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Codex Alimentarius Commission
Maximum Residue Limits for Veterinary Drugs in Foods
Updated as at the 34th Session of the Codex Alimentarius Commission (July 2011)
Veterinary Drug
Veterinary Drug
Benzylpenicillin/Procaine benzylpenicillin Chlortetracycline/Oxytetracycline/Tetracycline Codex Alimentarius Commission
Maximum Residue Limits for Veterinary Drugs in Foods
Updated as at the 32nd Session of the Codex Alimentarius Commission (July 2009)
ABAMECTIN (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake : 0-2 µg/kg body weight (1997) Established for the sum of abamectin and (Z)-8,9
Residue Definition:
Species Tissue MRL CAC Notes
(µg/kg)
ALBENDAZOLE (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-50 µg/kg body weight (34th JECFA, 1989).
Residue Definition:
Except milk, 2-aminosulfone metabolite; Milk, not yet identified. Species Tissue MRL CAC Notes
(µg/kg)
AVILAMYCIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-2 mg/kg body weight on the basis of a NOAEL of 150 mg avilamycin activity/kg
body weight per day and a safety factor of 100 and rounding to one significant figure (70th JECFA, 2008). Residue Definition:
Species Tissue MRL CAC Notes
(µg/kg)
AZAPERONE (tranquilizing agent)
JECFA Evaluation:
38 (1991); 43 (1994); 50 (1998); 52 (1999) Acceptable Daily Intake: 0-6 µg/kg body weight (50th JECFA, 1998).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
BENZYLPENICILLIN/PROCAINE BENZYLPENICILLIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 30
µg-penicillin/person/day (50th JECFA, 1998). Residues of benzylpenicillin and procaine benzylpenicillin should be kept below this level. Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
23rd (1999) Applies to procaine benzylpenicillin only. 23rd (1999) Applies to procaine benzylpenicillin only. 23rd (1999) Applies to procaine benzylpenicillin only. CARAZOLOL (beta-adreniceptor-blocking agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-0.1 µg/kg body weight (43rd JECFA, 1994). ADI based on the acute
Residue Definition:
Carazolol.
Species Tissue MRL
CAC Notes
(µg/kg)
26th (2003) The concentration at the injection site two hours after treatment may result in an intake that exceeds the acute RfD and therefore, an appropriate withdrawal period should be applied. 26th (2003) The concentration at the injection site two hours after treatment may result in an intake that exceeds the acute RfD and therefore, an appropriate withdrawal period should be applied. CEFTIOFUR (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-50 µg/kg body weight (45th JECFA, 1995).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
CHLORTETRACYCLINE/OXYTETRACYCLINE/TETRACYCLINE (antimicrobial agent)
JECFA Evaluation:
45 (1995); 47 (1996); 50 (1998); 58 (2002) Acceptable Daily Intake: 0-30 µg/kg body weight (50th JECFA, 1998). Group ADI for chlortetracycline,
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
26th (2003) Applies only to oxytetracycline. 26th (2003) Applies only to oxytetracycline. CLENBUTEROL (adrenoceptor agonist)
JECFA Evaluation:
Acceptable Daily Intake: 0-0.004 µg/kg body weight (47th JECFA, 1996).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. CLOSANTEL (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-30 µg/kg body weight (40th JECFA, 1992).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
COLISTIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-7 µg/kg body weight (66th JECFA, 2006).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
CYFLUTHRIN (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-20 µg/kg body weight (48th JECFA, 1997).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
CYHALOTHRIN (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-5 µg/kg body weight (62nd JECFA, 2004).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
CYPERMETHRIN AND ALPHA-CYPERMETHRIN (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: JECFA established a common ADI of 0-20 µg/kg bw for both cypermethrin and
Residue Definition:
Total of cypermethrin residues (resulting from the use of cypermethrin or alpha-cypermethrin as veterinary drugs). Species Tissue
MRLs(µg/kg)
DANOFLOXACIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-20 µg/kg body weight (48th JECFA, 1997).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
24th (2001) Fat/skin in normal proportion. DELTAMETHRIN (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-10 µg/kg body weight (1982). Established by the 1982 JMPR.
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
DEXAMETHASONE (glucocorticosteroid)
JECFA Evaluation:
Acceptable Daily Intake: 0-0.015 µg/kg body weight (42nd JECFA, 1995).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
DICLAZURIL (antiprotozoal agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-30 µg/kg body weight (50th JECFA, 1998).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
DICYCLANIL (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-7 µg/kg body weigh (54th JECFA, 2000).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
DIHYDROSTREPTOMYCIN/STREPTOMYCIN (antimicrobial agent)
JECFA Evaluation:
43 (1994); 48 (1997); 52 (1999); 58 (2002) Acceptable Daily Intake: 0-50 µg/kg body weight (48th JECFA, 1997). Group ADI for combined residues of
Residue Definition:
Sum of dihydrostreptomycin and streptomycin. Species Tissue MRL
CAC Notes
(µg/kg)
DIMINAZENE (trypanocide)
JECFA Evaluation:
Acceptable Daily Intake: 0-100 µg/kg body weight (42nd JECFA, 1994).
Residue Definition: Diminazene.
Species Tissue MRL CAC Notes
(µg/kg)
Milk (μg/l) 150 22nd (1997) Limit of quantitation of the analytical method. DORAMECTIN (anthelmintic agent)
JECFA Evaluation:
45 (1995); 52 (1999); 58 (2002); 62 (2004) Acceptable Daily Intake: 0-1 µg/kg body weight (58th JECFA, 2002).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
22nd (1997) High concentration of residues at the injection site over a 35 day period after subcutaneous or intramuscular administration of the drug at the recommended dose. 22nd (1997) High concentration of residues at the injection site over a 35 day period after subcutaneous or intramuscular administration of the drug at the recommended dose 29th (2006) Depending on the route and/or time of administration the use of doramectin in dairy cows may result in extended withdrawal periods in milk. This may be addressed in national/regional regulatory programmes. EPRINOMECTIN (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-10 µg/kg body weight (50th JECFA, 1998).
Residue Definition: Eprinomectin
Species Tissue MRL
CAC Notes
(µg/kg)
ERYTHROMYCIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-0.7 µg/kg body weight (66th JECFA, 2006).
Residue Definition: Erythromycin
Species Tissue MRL
CAC Notes
(µg/kg)
ESTRADIOL-17BETA (production aid)
JECFA Evaluation:
Acceptable Daily Intake: unnecessary
(32nd JECFA, 1987); 0-0.05 µg/kg body weight (52nd JECFA, 1999). Residue Definition: Estradiol-17beta.
Species Tissue MRL
CAC Notes
(µg/kg)
21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. FEBANTEL/FENBENDAZOLE/OXFENDAZOLE (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-7 µg/kg body weight (50th JECFA, 1998). Group ADI
Residue Definition:
Sum of fenbendazole, oxfendazole and oxfendazole sulphone, expressed as oxfendazole sulphone equivalents. Species Tissue MRL
CAC Notes
(µg/kg)
FLUAZURON (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-40 µg/kg body weight (48th JECFA, 1997).
Residue Definition: Fluazuron.
Species Tissue MRL
CAC Notes
(µg/kg)
FLUBENDAZOLE (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-12 µg/kg body weight (40th JECFA, 1992).
Residue Definition: Flubendazole.
Species Tissue MRL
CAC Notes
(µg/kg)
FLUMEQUINE (antimicrobial agent)
JECFA Evaluation:
42 (1994); 48 (1997); 54 (2000); 60 (2002); 62 (2004); 66 (2006) Acceptable Daily Intake: 0-30 µg/kg body weight (62nd JECFA, 2004).
Residue Definition: Flumequine.
Species Tissue MRL
CAC Notes
(µg/kg)
28th (2005) Muscle including normal proportion of skin GENTAMICIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-20 µg/kg body weight (50th JECFA, 1998).
Residue Definition: Gentamicin.
Species Tissue MRL
CAC Notes
(µg/kg)
IMIDOCARB (antiprotozoal agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-10 µg/kg body weight (50th JECFA, 1998).
Residue Definition: Imidocarb.
Species Tissue MRL CAC Notes
(µg/kg)
ISOMETAMIDIUM (trypanocide)
JECFA Evaluation:
Acceptable Daily Intake: 0-100 µg/kg body weight (40th JECFA, 1992).
Residue Definition: Isometamidium.
Species Tissue MRL
CAC Notes
(µg/kg)
IVERMECTIN (anthelmintic agent)
JECFA Evaluation:
36 (1990); 40 (1992); 54 (2000); 58 (2002) Acceptable Daily Intake: 0-1 µg/kg body weight (40th JECFA, 1992).
Residue Definition:
Species Tissue MRL
CAC Notes
(µg/kg)
LEVAMISOLE (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-6 µg/kg body weight (42nd JECFA, 1994).
Residue Definition: Levamisole.
Species Tissue MRL
CAC Notes
(µg/kg)
LINCOMYCIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-30 µg/kg body weight (54th JECFA, 2000).
Residue Definition: Lincomycin.
Species Tissue MRL
CAC Notes
(µg/kg)
26th (2003) Additional MRL for skin with adhering fat of 300 26th (2003) Additional MRL for skin with adhering fat of 300 MELENGESTROL ACETATE (production aid)
JECFA Evaluation:
Acceptable Daily Intake: 0-0.03 µg/kg body weight.
Residue Definition: Melengestrol
Species Tissue MRL
CAC Notes
(µg/kg)
MONENSIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0–10
μg/kg body weight on the basis of a NOAEL of 1.14 mg/kg body weight per day and a safety factor of 100 and rounding to one significant figure (70th JECFA, 2008). Residue Definition: Monensin.
Species Tissue MRL
CAC Notes
(µg/kg)
MOXIDECTIN (anthelmintic agent)
JECFA Evaluation:
45 (1995); 47 (1996); 48 (1998); 50 (1998) Acceptable Daily Intake: 0-2 µg/kg body weight (45th JECFA, 1995).
Residue Definition: Moxidectin.
Species Tissue MRL
CAC Notes
(µg/kg)
22nd (1997) Very high concentration and great variation in the level of residues at the injection site in cattle over a 49 day period after dosing. NARASIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-5
μg/kg body weight on the basis of a NOAEL of 0.5 mg/kg body weight per day and a safety factor of 100 (70th JECFA, 2008). Residue Definition: Narasin
Species Tissue MRL
CAC Notes
(µg/kg)
NEOMYCIN (antimicrobial agent)
JECFA Evaluation:
43 (1994); 47 (1996); 52 (1999); 58 (2002); 60 (2003) Acceptable Daily Intake: 0-60 µg/kg body weight (47th JECFA, 1996).
Residue Definition: Neomycin.
Species Tissue MRL CAC Notes
(µg/kg)
NICARBAZIN (antiprotozoal agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-400 µg/kg body weight (50th JECFA, 1998).
Residue Definition: N,N'-bis(4-nitropheyl)urea.
Species Tissue MRL CAC Notes
(µg/kg)
PHOXIM (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-4 µg/kg body weight (52nd JECFA, 1999).
Residue Definition: Phoxim
Species Tissue MRL CAC Notes
(µg/kg)
PIRLIMYCIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-8 µg/kg bw (62nd JECFA, 2004).
Residue Definition: Pirlimycin.
Species Tissue
MRLs(µg/kg)
29th (2006) JECFA evaluated the effect of pirlimycin residues on starter cultures and for this reason recommended an MRL of 100 µg/kg of milk. Codex Members may therefore adapt national/regional MRLs in order to address this technological aspect for trade of fresh liquid milk intended for processing using starter culture. PORCINE SOMATOTROPIN (production aid)
JECFA Evaluation:
Acceptable Daily Intake: Not Specified (52nd JECFA, 1999).
Residue Definition: Not
Species Tissue MRL CAC Notes
(µg/kg)
PROGESTERONE (production aid)
JECFA Evaluation:
Acceptable Daily Intake: 0-30 µg/kg body weight (52nd JECFA, 1999).
Residue Definition: Progesterone.
Species Tissue MRL CAC Notes
(µg/kg)
21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health SARAFLOXACIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-0.3 µg/kg body weight (50th JECFA, 1998).
Residue Definition: Sarafloxacin.
Species Tissue MRL
CAC Notes
(µg/kg)
SPECTINOMYCIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-40 µg/kg body weight (42nd JECFA, 1994).
Residue Definition: Spectinomycin.
Species Tissue MRL
CAC Notes
(µg/kg)
SPIRAMYCIN (antimicrobial agent)
JECFA Evaluation:
38 (1991); 43 (1994); 47 (1996); 48 (1997) Acceptable Daily Intake: 0-50 µg/kg body weight (43rd JECFA, 1994).
Residue Definition:
Cattle and chickens, sum of spiramycin and neospiramycin; Pigs, spiramycin equivalents (antimicrobially active residues). Species Tissue MRL CAC Notes
(µg/kg)
SULFADIMIDINE (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-50 µg/kg body weight (42nd JECFA, 1994).
Residue Definition: Sulfadimidine.
Species Tissue MRL CAC Notes
(µg/kg)
TESTOSTERONE (production aid)
JECFA Evaluation:
Acceptable Daily Intake: 0-2 µg/kg body weight (52nd JECFA, 1999).
Residue Definition: Testosterone.
Species Tissue MRL CAC Notes
(µg/kg)
Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. THIABENDAZOLE (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-100 µg/kg body weight (40th JECFA, 1992).
Residue Definition:
Sum of thiabendazole and 5-hydroxythiabendazole. Species Tissue MRL
CAC Notes
(µg/kg)
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use. 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.
TILMICOSIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-40 µg/kg body weight (47th JECFA, 1996).
Residue Definition: Tilmicosin.
Species Tissue MRL
CAC Notes
(µg/kg)
TRENBOLONE ACETATE (growth promoter)
JECFA Evaluation:
26 (1982); 27 (1983); 32 (1987); 34 (1989) Acceptable Daily Intake: 0-0.02 µg/kg body weight (34th JECFA, 1989).
Residue Definition:
Cattle muscle, beta-Trenbolone; Cattle liver, alpha-Trenbolone. Species Tissue MRL
CAC Notes
(µg/kg)
TRICHLORFON (METRIFONATE) (insecticide)
JECFA Evaluation:
Acceptable Daily Intake: 0-2 µg/kg bw (60th JECFA, 2003)
Residue Definition:
JECFA confirmed the MRL for cows’s milk and the guidance levels for muscle, liver, kidney and fat of cattle recommended at the 54th meeting (WHO TRS 900, 2001) Species Tissue
MRLs(µg/kg)
TRICLABENDAZOLE (anthelmintic agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-3 µg/kg body weight (40th JECFA, 1993).
Residue Definition: Ketotriclabnedazole
Species Tissue MRL CAC Notes
(µg/kg)
TYLOSIN (antimicrobial agent)
JECFA Evaluation:
Acceptable Daily Intake: 0-30 µg/kg body weight based on a microbiological end-point derived from in vitro
MIC susceptibility testing and faecal binding data (MICcalc = 1.698) (70th JECFA, 2008). Residue Definition: Tylosin
Species Tissue
MRLs(µg/kg)
ZERANOL (growth promoter)
JECFA Evaluation:
Acceptable Daily Intake : 0-0.5 µg/kg body weight (32nd JECFA, 1987).
Residue Definition:
Zeranol.
Species Tissue MRL
CAC Notes
(µg/kg)

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SIDE EFFECTS Eplerenone Most Common ( e h - P L E H - r e h - n o n e ) Hyperkalemia, diarrhea, abdominal pain, diz-ziness, coughing, fatigue, flu-like symptoms. Classification(s): Aldosterone receptor Hyperkalemia is the primary risk; can result in de-creased renal function and serious, sometimes fa- tal arrhythmias. GI: Diarrhea, abdominal pain. Pregnancy Category: B

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