Icdb.cl

CURRICULUM VITAE INVESTIGATOR
PERSONAL DATA
Father’s name
Institution (Department, Faculty, Institution) University of Chile, Faculty of Chemical and Pharmaceutical Sciences EDUCATION, ACADEMIC AND PROFESSIONAL EXPERIENCE
National Institutes of Health, USA
Fogarty International Fellow 1966 Molec. Pharmacol.

RESEARCH AND/OR PROFESSIONAL EXPERIENCE

ACADEMIC EMPLOYMENT
1970-1974
Associate Professor of Pharmacology, University of Toronto Professor of Pharmacology, Faculty of Medicine, University of Toronto Professor of Medicine, University of Toronto Director, Clinical Research Institute, Addiction Research Foundation, Canada Chairman, Nervous System Teaching, University of Toronto Faculty of Medicine, Professor of Pathology and Cell Biology, Thomas Jefferson University 1997-Present Adjunct Professor of Pathology and Cell Biology, Thomas Jefferson University
1997-Present Professor of Pharmacology, University of Chile.
Ph.D. Students.
Currently one Ph.D student; two students pending funding.
Benjamin Erranz (gene delivery, stem cell)
HONORS AND AWARDS and EDITORIAL POSITIONS.
2006 Thurman Award, Univ. North Carolina, USA
2003 Eraddictions Award. International Society for Addiction Medicine
2001 Member (Corresponding) Academy of Sciences of Chile
1999-2001President U.S. Research Society on Alcoholism
1998-2000 Presidential Chair in Science Award (Chile)
1995 Merit Award, National Institutes of Health (USA)
1990 Innovations Award, Government of Canada
1990 Distinguished Research Award, U.S.Research Society on Alcoholism
1980 Jellinek International Award, The Jellinek International Foundation
1979 Pharmacological Society of Canada Award
1965 Reeve Award, University of Toronto

Editorial Boards.
1974-1993
Executive Editor, Research Advances on Alcohol and Drug Problems;
Associate Editor, Alcoholism: Clin. Exp. Res.; 1990 and 1993 Editorial Board: Alcohol and Health for U.S. Congress 3; 1986- 2010 Editorial Board J.Studies on Alcohol; 1989- present Editorial Board Alcohol; 1998- present Editorial Board Frontiers in BioSciences 2004-2011 Editorial Board Alcoholism: Clinical and Experimental Research 2011- present Field Editor: Alcoholism: Clinical and Experimental Research MAIN PUBLICATIONS IN MEDIA WITH EDITORIAL COMMITTEE
192 publications with Editorial Committee
35 Book chapters
12 Book edited
Tu G-C, Cao Q-N and Israel Y. (1995) inhibition of gene expression by triple helix formation in
hepatoma cells. J. Biol. Chem. 270: 28402-28407.
Tu G-C, Cao Q-N, Zhou F and Israel Y. (1998) Tetranucleotide ggga motif in primary transcripts:
novel target site for antisense design, J. Biol. Chem. 273: 25125-15131.
Anni H and Israel Y. (1999) Characterization of adducts of ethanol metabolites with
cytochrome c Alcoholism: Clin. Exp Res. 23: 26-37.
Tu GC, Cao QN, Zhou F and Israel Y. (1999) Inhibition of tumor necrosis alpha synthesis
Emerging Therapeutic Targets 2: 23-25.
Moncada C and Israel Y. (1999) Generation of acetate and production of ethyl lysine in the
reaction of acetaldehyde plus albumin. ,Alcohol 17: 87-91.
Garver E, Ross AD, Tu G-C, Cao Q-N, Zhou F and Israel Y. (2000) Paradigm to test a drug-
induced aversion to ethanol. Alcohol and Alcoholism 35: 435-438.

Viitala K, Makkonen K, Israel Y, Lehtimaki T, Jaakkola O, Koivula T, Blake JE, Niemela O.
(2000) Autoimmune responses against oxidant stress and acetaldehyde-derived epitopes in
human alcohol consumers Alcoholism: Clin. Exp. Res. 24:1103-9.
Anni H, Nikolaeva O and Israel Y. (2001) Selection of phage-display library peptides
recognizing ethanol targets on proteins. Alcohol 25: 201-209.
Le AD, Israel Y, Juzytsch W, Quan B and Harding S. (2001) Genetic selection for voluntary
alcohol consumption of high (HARF) and low (LARF) lines in a limited access paradigm.
Alcoholism: Clin. Exp. Res. 25: 1613-1620.
Ponnappa BC, Dey I, Tu GC, Zhou F, Aini M, Cao QN and Israel Y. (2001) In vivo delivery of
antisense oligonucleotides in ph sensitive liposomes inhibit lipopolysaccharide-induced
production of tumor necrosis factor alpha in rats J. Pharmacol. Exp. Ther. 297: 1129-1135.
Moncada C. and Israel Y. (2001) Protein binding of -hydroxyethyl free radicals. Alcoholism:
Clin. Exp. Res. 25: 1723-1728.
***Garver E, Tu GC, Cao QN, Aini M, Zhou F, and Israel Y. (2001) Eliciting the low-activity
aldehyde dehydrogenase asian phenotype by an antisense mechanism results in an aversion to
ethanol J. Exp. Med. 194: 571-580. (Note: first gene therapy in the field of alcoholism
research)
Israel Y, FT Crews, RG Thurman, G-C Tu, Garver B, Ponnappa B, Rubin R, Karahanian E,
Hoplight M, Sethna M, Hanes MB, Wilkie MB and Wheeler MD. (2002) Gene and antisense
delivery in alcoholism research ,Alcoholism: Clin. Exp. Res. 26: 582-5.
Fernandez V, Videla LA, Tapia G and Israel Y. (2002) Increases in tumor necrosis factor in
response to thyroid hormone-induced liver oxidative stress in the rat. Free Radical Res. 36:
719-725.
Anni H and Israel Y. (2002) Proteomics: in alcoholism research. Alcohol Research and Health
26: 219-232.
Ponnappa BC and Israel Y. (2002) Targeting Kupffer cells with antisense oligonucleotides
Frontiers in Biosciences. 7: e223-233.
Israel Y and Lieber CS. The Research Society On Alcoholism. Addiction 97: 483-486, 2002
Moncada C, Fuentes N, Lladser A, Encina G, Sapag A, Karahanian E, Israel Y. (2003) Use of
an “acetaldehyde clamp” in the determination of the low Km aldehyde dehydrogenase activity
in H4-II-E-C3 rat hepatoma cells, Alcohol 31: 19-24.
Anni H, Pristatsky P, Israel Y. (2003) Binding of acetaldehyde to a glutathione metabolite: mass
spectrometric characterization of an cetaldehyde-cysteinylglycine conjugate. Alcoholism: Clin.
Exp. Res. 27: 1613-1621.
Sapag A, Tampier L, Valle-Prieto A, Quintanilla ME, Moncada C, Israel Y. (2003) Mutations
in mitochondrial alcohol dehydrogenase (aldh2) change cofactor affinity and segregate with
voluntary alcohol consumption. Pharmacogenetics 13: 509-515.
Videla LA, Tapia G, Varela P, Cornejo P, Guerrero J, Israel Y, Fernandez V. (2004) Effects of
acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear
factor-kappab, cytokine gene expression, and liver injury in the rat. Antioxid Redox Signal.
6:471-80.
Rodriguez DA, Moncada C, Nunez MT, Lavandero S, Ponnappa BC, Israel Y. (2004) Ethanol
increases tumor necrosis factor-alpha receptor-1 (tnf-r1) levels in hepatic, intestinal, and cardiac
cells. Alcohol 33:9-15.
Ponnappa BC, Israel Y, Aini M, Zhou F, Russ R, Cao QN, Hu Y, Rubin R. (2005) Inhibition of
tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by
antisense oligonucleotides. Biochem Pharmacol. 69: 569-77.
Quintanilla ME, Tampier L, Valle-Prieto A, Sapag A, Israel Y. (2005) Complex i regulates
mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in
rats. FASEB J. 19: 36-42.
Ezquer F, Nunez MT, Israel Y. (2005) Antisense gene delivered by an adenoassociated viral
vector inhibits iron uptake in intestinal cells. Potential application for hemochromatosis.
Biochem Pharmacol. 69: 1559-1566.
Ezquer F, Núñez MT , Asenjo J, Israel Y. (2006) Hereditary hemochromatosis: an opportunity
for gene therapy. Biol Res 39: 113-124.
Karahanian E, Ocaranza P, Israel Y. (2005) Aldehyde dehydrogenase (aldh2) activity in rat
hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA.
Alcohol Clin Exp Res, 29, 1384–1389
Quintanilla ME Tampier L. Sapag A, Israel Y. (2005) Polymorphisms in the mitochondrial
aldehyde dehydrogenase-2 gene (aldh2) determine peak blood acetaldehyde levels and
voluntary ethanol consumption in rats. Pharmacogenetics Genomics 15: 427-431.
Israel, Y., Quintanilla, M.E., Sapag,A., Tampier, L. (2006) Autosomal and maternal genes
influence alcohol intake in alcohol drinker and mondrinker rat lines: role of the acetaldehyde
burst. Alcoholism, Clinical and Experimental Research, 30, 276
Quintanilla, M.E., Israel, Y., Sapag, A., Tampier, L., (2006) The UChA and UChB rat lines:
metabolic and genetic differences influencing ethanol intake.Addiction Biology, 11, 310-323.
Quintanilla, M.E., Bustamante, D., Tampier, L., Israel, Y. and Herrera-Marschitz, M. (2007)
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer
or avoid alcohol. Eur. J. Pharmacology, 573, 84-92.
Quintanilla, M.E., Tampier, L., Sapag, A., Gerdtzen, Z. and Israel Y. (2007) Sex differences,
alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems
perspective. Am. J. Physiol Endocrinol Metab. 293, 531-537.
Karahanian, E., Sapag, A., Israel, Y., Ocaranza, P., Quintanilla, ME, Tampier, L. (2007) Gene
Therapy Reduces Etanol Intake in an Animal Model of Alcohol Dependence. Alcohol Clinical
and Experimental Research, 32, 52-57
***Ocaranza, P., Quintanilla, ME., Tampier, L., Karahanian, E., Sapag, A. and Israel,Y. (2008)
Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Alcohol Clin
Exp Res 32, 52-57 (Note: Single administration of a viral vector reduces alcohol consumption
of 35 day. Under translational research funding to Asenjo et al).
Tampier, L., Quintanilla, ME. and Israel Y. (2008) Tolerance to disulfiram induced by chronic alcoh.ol intake in the rat. Alcohol Clin Exp Res. 32, 937-41. Bustamante, D., Quintanilla, ME., Tampier, L., Gonzalez-Lira, V., Israel Y. and Herrera-Marschitz, M. (2008) Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats. Eur J Pharmacol. 591, 153-158 Sapag, A., Gonzalez-Martínez, G., Lobos-González, L., Encina, G., Tampier L., Israel, Y. and Quintanilla, M.E. (2009) Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. Pharmacogenet Genomics, 19, 528-537.
Cortinez, G., Sapag, A. and Israel, Y. (2009) RNA interference against aldehyde
dehydrogenase-2: development of tools for alcohol research. Alcohol, 3, 97-104
***Rivera, M., Quintanilla, M.E, Tampier, L., Mura, C., Sapag, A., Israel, Y. (2010)
Mechanism of Protection against alcoholism by an alcohol dehydrogenase polymorphism:
Development of an animal model. FASEB Journal 24, 266-274. (Note: Solves mechanism of
major genetic protection against alcoholism).
Pautassi RM, Camarini R., Quadros IM; Miczek KA Israel Y. (2010) Genetic and
environmental influences on alcohol consumption: prespectives from preclinical research.
Alcohol Clin Exp. 234, 976-987.
Israel Y, Rivera-Meza M, Quintanilla ME, Sapag A, Tampier L.(2011) Acetaldehyde burst
protection of ADH1B*2 against alcoholism: an additional hormesis protection against
esophageal cancers following alcohol consumption? Alcohol Clin Exp Res 35(5), 806-810.
***Karahanian E, Quintanilla M.E, Tampier L, Rivera-Meza M, Bustamante D, Gonzalez-Lira
V, Morales P, Herrera-Marschitz M, Israel Y. (2011) Ethanol as a prodrug: brain metabolism of
ethanol mediates its reinforcing effects. Alcohol Clin Exp Res 35, 606-612. (Note: The Journal
commissioned an Editorial that appeared in the same issue, to emphasize this work).
***Quintanilla ME, Tampier L, Karahanian E, Rivera-Meza M, Herrera-Marschitz M and Yedy
Israel (2011) Reward and relapse: Complete gene-induced dissociation in an animal model of
alcohol dependence. Alcohol: Clin Exp Res, 2011 (in Press) (Note: Demostrates complete
suppression of alcohol intake in alcohol dependent “alcoholic” rats. Invited to address topic to
open the University-wide open Inaugural Lecture on Pharmacogenetics at the University of
Toronto, Canada on March 2011)

PATENTS

Israel, Y., Karahanian, E., Quintanilla, M.E., Tampier, L., Bustamante, D., Herrera-Marschitz
(2010 and 2011) Patents pending in Chile United States. Method to reduce alcohol ingestion.
Tu G-C and Israel Y (2001)
US Patent 6,277,981 Method for design and selection of efficacious antisense
oligonucleotides.
Israel Y. Kapur B and Tu G-C (1994)
US Patent 5,290,683 Rapid analysis of ethanol in body fluids.
Giles G and Israel Y. (1991)
US Patent 4,997,770 Method for detecting blood alcohol in humans by testing vapor above the
eye
Israel Y and Arnon R (1990)
US Patent 4,900,664 Reagent for detection and measurement of acetaldehyde-protein
condensates in a fluid together with its preparation and method of use
Israel Y, Oporto B and Mcdonald A (1986)
US Patent 4,628,866 Simultaneous matched feeding apparatus

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