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Drug information bulletin

(E-News Letter)
Drug Information & Pharmacovigilance Centre,
Tamil Nadu Pharmacy Council,
Tele fax: 91 - 044 - 2473 0061,
e -mail:
Web site: http://tnpc.ac.in
Contact: 91 44 -24338421

Antidepressants as Treatment
Immediately after Stroke?
IN SIGHT
Research suggests a new strategy for the treatment of stroke. Research in rodents • Antidepressants as
Treatment Immediately
after Stroke?

known as neurogenesis, lessens the severity function following a stroke. The research • List Of Approved Drug
neurogenesis in rodents could have benefits From 01.01.2010 To
28.2.2010
suitable for study in human clinical trials.
Results of the research appear the week of "What this study shows more convincingly than in the past is that the production of new involve screening any of the existing drugs neurons after stroke is beneficial in rodents," that support neurogenesis, compared stroke said Buck faculty member. "Assuming that neurogenesis is also beneficial in humans, genetically altered and treated to either grow or not grow new neurons prior to stroke. purposes and already shown to promote new percent larger in the animals that did not studying as a potential treatment for stroke grow new neurons; the rodents that did grow in humans. For example, antidepressants are often used to treat post-stroke depression, in motor function following the stroke. The but their potential for improving outcome exact mechanism by which the new neurons Previous research by the same group at the Although the possibility of using existing drugs for the treatment of stroke is one that attempts to heal itself following stroke by may excite patients and patient advocates, growing new neurons, but it has not been those suffering from stroke should not treat themselves, even with FDA-approved drugs, without medical advice. "Everything has each year. Stroke is the third leading cause antidepressant carries the possibility of of death in the U.S. and is the leading cause making someone worse. These drugs need to be tested in a controlled clinical setting." country. Treatments for stroke are limited. Clot busting drugs, which have to be given within hours of the stroke, have been of great benefit to a small number of patients, but stroke is not usually diagnosed in time When taken with methotrexate, a new pill including interleukin-6 and matrix
metalloproteinase-3 (mmp-3) levels
arthritis drug. There was not a significant (fostamatinib disodium) is part of a new
class of rheumatoid arthritis drugs that blocks syk kinase, which can trigger the injection or infusion, this new rheumatoid arthritis drug is taken by mouth, which is lymphoma, lupus and type I diabetes.
College of Medicine, in Rochester, Minn.
drug methotrexate, those participants who effect and it is kind of exciting that they the new syk kinase inhibitor twice a day are oral,” he says. If the new findings are act differently. “Together with biologics, LIST OF APPROVED DRUG FROM 01.01.2010 TO 28.2.2010
PRODUCT NAME
INDICATION
APPROVAL
Ferrous ascorbate 100mg + Folic For iron, folic acid & omega-3-fatty acid 1.1 mg tablet and Omega-3- acid deficiency Sphaeranthus Indicus Extract For the management of psoriasis.
conjunctivitis and urticaria) and for prevention and treatment of motion sickness advanced or metastatic Non Smal Cel Lung Cancer (NSCLC) other than predominantly squamous cel histology in patients whose disease has not progressed immediately following platinum-based chemotherapy. First line treatment should be a platinum doublet with gemcitabine, paclitaxel or docetaxel. 16-Jan-10 Levobetaxolol HCl Opthalmic pressure in patients with chronic open-angle glaucoma or occular hypertension.
Sarpogrelate Hydrochloride film symptoms including ulcer, associated with chronic arterial occlusion.
associated with acute upper respiratory tract inflammation, acute musculoskeletal disorders, pain after operative intervetion and following trauma, chronic condition like rheumatoid arthritis, osteoarthritis etc for short term management of acute painful episodes.
tocopherol 163-225mg + glycerol (anhydrous) 25gm + Egg lecithin 12gm + sodium hydroxide (to approx pH 8) + sodium pleate 0.3mg emulsion for infusion in 100ml.
retroviral agents for the treatment of human immunodeficiency virus experienced patients with evidence of HIV-1 replication despite ongoing retroviral therapy.
Pregabalin SR Tablet 75mg (Additional Strength) Rivaroxaban film coated Tablets thromboembolism in patients (VTE) in adult patients undergoing hip or knee replacement surgery.
Gel 14mg/ml, 18mg/ml, 25.5mg/ml (Additional Strength) staple lines in lung resection procedures. (2)Patients undergoing cardiac surgery to prevent or reduce the incidence, severity and extend of post surgical adhesion formation. (3)Patients undergoing laparotomy or laproscopic abdomino-pelvic surgery as an adjunct to good surgical technique intended to reduce the incidence, severity and extent of post surgical adhesion formation.
chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm, indicated in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose and whose heart rate is >60bpm.
anticancer drugs is indicated for remission induction in acute non-lymphocytic leukemia of adults and children. It has also been found useful in the treatment of acute lymphocytic leukemia and the blast phase of chronic myelocytic leukemia. Intrathecal administration of cytarabine is indicated in the prophylaxis and treatment of meningal leukemia.
Olopatadine Hcl Nasal Spray 0.6% seasonal al ergic rhinitis in patients 6 w/w (Additional Indication) acetate trihydrate 3.27gm + L-malic acid 0.67gm in 1000ml solution for infusion Chemical y Modified Sodium surgery for reducing the incidence, extent and severity of postoperative 11-Feb-10 Thiocolchicoside 4mg/8mg tablets acute painful musculoskeletal with upper & lower respiratory tract infections, skin and soft tissue infections pediatric patients using this medication.
Warning on severe liver injury with
propylthiouracil
hyperthyroidism it may be appropriate to reserve use of propylthiouracil for those Warning to the label for propylthiouracil, who cannot tolerate other treatments such information about reports of severe liver occurrence of birth defects that have been treatment of choice during and just before patients who cannot tolerate methimazole Propylthiouracil may be the treatment of propylthiouracil as well as meetings with methimazole use during the first trimester use in pediatric patients, except in rare Healthcare professionals should be aware of this new safety information in the drug outlined above. Patients should carefully read the Medication Guide each time they get their prescription so they are aware of the risks and benefits of this medication.
Information for Healthcare
Professionals
acute liver failure, including fatal cases, have been reported in adult and pediatric dose inhalers (MDI) used to treat asthma international agreement to ban substances that deplete the Earth’s ozone layer. The the inhaler and into the lungs of patients. Asthma and COPD Inhalers That
The decision to phase out the products is Contain Ozone-depleting CFCs to be
the latest in a series of decisions related Phased Out
from the market as required by the Clean the ozone layer miles above the Earth that out the seven remaining products in 2007 eliminated the production of CFCs in the United States as of Jan. 1, 1996, except for certain limited uses, such as MDIs.
The affected products and their phase out schedule include
Inhaler Medication
Last Date to be
Manufacturer
manufactured, sold or
dispensed in U.S.

Aerosol (triamcinolone)Intal Inhaler (cromolyn) ipratropium in combination)Maxair Autohaler removal of all or a part of the pancreas FDA has approved three PEPs. What
What are pancreatic enzyme products
happens to the unapproved PEPs?
(PEPs)? How are they used?
pancrelipase, a mixture of the digestive available to patients because they do not effectiveness, and product quality. In the improve food digestion in patients whose had four years to obtain FDA approval of pancreatic enzymes because of conditions preparing and submitting applications for their treatment will be safe, effective, and What are the key points patients need
to know about PEPs?
approved PEPs sold in the United States.
professional to make sure they have a plan weeks to adjust the dose of the new PEP.
with each prescription of an FDA-approved PEP. The Medication Guide is written for additional PEPs even after the April 28, professional about any concerns they have approved PEP. This will help ensure that conducting tests to evaluate the feasibility data-driven recommendations are available to guide the use for all patients requiring interchangeable at the pharmacy. Patients standards for safety, effectiveness, and weeks for a patient to adjust their dose of the new PEP. Individual patient response an unapproved PEP to an approved one.
that PEPs should only be taken as directed.
for administration via gastrostomy tubes, a small number of patients may require PEPs

Source: http://tnpc.ac.in/pdf/DIC%20Bulletein-2.pdf

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