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Hill

Over-the-Counter Medications
in Pregnancy
RONALD A. BLACK, M.D., and D. ASHLEY HILL, M.D.
Florida Hospital Family Practice Residency, Orlando, Florida
Pregnant women commonly use over-the-counter medications. Although most over-
the-counter drugs have an excellent safety profile, some have unproven safety or are
known to adversely affect the fetus. The safety profile of some medications may
change according to the gestational age of the fetus. Because an estimated 10 percent
or more of birth defects result from maternal drug exposure, the U.S. Food and Drug
Administration has assigned a risk category to each drug. Many drugs have not been
evaluated in controlled trials and probably will not be because of ethical considera-
tions. Of the commonly used over-the-counter medications, acetaminophen, chlor-
pheniramine, kaolin and pectin preparations, and most antacids have a good safety
record. Other drugs, such as histamine H -receptor blockers, pseudoephedrine, and

atropine/diphenoxylate should be used with caution. If use of smoking cessation prod-
ucts is desired, the intermediate-release preparations minimize the amount of nicotine
while maintaining efficacy. With all over-the-counter medications used during preg-
nancy, the benefit of the drug should outweigh the risk to the fetus. (Am Fam Physi-
cian 2003;67:2517-24. Copyright 2003 American Academy of Family Physicians.)

has changed dramatically since the early1970s, largely because of the problemswith thalidomide and diethylstilbestrol.
care of pregnant womeninvolves the use of over-the-counter (OTC) med- required before a drug can be labeled for nancy risk factors to all drugs used in the United States (Table 1).4 Unfortunately, because of ethical considerations, proba- patients consult a health care professional Pain Medications
when selecting an OTC product.1 Manyphysicians are cautious in their OTC rec- fetus. At least 10 percent of birth defects the fact that the safety and efficacy profile See editorial
on page 2476.
association with teratogenicity, few clinical TABLE 1
FDA Classification of Drug Safety During Pregnancy
Controlled studies in women fail to demonstrate a risk to the fetus in the first trimester (and there is no evidence of risk in later trimesters), and the possibility of fetal harm appears remote.
Either animal reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of risk in later trimesters).
Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women, or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease in which safer drugs cannot be used or are ineffective).
Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
FDA = U.S. Food and Drug Administration. Information from Briggs GG, Freeman RK, Yaffe SJ, eds. Drugs in pregnancy and lactation: a reference guideto fetal and neonatal risk. 5th ed. Baltimore: Williams & Wilkins, 1998:577-8,627-8. TABLE 2
Use of OTC Pain Medications in Pregnancy
FDA pregnancy risk classification by trimester OTC = over-the-counter; FDA = U.S. Food and Drug Administration; NSAID = nonsteroidal anti-inflammatorydrug. *—Associated with increased perinatal mortality, neonatal hemorrhage, decreased birth weight, prolongedgestation and labor, and possible teratogenicity.5—Associated with oligohydramnios, premature closure of the fetal ductus arteriosus with subsequent per-sistent pulmonary hypertension of the newborn, fetal nephrotoxicity, and periventricular hemorrhage.6 Information from Collins E. Maternal and fetal effects of acetaminophen and salicylates in pregnancy. ObstetGynecol 1981;58(5 Suppl):57S-62S, and Macones GA, Marder SJ, Clothier B, Stamilio DM. The controversysurrounding indomethacin for tocolysis. Am J Obstet Gynecol 2001;184:264-72. TABLE 3
OTC Decongestants, Expectorants, and Nonselective Antihistamines in Pregnancy
OTC = over-the-counter; FDA = U.S. Food and Drug Administration. *—Possible increased risk of neural tube defects. Information from Werler MM, Mitchell AA, Shapiro S. First trimester maternal medication use in relation togastroschisis. Teratology 1992;45:361-7, and The use of newer asthma and allergy medications during preg-nancy. The American College of Obstetricians and Gynecologists (ACOG) and the American College of Allergy,Asthma, and Immunology (ACAAI). Ann Allergy Asthma Immunol 2000;84:475-80. data are available to support the lack of associ- hypertension of the newborn, fetal nephro- ation.5 The extensive use of acetaminophen in toxicity, and periventricular hemorrhage.6 pregnancy combined with the paucity of docu- mented adverse effects have served to validate been studied less often during pregnancy.
the selection of this medication as the pain However, an analysis8 of 50 pregnant patients reliever of choice during pregnancy.
who overdosed on ibuprofen revealed no evi- dence of fetal abnormalities. Because of the increased perinatal mortality, neonatal hemor- possibility of adverse effects of NSAIDs on the rhage, decreased birth weight, prolonged ges- fetus, it is our opinion that these medications tation and labor, and possible birth defects.5 should be used sparingly during pregnancy.
However, one study7 found that low-doseaspirin is not associated with an increased risk Decongestants, Expectorants,
of abruptio placentae or increased rates of and Antihistamines
perinatal mortality. Pregnant women should use salicylates only under the guidance of a during pregnancy. These medications, like most of the other OTC drugs, have not been Indomethacin (Indocin) is the most studied studied well in pregnancy (Table 3).9,10 As a result, some physicians are disinclined to rec- nancy. Physicians may employ indomethacinduring pregnancy to treat pain from degener-ating leiomyomata, or as a tocolytic agent.
Because of potential adverse effects on the fetus from use of salicylates and nonsteroidal anti-inflammatory drugs, aceta- pregnancy may result in oligohydramnios,premature closure of the fetal ductus arterio- minophen is the preferred pain reliever during pregnancy. ommend any treatment for the common cold.
cians and Gynecologists and the American Col- include decongestants and expectorants such released a position statement10 regarding the as pseudoephedrine (Novafed), guaifenesin use of asthma and allergy medications, includ- ing antihistamines and oral decongestants.
(Benylin DM), and the antihistamines diphen- Chlorpheniramine and tripelennamine (PBZ) (Chlor-Trimeton), and clemastine fumarate choice. Pseudoephedrine was recommended as the oral decongestant of choice, based on ani- The use of vasoconstrictive agents such as mal studies and a large prospective human pseudoephedrine may activate alpha-adrener- experience with the drug during pregnancy.
gic receptors, elevating blood pressure or causing vasoconstriction in the uterine arter- associated with gastroschisis and because other ies, and potentially adversely affecting blood choices are available, it may be prudent to avoid flow to the fetus. This process could explain using this medication during the first trimester the reported association between the use of unless the benefit outweighs the risk.
pseudoephedrine in the first trimester and the development of gastroschisis.9 This theory is with birth defects in chicken embryos. The debatable; evidence suggests that this effect is Collaborative Perinatal Project14 monitored nancy as a sedative, an antihistamine, and an trimester. Birth defects did not increase above anti-nausea drug, although few data confirm the baseline rate. Another study15 of 59 women its safety during pregnancy. The drug has been who had used dextromethorphan in the first shown to have oxytocin-like effects, especially trimester documented one malformation.
in high dosages.12 In addition, adverse drug Thus, sufficient evidence indicates a lack of interactions that do not occur in nonpregnant adverse effects of dextromethorphan use dur- patients may occur in pregnant patients. For example, one study13 showed a significant When used during the first trimester in the increase in fetal morbidity when diphenhy- presence of a febrile illness, guaifenesin has been associated with an increased risk of neural tube defects.16 It is unclear whether this In 2000, the American College of Obstetri- increased risk derives from the medicationuse, the illness, or both.
“clemastine,” “clemastine and pregnancy,” and “clemastine and teratogen” found no studies RONALD A. BLACK, M.D., is currently in private practice in Towanda, Pa. He recently addressing the safety or potential teratogenic- completed a fellowship in family practice obstetrics at Florida Hospital, Orlando. Dr.
ity of clemastine fumarate in pregnancy.
Black received his medical degree from Loma Linda University School of Medicine inLoma Linda, Calif., and completed a residency in family medicine at the Florida Hospi-tal Family Practice Residency Program.
Antidiarrheal Agents
D. ASHLEY HILL, M.D., is associate director of the Department of Obstetrics and Gyne- cology at the Florida Hospital Family Practice Residency Program. He received his med- medications include kaolin and pectin prepa- ical degree from the University of South Florida College of Medicine, Tampa. Dr. Hill rations (such as Kaopectate), bismuth subsali- served an internship at Charity Hospital in New Orleans and a residency in obstetricsand gynecology at the University of South Florida College of Medicine.
cylate (Pepto Bismol), loperamide (Imod-ium),4 and atropine/diphenoxylate (Lomotil).
Address correspondence to D. Ashley Hill, M.D., 500 E. Rollins St., Suite 201, Orlando,FL 32803. Reprints are not available from the authors. The safety of the various agents is outlined in OTC Drugs in Pregnancy
Table 4.4 Kaolin and pectin preparations arenot absorbed. A possible association has been Because kaolin and pectin preparations are not absorbed, identified between the ingestion of clays con- they are preferred over bismuth subsalicylate and taining kaolin and the development of iron atropine/diphenoxylate products during pregnancy. deficiency anemia.17 Use of bismuth subsali-cylate can result in absorption of salicylate andshould be avoided in pregnancy. Loperamidehas not been found to be teratogenic in ani- during pregnancy.19 Data are insufficient to mals. However, at least one study4 involving determine if these associations are significant.
first-trimester exposure in humans showed a possible increase in fetal cardiac malforma- sulfate, a known tocolytic agent. Despite the tion. Atropine/diphenoxylate has been found to be teratogenic in animals; however, there is with antacid ingestion, some clinicians prefer insufficient evidence of teratogenicity in the use of calcium-containing preparations.
Simethicone (Mylanta Gas) is not absorbed.
Antacid Preparations
effective in treating symptoms of heartburn Several antacids are available in OTC forms, and gastroesophageal reflux disease in preg- including preparations that contain alginic nancy,20 but these drugs readily cross the pla- acid, aluminum, magnesium, and calcium. All centa.21 Their use is recommended in preg- of these preparations generally are regarded as safe in pregnancy (Table 5). There have been adequately controlled with lifestyle modifica- sporadic reports of fetal maldevelopment and injury associated with prolonged use of high dine (Tagamet) and ranitidine (Zantac). Stud- TABLE 4
OTC Antidiarrheal Medications in Pregnancy
FDA pregnancy risk classification by trimester OTC = over-the-counter; FDA = U.S. Food and Drug Administration. *—Possible increase in fetal cardiac malformation with first-trimester use.4 Information from Briggs GG, Freeman RK, Yaffe SJ, eds. Drugs in pregnancy and lactation: a reference guideto fetal and neonatal risk. 5th ed. Baltimore: Williams & Wilkins, 1998:577-8,627-8. TABLE 5
OTC Antacids, Simethicone, and H -Receptor Selective Antihistamines in Pregnancy
OTC = over-the-counter; FDA = U.S. Food and Drug Administration. ies of these agents generally have shown sig- 18,515 case pregnancies and 32,804 control significant adverse effects. Animal studies also between fetal malformations and the use of fail to show an increased fetal risk with the use of these medications in pregnancy, the notable butoconazole and miconazole are likely to be safe during the second and third trimesters.
increased risk of fetal death, spontaneous Insufficient data are available regarding the abortion, and decreased fetal weight in rab- bits.22 These studies used the common pre- Many clinicians use oral fluconazole (Diflu- scription-strength doses. The OTC doses are can) to treat vulvovaginal candidiasis. A study26 one half of the prescription strength.
of 226 women exposed to fluconazole during Although studies have indicated that there is the first trimester of pregnancy revealed that probably no increased risk of fetal morbidity patients taking fluconazole were no more likely or mortality, few studies have evaluated first- than unexposed control patients to experience trimester use of H2 blockers. Therefore, most miscarriage, stillbirth, or congenital anomalies.
Ketoconazole (Nizoral), flucytosine (Anco- bon), and griseofulvin (Grisactin) may be ter-atogenic or embryotoxic in animals.25 Antifungals
vention recommends using only topical vagi- available as OTC drugs include the imidazole nal antifungal agents (including butoconazole, agents clotrimazole (Mycelex), butoconazole clotrimazole, miconazole, and the prescription (Femstat), miconazole (Monistat), and tio- medications terconazole [Terazol] and nystatin conazole (Vagistat-1). Table 623,24 describes the [Mycostatin]) in pregnancy.27 Because imidaz- safety of various OTC antifungal agents in ole agents are likely to be safe when used dur- pregnancy. One of the largest studies24 to date ing pregnancy and may be more effective than investigated the teratogenicity of clotrimazole.
nystatin,28 they should be considered as first- The population-based, case-control study of OTC Drugs in Pregnancy
Smoking Deterrents
Histamine H -receptor blockers should not be used during the first trimester unless symptoms cannot be controlled with interesting clinical dilemma. Researchers lifestyle modification and antacids. believe that nicotine and its metabolic by-product, cotinine, are harmful to the develop-ing fetus because smoking is known to causeharmful fetal effects, including intrauterine therapy, particularly because cigarette smoke growth retardation, premature birth, hyper- contains more than 3,000 different chemicals viscosity in the newborn, spontaneous abor- that can potentially harm humans, and one of the main components of cigarette smoke is defects, and an increased risk of sudden infant carbon monoxide, a known fetal toxin. There- death syndrome.29 For these reasons, the FDA fore, it is reasonable to consider the use of classifies nicotine as a Pregnancy Category D nicotine replacement products in patients drug. The primary mechanism of these dele- terious effects is believed to be uteroplacental genated blood through the placenta at various replacement to quit smoking, the amount of stages of development may cause the various nicotine administered should be minimized as manifestations of fetal maldevelopment and much as possible while still maintaining effi- cacy. Until further research is available, physi- patients about the harmful effects of smoking intermediate-release nicotine preparations to themselves and the developing fetus, and (nicotine gum, nicotine spray, and nicotine help these patients develop a plan for smoking inhaler) rather than the continuous-release cessation. The safety of nicotine replacement products in pregnancy has not been ade-quately studied. However, smoking is likely to The authors indicate that they do not have any con- be more harmful than nicotine replacement flicts of interest. Sources of funding: none reported. TABLE 6
OTC Topical Vaginal Antifungal Medications in Pregnancy
Safe in second and third trimesters (human trials),24 first trimester probably safe23 OTC = over-the-counter; FDA = U.S. Food and Drug Administration. Information from Lagace E. Safety of first trimester exposure to H blockers. J Fam Pract 1996;43:342-3, and Czeizel AE, Toth M, Rock- enbauer M. No teratogenic effect after clotrimazole therapy during pregnancy. Epidemiology 1999;10:437-40. OTC Drugs in Pregnancy
A. First-trimester drug use and congenital disor-ders. Obstet Gynecol 1985;65:451-5.
1. Jacobs LR. Prescription to over-the-counter drug 16. Shaw GM, Todoroff K, Velie EM, Lammer EJ.
reclassification. Am Fam Physician 1998;57:2209- Maternal illness, including fever and medication use as risk factors for neural tube defects. Teratol- 2. Matt DW, Borzelleca JF. Toxic effects on the female reproductive system during pregnancy, parturition, 17. Patterson EC, Staszak DJ. Effects of geophagia and lactation. In: Witorsch R J, ed. Reproductive (kaolin ingestion) on the maternal blood and toxicology. 2d ed. New York: Raven, 1995:175-93.
embryonic development in the pregnant rat. J Nutr 3. Wilson JG. Current status of teratology. In: Wilson JG, Fraser FC, eds. Handbook of teratology. New 18. Bonapace ES Jr, Fisher RS. Constipation and diar- rhea in pregnancy. Gastroenterol Clin North Am 4. Briggs GG, Freeman RK, Yaffe SJ, eds. Drugs in pregnancy and lactation: a reference guide to fetal 19. Gilbert-Barness E, Barness LA, Wolff J, Harding C.
and neonatal risk. 5th ed. Baltimore: Williams & Aluminum toxicity. Arch Pediatr Adolesc Med 5. Collins E. Maternal and fetal effects of aceta- 20. Larson JD, Patatanian E, Miner PB Jr, Rayburn WF, minophen and salicylates in pregnancy. Obstet Robinson MG. Double-blind, placebo-controlled study of ranitidine for gastroesophageal reflux 6. Macones GA, Marder SJ, Clothier B, Stamilio DM.
symptoms during pregnancy. Obstet Gynecol The controversy surrounding indomethacin for tocolysis. Am J Obstet Gynecol 2001;184:264-72.
21. Dicke JM, Johnson RF, Henderson GI, Kuehl TJ, 7. Hauth JC, Goldenberg RL, Parker CR Jr, Cutter GR, Schenker S. A comparative evaluation of the trans- Cliver SP. Low-dose aspirin: lack of association with port of H -receptor antagonists by the human and an increase in abruptio placentae or perinatal mor- baboon placenta. Am J Med Sci 1988;295:198- tality. Obstet Gynecol 1995;85:1055-8.
8. Barry WS, Meinzinger MM, Howse CR. Ibuprofen 22. Katz PO, Castell DO. Gastroesophageal reflux dis- overdose and exposure in utero: results from a ease during pregnancy. Gastroenterol Clin North postmarketing voluntary reporting system. Am J 23. Lagace E. Safety of first trimester exposure to H2 9. Werler MM, Mitchell AA, Shapiro S. First trimester blockers. J Fam Pract 1996;43:342-3.
maternal medication use in relation to gastroschi- 24. Czeizel AE, Toth M, Rockenbauer M. No terato- genic effect after clotrimazole therapy during preg- 10. The use of newer asthma and allergy medications during pregnancy. The American College of Obste- 25. Mastroiacovo P, Mazzone T, Botto LD, Serafini MA, tricians and Gynecologists (ACOG) and the Ameri- Finardi A, Caramelli L, et al. Prospective assessment can College of Allergy, Asthma, and Immunology of pregnancy outcomes after first-trimester expo- (ACAAI). Ann Allergy Asthma Immunol 2000;84: sure to fluconazole. Am J Obstet Gynecol 1996; 11. Smith CV, Rayburn WF, Anderson JC, Duckworth 26. King CT, Rogers PD, Cleary JD, Chapman SW. Anti- AF, Appel LL. Effect of a single dose of oral pseu- fungal therapy during pregnancy. Clin Infect Dis doephedrine on uterine and fetal Doppler blood flow. Obstet Gynecol 1990;76(5 Pt 1):803-6.
27. Centers for Disease Control and Prevention. 1998 12. Brost BC, Scardo JA, Newman RB. Diphenhy- guidelines for treatment of sexually transmitted dis- dramine overdose during pregnancy: lessons from eases. MMWR Recomm Rep 1998;47(RR-1):1-111.
the past. Am J Obstet Gynecol 1996;175:1376-7.
28. Young GL, Jewell D. Topical treatment for vaginal 13. Kargas GA, Kargas SA, Bruyere HJ Jr, Gilbert EF, candidiasis (thrush) in pregnancy. Cochrane Data- Opitz JM. Perinatal mortality due to interaction of diphenhydramine and temazepam. N Engl J Med 29. DiFranza JR, Lew RA. Effect of maternal cigarette smoking on pregnancy complications and sudden 14. Einarson A, Lyszkiewicz D, Koren G. The safety of infant death syndrome. J Fam Pract 1995;40:385-94.
dextromethorphan in pregnancy: results of a con- 30. Dempsey DA, Benowitz NL. Risks and benefits of trolled study. Chest 2001;119:466-9.
nicotine to aid smoking cessation in pregnancy.
15. Aselton P, Jick H, Milunsky A, Hunter JR, Stergachis

Source: http://giving.xula.edu/cop/documents/OTCDrugsinPregnancy.pdf

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