PLASMAPHERESIS IN HEMATOLOGY PLASMAPHERESIS INDICATIONS CONTRAINDICATIONS CRITERIA OF EFFICIENCY IN PARAPROTEINEMIC HEMOBLASTOSIS
Paraproteinemic hemoblastosis is a group of
diseases characterized by monoclonal proliferation of
immunoglobulins, to which, first of all, belong
hyperparaproteinemia; hyperviscose syndrome (with
a level of monoclonal protein Ig G or Ig A over 50 g/l),
paraproteinemic coma, osteoporosis and osteolysis,
(accumulation of myelomic protein and amyloid in
Waldenstroem’s macroglobulinemia, due to the high
content of immunoglobulin M, as well as to
For more information visit our web site: www.plasmatech-fzc.com or contact us by e-mail: [email protected]PLASMAPHERESIS IN HEMATOLOGY PLASMAPHERESIS INDICATIONS CONTRAINDICATIONS CRITERIA OF EFFICIENCY IN PATIENTS WITH APLASTIC ANEMIA (IN CASE OF SENSIBILIZATION AND REFRACTORINESS TO TRANSFUSION)
Aplastic anemia (ApAn is a disease characterized
by deep pancytopenia and insufficiency of medullar
hematopoiesis conditioned by development of
The given nosology calls for frequent and
sensibilization. In its turn, allosensibilization causes
refractoriness to the transfused components of
For more information visit our web site: www.plasmatech-fzc.com or contact us by e-mail: [email protected]PLASMAPHERESIS IN HEMATOLOGY PLASMAPHERESIS INDICATIONS CONTRAINDICATIONS CRITERIA OF EFFICIENCY IN THE TREATMENT OF PORPHYRIA
Plasmapheresis (PA) is used for integral
treatment of porphyria in the period of exacerbation,
basically when fighting such its forms as acute
intermittent porphyria and porphyria cutanea.
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Plasmapheresis (PA) is used for integral
syndrome (APhS) in the period of exacerbation.
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themselves by the hypercoagulation syndrome in
case of availability of determined defects of cellular
and plasmatic elements of blood that bring about
This occurs under deficit of AT III, anomaly of the
system of protein С and protein S, with mutant V
methylentetrahydrofolate-reductase (MTHFR) and
G202210А, mutations of integrins, presence of lupus
anticoagulant - autoantibodies to phospholipids,
thrombocytes - the "sticky thrombocytes" syndrome,
multidimensionality of the Willebrand factor, activity
of the factor VIII, high level of the factor XIII of the
For more information visit our web site: www.plasmatech-fzc.com or contact us by e-mail: [email protected]PLASMAPHERESIS IN HEMATOLOGY PLASMAPHERESIS INDICATIONS CONTRAINDICATIONS CRITERIA OF EFFICIENCY IN INCOMPATIBILITY OF THE RECIPIENT WITH THE DONOR AS TO ANTIGENS OF THE AVO SYSTEM BEFORE ALLOGRAFTING OF BONE MARROW
The presence of incompatibility between donor
and recipient as to antigens of the AVO system does not
constitute a contraindication for performing allogenic
According to international classification, there are
2 types of incompatibility as to antigens of the AVO
system. By big incompatibility is meant the presence in
the recipient’s blood of natural antibodies to
erythrocytary antigens of the donor, arising in such
situation the risk of hemolytic complications. For
avoiding such sort of complications, it is necessary to
remove a maximal quantity of erythrocytes of the
donor from the transplantat and to perform exchange
plasmapheresis in the recipient in order to remove
antibodies. As small incompatibility as to antigens of
the AVO system is identified the presence in the
donor’s blood of isohemagglutinins to erythrocytary
antigens of the recipient, resulting in such cases enough
to remove the plasma from the transplantat.
For more information visit our web site: www.plasmatech-fzc.com or contact us by e-mail: [email protected]PLASMAPHERESIS IN HEMATOLOGY PLASMAPHERESIS INDICATIONS CRITERIA OF EFFICIENCY AND LEUCOCYTAPHERESIS IN THE TREATMENT OF HYPERLEUCOCYTOSIS Indications for performing leucocytapheresis in patients with acute myeloblastic leucosis
When the quantity of leucocytes in the patient’s blood is above 100 x 109/l,
Hyperleucocytosis is an urgent condition in
hematological patients, associated with severe vitally-
On the background of the therapy with hydroxyurea, when the content of
dangerous complications and so requiring emergency,
leucocytes in the blood is over 100 x 109/l
When presenting clinical signs of leucostasis
In case of a very quick progression of the disease: duplication of the number
By hyperleucocytosis is meant an increase of the
level of leucocytes in peripheral blood over 30 x 109/l.
Inefficiency of the treatment with hydroxyurea during 1 day, that is, drop of
An increase of the amount of leucocytes above 100 x
the level of leucocytes by less than 30% from the initial level
109/l (in cases of acute leucosis) is considered
Indications for performing LCA in patients with chronic myeloleucosis:
Under hyperleucocytosis, in the vessels of the
Pronounced intoxication on the background of hyperleucocytosis of over 50-
100 x 109/l and hyperthrombocytosis of above 350 x 109/l, which bring
cerebrum, kidneys and heart are formed clumps of
leucoaggregates and thrombs from leucosis cells.
Developed resistance to polychemotherapy (with progressing stage and
blastic crisis), when the procedure is applied in order to remove a big
tumoral mass, thus allowing to intensify the proliferative activity of the bone
marrow and increase the efficiency of further courses of PChT
Indications for performing LCA in patients with ChLL:
hyperuricemic syndrome, which bring about renal
failure. As a consequence of a high level of proliferation
Hyperleucocytosis of over 150-200 x 109/l, matching with anemia,
thrombocytopenia, splenomegaly and inefficacy of the different schedules of
of tumoral cells, metabolism and cellular breakdown,
severe metabolic disorders may develop, including
LCA is performed in blood separators under the LCA program, with a course
hyperkaliemia, hypocalciemia and hyperphosphatemia.
of up to 2-3 procedures and an interval of 7-10 days. Administration of
heparin and protein blood substitutes is to be realized according to
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The Effect of Short-Contact Topical Tretinoin Therapy for Foot Ulcers in Patients With Diabetes Wynnis L. Tom, MD; David H. Peng, MD, MPH; Atabak Allaei, BS; Daniel Hsu, DPM; Tissa R. Hata, MD Objective: To determine the efficacy and safety of short- Main Outcome Measures: The proportion of ulcers that contact administration of topical tretinoin on foothealed in each group and the degr
tività alla luce del giorno e, di conseguenza, il suo periodo• alla continuità - discontinuità del turno (interruzione oQuesto comportamento sociale risulta principalmentedovuto alle fluttuazioni ritmiche delle diverse funzioni psi-co-fisiologiche che ricorrono nel tempo con estrema rego- 2 - Lavoro a turno, notturno e salute Una delle proprietà fondamentali della materia viventeÈ no
PLASMAPHERESIS IN HEMATOLOGY 
PLASMAPHERESIS IN HEMATOLOGY 
PLASMAPHERESIS IN HEMATOLOGY 
PLASMAPHERESIS IN HEMATOLOGY 
PLASMAPHERESIS IN HEMATOLOGY 
PLASMAPHERESIS IN HEMATOLOGY 
PLASMAPHERESIS IN HEMATOLOGY