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¨  Incidence: 1% of World Population ¨  Inherited Predisposition: > 50% Concordance in ¨  Typical Onset Between 15-26 yrs ¨  Higher incidence in northern Scandinavia and ¨  Ancient times to year 1800: Belief in possession by evil spirits…. treatments included exorcism and trepanation (drilling holes in skull). ¨  1800: Recognition of SZ as mental disease. ¨  1905: Belief SZ caused by negative life experiences; ¨  1950: Use of antipsychotic medications. ¨  1975: Advent of biological psychiatry…. focus on ¨  Failure to recognize that schizophrenia is an “umbrella term” given to several different mental disorders. ¨  The schizophrenia phenotypes likely have different causes, and involve differences in brain chemistry. ¨  Optimal treatment requires a therapy tailored to Identification of Schizophrenia Phenotypes ¨  Chemical studies of 25,000 schizophrenics by Pfeiffer (Princeton, NJ) and Walsh ( Naperville, IL). ¨  > 1 million chemical assays of blood & urine. ¨  Very high incidence of chemical abnormalities, ¨  About 50-150 symptoms, traits, and physical characteristics were recorded for each patient and research subject, ¨  The symptoms & traits associated with specific ¨  Biochemical classifications of schizophrenia were ¨  27% - Pyrrole disorder (severe oxidative stress) ¨  Elevated SAMe/SAH ratio in blood ¨  Depressed whole-blood histamine ¨  Overmethylation dominant imbalance ¨  High norepinephrine & dopamine
Note: The most common psychiatric diagnosis is
Paranoid Schizophrenia
¨  Intolerance to SSRI Antidepressants ¨  Metallothionein Promotion Therapy - SSRI Antidepressants must be avoided - Antihistamines must be avoided - Klonapin may assist in reducing anxiety. Symptoms & Traits
¨  Severe Deficiencies of B-6, Zinc ¨  Benzodiazapines (especially Klonapin) Medication support may become unnecessary after ¨  Incomplete Breakdown of Gluten Proteins in the ¨  Short Peptides with Opioid Properties
Treatment: Dietary Avoidance of Wheat, Oats,
Initiation of Nutrient Therapy: Meds continued at full dosage for several months, unless sedation becomes excessive. Months 4-12: After significant improvement, med dosages may be cautiously reduced to tolerance; Long-Term Care: Low-dose medication support usually ¨  Overmethylation: Major Improvement ¨  Pyrrole Disorder: Moderate Improvement ¨  Undermethylation: Slight Improvement ¨  Oxidative stresses gradually increase until GSH and MT proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT levels, and disruption of the blood brain barrier. ¨  As in Wilson’s Disease, sudden onset of a mental illness ¨  All major phenotypes of schizophrenia involve severe ¨  Oxidative overload depletes GSH and reduces ¨  Clear evidence of brain cell loss in schizophrenia: Archives
of General Psychiatry, January 2006.
¨  Most antipsychotic medications have antioxidant ¨  Abnormal methylation and severe oxidative stress ¨  Greater than 95% of schizophrenics exhibit abnormal methylation or oxidative overload. ¨  This could explain failure of schizophrenia to obey ¨  85% report that “life is better” after nutrient ¨  75% report ability to reduce medication, ¨  Highest efficacy for overmethylation and pyrrole ¨  Many cases of complete recovery.

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