¨ Incidence: 1% of World Population
¨ Inherited Predisposition: > 50% Concordance in
¨ Typical Onset Between 15-26 yrs
¨ Higher incidence in northern Scandinavia and
¨ Ancient times to year 1800: Belief in possession by evil
spirits…. treatments included exorcism and trepanation (drilling holes in skull).
¨ 1800: Recognition of SZ as mental disease.
¨ 1905: Belief SZ caused by negative life experiences;
¨ 1950: Use of antipsychotic medications.
¨ 1975: Advent of biological psychiatry…. focus on
¨ Failure to recognize that schizophrenia is an
“umbrella term” given to several different mental disorders.
¨ The schizophrenia phenotypes likely have different
causes, and involve differences in brain chemistry.
¨ Optimal treatment requires a therapy tailored to
Identification of Schizophrenia Phenotypes
¨ Chemical studies of 25,000 schizophrenics by Pfeiffer
(Princeton, NJ) and Walsh ( Naperville, IL).
¨ > 1 million chemical assays of blood & urine.
¨ Very high incidence of chemical abnormalities,
¨ About 50-150 symptoms, traits, and physical
characteristics were recorded for each patient and research subject,
¨ The symptoms & traits associated with specific
¨ Biochemical classifications of schizophrenia were
¨ 27% - Pyrrole disorder (severe oxidative stress)
¨ Elevated SAMe/SAH ratio in blood
¨ Depressed whole-blood histamine
¨ Overmethylation dominant imbalance
¨ High norepinephrine & dopamine Note: The most common psychiatric diagnosis is
¨ Intolerance to SSRI Antidepressants
¨ Metallothionein Promotion Therapy
- SSRI Antidepressants must be avoided - Antihistamines must be avoided - Klonapin may assist in reducing anxiety.
Symptoms & Traits
¨ Severe Deficiencies of B-6, Zinc
¨ Benzodiazapines (especially Klonapin)
Medication support may become unnecessary after
¨ Incomplete Breakdown of Gluten Proteins in the
¨ Short Peptides with Opioid Properties Treatment:
Dietary Avoidance of Wheat, Oats,
Initiation of Nutrient Therapy: Meds continued at full
dosage for several months, unless sedation becomes excessive.
Months 4-12: After significant improvement, med
dosages may be cautiously reduced to tolerance;
Long-Term Care: Low-dose medication support usually
¨ Overmethylation: Major Improvement
¨ Pyrrole Disorder: Moderate Improvement
¨ Undermethylation: Slight Improvement
¨ Oxidative stresses gradually increase until GSH and
MT proteins are overwhelmed, resulting in sudden brain inflammation, alteration of NT levels, and disruption of the blood brain barrier.
¨ As in Wilson’s Disease, sudden onset of a mental illness
¨ All major phenotypes of schizophrenia involve severe
¨ Oxidative overload depletes GSH and reduces
¨ Clear evidence of brain cell loss in schizophrenia: Archives
of General Psychiatry, January 2006.
¨ Most antipsychotic medications have antioxidant
¨ Abnormal methylation and severe oxidative stress
¨ Greater than 95% of schizophrenics exhibit
abnormal methylation or oxidative overload.
¨ This could explain failure of schizophrenia to obey
¨ 85% report that “life is better” after nutrient
¨ 75% report ability to reduce medication,
¨ Highest efficacy for overmethylation and pyrrole
¨ Many cases of complete recovery.
Accumetrics, Inc. Announces GRAVITAS Trial 50 Percent Enrolled June 30, 2009, San Diego, Calif. -- Accumetrics, Inc. announces that it has reached the halfway mark (1,600 patients) in the enrollment of its landmark clinical trial, GRAVITAS ( G auging R esponsiveness with A V erifyNow® Assay I mpact on T hrombosis A nd S afety). The trial is specifically designed to demonstrate the
TCA Cycle pyruvate pyruvate carboxylase 1 pyruvate carboxylase 2 cytoplasmic malate dehydrogenase mitochondrial malate dehydrogenase phosphate acetyl-CoA malate dehydrogenase oxaloacetic acid citrate synthase 3 citrate synthase 1 citrate synthase 2 Gene Database Coenzyme A Sc-Std_20070817.gdb Expression Dataset Name: all Color Sets: fumar