these compounds exert a chrysophanic acid, emodin, ethereal oil, ester powerful purgative effect. Topically they can of cinnemonic acid, isobarbaloin, and absorb ultraviolet light, inhibit tyronase activity, reduce the formation of melanin [57, 61].
There are 8 Enzymes isolated from Aloe vera, Most of the enzymes help in the break-down of including aliiase, alkaline phosphotase, food-sugars and fats. Some of the enzymes may carboxypeptidase, inactivates bradykinins, produces anti-inflammatory effect [46, 47].
Two Hormones are known from Aloe vera , Both of these play an important role in wound- healing and anti-inflammatory effect.
This woody substance provides penetrating power in Aloe vera skin-penetrations, so having the ability to carry other active ingredients deep into the skin to nourish the dermis [62].
These are essential for good health and known to work in certain combination with each other, Manganese, Potasium, Sodium and Zinc.
vitamins and other trace-elements. Magnesium lactate inhibits histidine decarboxylase and prevents the formation of histamine from amino acid, histadine [47]. Histamine is released in many allergic conditions and causes intense itching and pain.
These soapy substances form 3% of the gel and are general cleansers, having antiseptic properties [63].
The plant provides 4 main plant-steroids: Sterols are anti-inflammatory agents, whereas lupeol also possesses antiseptic and analgesic Aloe vera provides both monosaccharides, Monosaccharides have anti-inflammatory action (glucose and fructose) and polysaccharides and polysaccharides posses antiviral, immune-
(glucomannans and polymanose).
modulating activity [64-67, 68] such as Acemannan [66-68].
Aloe vera contains many vitamins, except Vitamin B’s and Choline are involved in amino- acid metabolism, B12 plays an important role in production of RBCs, Folic acid is involved in the Riboflavin, B12), F, Choline and Folic acid.
Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
M.A. Saeed, Ishtiaq Ahmad, Uzma Yaqub, Shazia Akbar, Amran Waheed, M. Saleem, and Nasir-ud-Din a) Polysaccharides: glucomannan [42,45] and found to have a proliferation-promoting activity on human (d) Lectins: Lectins [48,49,70,71] with different
haemagglutinating activities have been isolated. Aloctin
Low molecular weight constituents e.g.
I and Aloctin II were isolated from leaf pulp [70]. The anthaquinones, vitamins, saponins, sterols, etc.
Aloctin II activity was inhibited by N-acetyl-D-galactosamine, whereas the Aloctin I was not inhibited (a) Polysaccharides: The polysaccharides make up
by different sugars (twenty) tested for specificity. Two approximately 20 percent of the solid content and lectins [48] had also been isolated from leaves of Aloe comprise mostly a mixture of polysaccharides of a arborescence, the P-2 with molecular weight 18000 linear, highly acetylated β 1-4 Mannan, branched and S-1 with molecular weight 24 kDa. The P-2 and dextrans, pectic acids and other polysaccharides with S-1 contain more than 18% and 50% neutral negative charge. Polysaccharides hexose makes up carbohydrates by weight, respectively. Both of these 5 to < 10 % of the total solids. Associated closely exhibit haemagglutinating activity, whereas P-2 also with these polysaccharides are small molecules, exhibits mitogenic activity on lymphocytes.
primary charged ions. The gel or mucilage obtained Interestingly, both of them contain a high proportion of from the leaf flesh contains quite different compounds acidic amino acids (i.e. Asp and Glu), and low from the bitter latex extracted from the leaf-lining. Aloe proportion of Met and His. A lectin with a molecular gel is 99% water with a pH of 4.5 and is a common weight 35 kDa was isolated from leaf-skin of Kidachi ingredient in many non-prescriptional skin conditioners.
Aloe [71] that showed Haemagglunating and The gel contains an emollient polysaccharide, mitogenic activity. The sequence of this protein is highly glucomannan [42,45]. It is a good moisturizer, which homologous to that of mannose-binding lectin from accounts for its use in many cosmetics. Acemannan [44], the main carbohydrate in the gel, is a water-soluble long-chain mannose polymer, which (e) Anthraquinones: The leaf lining (latex, resin or
accelerates wound-healing, modulates immune sap) contains anthraquinone glycosides [35-38] (aloin, function (particularly macrophage activation and Aloe-emodin and barbaloin) that are potent stimulant production of cytokines) and demonstrates laxatives. These water-soluble glycosides are split by antineoplastic and antiviral effects.
intestinal bacteria into a glycones which effect thelaxative action. The laxative effect from Aloe is stronger (b) Proteins: Proteins in the gel, on the other hand,
than from any other herb, including senna, cascara or make up 1 % of the solid content of the gel extract.
rhubarb root; it also has more severe side-effects, such The predominant proteins in gel-extracts are lower as cramping, diarrhea, and nausea [72]. For medicinal molecular-weight (11,000 and 14,000 kDa respectively, use, the leaf-lining is dried and the residue is used as for the two peptide chains). They are probably herbal laxative. The products are usually taken at associated with lectin and may account for the bedtime. They are poorly absorbed after oral administration, but moderately well-absorbed afterbacterial hydrolysis. They are eliminated in the urine, (c) Glycoproteins: Glycoproteins have been isolated
bile, feces and breast milk. They turn alkaline urine from Aloe. The homogeneous glycoprotein [69] having red. Most of herbalists recommend that they should 34% carbohydrates, of molecular weight 40 kDa, be avoided during pregnancy, due to the risk of stimulates DNA synthesis in baby hamster kidney- stimulating uterine contractions and also avoided cells and exhibits lectin properties by reacting with during lactation, due to the risk of excretion in breast sheep cells. The glycopreotein fraction from Aloe vera milk. Aloe is seldom recommended as a first choice gel exhibits proliferation-promoting activity in human among laxative preparations, due to the severe and hamster cells and enhances wound-healing with cramping and nausea associated with its use.
significant cell- proliferation and migration. Anotherglycoprotein fraction (protein 82%, carbohydrate 11%)with a molecular weight 29 kD from Aloe vera gel was Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
Aloe Vera: A Plant of Vital Significance
values were completely restored after six month. It isalso suggested that the mucopolysaccharides, one The Aloe had been used for the treatment of many of the ingredients in Aloe, play an important role, by ailments i.e. gastrointestinal, gout boils, etc. by folks acting as a growth factor. This growth-factor contributes of many nations since long. However, real scientific to wound-healing by stimulating fibroblasts (connective- research into Aloe vera resulted in the isolation of Aloin tissue cells) to produce more collagen, which in turn in 1900s, which was used as laxative until World War increases the remodeling of the wound and fills in the II. In the 1930s research began focusing in Aloe’s wound area. Acting synergestically, Aloe may keep benefits. Aloe has been used to cure X-ray dermatitis the wound moist and at the same time allow oxygen [73]. It was concluded that results as a whole had to penetrate the wound, adding to regeneration.
been satisfactory when the treatment of Aloe vera leaf Grindlay and Reynolds [81] revealed that Aloe seems was given to more than 50 cases of X-Ray dermatitis.
to promote healthy-cell growth: if a cell is cancerous, Further research confirmed these findings for Aloe, growth is not stimulated. Winters [82] found that fresh helping to relieve eczema, thermal burns, scalding, Aloe vera leaves contained lectin-like compound, which sunburn, minor injuries, and certain allergies, including enhanced the growth of normal human cells in tissue- culture, but not tumor cells. This was further confirmedin case-reports of El Zawarhy et al., [83] in which it is Detailed studies explored Aloe’s several other pointed out that Aloe vera gel promotes the characteristics, including that of antibacterial, anti- regeneration of normal tissue but does not have the inflammatory, and antiseptic properties of Aloe vera.
similar growth-patterns in carcinogenic tissue. Jeffrey Aloe may penetrate injured tissue, relieve pain, dilate Bland [7] studied the effects of Aloe vera juice- capillaries, and work as an anti-inflammatory agent.
consumption on urinary indican, stool specific-gravity, It has also been shown by Davis and co-workers gastric and bowel motility. Urinary indican values [22,23,74-76] that certain amino acids, vitamins, RNA decreased, indicating lowered conversion of tryptophan act as anti-inflammatory. These and other compounds by bowel bacteria, an improved protein-digestion and are grouped together to form the inhibitory systems absorption, as well as reduced bowel putrefaction. This [22,74]. Glycoproteins (enzymes) form a part of this change, by itself, could help in preventing colon cancer.
system [5]. Immune stimulators, growth-factors andmuco-polysaccharides heal wounds and are grouped The biological and biochemical research has delineated together to form stimulatory system [23,75,76]. Many various properties and mechanisms leading to clinical active components in both systems synergize, so that implications of Aloe. Attributes, such as moisturizing the final total activity in each system is greater than and penetrating properties, are well known, but its healing abilities and analgesic action as well asbacterial activity need to be further elaborated.
Diabetics exhibit poor wound-healing, due to poorcollagen formation and reduced wound-healing and The research conducted during the last two decades reduced wound-tensile strength. The diabetic fibroblast contributes further to the useful effects of Aloe suffers from premature aging. Aloe vera reduced biochemicals that are miraculously effective and a inflammation and improved wound-healing in both the summary of clinical applications of Aloe vera is normal and diabetic states, in a dose dependent- response fashion [77]. Aloe vera activates enzymesfound in the pancreas; it helps the blood sugar-content COMMERCIAL SIGNIFICANCE OF ALOE
in individuals suffering from hypoglycemia and diabetes[78,79].
The original commercial use of the plant was to growit for the production of a latex substance called Aloin A mixture of Aloe vera and Aloe arborescence was [30], which is yellow and, possess bitter and lingering studied for its therapeutic effects on the cirrhosis taste. The latex of Aloe contains the laxative patients by a Japanese research team [80]. The liver- anthraquinones that have been shown to possess function tests have shown that AST, ALT and total substantial antimicrobial activity against a wide variety bilirubine values were significantly reduced and normal Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
M.A. Saeed, Ishtiaq Ahmad, Uzma Yaqub, Shazia Akbar, Amran Waheed, M. Saleem, and Nasir-ud-Din Table 3: Clinical Applications of Aloe vera
1. Antimicrobial
Aleo gel is bacteriostatic or bactericidal against a variety of common wound-infecting bacteria in vitro:Staphylococcus auerus, Streptococcus pyogenes, Serratia marcescens, Klebsiella pheumoniae, Pseudomonas aeruginosa, E. coli, Salmonella typhosa and Mycobaterium tuberculosis[4,59].Aloe-emodin also inhitbits the growth of Helicobacter pylori in a dose- Acemannan acts alone and synergistically with azidothymidine(AZT) [64,65,85] and acemannan hydrogel is used as treatment for persons infected with HIV relevant to CD44 Aloe vera extract (0.5%) in a hydrophilic cream had a significantly enhanced healed lesions Aloe extract treatment of guinea pig feet that had been infected with Trichophyton mentagrophytes resulted in a 70% growth inhibition compared with untreated animals [87]. 2. Antineoplastic
Aloin A and B, aloesin and aloeresin were devoid of antitumor activity effects on human K562 leukemia cell lines [66]. Acemannan has demonstrated activity against feline leukemia virus and solid [88-93], and maligrant tumors 28 and inhibits hepatic tumor induction [94,95]. In preliminary studies it has been significantly enhanced neatly a year survival [96] 3. Endocrine
Aloe gel has been shown to lower blood sugar in diabetic mice [97,98], as well as normal mice [99]. Nearly half of diabetic patients surveyed in Texas reported using Aloe vera or other herbal remedies as complementary therapies for their diabetes [100]. Aloe gel to enhance the hypoglycemic effect of glibenclamide when given orally to diabetic patients [99,101]. 4.Gastrointestinal
Stimulant laxative (leaf lining), gastric and duodenal ulcers (gel), inflammatory bowel disease. Barbaloin, or loin, derived from inner sheath cells of the leaves, is a bitter, yellow laxative. Affects the sodium/potassium pump and chloride channels at colonic membrane [102,103]. Aloe’s Anthraquinones enhance intestinal propultion and water secretion in mice [104]. The Anthraquinones present in latex stimulate chloride and water secretion in large intestine, inhibits its reabsorption and stimulate peristalsis [105,106], and acts as a cathartic in Aloe-emodim inhibits growth Helicobactor pylori in a dose –dependent fasion [84]. Aloe vera inhibits gastric acid secretion in mice and rats and has protective effects against gastric mucosal demage in rats [108], Aloe vera extract reduced asprin-induced gastric mucosal injury in experimental rats [109], and extracts also suppressed the ulcerogenic effects of stress in Acemannan is under consideration as an experimental remedy for inflammatory bowel disease 5.Immune
Acemannan acts as immune stimulant and anti-inflammatory [113,114], increases monocyte modulation
and macrophage activity and cytotoxicity, stimulates killer T-cells and enhances macrophage candidacidal activity in vitro [115-117]. Acemannan enhances macrophage release of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interferon gama (INF-γ) in a dose dependent fasion [115,118]. Aloe extracts also blocks prostaglandin and thromboxane production from arachidonic acid , reducing inflammation [4,119,120]. Acetylated mannans from Aloe in mice stimulated an increase in white blood counts, splenic cellularity, and absolute numbers of neutrophils, lymphocytes and monocytes [121-126]. Aloe reduced the production of interleukin-10 following exposure to ultraviolet radiation, reduces the suppression of delayed type hypersensitivity [127-129]. and blocked mast cell inflammatory responses to antigen-antibody complexes [130,131]. Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
Aloe Vera: A Plant of Vital Significance
The other main ingredient of Aloe is called gel, whichcovers inner portion of the leaves. It is clear, colourless, J.L. Vogelzang, “What You Need to Know About Dietry and tasteless. Aloe Vera gel, like most natural juices Supplements”, Home Health Nurse, 19, 50-52 in both fruits and vegetables, is unstable and subject to discoloration and spoilage from contamination by J.S. Williamson and C.M. Wyadat, “The Herbal microorganisms. It is, therefore, most important to Generation: Legal and Regulatory Considerations”, stabilize and concentrate the gel in powder natural Trends in Pharmacy and Pharmaceutical Care, 19, form, for commercial use in nutritional foods and P. Atherton, “Aloe vera: Magic or Medicine”, Nurs. Stand.
M.C. Robson, J.P. Heggers and W.J. Hagstrom, “Myth, Today the Aloe industry in USA and Mexico has established high ethical standards for businesses and Journal of Burn Cure and Rehabilitation, 3, 157-163 Aloe products. Through the International Aloe Science Council of America (IASC), the Aloe Industry in America I.E. Dandhof, “Remarkable Aloe”, Omnimedicus and Mexico solidified its dedication to providing the Press, Grand Prairie, Texas, (1987).
world with highest quality Aloe and Aloe products. The I.E. Dandhof , “Some External Uses of Aloe”, Aloe wide acceptance of Aloe by society in so many Jeffrey Bland, “Effect of Orally Consumed Aloe Juice consumer-products suggests that the IASC is moving on Gastrointestinal Function in Normal Humans”, in the right direction. The IASC has committed Linus Pauling Institute of Science and Medicine, Palo professionals to the further growth of Aloe products by Alto, Cal., Preventive Medicine, (1985).
A. Kandil and W. Gobran, “Protection of Gastric Mucosa by Aloe vera”, J. Drug Res.(Egypt), 11, 191- CONCLUSIONS
A. Kandil and W. Gobran, “Protection of Gastric The ease in growth and maintenance of Aloe plant Mucosa by Aloe vera”, Ull Islamic Med., 2, 508-511 and multiple uses of its constituents have prompted 10. F. Borrelli, A.A. Izzo, “The Plant Kingdom as a Source several elaborate investigations in the private and of Anti Ulcer Remedies”, Phytother. Res.,14, 581-591 public sector. Aloe Vera research based on comprehensive biological, biochemical, chemical and 11. N.S. Parmer, M.A. Teri, A.M. Angel, M.S. Asaid, clinical studies have opened up new areas, and many “Evaluation of Aloe vera Leaf Gel and Exudate for more effective uses are likely to be developed. There Gastric and Duodenal Anti Ulcer Activity”, Fitoterapia is a major scope in the promotion of recombinant-DNA based studies, targeting compounds of value to be 12. J.J. Blitz, J.W. Smith and H.R. Gerad, “Aloe vera Gel isolated and produced in stable and realistic quantities.
in Peptic Ulcer Therapy: Preliminary Report”, J. Amer.
The procedures of isolation and maintenance of Aloe- Osteopathic Assc., 62, 731-735 ( 1963).
13. J.E. Crew, “Aloes in the Treatment of Burns and products in stable form required special care and these Scalds”, Minnesota Med, 22, 538-539 (1939).
have been established after painstaking efforts.
14. T. Rowe, “Further Observation on the Use of Aloe vera Leaf in the Treatment of Third Degree X-RayReactions”, J. Am. Pharm. Assoc. 30, 266 (1941).
Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
M.A. Saeed, Ishtiaq Ahmad, Uzma Yaqub, Shazia Akbar, Amran Waheed, M. Saleem, and Nasir-ud-Din 15. L.M. Cera, J.P. Heggers, M.C. Robson and W.J.
29. S.W. Choi, K.W. Kim, J.S. Choi, S.T. Han, Y.I. Park, Hagstrom, “The Therapeutical Efficacy of Aloe vera S.K. Lee, M.H. Chung “Angiogenic Activity of beta- Cream (Dermaid Aloe) in Thermal Injuries: Two Case Sitosterol in The ischemia/reperfusion-demaged Reports”, Journal of the American Animal Hospital brain of Mangolian Gerbil,” Planta Med., 68, 330-335 16. M. Egawa, K. Ishida, M. Maekawa and Y. Sato, “Anti- 30. T.A. Waller, “Comparative Studies of Aloe from inflammatory and Wound Healing Topical Skin Commercial Sources”, Aloe Today Spring, 22-26 Preparations Containing Aloe Extract and Elagic Acids”, Patent-Japan Kokai Tokkyo Koho-02 231,408 31. G.R. Waller, S. Mangiofico and C.R. Ritchey, “A Chemical Investigation of Aloe barbadensis”, 17. J.S. Brown, S. A. Marky, “ The Use of Botanicals for Proc.Okla. Acad. Sci., 59-69 (1978).
Health Purposes by Members of a Prepaid Health 32. N. Paugh, S.A Ross, M.A. Elsohly, D.S. Pasco, Plan”, Res. Nurs. Health, 14, 399-350 (1991).
“Characterisaton of Aloeride, a New High Molecular 18. R.H. Davis, J.M. Kabbani and N.P. Maro, “Aloe vera Weight Polysaccharide from Aloe vera with Potent and Inflammation”, Proc. Penn. Acad. Sci., 60, 67-70 Immunostimulatory Activity”, J. Agric. Food Chem., 19. T.D. Rowe and L.M. Parks, “A Phytochemical Study of 33. T. Reynolds, A.C. Dweek, “Aloe vera Leaf Gel: A Review Aloe vera Leaf”, J. Amer, Pharm Ass. Sci Ed., 30, Update”, J. Ethnopharmacol., 15, 3-37 (1999).
34. G.D. Bouchey and G. Gjerstad, “Chemical Studies of 20. M.H. Odus, B.R. Cook, “Aloe Myth-Magic Medicine” Aloe (barabadensis) Juice.II: Inorganic Ingredients”, 2nd Edition,Universal Graphics, (1989).
J. Crude Drug Res., 9, 1445-1453 (1969).
21. I. Suzuki, H. Siato, S. Inove, S. Mijita, T. Takahashi, 35. J.P. Brown, “A Review of the Genetic Effects of Naturally “Purification and Characterization of Two Lectins from Occuring Flavanoids, Anthraquinones and Related Aloe arborescense Miller”, J. Biochem. (Tokyo) 85, Compounds”, Mutat. Res., 75, 243-277 (1980).
36. L.E. Sandelbach, “A Review of the Toxicity and 22. R.H. Davis, W.L. Parker, R.T. Samson and D.P.
Carcinogenicity of Anthraquinone Derivatives”, Murdoch, “The Isolation of an Active Inhibitory System from an Extract of Aloe vera”, J.Amer Podiatr. Med.
37. J. Westendorf, H. Marquardt, B. Poginnsky, M.
Dominiak, and J. Schmidt, “Genotoxicity of Naturally 23. R.H. Davis, “Isolation of a Stimulatory System in an Occurring Hydroxy-anthraquinones”, Mutat. Res., Aloe vera Extract”, J. Amer. Podiatric Med. Assoc., 38. D.Wolfe, C. Schumatte, J. Westendorf, and H.
24. R.H. Davis, J.J. Donato, G.M. Hartman, R.C. Hass, Marquardt, “Hydroxy-anthraquinines as Tumor “Anti-Inflammatory and Wound Healing Activity of a Growth Substance in Aloe vera”, Am. Poddiatr. Med.
Transformation of C3H Mouse Fibroblasts and Growth Simulation of Primary Rat Heptocytes”, 25. A.Yagi, T. Egusa, M. Arase, M. Tanabe, H. Tsugi, “Isolation and characterization of Glycoprotein 39. J.E. Hodge, and B.T. Hofrieter, “Determination of Fraction with a Proliferation-Promoting Activity on Reducing Sugars and Carbohydrates”, Methods of Human and Hamster Cells in Vitro form Aloe vera Carbohydrate Chemistry, 1, 380-394 (1962).
Gel”, Planta Med., 63, 18-21 (1997).
40. D.C. Gowda, B. Neelisiddaiah and Y.V. Anjaneyalu, 26. M.I. Ali, N.M. Shalaby, M.H. Algamal, A.S. Mousa, “Structural Studies of Polysaccharides from Aloe “Antifungal effects of different Plant Extracts and their vera”, Car. Res., 72, 201-205 (1979).
major components of selected Aloe Species”, 41. G. Mendal, and A. Das, “Characterisation of the Polysaccharides of Aloe barbadensis, Part I: Structure 27. T. Pecere, M.V. Gazzola, C. Mucignat, C. Parolin, F.D.
of D-Galactan Isolated from Aloe barbadensis Miller”, Vacchia, A. Cavagioni, G.Basso, A. Diaspro, B.Salvato, M.Carli, G.Palu, “Aloe Emodin is a New Type of Anti- 42. G. Mendal and A. Das, “Characterisation of the Cancer Agent with Selective Activity Against Polysaccharides from Aloe barbadensis, PartII, Neuroactodermal Tumors”, Cancer Res., 60, 2800- Structure of the Glucomannan Isolated from the Leaves of Aloe barbadensis Miller”, Carb. Res., 87, 28. S.W. Choi, B.W. Son, Y.S. Son, Y.I. Park, S.K. Lee, M.H.
Chung, “The Wound-Healing Effect of a Glycoprotein 43. G. Mendal, , R. Ghosh and A. Das, “Characterisation Fraction Isolated from Aloe vera”, Br. J.Dermatol., 145, of the Polysaccharides of Aloe Barbadensis, Part III, Structure of Acidic Oligosaccharide”, Indian J. Chem., Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
Aloe Vera: A Plant of Vital Significance
61. F.M. Strickland et al., “Prevention of ultraviolet raditions 44. A.H. McAnalley, “Identification of Polysaccharides (the and induced suppression of contact and delayed Acetylated B1-4 Mannan)”, U.S. Patents, 4, 735, 935, hypersensitivity by Aloe barbadensis gel extract”, 4, 851, 22, 4, 959, 214 and 4, 966, 892 (1988).
Journal of Investigative Dermatology, 9, 197-204, 45. Q.N. Haq and A. Hannan, “Studies of Glucogalactomannan from the Leaves of Aloe Vera 62. B.C. Coats, “The silent healer, a modern study of Tourn. (Ex.linn)”, Bangaldesh J.Sci. and Ind. Res., Aloe vera”, Texas Garland, (1979).
63. T.Hirat and T. Suga, “The efficiency of aloe plants, 46. M. Obata, “Mechanism of Anti-Inflammatory and Anti- chemical constituents and Biological activities”, Thermal Burn Action of Carboxypeptidase Aloe Cosmetics and toiletries, 98, 105-108, (1983).
arborescence Miller, Netalensis Berger in Rats and 64. J.B. Kahlon, M.C. Kemp, N. Yawei, R.H. Carpenter, Mice”, Phsiotherapy Research, 7, Special Issues, W.M. Shannon, B.H. McAnalley, “In Vitro Evaluation of the Synergistic Antiviral Effects of Acemannan in 47. M.S. Shelton, “Aloe vera, Its Chemical and Combination with Azidothymidine and Acyclovir”, Mol.
Therapeutic Properties”, International Journel of 65. J.B. Kahlon, M.C. Kemp, R.H. Carpenter, B.H.
48. I. Suzuki, H. Saito, S. Inueo, and Takahashi, McAnalley, H.R. McDaniel, W.M. Shannon, “Inhibition “Purification and Characterisation of Two Lectins from of AIDS Virus Replication by Acemannan in Vitro”, Aloe barbadensis Miller”, Jap. Biochem., 85, 163- 66. J.S. Montaner, J. Gill, J. Singer, “Double-Blind 49. D. Winters Wendal, “Immunoreactive Lectin- Placebo-Controlled Pilot Trial of Acemannan in Mitogenes From Aloe Barbadensis Mill” International Advanced Human Immunodeficiency Virus Disease”, Congress of Phytotherapy, organised by The J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 12, Pharmaceutical Society of Korea and Aloe Research Foundation, U.S.A., October abstract SB1(1991).
67. J. Singer, J. Gill, R. Arseneau, B. McLean, “A 50. B.C. Coats, The Silent Healer, “A Modern Study of Randomized, Placebo-Controlled Trial of Oral Aloe vera, Texas”, Garland (1998).
Acemannan as an Adjunctive to Antiretroviral Therapy 51. Wang Yin-Tung, “Long- term Monitoring of Field- in Advanced Disease”, Int. Conf. AIDS, 9, 494 (1993).
grown Aloe vera, IASC. 12th Annual Aloe Scientific 68. M.A. Sheets, B.A. Unger, G.F. Giggleman Jr., Tizard Seminar”, Irving TX, 3, July 17th (1993).
IR. “Studies of the Effect of Acemannan on Retrovirus 52. P. Atherton, “The Essentials of Aloe vera, The Actions Infections: Clinical Stabilization of Feline Leukemia and The Evidence”, 2nd Eddition, (1997).
Virus-Infected Cats”, Mol. Biother., 3, 41-5 (1991).
53. G.P. Lawrence, “The Health and Medical Use of Aloe 69. A. Yagi, K. Machi, H. Nishimura, T. Shida, I. Nishioka, vera” {ISBN: 0-943685-21-4}, (1998).
“Effect of Aloe Lectin on Deoxyriboneuclic Acid 54. R.H. Davis, “Aloe vera: A Scientific Approach” {ISBN: Synthesis in Baby Hamster Kidney Cells”, Experientia 55. B.C. Coats And R. Ahola, “The Silent Healer, a Modern 70. N. Akev, A. Can, “Seperation and Some Properties of Study of Aloe vera” 3rd Eddition, (1996).
Aloe vera Pulp Lectins”, Phytother. Res., 13, 489-493 56. D. Gage, “Aloe Vera: Nature's soothing Healer” {ISBN: 71. T. Koike, H. Beppu, H. Kuzuya, K. Maurata, K. Shimpo, 57. E. Mckeon, “Anthraquinones and Anthracenic M. Suzuki, K. Titani, K. Fujita, “A 35 kDa Mannose- Derivatives Absorb UV light”, Cosmetics and Binding Lectin with Hemaglutinating and Mitogenic Activities from ‘Kidachi Aloe’ (Aloe brborescence Miller 58. F. M. Strickland, R.P. Pelly, M.L. Kripke, “Prevention of Var. Natalensis Berger)”, J. Biochem. (Tokyo), 118, Ultraviolet Radiation and Induced Supperssion of Contact and Delayed Hypersensitivity by Aloe 72. F.M. Strickland, R.P. Pelly, D. Hill and M.I. Kripke, “The barbadensis Gel Extrect”, Journel of Investigative Effect of Topical Administration of Aloe barbadensis Gel Extract Upon UVB-Induced Suppression of 59. L. Lorenzetti, R. Salisbury, J. Beal, J. Baldwin, Contact Hepersensitivity in C3H Mice”, J. Invest.
“Bacteriostatic Property of Aloe vera”, J. Pharmacol.
73. C.E. Collins and C. Collins, J. Amer, “Roentgen 60. P.Sims, M. Ruth., E.R. Zimmerman., “Effect of Aloe Dermatitis Treated with Fresh Whole Leave of Aloe vera on Herps Simplex and Herps virus (strain vera”, Roentgen, 33, 396-397 (1937).
Zoster)”, Aloe vera of American Archives, 1, 239-240, 74. R.H. Davis, “Inhibitory and Stimulatory Systems in Aloe vera”, Aloe Today Winter, 6-8 (1991/1992).
75. R.H. Davis, M.G. Leitner, J.M. Russo and M.E. Barne, Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
M.A. Saeed, Ishtiaq Ahmad, Uzma Yaqub, Shazia Akbar, Amran Waheed, M. Saleem, and Nasir-ud-Din “Wound Healing Oral and Topical Activity of Aloe vera”, Tumor-Bearing Rats” Int. J. Tissue React., 20, 115-8 J. Amer. Podiatr. Assoc., 79, 559-562 (1989).
76. R.H. Davis, J.M. Kabbani and N.P. Maro, “Aloe vera 90. C. Harris, K. Pierce, G. King, K.M. Yates, J. Hall, I.
and Wound Healing”, J. Am. Podiatr. Med. Assoc., 77, Tizard, “Efficacy of Acemannan in Treatment of Canine and Feline Spontaneous Neoplasms”, Mol. Biother., 77. R.H. Davis and N.P. Maro, “Aloe vera and Gibberllin Anti-Inflammatory Activity in Diabetes”, J. Amer.
91. G.K. King, K.M. Yates, P.G. Greenlee, “The effect of Podiatr. Med. Assoc., 79(1), 24-26 (1989).
Acemannan Immunostimulant in Combination with 78. S. Yongchaiyudha, “Antidiabetic Activity of Aloe vera L.
Surgery and Radiation Therapy on Spontaneous Juice. I , Clinical Trial in new cases of Diabetes Canine and Feline Fibrosarcomas”, J. Am. Anim.
mellitus”, Phytomed., 3(3), 241-3 (1996).
79. N. Bunyapraphatsara, “Antidiabetic Activity of Aloe 92. K.M. Yates, L.J. Rosenberg, C.K. Harris, “Pilot Study vera L. Juice. I, “Clinical Trial in diabetes mellitus of the Effect of Acemannan in Cats Infected with patients in combination with Glibenclamide”, Feline Immunodeficiency Virus”, Vet. Immunol.
80. You-Jin, Jin Tai Hong, Loan Kim, Sin-koa and Yeo- 93. K.N. Desai, H. Wei, C.A. Lamartiniere, “The preventive Pyo Yun, “Effects of Aloe vera and arborescnce Mixture and therapeutic potential of the Squalene-Containing on Cirrhosis Patients”, International Congress of Phytotherapy, Organised by The Pharm. Soc. of Korea Regression”, Cancer Lett., 101, 93-6 (1996).
and Aloe Research Foundation,USA., Abstract. page 94. H. Tsuda, K. Matsumoto, M. ITo, I. HIrono, K. Kawai, H. Beppu, “Inhibitory Effect of Aloe arborescense 81. Grindlay and Reynolds, “Aloe Promotes only Healthy Miller var. natalensis Berger (Kidachi Aloe) on Cell: If a Cell is Cencerous, Growth is not Stimulated”, Induction of Preneoplastic Focal Lesions in the Rat J. Ethnopharmacology, 117-151 (1986).
Liver”, Phytother. Res., 7, S43-S47 (1993).
82. W.D. Winters, R. Beavides and W.J. Clouse, “Effects 95. N.A. Shamaan, K.A. Kadir, A. Rahmat, W.Z. Ngah, of Aloe Extracts on Human Normal Tumor Cells in “Vitamin C and Aloe vera Supplementation Protects Vitro”, Econ. Bot., 35, 89-95 (1981).
from Chemical Hepatocarcinogenesis in the Rat”, 83. M. El Zawahry, “Ueses of Aloe in Treating Leg Ulcers and Dermatosis”, Dermatology, Jan-Feb (1973).
96. P. Lissoni, L. Giani, S. Zerbini, P. Trabattoni, F. Rovelli, 84. H. Wang, J. Chung, C. Ho, L. Wu, S. Chang, “Aloe- “Biotherapy with the Pineal Immunomodulating Emodin Effects on Arylamin N-Acetyltransferase Hormone Melatonin Versus Melatonin Plus Aloe vera Activity in the Bacterium Helicobacter pylori”, Planta.
in Untreatable Advanced Solid Neoplasms, Nat.
85. M. Kemp, J. Kahlon, A. Chinnah, "In vitro Evaluation 97. M. Ajabnoor, “Effect of Aloes on Blood Glucose Levels of the Antiviral Effects of Acemannan on the in Normal and Alloxan Diabetic Mice”, J.
Replication and Pathogenesis of HIV-1 and Other Ethnopharmacology, 28, 215-20 (1990).
Enveloped Viruses: Modification of the Processing 98. N. Ghannam, “The Antidiabetic Activity of Aloes: of Glycoprotein Precursors”, Antiviral Res. Suppl., 1, Preliminary Clinical and Experimental Observations”, 86. T. Syed, M. Afzal, A. Ashfaq, A. Holt, A. Ali, S. Ahmad, 99. H. Beppu, Y. Nagamura, K. Fujita, “Hypoglycemic and “Management of Genital Herpes in Men with 0.5% Antidiabetic Effects in Mice of Aloe arborescens Miller Aloe Vera extract in a Hydrophilic Cream: a Placebo- var. natalensis Berger”, Phytotherapy Research, 7, Controlled Double Blind Study”, Journal of Dermatological Treatment, 8, 99-102 (1997).
100.P. Noel, J. Pugh, A. Larme, G. Marsh, “The Use of 87. K. Kawai, H. Beppu, K. Shimpo, “In Vivo Effects of Traditional Plant Medicines for Non-Insulin Aloe arborescens Miller Var. natalensis berger on Dependent Diabetes Mellitus in South Texas”, Experimental Tinea Pedis in Guinea pig Feet’, Phytotherapy Research, 11, 512-17 (1997).
Phytotherapy Research, 12, 178-82 (1998).
101.M.S. Williams, M. Burk, C.L. Loprinzi, “Phase III 88. S.Y. Peng, J. Norman, G. Curtin, D. Corrier, H.R.
Double-Blind Evaluation of an Aloe vera Gel as McDaniel, D. Busbee, “Decreased Mortality of Amprophylactic Agent for Radiation-Induced Skin Norman Murine Sarcoma in Mice Treated with the Toxicity”, Int. J. Radiat. Oncol. Biol. Phys. 36, 345-937 Immunomodulator, Acemannan”, Mol.Biother, 3, 79- 102.Y. Ishii, H. Tanizawa, Y. Takino, “Studies of Aloe III 89. M.M. Corsi, A.A. Bertelli, G. Gaja, A. Fulgenzi, M.E.
Mechanism of Cathartic Effect (2)”, Chem. Pharm.
Ferrero, “The Therapeutic Potential of Aloe vera in Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
Aloe Vera: A Plant of Vital Significance
103.J. Honig, P. Geck, H. Rauwald, “Inihibition of Cl- Acemannan”, Int. J. Immunopharmacol., 19, 75-82 Channels as a Possible Base of Laxative Action of Certain Anthraquinones and Anthrones”, Planta 118.Marshall, A. Gibbons, L. Parnell, “Human Cytokines Induced by Acemannan”, J. Allergy Clin. Immunol., 104.T. Yagi, “The Synergistic Purgative Action of Aloe- Emodin Anthrone and Rheinanthrone in Mice: 119.L. Cera, J. Heggers, M. Robson, “The Therapeutic Effect of Aloe vera Cream (Dermaid Aloe) in Thermal Synergism in Large Intestinal Propulsion and Water Injuries: Two Case Reports”, J. Am. Animal Hosp.
Secretion”, J. Pharm. Pharmacol., 49, 22-25 (1997).
120.B. Vazquez, G. Avila, D. Segura, B. Escalante, Phytopharmaceuticals. Stuttgart: MedPharm CRC “Antiinflammatory Activity of Extracts from Aloe vera Gel”, J. Ethnopharmacol., 55, 69-75 (1996).
106.M. Blumenthal, “The complete German Commission 121.S.F. Egger, G.S. Brown, L.S. Kelsey, K.M. Yates, L.J.
E Monographs: Therapeutic Guide to Herbal Rosenberg, J.E. Talmadge, “Hematopoietic Medicines”, Austin: American Botanical Council, Augmentation by a Beta-(1,4)-Linked Mannan”, Cancer Immunol. Immunother, 43, 195-205 (1996).
107.H. Odes, Z. Madar, “A double-blind trial of a Celandin, 122.S.F. Egger, G.S. Brown, L.S. Kelsey, K.M. Yates, L.J.
Aloe Vera, and Psyllium Laxative Preparation in Adult Rosenberg, J.E. Talmadge, “Studies on Optimal Dose Patients with Constipation”, Digestion, 49, 65-71 and Administration Schedule of a Hematopoietic Stimulatory Beta-(1,4)-Linked Mannan”, Int. J.
Immunopharmacol., 18, 113-26 (1996).
108.W. Suvitayat, N. Bunyapraphatsara, S. Thirawarapan, 123.R.H. Davis, M.G. Leitner, J.M. Russo, “Topical anti- K. Watanabe, “Gastric Acid Secretion in Inhibitory and inflammatory activity of Aloe Vera as Measured by Gastric Lesion Protective Effects of Aloe Preparation”, Ear Swelling”, J. Am. Podiatr Med. Assoc., 77, 610-2 Thai Journal of Phytopharmacy, 4, 1-11 (1997).
109.G. Maze, R. Terpolilli, M. Lee, “Aloe vera Extract 124.R.H. Davis, K.Y. Rosenthal, L.R. Cesario, G.A. Rouw, Prevents Aspirin-Induced Gastric Mucosal Injury in “Processed Aloe Vera Administered Topically Inhibits Rats”, Medical Science Research, 25, 765-66 (1997).
Inflammation”, J. Am. Podiatr Med. Assoc., 79, 395-7 110.R. Teradaira, M. SIngzato, H. Beppu, K. Fujita, “Antigastric Ulcere Effects in Rats of Aloe 125.R.H. Davis, M.G. Leitner, J.M. Russo, M.E. Byrne, “Anti- arborescens Miller var. natalensis Berger”, Inflammatory Activity of Aloe vera Against a Spectrum of Irritants”, J. Am. Podiatr Med. Assoc., 79, 263-76 111. M. Robinson, “Optimizing Therapy for Inflammatory Bowel Disease”, Am. J. Gastroenterol, 92, 12S-17S 126.R.H. Davis, G.J. Stewart, P.J. Bregman, “Aloe vera and the Inflamed Synovial Pouch Model”, J. Am.
112.M. Robinson, “Medical Therapy of Inflammatory Podiatr Med. Assoc., 82, 140-8 (1992).
Bowel Disease for the 21st century”, Eur. J. Surg.
127.S. Byeon, R. Pelley, S. Ullrich, T. Waller, C. Bucana, R. Strickland, “Aloe Barbadensis Extracts Reduce 113.L.A. t’Hart, P.H. van Enckevort, H. van Dijk, R. Zaat, the Production of Interleukin-10 After Exposure to K.T. de Silva, R.P. Labadie, “Two Functionally and Ultraviolet Radiation”, J. Invest. Dermatol., 110, 811- Chemically Distinct Immunomodulatory Compounds in the Gel of Aloe vera”, J. Ethnopharmacol. 23, 61- 128.K. Chong, S. Seong, K. Young, S. Ro, H. Myung, "Prevention of Ultraviolet Radiation-Induced 114.t'Hart LA, van den Berg AJ, Kuis L, van Dijk H, Labadie Suppression of Accessory Cell Function of RP, “An Anti-Complementary Polysaccharide with Immunological Adjuvant Activity from the Leaf Immunopharmacology, 37, 153-62 (1997).
Parenchyma Gel of Aloe vera”, Planta Med. 55, 509- 129.F. Strickland, R. Pelley, M. Kripke, “Prevention of Ultraviolet Radiation-Induced Suppression of Contact 115.L. Zhang, I.R. Tizard, "Activation of a Mouse and Delayed Hypersensitivity by Aloe barbadensis Macrophage Cell Line by Acemannan: the Major Gel Extract”, Journal of Investigative Dermatology, Carbohydrate Fraction from Aloe vera Gel”, Immunopharmacology, 35, 119-28 (1996).
130.J. Ro, B. Lee, M. Chung, “The Inhibitory Mechanism 116.D. Womble, J.H. Helderman, “Enhancement of Allo- of Aloe Glycoprotein (NY945) on the Mediator Release in the Guinea Pig Lung Mast Cell Activated with Acemannan (Carrisyn)”, Int. J. Immunopharmacol., Antigen-Antibody Complexes”, Korean J. Physiol.
117.R.W. Stuart, D.L. Lefkowitz, J.A. Lincoln, K. Howard, 131.M. Yamamoto, K. Sugiyama, M. Yokota, Y. Maeda, M.P. Gelderman, S.S. Lefkowitz, “Upregulation of “Inhibitory Effects of Aloe Extracts on Antigen- and Phagocytosis and Candidicidal Activity of Compound 48/80 Induced Histamine Release from Macrophages Exposed to the Immunostimulant Rat Peritoneal Mast Cells”, Japanese Journal of Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)
M.A. Saeed, Ishtiaq Ahmad, Uzma Yaqub, Shazia Akbar, Amran Waheed, M. Saleem, and Nasir-ud-Din Toxicology and Environmental Health, 39, 395-400 136.P. Chithra, G.B. Sajithlal, G. Chandrakasan, “Influence of Aloe vera on the Healing of Dermal Wounds in 132.I.A. Ross, “Medicinal Plants of the World: Chemical Diabetic Rats”, J. Ethnopharmacol, 59, 195-201 Constituents, Traditional, and Modern Medicinal Uses”, Totowa, N.J.: Humana Press, xi, 415 (1999).
137.P. Chithra, G.B. Sajithlal, G. Chandrakasan, “Influence 133.V.E. Tyler, “The Honest Herbal: a Sensible Guide to of Aloe vera on Collagen Characteristics in Healing the Use of Herbs and Related Remedies”, New York: Dermal Wounds in Rats”, Mol. Cell Biochem., 181, Pharmaceutical Products Press, xviii, 375 (1992).
134.W.J. Brasher, E.R. Zimmermann, C.K. Collings, “The 138.T.A. Syed, S.A. Ahmad, A.H. Holt, S.H. Ahmad, M. Afzal, Effects of Prednisolone, Indomethacin, and Aloe vera “Management of Psoriasis with Aloe vera Extract in a Gel on Tissue Culture Cells”, Oral Surg. Oral Med.
Hydrophilic Cream: A Placebo-Controlled, Double- Blind Study”, Trop. Med. Int. Health, 1, 505-9 (1996).
135.R.H. Davis, M.G. Leitner, J.M. Russo, “Aloe vera: A Natural Approach for Treating Wounds, Edema, and Pain in Diabetes”, J. Am. Podiatr Med. Assoc., 78, 60- Quarterly SCIENCE VISION Vol.9 No.1-2 (Jul - Dec, 2003) & 3-4 (Jan - Jun, 2004)

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