567_00143_V4_KETOCID:567_00143_V4 28/01/09 8:29 Page 1 PACKAGE LEAFLET: INFORMATION FOR THE USER Ketocid® 200 mg Capsules
Important things you need to know about Ketocid
Ketocid is a non-steroidal anti-inflammatory medicine, prescribed to reduce
swelling and ease inflammation in conditions affecting the joints and muscles.
You need to take it regularly to get the maximum benefit. Do not stop taking it
Ketocid can cause serious side effects in some people (read Section 4 for
details). If you experience difficulty in breathing, an allergic reaction such asskin rashes, signs of bleeding from your intestines or vomit blood contact yourdoctor immediately.
• If you are elderly, your doctor may regularly monitor your condition to check you
are taking the correct dose of Ketocid.
Taking other medicines, including other NSAIDs, may sometimes cause problems.
Check with your doctor or pharmacist before taking any other medicines.
• If you are (or might become) pregnant while taking Ketocid, it is important to
talk to your doctor about this.
Read all of this leaflet carefully before you start taking this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you. Do not pass it on to others. It may harm
them, even if their symptoms are the same as yours.
- If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
This leaflet was last updated on 12/2008.
In this leaflet:
1. What Ketocid is and what it is used for
2. Before you take Ketocid
3. How to take Ketocid
4. Possible side effects
5. How to store Ketocid
6. Further information
1. What Ketocid is and what it is used for

Ketocid Capsules contain ketoprofen which belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) that reduce pain and inflammation. They arecalled modified-release capsules because they are manufactured in a way that allows theketoprofen to be released and slowly absorbed by your body over a period of several hours. Ketocid Capsules relieve pain, reduce swelling and ease inflammation in the followingconditions:• rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (form of spinal arthritis) • musculoskeletal conditions such as bursitis, capsulitis, synovitis, tendinitis, fibrositis • sciatica (pain which is felt in the buttocks, the back of the thigh and the outside and 2. Before you take Ketocid
Do not take Ketocid:
• if you are allergic to ketoprofen, aspirin, ibuprofen, any other NSAID or any of the
other ingredients in the capsules (these are listed in section 6, Further Information).
Signs of an allergic reaction include breathing problems, runny nose, or a skin rash.
• if you have a peptic ulcer (ulcer in your stomach or duodenum) or bleeding in your stomach, or have had two or more episodes of peptic ulcers, stomach bleeding orperforation.
• if you have severe heart, liver or kidney problems. • if you are pregnant (you will need to discuss this with your doctor).
Take special care with Ketocid and always tell your doctor if:
• you have kidney or liver problems
• you have, or have ever suffered from a disease of the bowel or intestine, such as
• you have, or have ever suffered from asthma• you have heart problems, previously had a stroke or think that you might be at risk of these conditions (for example, if you have high blood pressure, diabetes or highcholesterol or are a smoker) • you have SLE (systemic lupus erythematosis) or any similar condition with symptoms • you experience skin redness, itching and scalling or blistering of the skin, mouth, eyes Ketocid may make it more difficult to become pregnant. You should inform your doctor ifyou are planning to become pregnant or if you have problems becoming pregnant.
Medicines such as Ketocid may be associated with a small increased risk of heart attack
or stroke. Any risk is more likely with high doses and prolonged treatment. Do not
exceed the recommended dose or duration of treatment.
If you are elderly, suffer from kidney, liver or heart problems or have been taking thismedicine or similar NSAIDs for a long time, your doctor may want to perform regular teststo monitor your condition and may need to carry out blood tests from time to time.
Taking other medicines
Before starting treatment, please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines obtained without a prescription. If
you have to go to a doctor, dentist or hospital for any reason, tell them that you are taking
In particular, tell your doctor if you are taking:• lithium, to treat depression• methotrexate, to treat some inflammatory diseases and cancers• aspirin, ibuprofen or any other NSAIDs• ciclosporin, to treat some inflammatory diseases and after transplants• quinolone antibiotics, such as ciprofloxacin to treat bacterial infections• water tablets (diuretics), such as amiloride• anticoagulants, such as warfarin to stop the blood clotting• sulphonamides, to treat bacterial infections• hydantoins, such as phenytoin to treat seizures• medicines to treat diabetes, such as gliclazide • aminoglycosides, such as gentamycin to treat bacterial infections• probenecid, to treat gout • medicines to treat high blood pressure, such as beta-blockers • cardiac glycosides, such as digoxin to treat heart problems• mifepristone, used to terminate pregnancy• oral steroids, such as prednisolone • tacrolimus, used to dampen down the body’s immune response and may be used for severe skin complaints and following organ transplantation • zidovudine, used to treat viral infections• anti-platelet agents such as aspirin, used to reduce the formation of blood clots• antidepressants of the selective serotonin reuptake inhibitors type (SSRIs) Please read the back of this leaflet →
567_00143_V4_KETOCID:567_00143_V4 28/01/09 8:29 Page 2 Pregnancy and breast-feeding
If you are pregnant or breast-feeding, or could become pregnant, talk to your doctor
before taking your tablets.
Driving and using machines:
If you experience headaches, fatigue, nausea, confusion, blurred vision, dizziness or
drowsiness after taking these capsules, then do not drive or operate machinery.
Important information about some of the ingredients of Ketocid
Ketocid contains sucrose. If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before taking this medicinal product.
3. How to take Ketocid
Always take your capsules exactly as your doctor has told you to. You should check withyour doctor or pharmacist if you are not sure.
• Ketocid is formulated so that you only have to take your capsule once a day. The
label on the carton will tell you how many capsules you should take and when.
• Take your capsules at the same time each day, with or after food.
• Swallow your capsules whole, do not break or chew your capsules.
Do not stop treatment even if you feel better unless told to do so by your doctor.
Adults and the elderly
The usual daily dose is one Ketocid 200 mg capsule once a day.
If you are elderly and are frail or have a low body weight your doctor will prescribe thelowest effective dose for you to take. Your doctor may monitor you for any bleeding fromyour stomach during the first four weeks after you start your treatment and may need tocarry out blood tests from time to time. Children must not take this medicine.
If you take more Ketocid than you should
If you accidentally take more Ketocid than you should, contact your nearest casualty
department or tell your doctor or pharmacist immediately. Remember to take the pack
and any remaining capsules with you.
If you forget to take Ketocid
Do not worry. Simply leave out that dose completely and then take your next dose at the
right time. Do not take a double dose to make up for a missed dose.
4. Possible side effects
Like all medicines, Ketocid can cause side effects, although not everyone gets them. Allergic reactions have been reported. If you experience any of these, contact your
doctor or nearest casualty department immediately.
- tight chest, severe difficulty in breathing or anaphylaxis where symptoms may be a rapid pulse, profuse sweating, fever and if severe, shock and collapse - skin rashes including itching, “nettle" rash or hives, purple spots and patches on the skin, swelling of the face and throat, peeling, scaling and blistering.
If you experience any of the following serious side effects stop taking your capsules and
contact your doctor or nearest casualty department immediately.
• vomiting blood or dark particles • perforations or ulcers of Stop taking your medicine and tell your doctor if you experience:
• indigestion or heartburn
• abdominal pain (pains in your stomach) or other abnormal stomach symptoms.
The following side effects have also been reported, tell your doctor or pharmacist if younotice any of these: risk of bleeding or bruising • pancreatitis - causing If any side effects gets serious, or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.
5. How to store Ketocid

• Keep out of the reach and sight of children.
• Do not use Ketocid after the expiry date which is stated on the blister and carton. The expiry date refers to the last day of that month.
• Do not store above 25ºC. Store in the original packaging. • Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will helpprotect the environment.
6. Further Information
What Ketocid contains:
The active substance in your capsules is ketoprofen. Each capsule contains 200 mg of
The other ingredients are sucrose, corn starch, macrogol 4000, polymers of methacrylic
acid, acrylic acid esters and methacrylic acid esters, ethylcellulose, stearic acid, talc,
gelatin, titanium dioxide (E171) and erythrosine (E127).
What Ketocid looks like and the contents of the pack:
Ketocid 200 mg capsules are transparent and pink marked with "KET 200 CR". It is
packed in blister packs of 28 capsules.
Marketing Authorisation Holder and Manufacturer:
The Marketing Authorisation holder and manufacturer is Chiesi Limited, Cheadle Royal
Business Park, Highfield, Cheadle, SK8 3GY, UK.
Is this leaflet hard to see or read? Phone 0161 488 5555 for help.

Source: http://chiesigroup.co.uk/system/files/24/original/Ketocid_-_PIL.pdf?1276604324


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