Clinically Useful Antibiotics -- Beta-Lactams Organism Enteric G- Pseudomonas Anaerobes Penicillin Ampicillin PO/IV Amoxicillin PO (better absorption) Ampicillin + Sulbactam (Unasyn) Amoxicillin + Clavulanate (Augmentin) Nafcillin Oxacillin Dicloxacillin Piperacillin Ticarcillin (less active vx. Pseudomonas) Piperacillin + Tazobactam (Zosyn) Ticarcillin + Clavulanate (Timentin) Cefazolin (Kefzol)
PO Cephalexin (Keflex) Cefadroxil (Duracef) Cefuroxime (Zinacef)
PO Cefuroxime (Ceftin) Loracarbef (Lorabid) Cefprozil (Cefzil) Cefaclor (Ceclor) (last choice -- rash, decr. Activity) Cefotetan (Cefotan) Cefoxitin (Mefoxin) Ceftriaxone (Rocephin) Cefotaxime (Claforan)
PO Cefpodoxime (Vantin) Ceftibuten (Cedax) Cefdinir (Omnicef)
PO Cefixime (Suprax) Ceftazidime (Fortaz, Tazicef, Tazidime) Cefepime (Maxipime) Aztreonam (Azactam) Imipenem/Cilastatin (Primaxin) Meropenem (Merrem)
No handout would be complete without its disclaimer… This brief summary should not replace clinical judgment. Refer to primary sources for more detailed information. Blah blah blah…
From J. Durbin (2000) and The Sanford Guide (2005)
Clinically Useful Antibiotics -- Non-Beta-Lactams Organism Enteric G- Pseudomonas Anaerobes Gentamycin Tobramycin Amikacin Erythromycin (Bacteriostatic, mostly used for Legionella, Pertussis, Mycoplasma, Genital Mycoplasma, Chlamydia, Lyme dz; SE include GI upset, phlebitis) Azithromycin (Zithromax) Clarithromycin (Biaxin) (used for same organisms as Erythro; also toxo & MAI; good w/ AIDS; chlamydia PID - one dose) Ciprofloxadin (Cipro) (cartilage damage in baby beagles) Ofloxacin (Floxin) (not as good for Pseudomonas) Levofloxacin (Levaquin) (good for gm+, QD dosing) Moxifloxacin (Avelox) Gatifloxacin (Tequin) Norfloxadin (Noroxin) (UTI and diarrhea use) Tetracycline Doxycycline (Vibramycin, Doryx) Minocycline (Minocin) Vancomycin (Vancocin) (not absorbed PO, good for MRSA and SNA, C. diff) Clindamycin (bacteriostatic, not for endocarditis, not good for SNA, C. diff) Trimethoprim-Sulfamethoxazole (Bactrim, Septra) (for outpt UTI, OM, PCP) Chloramphenicol (Chloromycetin) (idiosyncratic rare irreversible aplastic anemia, dose-related toxicity causing reversible BM suppression) Metronidazole (Flagyl)
No handout would be complete without its disclaimer… This brief summary should not replace clinical judgment. Refer to primary sources for more detailed information. Blah blah blah…
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