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A *Chloroquine *Ethinyl oestradiol *Mebendazole Acetaminophen *Chlorothiazide Ethoheptazine citrate Mecamylamine Acetazolamide Chlorpheniramine Meclizine HCl Acetylcholine Chlorpromazine F Meclozine Acetylsalicylic acid *Cimetidine Famotidine Mefenamic acid Actinomycin D Cisplatin Fenbrufen *Melphalan Acyclovir Clavulanic acid Fenoprofen Mersalyl Adenosine Clofibrate Fentanyl Meperidine monophosphate Clomiphene citrate *Flucytosine Mequitazine Adrenaline *Clonazepam Flurbiprofen Metformin Alclofenac Cloxacillin Folic acid Methadone Allopurinol *Cocaine FSH Methenamide Alpha tocopheryl Co-Codamol *Methotrimeprazine acetate Codeine Phosphate G Methylphenidate Amethocaine Colchicine Gabapentin Methyluracil Amiloride *Corticosteroids Gallamine Metipropranolol Aminoglycosides Corticotrophin Gentamicin Metoprolol Aminocaproic acid *Co-Trimoxazole Glafenine Mianserin Amitryptyline Coumarins Glipizide *Midazolam Amoxycillin Curare Glucagon Minaxolone Amphotericin Cyclizine Glucose Morphine Ampicillin *Cyclophosphamide Glucocorticoids Anesthetic ether Cyclopropane Glyceryl trinitrate N Antipyrine *Cyproterone acetate Guanethidine Nadolol Ascorbic acid Naftidrofuryl oxalate Aspirin D H Naloxone Atenolol Danthron Heme arginate Naproxen sodium Atropine Demerol Heparin Narcotic analgesics Azathioprine Desferrioxamine Hexamine Natamycin Dexamethasone *Hydrocortisone Nefopam HCl B *Dextromoramide *Hydrallazine Neostigmine Beclomethasone Diamorphine Hyoscine *Nitrofurantoin Benzhexol *Diazepam Hypocine Nitroglycerin Benzylpenicillin Diazoxide Nitroprusside potassium Dicumarol I Nitrous oxide Beta-carotene Dicoumarol Ibuprofen *Nortriptyline Bethamidine anticoagulants *Imipramine Biguanides Dicyclomine HCl Indomethacin O Bleomycin HCl Diflunisal Insulin *Oxazepam *Bromazepam Digitalis compounds Iron Oxybuprocaine Bromides Digoxin Oxylate/sodium Bumetanide Dihydrocodeine K *Oxyphenbutazone Bupivacaine Dimercaprol *Ketamine Oxytocin Buprenorphine Dimethicone *Ketoprofen Buserelin *Diphenhydramine *Ketotifen P Butacaine Diphenoxylate HCl *Pancuronium bromide C Domperidone Labetalol *Paraldehyde Canthaxanthin Dothiepin HCl LHRH Penicillamine Carbimazole Doxorubicin HCl Liquorice Penicillin Calcium salts Droperidol Lithium salts Pentanethonium Cephalexine *Loperamide Pentolinium *Cephalosporins E *Lorazepam *Pethidine Chloral hydrate EDTA Phenformin *Chloramphenicol Ergotaminetartrate M Phenoperidine Chloralhydrates Ethacrynic acid Magnesium sulphate Phenothiazines Chlordiaze poxide Ethambutol Mandelamine Phentolamine mesylate *Chlormethiazole Ether Mandelate *Phenylbutazone Pipothiazine palmitate *Pyridoxine Sulindac Trifluoperazine Pirbuterol Pyrimaquine Sulfadoxine Tripelennamine Pirenzepine *Pyrimethamine Suxamethonium Tubocurarine *Prazosin *Prednisolone Q T V Primaquine Quinidine Talampicillin *Valproate Probucol Quinine Temazepam Vancomycin Procaine Tetracaine Vecuronium Prochlorperazine R *Tetracyclines Vigabatrin Proguanil HCl *Ranitidine Tetraethylammonium Vinblastine sulfate Promazine Rauwolfia alkaloids bromide *Vincristine *Promethazine Reserpine Thiazides Vitamin A,B,C,D,E Propanidid Resorcinol Thiouracils Propantheline bromide Rifampicin Thyroxine W Propitocaine HCl Tiaprofenic acid Warfarin *Propofol S Timolol maleate Propoxyphene Salbutamol Tolazoline Z Propranolol Senna Tranexamic acid Propylthiouracil *Sodium Ca EDTA Triamterene Zinc preparations Prostigmine Sodium Fusidate Triazolam (topical) *Proxymetacaine Streptomycin Trifluoperazine Pseudoephedrine HCl Succinylcholine *Trichlormethiazide "*" 禁忌であるという報告もある。 A Captopril Dextropropoxyphene Etidocaine Alcuronium Carbamazepine Diazepam Etomidate Ally-containing Carbromal Dichloralphenazone Eucalyptol compounds Cardiazole Diclofenac (in mouthwash) Alphazalone Carisoprodol Diclotenac (alphadolone) Cefuroxime Dienestrol F Alprazolam Cephalexine Diethylpropion Felbamate Aluminium Preparations Cephalosporins Diethylstilbestrol Fentanyl Aminoglutethimide Cephradine Dihydroergotamine Flucloxacillin Aminopyrine Chlorambucil Diltiazem Flufenamic acid Amidopyrine Chloramphenicol Dimenhydrinate Flunitrazepam Amiodarone Chlordiazepoxide Diphenhydrantoin Flurazepam Amitriptyline Chlormezanone Dipyrone Fluroxine Amphetamines Chloromethazone Dixyrazine Frusemide Amylobarbitone Chloroform Doxycycline Furoxene Anticonvulsants Chloroquine Dramamine Antipyrine Chlorpropamide Drotaverine G Apronalide Chlorzoxazone Dydrogesterone Glutethimide Auranofin Cinnarizine Glymidine Azapropazone Clemastine E Gold preparations B Clomipramine Enflurane Griseofulvin Barbamazepine Clonidine Ergot compounds Guaiphenesin Barbiturates Clorazepate Ergotamine maleate Bemegride Cocaine Erythromycin H Bendrofluazide Colistin Estrogens Halothane Benoxaprofen Contraceptives (oral) Ethamsylate Hexestrol Bromocriptine Cyclophosphamide Ethanol excess Heavy metals Busulphan Cyclosporin Ethchlorvynol Hydantoins N-Butylscopolammonium Ethinamate Hydralazine Br D Ethionamide Hydrochlorothiazide C Dapsone Ethotoin Hyoscine butylbromide I Imipramine Metyrapone Piritramide Sulfonethylmethane Iproniazid Isometheptene mucate Minoxidil Pivampicillin Sulphadimidine Isoniazid Prazepam Sulphasalazine Isopropyl antipyrine N Prenylamine Sulphinpyrazone Isopropylmeprobamate Nalidixic acid Prilocaine Sulpiride L Lamotrigine Lignocaine Lisinopril Nortriptyline Propanidid Terfenadine Lofepramine Loprazolam Pyrazolone derivatives Thiopentone sodium Lysuride maleate O Pyrimethamine Thioridazine Oral contraceptives Pyrrocaine Tiagabine M Orphenadrine Tilidate Mefenamic acid Oxanamide Q Tolazamide Megestrol acetate Oxazepam Quinalbarbitone Tolbutamide Mephenezin Oxycodone Tranylcypromine Mephenyltoin Oxymetazoline R Trazodone HCl Mepivacaine Oxyphenbutazone Rifampicin Trimethadione Meprobamate Oxytetracycline Trimethoprim Mercaptopurine S Trimipramine Mercury compounds P Sedormid Trional Mestranol Paramethadione Scopolamine Troxidone Methallenestril Pargyline butylbromide Tybamate(tranquilizer) Methamphetamine Pentazocine Sodium Methohexitone Pentylenetetrazol aurothiomalate V Methotrexate Phenacetin Sodium oxybate Valproate Methoxyflurane Phenelzine Sodium valproate Verapamil Methsuximide Phenobarbitone Spironolactone Viloxazine HCl Methyldopa Phenoxybenzamide Steroids Methlyl sulphonal Phensuximide Stanozolol X Methyprylone Phenylbutazone Succinimides Xylocaine Metoclopramide Phenylhydrazine Sulfonal ポルフィリン症に理論的に禁忌 Alcuronium Erythromycin Nitrazepam Alfadolone acetate Fluroxene Nartriptyline Alfaxalone Food additives (selected) O,P'-DDD Allyl-containing compounds Flurosemide Pargyline Amphetamines Heavy metals Penylenetetrazole Bupivacaine Hydralazime Phenoxybenzamne Camphor Lamotrigine Prilocaine Chloroform Lidocaine Pyrocaine Clonazepam (large doses) Mepivacaine Rifampicin Clonidine Methylchlothiazide Sulfonylureas Colistin Metoclopramide Spironolactone Dramamine Metyrapone Terpenes Etidocaine Mitotane (O,P'-DDD) Tiagabine Etomidate Nalidixc acid Tranylcypromine All agents known to induce CYP or to increase hepatic heme turnover 表４． 二次性ポルフィリン症を引き起こす Anemias: Dyserythropoietic, aplastic, hemolytic, pernicious, thalassemia, iron-deficiencyLeukemias/lymphomas: AML, CML, ALL, CLL, Hodgkin's disease Chemicals and drugs: Barbiturates, benzene, estrogen, ethanol, carbamazepine, carbontetrachlo-ride, halogenated aromatic hydrocarbons, heavy metal exposure (Pb,Hg,As), phenytoin, progesterons Hereditary conjugated hyperbilirubinemias: Dubin-Johnson and Rotor's syndromes Liver disieases: Alcoholic, cholestatic, chronic hepatitis, cirrhosis, vial hepatitis (especially hepatitis C) Malignancies: Hepatocellular tumors, hepatic metastases, pancreatic carcimoma, lympomatosis, other systemic diseases Vitamin deficiency: Niacine, B2 Hypermetabolic state: Thyrotoxicosis, Fever, Strenuos exercise Miscellaneous causes: Bronze baby syndrome, diabetes mellitus, infectionus diseases, myocardial infarction, pregnancy, starvation 略語：ALL, acute lymphocytic leukemia; AML,acute myelocytic leukemia; CLL,chron- ic lymphocytic leukemia; CML, chronic myelocytic leukemia; Hg,mercury; Pb,lead; As,arsenic

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