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Chronic Daily Cannabis Smoking: Neuroadaptation, Residual
Cannabinoid Excretion & Psychomotor Impairment
Professor Dr. Dr. (h.c.) Marilyn A. Huestis
Chief, Chemistry and Drug Metabolism Section, Intramural Research Program
National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore
USA, and Adjunct Professor, School of Medicine, University of Maryland

Professor Huestis’ research program seeks to discover mechanisms of action of cannabinoid agonists and antagonists, effects of in utero drug exposure, and the neurobiology and pharmacokinetics of MDMA (Ecstasy). Her research focuses on new medication targets for cannabis dependence, including oral tetrahydrocannabinol (THC) and Sativex, a 1:1 ratio of tetrahydrocannabinol and cannabidiol, and was the first to evaluate the effects of the CB-1 cannabinoid receptor antagonist rimonabant in cannabis users. Recently, Professor Huestis and colleagues documented that CB1-cannabinoid receptors are significantly down regulated in specific brain regions in chronic daily cannabis smokers, but these receptors significantly increased with sustained cannabis abstinence. This seminar will present the latest NIDA research in this area, which has a considerable impact on driving under the influence of drug issues.
For any enquiries please contact
the secretary:

Professor Huestis studies the disposition of drugs and metabolites in a wide variety of biological fluids and tissues following controlled drug administration; data that provide a scientific database for interpreting drug concentrations in alternative matrices, such as oral fluid, sweat and hair. An area of special interest is investigating the effects of in utero drug exposure on child development and whether concentrations of drugs and/or metabolites in meconium predict adverse developmental outcomes. She has published 281 peer-reviewed manuscripts and book chapters and over 300 abstracts presented at national and international meetings. She received a bachelor‘s degree in biochemistry from Mount Holyoke College, a master’s degree in clinical chemistry from the University of New Mexico, a doctoral degree in toxicology from the University of Maryland, and a Doctor Honoris Causa from the Faculty of Medicine, University of Helsinki in Finland in 2010. Other important awards include TIAFT Alan Curry Award, AACC Outstanding Contributions in a Selected Area of Research Award, IATDMCT Irving Sunshine Award, AAFS Rolla N. Harger Award, and the Irving Sunshine Award for Outstanding Research in Forensic Toxicology. Clinical Chemistry recently featured her as an “Inspiring Mind”. Professor Huestis is past president of the SOFT, past Chair of the Toxicology Section of AAFS, and the first woman president of TIAFT.
Tuesday 18th December 2012
Location: University of
Building 12

Room: B2
Time : 7.00 pm for 7.30 pm
For any enquiries please contact
the secretary:

ACT Branch ANZFSSPO Box 3601Weston ACT 2611


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