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Olympic movement anti-doping code 1999

SUBSTITUTES APPENDIX A OF THE OMAC 1999
OLYMPIC MOVEMENT ANTI-DOPING CODE
APPENDIX A
PROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS
1 January 2003
PROHIBITED CLASSES OF SUBSTANCES
A. STIMULANTS
Prohibited substances in class A.a include the following examples with both their L-
and D-isomers
amiphenazole, amphetamines, bromantan, caffeine*, carphedon, cocaine,
ephedrines**, fencamfamin, mesocarb, pentetrazol, pipradrol,
. and related substances.

* For caffeine the definition of a positive is a concentration in urine greater ** For ephedrine and methylephedrine, the definition of a positive is a concentration in urine greater than 10 micrograms per millilitre. For cathine, thedefinition of a positive is a concentration in urine greater than 5 micrograms permillilitre. For phenylpropanolamine and pseudoephedrine, the definition of a positiveis a concentration in urine greater than 25 micrograms per millilitre.
NOTE: All imidazole preparations are acceptable for topical use. Vasoconstrictorsmay be administered with local anaesthetic agents. Topical preparations (e.g. nasal,ophthalmological, rectal) of adrenaline are permitted. Bupropion, synephrine andphenylephrine are permitted Prohibited substances in class A.b include the following examples with both their L-
and D-isomers
formoterol***, salbutamol***, salmeterol*** and terbutaline*** … and related
substances

*** permitted by inhaler only to prevent and/or treat asthma and exercise-induced asthma.
Written notification by a respiratory or team physician that the athlete has asthma and/orexercise-induced asthma is necessary to the relevant medical authority prior to competition.
At the Olympics Games, athletes who request permission to inhale a permitted beta-2agonist, will be assessed by an independent medical panel.
B. NARCOTICS
Prohibited substances in class (B) include the following examples:
buprenorphine, dextromoramide, diamorphine (heroin), methadone, morphine,
pentazocine, pethidine,. and related substances.

NOTE: codeine, dextromethorphan, dextropropoxyphene, dihydrocodeine,diphenoxylate, ethylmorphine, pholcodine, propoxyphene and tramadol arepermitted.
C. ANABOLIC AGENTS
Prohibited substances in class (C) include the following examples:
1. Anabolic androgenic steroids
clostebol, fluoxymesterone, metandienone, metenolone, nandrolone,
19-norandrostenediol, 19-norandrostenedione, oxandrolone, stanozolol,
. and related substances.

androstenediol, androstenedione, dehydroepiandrosterone (DHEA),
dihydrotestosterone, testosterone*,
. and related substances.

Evidence obtained from metabolic profiles and/or isotopic ratio measurements may be used to draw definitive conclusions.
* The presence of a testosterone (T) to epitestostrone (E) ratio greater than six (6) to one (1) in the urine of a competitor constitutes an offence unless there isevidence that this ratio is due to a physiological or pathological condition, e.g. lowepitestosterone excretion, androgen producing tumour, enzyme deficiencies.
In the case of T/E greater than 6, it is mandatory that the relevant medical authority conducts an investigation before the sample is declared positive. A fullreport will be written and will include a review of previous tests, subsequent testsand any results of endocrine investigations. In the event that previous tests are notavailable, the athlete should be tested unannounced at least once per month forthree months. The results of these investigations should be included in the report.
Failure to co-operate in the investigations will result in declaring the sample positive.
2. Other anabolic agents
clenbuterol, salbutamol *
* For salbutamol, a concentration in urine greater than 1000 nanograms per millilitre of non-sulphated salbutamol constitutes a doping violation.
D. DIURETICS
Prohibited substances in class (D) include the following examples:
acetazolamide, bumetanide, chlortalidone, etacrynic acid, furosemide,
hydrochlorothiazide, mannitol*, mersalyl, spironolactone, triamterene,
. and related substances.

* Prohibited by intravenous injection.
E. PEPTIDE HORMONES, MIMETICS AND ANALOGUES
Prohibited substances in class (E) include the following examples and their
analogues and mimetics:
1. Chorionic Gonadotrophin (hCG) prohibited in males only;
2. Pituitary and synthetic gonadotrophins (LH) prohibited in males only;
3. Corticotrophins(ACTH, tetracosactide);
4. Growth hormone (hGH);
5. Insulin-like Growth Factor (IGF-1); and all the respective releasing factors
6. Erythropoietin (EPO);
7. Insulin*
*permitted only to treat athletes with certified insulin-dependent diabetes.
The term ‘insulin-dependent’ is used here to describe people with diabetes in whom insulin treatmentis required, in the judgement of a suitably qualified physician. It will always be the case in Type 1 andsometimes in Type 2 diabetes mellitus.
Written certification of insulin-dependent diabetes must be obtained from an endocrinologist or teamphysician.
The presence of an abnormal concentration of an endogenous hormone in class (E) or its diagnostic marker(s) in the urine of a competitor constitutes an
offence unless it has been proven to be due to a physiological or pathologicalcondition.
F. AGENTS WITH ANTI-OESTROGENIC ACTIVITY
Aromatase inhibitors, clomiphene, cyclofenil, tamoxifen are prohibited only in
males.

G. MASKING AGENTS
Prohibited substances in class (G) include the following examples:
diuretics, epitestosterone*, probenecid, plasma expanders (e.g . hydroxyethyl
starch
)
Masking agents are prohibited. They are products that have the potential to impairthe excretion of prohibited substances or to conceal their presence in urine or othersamples used in doping control.
* The presence of a urinary concentration of epitestosterone greater than 200 ng/mL constitutes an anti-doping violation unless there is evidence that it is due to aphysiological condition. Isotopic ratio mass spectrometry (IRMS) may be used todraw definitive conclusions. If the results of the IRMS are inconclusive, the relevantmedical authority shall conduct an investigation before the sample is declaredpositive.
PROHIBITED METHODS
A. ENHANCEMENT OF OXYGEN TRANSFER
a. Blood doping. Blood doping is the administration of autologous,
homologous or heterologous blood or red blood cell products of any origin,other than for legitimate medical treatment.
b. The administration of products that enhance the uptake, transport or
delivery of oxygen, e.g. modified haemoglobin products including but notlimited to bovine and cross-linked haemoglobins, microencapsulatedhaemoglobin products, perfluorochemicals, and RSR13.
B. PHARMACOLOGICAL, CHEMICAL AND PHYSICAL MANIPULATION
Pharmacological, chemical and physical manipulation is the use of substances andmethods, including masking agents (ref I . G), which alter, attempt to alter or mayreasonably be expected to alter the integrity and validity of specimens collected indoping controls. These include, without limitation, catheterisation, urine substitutionand/or tampering, inhibition of renal excretion and alterations of testosterone andepitestosterone (ref I. G) measurements.
C. GENE DOPING
Gene or cell doping is defined as the non-therapeutic use of genes, geneticelements and/or cells that have the capacity to enhance athletic performance.
CLASSES OF PROHIBITED SUBSTANCES IN CERTAIN
SPORTS

A. ALCOHOL
Where the rules of the governing body so provide, tests will be conducted forethanol.
B. CANNABINOIDS
Where the rules of the governing body so provide, tests will be conducted forcannabinoids (e.g. Marijuana, Hashish). At the Olympic Games, tests will beconducted for cannabinoids. A concentration in urine of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (carboxy-THC) greater than 15 nanogramsper millilitre constitutes doping.
C. LOCAL ANAESTHETICS
Injectable local anaesthetics are permitted under the following conditions: a. bupivacaine, lidocaine, mepivacaine, procaine, and related substances, can be used but not cocaine. Vasoconstrictor agents may be used in conjunctionwith local anaesthetics; b. only local or intra-articular injections may be administered;c. only when medically justified.
Where the rules of the governing body so provide, notification of administration maybe necessary.
D. GLUCOCORTICOSTEROIDS
The systemic use of glucocorticosteroids is prohibited when administered orally,rectally, or by intravenous or intramuscular injection.
When medically necessary, local and intra-articular injections of glucocorticosteroidsare permitted.
Where the rules of the governing body so provide, notification of administration maybe necessary E. BETA-BLOCKERS
Prohibited substances in class (E) include the following examples:
acebutolol, alprenolol, atenolol, labetalol, metoprolol, nadolol, oxprenolol,
propranolol, sotalol,
. and related substances.

Where the rules of the governing body so provide, tests will be conducted for beta-blockers.
SUMMARY OF URINARY CONCENTRATIONS ABOVE WHICH
A DOPING VIOLATION HAS OCCURED

phenylpropanolamine > 25 micrograms / millilitrepseudoephedrine * referred to I.C.b and I.G.
SUBSTANCES AND METHODS PROHIBITED OUT-OF-
COMPETITION

LIST OF EXAMPLES OF PROHIBITED SUBSTANCES
AND PROHIBITED METHODS
CAUTION: This is not an exhaustive list of prohibited substances. Many substances
that do not appear on this list are considered prohibited under the term "and related
substances".
Athletes must ensure that any medicine, supplement, over-the-counter preparation
or any other substance they use does not contain any Prohibited Substance.
STIMULANTS:
amfepramone, amiphenazole, amphetamine, bambuterol, bromantan, caffeine,
carphedon, cathine, clobenzorex, cocaine, cropropamide, crotethamide,
ephedrine, etamivan, etilamphetamine, etilefrine, fencamfamin, fenetylline,
fenfluramine, fenproporex, formoterol, heptaminol, mefenorex,
mephentermine, mesocarb, methamphetamine, methoxyphenamine,
methylenedioxyamphetamine,
methylenedioxymethamphetamine,
methylephedrine, methylphenidate, nikethamide, norfenfluramine,
parahydroxyamphetamine, pemoline, pentetrazol, phendimetrazine,
phentermine, phenmetrazine
, phenylpropanolamine, pholedrine, pipradrol,
prolintane, propylhexedrine, pseudoephedrine, reproterol, salbutamol,
salmeterol, selegiline, strychnine, terbutaline.

NARCOTICS:
buprenorphine, dextromoramide, diamorphine (heroin), hydrocodone,
methadone, morphine, pentazocine, pethidine.

ANABOLIC AGENTS :
androstenediol, androstenedione, bambuterol, bolasterone, boldenone,
clenbuterol, clostebol, danazol, dehydrochlormethyltestosterone,
dehydroepiandrosterone (DHEA), dihydrotestosterone, drostanolone,
fenoterol, fluoxymesterone, formebolone, formoterol, gestrinone, mesterolone,
metandienone, metenolone, methandriol, methyltestosterone, mibolerone,
nandrolone, 19-norandrostenediol, 19-norandrostenedione, norbolethone,
norethandrolone, oxandrolone, oxymesterone, oxymetholone, reproterol,
salbutamol, salmeterol, stanozolol, terbutaline, testosterone, trenbolone.

DIURETICS
amiloride, acetazolamide, bendroflumethiazide, bumetanide, canrenone,
chlortalidone, ethacrynic acid, furosemide, hydrochlorothiazide, indapamide,
mannitol (by intravenous injection), mersalyl, spironolactone, triamterene.

MASKING AGENTS
diuretics (see above), epitestosterone, probenecid, hydroxy ethyl starch.
PEPTIDE HORMONES, MIMETICS AND ANALOGUES
ACTH, erythropoietin (EPO), hCG*, hGH, insulin, LH*, IGF-1.
SUBSTANCES WITH ANTIOESTREOGENIC ACTIVITY
clomiphene*, cyclofenil*, tamoxifen*.
* prohibited in males only
BETA BLOCKERS
acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol,
carvedilol, celiprolol, esmolol, labetalol, levobunolol, metipranolol, metoprolol,
nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol.

Source: http://www.x-99.ch/uploads/media/Doping_-_Liste_der_verbotenen_Substanzen_-_EN_Report_542.pdf

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