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JOM Volume 25, Number 1, 2010
Review Article
Nutrition and Cancer: Further Case
Studies Involving Salvestrol
Authors: Brian A. Schaefer, D.Phil.,1 Catherine Dooner, B.A.2 M. Danny Burke, Ph.D.,3
Gerard A. Potter, Ph.D.4
1Corresponding author: Clinical Intelligence Corp., 205-1095 McKenzie Avenue, Victoria, BC Canada V8P 2L5; email: bschaefer@aiinc.ca; 2CARE Technologies Corp.;3Professor Emeritus of Pharmaceutical Metabolism, Salvestrol Natural Products Ltd.; 4Professor, Head of Cancer Drug Discovery Group, De Montfort University, Leicester LE1 9BH, United Kingdom Abstract A nutritional approach to the treatment of cancer can provide great benefit to patients.
The nutritional approach focused on through these cases addresses deficiencies in dietary phytonutri- ents known as Salvestrols along with their co-factors. Salvestrols operate through a highly targeted mechanism that hinges on their metabolism by the universal cancer marker CYP1B1. This results in a very broadly applicable method in addressing a nutritional deficiency to the benefit of patients. Unfortunately modern farming practices have severely limited the availability of these specific phy- tonutrients in the modern diet. These phytonutrients are all phytoalexins and are not induced in abundance until the plant comes under attack from infection or predation. Six cases of recovery from cancer using this nutritional approach are discussed. To illustrate the breadth of this approach cases are presented representing five diverse cancers: breast; prostate; colon; liver; and Hodgkin’s lym- phoma. Two of the cases show how rapid and dramatic the improvement can be when nutritional Introduction
trols operate as natural prodrugs, completely In 2002, Prof. Gerry Potter1,2 identified targeted to killing diseased cancer cells while and outlined a nutritional rescue mechanism leaving the normal cells alone. Initial research that linked specific compounds in some of the indicates that this mechanism could operate common foods we eat with cancer cell death. both preventatively, killing off cells as they become cancerous, and therapeutically, kill- bolic activity of a certain cytochrome P450 ing off cells that are part of active disease. zyme was found to be expressed by all cancers, tions of this mechanism have been discussed.9-12 regardless of oncogenic origin, while being Within the context of a nutritional approach to absent from healthy tissue.5-7 It is now widely treating cancer, this mechanism appears to sig- nificantly reduce cancer cel s in the body and thus increase chances of a beneficial outcome specific class of dietary compound that Profs. for a cancer sufferer. It is also true that when Potter and Burke named Salvestrols. When one chooses to utilize Salvestrols in combat- Salvestrols are metabolized by CYP1B1, they ing this disease a broader nutritional approach create compounds that actually cause apop- will aid in the efficient operation of this res- tosis in the cancer cell. In this way, Salves- cue mechanism. Co-factors such as biotin, vi- Journal of Orthomolecular Medicine Vol 25, No. 1, 2010 Case #1. Stage 3 breast cancer
all known to be important. Other nutritional components, such as fatty acids, probiotics and physician with pain in her upper chest area selenium, also play important roles.
and tiredness. She was subsequently diag- A variety of cases are presented in this nosed with stage 3 breast cancer fol owing article. Written and valid consent has been ultrasound imaging. The diagnosis was con- obtained from each patient whose case is de- firmed through biopsy. Imaging revealed a scribed. Some represent situations where the 2.5 cm tumour in the left breast. She had a patient has refused conventional treatment. concurrent diagnosis of hypothyroidism.
Other cases highlight how patients wil find themselves undergoing conventional proce- with chemotherapy and radiotherapy, were dures to complement nutritional approaches. recommended. Chemotherapy was declined The cases represent a cross-section of cancers: and a surgery date was scheduled for exact- breast, prostate, colon, liver and Hodgkin’s lym- ly one month after the diagnosis had been phoma. Hopefully these cases will help encour- confirmed. In the interim, pain was managed age patients and their physicians to incorporate with Tylenol® 3 (2 tablets at onset of pain).
nutritional medicine into their approach for a cure, regardless of their choice of intervention.
sis, the patient began a course of Salvestrols. Throughout these cases the dosage of This comprised five Salvestrol Professional Salvestrols is given in number of Salvestrol (350 point) capsules and five Salvestrol Gold points. (Table 1, below) Salvestrol points (350 point) capsules, spread through the day
have been devised to help convey the selec- by taking a roughly equal number of capsules tivity of Salvestrols. Selectivity, rather than before each of the three main meals. This level milligrams, is the important element in deal- of Salvestrol supplementation (3,500 points ing with active disease. Salvestrols represent per day) was carried out for three months.
a class of compounds that differ in their se- lectivity, hence, representing capsule ingredi- tion, the patient embarked on an organic, ents in milligrams of active Salvestrols con- vegan diet (vegetables, greens, fruits, juices, veys very little useful information.
wheatgrass and tea) and an exercise program Table 1. Point profile of Salvestrol products
Salvestrol
Intended
Ingredients
points per
The ingredients from which the Salvestrols are extracted can differ from one product The ingredients from which the Salvestrols are extracted can differ from one product The ingredients from which the Salvestrols are extracted can differ from one product Nutrition and Cancer: Further Case Studies Involving Salvestrol of walking and yoga. Salvestrol specific co- sue and two in healthy portions of his liver. factors were also taken; biotin, 300mcg; nia- No chemotherapy or radiotherapy treatment cin, amount unknown; magnesium by way was prescribed due to the patient’s age, the of a calcium/magnesium tablet, amount un- number of liver tumours and his concurrent known; iron, 1 oz., amount unknown; and conditions, as he suffered from both cirrho- Vitamin C, 1,000 mg. In addition, her natur- sis of the liver and pulmonary tuberculosis. opathic physician added selenium (200 mg) In an attempt to downstage the tumours, a hepatic artery embolisation was performed.
breast self examination revealed that the he began taking 12 (350 point) Salvestrol tumour softened, the texture changed and supplements per day, commensurate with the tumour progressively decreased in size. his body weight. This comprised six Salves- Surgery removed a 1.3 cm tumour (about trol Professional (350 point) capsules and half the diameter of the tumour at time of six Salvestrol Gold (350 point) capsules, diagnosis one month earlier). The lymph spread through the day by taking two of each nodes were free of cancer, as was the blood. capsule after each main meal. This level of A hematology panel showed al results were Salvestrol supplementation (4,200 points per within normal limits. One month after sur- day) was maintained for four months. The gery, the patient received radiotherapy once level of supplementation was then lowered to a day for 30 days, as a preventive measure.
6 (350 point) Salvestrol supplements per day, comprising 3 Salvestrol Professional cap- mentation, the dosage was reduced to a total sules and 3 Salvestrol Gold capsules (2,100 of six capsules per day. This comprised three points per day). In addition to the Salvestrol Salvestrol Professional (350 point) capsules supplementation, he began receiving intrave- and three Salvestrol Gold (350 point) cap- nous vitamin C injections starting at 30 g per sules, spread through the day by taking one week. This dose was increased through the capsule of each before each main meal. This following weeks moving in large increments level of Salvestrol supplementation (2,100 until reaching 100 g per week. This level was points per day) has been maintained.
maintained for six months before it was re- Eight months after surgery the patient duced to an ongoing weekly injection of 40 g. was cancer free, pain free and experiencing Niacin was also added to his regimen about less tiredness. At 13 months after surgery, the four months after his diagnosis. He initially patient remains cancer free, pain free and ex- took 250 mg per day for one month and then periencing little tiredness. Her diagnosis of hy- increased this amount to 500 mg per day for pothyroidism remains. It seems reasonable to about five months. There were no significant conclude that the degree of tumour shrinkage dietary changes; however, he did commence a that she experienced during the one-month program of breathing exercises, chi exercises, wait for surgery is attributable to the Salvestrol meditation, stretching and stress avoidance.
supplementation, her focus on nutrition, exer- Due to the variety of conditions that he cise and Salvestrol co-factor supplementation. cal examinations. Eleven months after com- Case #2. Stage 2 liver cancer
mencing Salvestrol supplementation he was declared ‘al clear’. Although the patient still nosed with second-stage liver cancer follow- suffers from pulmonary tuberculosis and liver ing a scheduled examination to monitor his cirrhosis, he feels very comfortable. Given that alcohol-related liver cirrhosis. The patient hepatic artery embolisation is not a curative had lost a lot of weight and had noticed an procedure, this case leaves Salvestrol supple- unusual odour associated with bowel move- mentation, high dose Vitamin C, niacin, exer- ments. A CT scan revealed three tumours; cise and mental outlook as the possible candi- one in the centre of the liver in damaged tis- dates to explain his recovery. He provides the Journal of Orthomolecular Medicine Vol 25, No. 1, 2010 fol owing message: “Confidence and belief of ter that she returned to her doctor to ask for being cured is important. People say every- testing to monitor progression of the disease. thing comes from mind. Therefore, I think She was told there had been a misdiagnosis positive and stable mind is very important. I and that no tests would be ordered. think we all need confidence that we can over- After a period of seven months of Salves- trol supplementation her weight had returned to normal and her skin color had returned to Case #3. Colon cancer
normal. In order to assess the progression of A 64-year-old female went to her doctor the disease she arranged for a privately fund- after feeling ill, looking ill and losing weight ed ultrasound investigation. No cancer was over a period of three years. She was encour- found. From this point she has continued to aged to see her doctor by a registered nurse take two Salvestrol Gold (350 point) capsules each morning (700 points per day). She has great confidence in Salvestrols and attributes domen was continually distended leaving her her recovery to them.
with a bloated feeling. She was experiencing chronic, sharp pain in her abdomen that was Case #4. Prostate cancer
heightened after eating. This pain was suffi- ciently severe that she was unable to touch her diagnosis of prostate cancer as part of the rou- abdomen or lay face down. She had lost 9% of tine monitoring of his prior condition. This her weight and had a poor appetite, leaving her gentleman has a long-held belief that phar- underweight for her height. She was fatigued maceutical approaches to disease treatment to the point of fal ing asleep by mid-day. She should only be considered as a last resort and also experienced occasional nausea, vomiting preferred to look towards nutrition and nu- and blood in her stool. Her skin colour had tritional supplements to restore his health. taken on a gray/green tone. Her doctor also He had been diagnosed with prostate cancer suspected colon cancer and asked that she re- three years earlier, and had successfully treat- turn for testing to confirm his diagnosis. ed this occurrence with a combination of ex- She chose not to pursue conventional ercise, good nutrition, lycopene and a pollen- treatment and did not pursue testing to con- based supplement known as Protaphil®. He firm the diagnosis. She immediately started was subsequently pronounced “all clear” by taking Salvestrols. This comprised nine his physician. After three years of remission Salvestrol Gold (350 point) capsules, spread his regular prostate specific antigen (PSA) through the day by taking three capsules with test scores started to climb. To confirm a di- each meal. This level of Salvestrol supple- agnosis of prostate cancer, a uPM3™13 urine- mentation (3,150 points per day) was main- based genetic test for prostate cancer, from tained for three months. In addition to the Bostwich Laboratories, was ordered to test Salvestrol supplementation she took a daily for presence of the PCA3 gene that is pro- multivitamin, one ‘colon green’ capsule per fusely expressed in prostate cancer tissue. The day, one S-adenosyl L-methionine capsule results were positive for prostate cancer.
per day and used externally applied castor oil packs on the abdomen four days each week.
She reported feeling better after the ini- with a variety of other nutritional supple- tial three weeks of Salvestrol supplementa- tion. Within five weeks of supplementation garlic; lycopene; zinc; cranberries; 2 multi- she looked noticeably better to friends and vitamins without iron; and vitamin E. Un- relatives. By seven weeks the abdominal pain fortunately we are unable to verify the dos- had subsided, as had the distension. Three age of any of these supplements other than the Salvestrol. With breakfast on Monday, plementation, she was feeling so much bet- Wednesday and Friday this gentleman took Nutrition and Cancer: Further Case Studies Involving Salvestrol one Salvestrol Gold (1000 point) capsule.
receipt of his biopsy results and a consultation with his urologist. The urologist referred the ther PSA test was conducted and the result gentleman to the British Columbia Cancer was within normal limits. He was again pro- Agency. Two months later, he was interviewed nounced ‘all clear’. Upon receiving this news by an oncologist at the Agency, and chose the he started to take one Salvestrol Gold (350 option of hormone therapy rather than ra- point) capsule per day with his breakfast. diation treatment. During the interview, the He continues to be active, physically and gentleman received an initial 10.8 mg injec- mentally. He has had four further PSA tests tion of Zoladex® (Goserelin) to help control at three-month intervals and they have all the tumour growth along with a prescription shown results within normal limits. He is for repeat injections every 12 weeks. Casodex® now monitored annually. This gentleman has (bicalutamide), an antiandrogen, was also pre- successfully defeated cancer twice without scribed, 50 mg daily for twenty-one days. recourse to chemotherapy, hormone therapy, was found during the month following this injection. In the second month following this Case #5. Prostate cancer
injection the PSA test results began to de- cline. (Table 2, p. 22) During the following
ed PSA test results with one week between month the PSA test results indicated levels tests. A digital rectal examination indicated that led his oncologist, after carrying out a the presence of a tumour on the left side of digital rectal examination, to suggest no fur- the prostate. Prostate cancer was diagnosed ther treatment as the cancer was said to be in and a biopsy scheduled for confirmation. A remission. The gentleman would be followed Gleason Score of 6 (3+3) was assigned to the every three months for one year then every biopsy results. A full body scan was also car- ried out and results indicated that no metas- Upon receipt of the confirmed diagnosis Salvestrol Platinum (1,000 point) capsules this gentleman began taking Salvestrols on per day, with both taken in mid-afternoon a daily basis. This comprised five Salvestrol (2,000 points per day). Zoladex®, 10.8 mg, Platinum (1,000 point) capsules per day, with is an LHRH agonist intended for long term two taken in mid-afternoon and three taken use, administered every 12 weeks.14 This case near midnight (5,000 points per day). These suggests that for those individuals that utilise were taken in concert with his previous, thor- ough and long-term daily supplementation of trols or other nutritional therapy may bring vitamins and minerals that included known about a quicker response and diminish the Salvestrol co-factors such as biotin (625 mcg), need for further hormonal injections.
niacin and niacinamide (1,145 mg), magne- sium (606 mg), ascorbic acid (3,900 mg), and Case #6. Stage 3 B Hodgkin’s lymphoma
iron fumerate (20 mg). Vitamin D (800 I.U.), vitamin E (1,200 I.U.) and selenium (165 hospital for quadruple by-pass surgery. Af- mcg) also formed part of the daily supple- ter surgery the surgeon mentioned that he mentation. No dietary changes were made noticed abnormalities in the lymph nodes and no change in exercise level was made. that he encountered during the procedure In two months of supplementation the PSA and referred him to a cancer specialist for test result indicated a level lower than that follow up. Examination revealed a variety of reported prior to his diagnosis. Prescription tumours in lymph nodes in his neck, chest, medications for diabetes, and ongoing heart abdomen and groin. Some of these tumours and kidney conditions were maintained.
A period of three months elapsed between patient had suffered significant weight loss, Journal of Orthomolecular Medicine Vol 25, No. 1, 2010 loss of appetite and experienced pain in the be benign. The imaging also revealed that of area of his neck, stomach and groin. The pain the original tumours those in his neck, abdo- was significant with the patient taking be- men and groin still remained with those in tween 16 and 20 Tylenol® 3 tablets per day his neck and abdomen showing signs of con- for pain control. An endoscopic examination tinued growth during the course of chemo- was used to obtain material for biopsy. A di- therapy. No further treatment was provided.
agnosis of stage 3 Hodgkin’s Lymphoma was made. The patient was advised that his phy- chemotherapy this gentleman began taking a sicians felt that he had one to two years left course of Salvestrol Platinum. This comprised before the disease would end his life.
four Salvestrol Platinum (1,000 point) cap- sules, with two capsules taken in the morning apy was administered and maintained for six and two capsules taken in the evening (4,000 months (In British Columbia, Doxorubicin, points per day). This level of Salvestrol sup- Bleomycin, Vinblastine, and Dacarbazine is plementation was carried out for thirty eight the standard chemotherapy).15 No radiation days (two bottles of 75 capsules each were therapy was given. This individual found the used). There was no other concurrent treat- chemotherapy very difficult to tolerate. After ment, no dietary changes were made and no additional supplements were used. His ap- ed. A positron emission tomography scan re- petite returned to normal quite quickly after vealed a lesion on his pancreas that proved to starting to take Salvestrols and he began to Table 2. PSA test results
PSA Result
Full body bone scan – negative for metastases Biopsy consultation with urologist. Referral to BC Digital exam, 1 zoladex® 10.8 mg injection, Interview with Oncologist. Digital exam. Nutrition and Cancer: Further Case Studies Involving Salvestrol 2. Potter GA, Patterson LH, Wanogho E, et al: The Concurrent with completion of his course cancer preventative agent resveratrol is converted of Salvestrols a follow up visit with his on- to the anticancer agent piceatonnal by the cy- cologist revealed that the tumours that had re- tochrome P450 enzyme CYP 1B1. Br J Cancer, mained after his chemotherapy were gone. The 3. Potter GA, Burke DM: Salvestrols – Natural oncologist told him that he was in remission. Products with Tumour Selective Activity. J Ortho This gentleman has been followed up at inter- vals of three months, three times and each visit 4. Tan HL, Butler, PC, Burke, MD, et al: Salvestrols: has confirmed that he is cancer free. He has A New Perspective in Nutritional Research. J Or- not continued taking Salvestrols due to finan- 5. Murray GI, Taylor MC, McFadyen MCE, et al: cial constraints brought on by the long-term Tumor specific expression of cytochrome P450 nature of his medical condition. He attributes CYP 1B1. Cancer Res, 1997; 57: 3026-3031.
his remission to his use of Salvestrols and in- 6. McFadyen MCE, Melvin WT, Murray GI.: Cy- tends to continue taking Salvestrols as soon as tochrome P450 CYP1B1 activity in renal cell car- cinoma. Br J Cancer, 2004; 91: 966-971.
his financial situation improves. In the interim 7. McFadyen MCE, Cruickshank ME, Miller ID, et friends have stepped in to provide him with a al: Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Br J Can- Conclusion
8. Dana-Farber Cancer Institute: Cytochrome P450 1B1 is a Universal Tumor Antigen Elicit- ing Cytotoxic T Cell Responses, 2007. http:// that nutrition, and in particular nutrition www.danafarber.org/res/technology/available. that capitalizes on the unique metabolic asp?case_number=641&keywords=&category_ id=3&category_name=Researc+Reagents very favourable outcome for cancer sufferers. 9. Potter GA: The role of CYP 1B1 as a tumour sup- pressor enzyme. Br J Cancer, 2002; 86 (Suppl 1), Some of these cases outline the experience of individuals that did not utilise chemotherapy 10. Schaefer BA, Hoon LT, Burke DM, et al: Nutri- or radiation as part of their treatment plan. tion and Cancer: Salvestrol Case Studies. J Ortho These cases help to highlight the beneficial 11. Ware WR: Nutrition and the Prevention and Treatment of Cancer: Association of Cytochrome These cases are brought to light here in P450 CYP1B1 With the Role of Fruit and Fruit the hope that they wil provide cancer sufferers Extracts. Integrative Cancer Therapies, 2009; 8, 1: and their physicians with the confidence to ex- plore nutritional approaches before, or concur- 12. Ware WR: P450 CYP1B1 mediated fluorescent tu- rent with, conventional procedures to achieve a mor markers: A potentially useful approach for pho- todynamic therapy, diagnosis and establishing surgical margins. Medical Hypotheses, 2009; 72: 67-70.
13. Bostwick Laboratories Announces uPM3(TM) Conflict of Interest
Test, First Genetic Test for Prostate Cancer. September 23, 2005. http://www.psa-rising.com/ quired Intelligence Inc, the Canadian and US 14. Product Monograph. Zoladex® 10.8 mg Goser- distributor of Salvestrols. Professor Dan Burke elin/depot. Luteinizing Hormone – Releasing is a shareholder of Salvestrol Natural Products, Hormone Analog (LHRH Analog). February 24, the UK developer of the salvestrol technol- 2009. http://www.astrazeneca.ca/documents/Pro- ogy. Professor Gerry Potter is a shareholder of ductPortfolio/ZOLADEX%20LA_PM_en.pdf Salvestrol Natural Products, the UK developer 15. BCCA Protocol Summary for Treatment of Hodgkin’s Disease with Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine May 1, 2009. http:// www.bccancer.bc.ca/NR/rdonlyres/30FDD508- 96AC-4555-B682-294EA3635B06/34011/ References
1. Potter GA: The role of CYP 1B1 as a tumour sup- pressor enzyme. Br J Cancer, 2002; 86 (Suppl 1),

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