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Department of Pathology and
Diagnostic Pathology
Associate Professor
Hiroshi Uozaki, M.D., Ph.D., Shumpei Ishikawa, M.D., Ph.D. Lecturer
Yutaka Takazawa, M.D., Ph.D.* Junji Shibahara, M.D., Ph.D. (visiting researcher, USA) Lecturer (Hospital)
Rumi Hino, M.D., Ph.D., Aya Shinozaki, M.D., Ph.D., Yukako Shintani, M.D., Ph.D., Akiko Kunita, M.D., Ph.D. Tetsuo Ushiku, M.D., Ph.D.*, Masako Ikemura, M.D., Ph.D.*, Daichi Maeda, M.D., Ph.D.*, Keisuke Matsusaka, M.D., Ph.D.* Teppei Morikawa, M.D., Ph.D. * (visiting researcher, USA) Naoko Yamauchi, M.D., Ph.D. (Global COE Program) Technical Support Specialist
Yasuyuki Morishita, M.T., Shinichi Harada, Kei Sakuma

Introduction and Organization
Tokyo Medical College. Dr. Kunita moved here from University of Basel, and Dr. Matsusaka from Department of Pathology and Diagnostic Pathology is Metropolitan Cancer and Infectious Disease Center, responsible for the practice of diagnostic pathology, education, and research in conjunction with Division Four postgraduate students (Hibiya, Tanaka, of Diagnostic Pathology of the University Hospital*. Sung, Yoshida) finished the course and received Ph.D. Our aim is the construction of “pathology as clinical In the new fiscal year, 2011, five new students will medicine” as well as “next-generation pathology for enter the postgraduate course, and there will be 16 postgraduates (including one foreign student). Dr. Shibahara and Dr. Morikawa were working We are responsible for the pathology practice of as a visiting researcher in Mayo and Harvard the University Hospital, and carrying forward the University, USA, respectively.Dr. Nakaya moved to morphology-based research targeting human diseases. As for the education of Pathology, we take charge of related to medical treatment (DRMT) has been in the following courses for the medical students; operation since September 2005, and we continue to General Pathology course for the 1st grade students in be a member of the autopsy inspection of the project. collaboration with Department of Molecular Pathology, Systemic Pathology for the 2nd grade, Teaching activities
Clinical Clerkship for the 3rd grade, and Bedside-learning (BSL) for the 4th grade students, We take on General Pathology Course for the 1st grade respectively. Programs for postgraduates and junior of undergraduate students, especially in its residents are also included in our education activities. morphological field. The course program and lecture We held 100th Annual Meeting of Japanese notes are open to the public and available in UT Open Society of Pathology from April, 28-30, 2011 at Yokohama Pacifico (President Fukayama, Vice Each class of Systemic Pathology Course and President: Dr. Miyazono), with wish to recover from exercises are held in parallel with that of Systemic the Great East Japan Earthquake of March, 11, 2011, Medicine Course. Handouts are available in every half although we had to reduce the number of programs. course of the pathological exercises, and all slides The memorial ceremony was held on April 29, to used in the course are accessible on our website as celebrate the 100th Anniversary of the Japanese virtual slides (digital images of the slides). Society of Pathology in the very presence of Price Clinical clerkship for the 3rd grade, and BSL for the 4th grade are carried out. In BSL, following We had to postpone the Extension Lecture for courses are included; autopsy pathologic practices Citizens “Autopsy and Medical Safety” on May 1, but with a case presentation for paired students, surgical could hold it on September 23 at Sanjo Kaikan, the pathologic practices using various tumor sections, and University of Tokyo. The contents were included in a tour of the pathology laboratory. The past the book, “Autopsy in Medical Practice”. examinations for graduation and Systemic Pathology for the second grade students and are referred to the Clinical activities (diagnostic
pathology and autopsy)
We also have charge of the lecture series of tumor pathology for the Cancer Profession Training Together with Division of Diagnostic Pathology, we are responsible for the pathologic diagnosis and autopsy in the University Hospital (see the Research activities
corresponding section of Division of Diagnostic The first major theme is “chronic inflammation and Surgical pathology conferences are regularly held neoplasms”, especially Epstein-Barr virus (EBV) with each clinical division, and the cases of various associated gastric carcinoma (GC) (Drs. Uozaki, tumors, including thoracic organs, liver and pancreato- Ushiku, Hino, Shinozaki, Matsusaka, and Kunita). We biliary tract, urology, gynecology, breast, and are focusing on mechanisms of abnormalties in CpG orthopedics, as well as biopsy cases of lkidney, skin island methylation and microRNA molecules in the development and progression of EBV-associated GC Clinico-pathological conferences (CPCs) for two autopsy cases are held every month in the hospital. The second major theme is ‘traslational research Together with weekly autopsy conferences, they are pathology’. We are engaged in search of target useful for the education of clinical residents. Digest molecules for cancer therapy by global analysis of version of CPC slides is now open in the hospital, and expression profiles of various cancers, in collaboration we also started e-learning program for interns to with Research Center for Advanced Science and facilitate the understanding of the CPC contents. Technology (RCAST), the University of Tokyo. In A model project for the survey analysis of deaths addition, we take part in a global COE program, Comprehensive Center of Education and research RJ, Maeda D, Chen E, Jeng YM, Wang TL, Shih for Chemical Biology of the Diseases, in which we IeM. Mutation and loss of expression of ARID1A are investigating the morphological analysis of gene in uterine low-grade endometrioid carcinoma. Am expression abnormalities of the key molecules for several diseases (Dr. Yamauchi). We discovered (5) Hanamura K, Tojo A, Kinugasa S, Asaba K, expression of gastric type claudin 18 in intraepithelial Onozato ML, Uozaki H, Fukayama M, Fujita T. neioplasms of biliary and pancreatic ducts during the Detection of myeloperoxidase in membranous screening of cancer specific molecules (Drs. Shibahara, nephropathy-like deposits in patients with shinozaki) and pointed out the importance of gastric anti-neutrophil cytoplasmic antibody-associated metaplasia for the development of cancer (Shinozaki glomerulonephritis. Hum Pathol. 2011; 42(5): Dr. Ishikawa’s group is developing the methods (6) Inoue H, Yamazaki S, Shimizu M, Uozaki H, analyzing genome information precisely to establish a Goto T, Ohnishi S, Koike K. Liver injury induced by the Japanese herbal drug kamishoyosan. The third theme is to re-evaluate the disease Gastroenterol Hepatol (N Y). 2011; 7: 692-5. entities and tumor entities from the standpoint of (7) Ishida M, Gonoi W, Hagiwara K, Takazawa Y, classical histopathology. Dr. Ushiku reported a Akahane M, Fukayama M, Ohtomo K. Hypostasis micro-papillary subtype of gastric carcinoma, with in the heart and great vessels of non-traumatic high frequency of lymph node metastasis (ref. 32) . Dr. in-hospital death cases on postmortem computed Maeda discovered a subtype of ovarian tumor, tomography: relationship to antemortem blood microcystic stromal tumor of ovary, which was tests. Leg Med (Tokyo). 2011; 13(6): 280-5. characterized by beta catenin mutation (ref. 16). (8) Ishida M, Gonoi W, Hagiwara K, Takazawa Y, pathology practice will be described in Diagnostic Postmortem changes of the thyroid on computed tomography. Leg Med (Tokyo). 2011; 13(6): References
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List of Growers/Beneficiaries under Technology Mission for the year 2012-13 Biodata of Beneficiaries District Constituency Particulars of activity Amount paid Remarks if any Activity Gh.Hassan Dar S/o Late Qasim Dar R/o Dub Ganderbal Master Gh.Mohd Bhat S/o Late Mohd Sultan Bhat R/o Masooda Yasmin S/o Late Ahmadullah Gillani R/o Kharbagh

Diabetes and metformin: a research and clinical update, , 1985, 50 pages, hendrik michiel jan krans, royal society of medicine (great britain), royal society of medicine, 1985, ebook

Diabetes and metformin: a research and clinical update, , Hendrik Michiel Jan Krans, Royal Society ofMedicine (Great Britain), Royal Society of Medicine, 1985, 0199220182, 9780199220182, 50 pages. . Pathogenesis and treatment of diabetes mellitus , Jasper Katrinus Radder, H. H. P. J. Lemkes, Hendrik MichielJan Krans, Rijksuniversiteit te Leiden. Faculteit der Geneeskunde, 1986, Health & Fit

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