Mm00188 (00) asd case study - hijazi lrg secundum:layout 1.qxd
Closure of Large Secundum-Type ASD with theAMPLATZER Septal Occluder
Ziyad M. Hijazi, MD
George M. Eisenberg Professor
Department of Pediatrics and Medicine
Section of Pediatric Cardiology
The University of Chicago Hospital
Chicago, IL U.S.A.
the connecting waist was deployed in the left atrium)
A 67-year old female was diagnosed at the age of
resulted in successful closure. Correct device
57 to have an atrial septal defect. Primary symptoms
position was verified by TEE and by pulling and
were shortness of breath and easy fatigability. Her
pushing on the delivery cable to confirm secure
anchoring of the device (“Minnesota Wiggle”). The
considered to be in NYHA functional class III-IV due
device was released by counterclockwise rotation of
to severe right heart failure. She developed
the pin vise. Repeat TEE evaluation revealed
significant atrial dysrhythmias for which she was
complete closure of the defect (Figure 3). An
maintained on amiodarone, digoxin and Coumadin.
She was referred for the possibility of catheter
catheterization laboratory failed due to heart failure
closure. She was also maintained on lasix and
and pulmonary edema. Therefore, the patient was
allowed to recover in the Cardiac Care Unit. Shewas discharged home one week later on her above
medications. The fluoroscopic time was 30 minutes
A transesophageal echocardiogram (TEE) was
and total procedure time was 115 minutes. On
performed and revealed the presence of a large,
follow-up, her symptoms improved significantly and
secundum type ASD measuring 23mm with large
she is now in NYHA functional class I-II. Repeat
right atrium and ventricle (Figure 1).
TEE after 4 months revealed complete closure withdecrease in the right atrium and ventricle size
Under general endotracheal anesthesia andcontinuous TEE monitoring, routine right and left
heart catheterization was performed. The pulmonary
This case illustrates the major benefits of device
artery pressure was 38/16 (24) mm Hg with
closure in this high surgical risk patient. The risk of
descending aortic pressure of 83/43 (56) mm Hg.
surgery would have been significantly increased due
The Qp/Qs ratio was 2.2:1 The balloon diameter of
to her heart failure, pulmonary edema and atrial
the defect was measured to be 27mm (Figure 2). An
arrhythmia. Her defect size was big with a stop-flow
8 Fr sheath (AGA Medical Corp.) was passed over
diameter of 27mm. Conventionally, we would have
the guidewire into the left upper pulmonary vein. A
liked the device size to be equal or 1mm larger than
26mm AMPLATZER Septal Occluder was attached
the stop-flow diameter of the defect. However,
to the delivery cable, compressed into the loader
because of her condition, we decided to implant the
and introduced into the sheath. An initial attempt at
largest device available at the time, a 26mm
deploying the device resulted in pulling of the device
AMPLATZER Septal Occluder. The fact that the
across the thin septum into the right atrium.
device is easily recapturable and repositionable after
Therefore, the device was recaptured and a repeat
deployment of both discs increased our confidence
attempt with modification of the deployment (part of
in attempting the implantation which resulted incomplete closure of the defect.
Figure 1: Longitudinal TEE view revealing a 23mm secundum type ASD with left-to-right shunt and RA enlargement priorto closure. Note the thin inferior septum (arrow).
Figure 2: 4-chamber view TEE image during balloon sizing of the defect, the stop-flow diameter is 27mm.
Figure 3: Longitudinal TEE image with color after closure using a 26mm AMPLATZER Septal Occluder revealing gooddevice position and no residual shunt.
Longitudinal TEE images without (figure 4) and with color (figure 5) four months after device closure, revealing gooddevice position and no residual shunt. Note the change in the profile of the device.
Refer to Instructions for Use for a complete listing of indications and usage, contraindications, warnings, andprecautions. AMPLATZER is a registered trademark of AGA Medical Corporation. AGA Medical Corporation,2006. Not in any way connected with medical gas or equipment sold under the “AGA” brand by AGA AB orits successors. This device may not be available in all markets. Contact AGA Medical Corporation for availability.
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Title Sensitivity Analysis of a Meta-analysis with Unpublished butAuthor Noory Y. Kim. Advisors: Shrikant I. Bangdiwala, Gerald Gartlehner. Maintainer Noory Y. Kim <[email protected]>Description This package contains R functions to gauge the impact of unpublished stud-ies upon the meta-analytic summary effect of a set of published studies. (Credits: The re-search leading to these result