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SINEMET® & SINEMET® CR
Refer to Summary of Product Characteristics (SPC) before prescribing
Adverse events should be reported. Reporting forms and information can
be found at . Adverse events should also be
reported to MSD (tel: 01992 467272).
Sinemet 12.5 mg/50 mg Tablets contains 12.5 mg of anhydrous carbidopa and 50 mg
Sinemet 10 mg/100 mg Tablets contains 10 mg of anhydrous carbidopa and 100 mg levodopa.
Sinemet Plus 25 mg/100 mg Tablets contains 25 mg of anhydrous carbidopa and 100 mg
Sinemet 25 mg/250 mg Tablets contains 25 mg of anhydrous carbidopa and 250 mg levodopa.
Sinemet CR 50 mg/200 mg Prolonged-Release Tablets contains 50 mg of anhydrous
Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets contains 25 mg of anhydrous
Sinemet (excluding Sinemet CR & Half Sinemet CR)
For treatment of Parkinson’s disease and syndrome.
Idiopathic Parkinson’s disease, in particular to reduce off-period in patients previously treated
with levodopa/decarboxylase inhibitors, or with levodopa alone and who have experienced
motor fluctuations. Experience is limited with Sinemet CR and Half Sinemet CR in
DOSAGE AND ADMINISTRATION
Consult the Summary of Product Characteristics.
Oral use. Use in patients below the age of 18 is not recommended.
Sinemet (excluding Sinemet CR & Half Sinemet CR): The optimum daily dose must be
determined by careful titration. Sinemet tablets are available in a ratio of 1:4 or 1:10 of
carbidopa to levodopa to provide a facility for fine dosage titration. Dopa-decarboxylase is
fully inhibited (saturated) by carbidopa at doses between 70 and 100 mg a day. Patients
receiving less than this amount of carbidopa are more likely to experience nausea and
vomiting. Standard antiparkinsonian drugs, other than levodopa alone, may be continued
while Sinemet/Sinemet CR/Half Sinemet CR are being administered, although their dosage
may have to be adjusted. Monitor carefully during the dosage adjustment period. Involuntary
movements, particularly blepharospasm, are a useful early sign of excess dosage.
Patients not receiving levodopa:
Dosage may be best initiated with one tablet of Sinemet
Plus t.d.s (three times a day). Dosage may be increased by one tablet of Sinemet 12.5 mg/50
mg or Sinemet Plus every day or every other day, as necessary, until a dosage equivalent of 8
tablets of Sinemet Plus a day is reached. If Sinemet 10 mg/100 mg or Sinemet 12.5 mg/50 mg
is used, dosage may be initiated with one tablet t.d.s or q.d.s. (four times a day). Titration
upwards may be required. Dose may be increased by one tablet every day or every other day
until a total of 8 tablets (2 tablets q.d.s.) is reached. Fully effective doses usually are reached
within 7 days. Sinemet 12.5 mg/50 mg or Sinemet 10 mg/100 mg may be used to facilitate
Patients receiving levodopa:
Discontinue levodopa at least 12 hours (24 hours for slow-
release preparations) before starting therapy with Sinemet. The dose of Sinemet should be
approximately 20% of the previous daily dosage of levodopa. Patients taking less than
1,500 mg levodopa a day should take one tablet of Sinemet Plus t.d.s. or q.d.s. dependent on
need. Suggested starting dose for most patients taking more than 1,500 mg levodopa a day is
one tablet of 'Sinemet 25 mg/250 mg' t.d.s. or q.d.s.
Therapy with Sinemet should be individualised and adjusted gradually
according to response. Experience with a total daily dosage greater than 200 mg carbidopa is
Patients receiving levodopa with another decarboxylase inhibitor:
Discontinue dosage at
least 12 hours before Sinemet is started. The initial dosage of Sinemet should provide the
same levodopa dose as contained in the existing levodopa/decarboxylase inhibitor
May only be administered as whole tablets. To maintain the controlled release properties of
the product, tablets should not be chewed, crushed, or halved. Standard antiparkinson drugs,
other than levodopa alone, may be continued while Sinemet CR or Half Sinemet CR are being
administered, although their dose may have to be adjusted. Sinemet CR or Half Sinemet CR
can be given to patients receiving supplemental pyridoxine (vitamin B6).
Patients currently treated with conventional levodopa/decarboxylase inhibitor
When higher doses are given (more than 900 mg per day) Sinemet CR should
be substituted at an initial dose providing no more than approximately 10% more levodopa
per day. The dosing interval should be prolonged by 30 to 50% at intervals ranging from 4 to
12 hours. It is recommended to give the smaller dose, if divided doses are not equal, at the
end of the day. Titrate dose in line with clinical response. Please see Summary of Product
Characteristics for details of dose titration, and conversion of Sinemet to Sinemet CR and
Patients currently treated with levodopa alone:
Discontinue levodopa at least 8 hours
before Sinemet CR is started. For patients with mild to moderate disease, the initial
recommended dose is one tablet of Sinemet CR b.d.
Patients not receiving levodopa:
In patients with mild to moderate disease, the initial dose is
one tablet of Sinemet CR b.d. Initial dose of levodopa, should not exceed 600 mg per day and
should be given at intervals of less than six hours.
Following initiation, doses and dosing intervals may be varied depending upon
therapeutic response. Most patients have been adequately treated with 2 to 8 tablets per day of
Sinemet CR given at divided doses of 4 to 12 hours during the waking day. Doses of up to 12
tablets per day over shorter intervals are not recommended. When given at intervals of less
than 4 hours, or if the divided doses are unequal, the smaller doses should be given at the end
of the day. An interval of at least three days between dosage adjustments is recommended.
eriodic clinical evaluation is recommended. Dosage adjustment may be
required. Patients should be observed carefully if abrupt reduction or discontinuation is
required, especially if the patient is receiving antipsychotics.
Addition of other antiparkinson medication:
Sinemet CR or Half Sinemet CR -
Anticholinergic agents, dopamine agonists and amantadine can be given with Sinemet CR or
Half Sinemet CR. Dosage adjustment may be required. Sinemet (excluding Sinemet CR &
Half Sinemet CR) - Other antiparkinsonian agents may be continued. Dose adjustment may
Non-selective MAO inhibitors. These inhibitors must be discontinued at least 2 weeks before
starting dosing (may be co-administered with the manufacturer’s recommended dose of MAO
Type B selective inhibitors). Patients with narrow-angle glaucoma, known hypersensitivity to
any component of this medication, suspicious undiagnosed skin lesions or a history of
melanoma, patients with severe psychoses.
Sinemet CR or Half Sinemet CR should not be given when administration of a
sympathomimetic amine is contraindicated.
Monitor carefully for the development of mental changes, depression with suicidal tendencies,
and other serious anti-social behaviour. Patients with psychoses should be treated with
caution. Not recommended for the treatment of drug-induced extrapyramidal reactions.
Dyskinesias may occur in patients previously treated with levodopa alone and may require
dosage reduction. Administer with caution to patients: with severe cardiovascular or
pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease, or history of peptic
ulcer disease. In patients with a history of myocardial infarction who have residual, atrial,
nodal, or ventricular arrhythmias, cardiac function should be monitored during the period of
initial dosage adjustment and titration. Sudden onset of sleep during daily activities, in some
cases without awareness or warning signs has been reported very rarely. Patients must be
informed of this and advised to exercise caution while driving or operating machines during
treatment with levodopa. Patients who have experienced somnolence and/or an episode of
sudden sleep onset must refrain from driving or operating machines. A reduction in dose or
termination of therapy may be considered. Patients with a history of severe involuntary
movements or psychotic episodes when treated with levodopa alone should be observed
carefully. Dose reduction may be required. A syndrome resembling the neuroleptic malignant
syndrome including muscular rigidity, elevated body temperature, mental changes and
increased serum creatine phosphokinase has been reported with the abrupt withdrawal of
antiparkinsonian agents. An abrupt dose reduction or withdrawal of Sinemet should be
carefully observed, particularly in patients who are also receiving neuroleptics or
antipsychotics. Pathological gambling, increased libido and hypersexuality have been
reported. Patients with chronic wide-angle glaucoma may be treated cautiously with Sinemet,
provided the intra-ocular pressure is well controlled and the patient monitored carefully for
changes in intra-ocular pressure during therapy. Periodic evaluation of hepatic,
haematopoetic, cardiovascular and renal function are recommended during extended therapy.
Monitor for melanomas on a regular basis. Patients with a history of convulsions should be
When patients are receiving levodopa monotherapy, levodopa must be discontinued at least 8
hours before therapy with Sinemet CR or Half Sinemet CR is started (at least 12 hours if
slow-release levodopa has been administered).The onset of effect in patients with early
morning dyskinesias may be slower than with conventional 'Sinemet'.
Symptomatic postural hypotension. Dose adjustment of the
antihypertensive agent may be required. Antidepressants:
hypertension and dyskinesia have
been reported with the concomitant use of tricyclic antidepressants. Anticholinergics:
affect Sinemet's absorption. Iron:
when ingested a decrease has been shown in the carbidopa
and/or levodopa bioavailability. Other interactions:
Dopamine D2 receptor antagonists and
isoniazid, may reduce the effects of levodopa. Effects reduced by phenytoin and papaverine.
Patients should be carefully observed. Concomitant use with selegiline and may be associated
with severe orthostatic hypotension. The absorption of Sinemet may be impaired in some
Use in pregnancy and lactation:
Do not use during pregnancy or breast-feeding.
Refer to SPC for complete information on side effects
Most frequently reported: dyskinesias including choreiform, dystonic and other involuntary
movements and nausea. Muscle twitching and blepharospasm may be taken as early signs to
consider dosage reduction. Other adverse reactions : syncope, chest pain, anorexia, cardiac
irregularities and/or palpitations, hypotensive episodes, hypertension, phlebitis, vomiting,
gastro-intestinal bleeding, diarrhoea, leucopenia, haemolytic and non-haemolytic anaemia,
thrombocytopenia, agranulocytosis, angioedema, urticaria, pruritus, Henoch-Schonlein
purpura, neuroleptic malignant syndrome, bradykinetic episodes, dizziness, paraesthesia,
psychotic episodes including delusions, hallucinations and paranoid ideation, depression with
or without development of suicidal tendencies, dementia, dream abnormalities, agitation,
confusion, increased libido, somnolence, sudden sleep onset episodes,dyspnoea, alopecia.
treat as per acute levodopa overdose. ECG monitoring should be instituted.
PACKAGE QUANTITIES AND BASIC NHS COST
Sinemet 12.5 mg/50 mg Tablets – PVC/AL blister packs of 90 tablets £6.28
Sinemet 10 mg/100 mg Tablets – PVC/AL blister packs of 100 tablets £7.30
Sinemet Plus 25 mg/100 mg Tablets - PVC/AL blister packs of 100 tablets £15.24
Sinemet 25 mg /250 mg Tablets - PVC/AL blister packs of 100 tablets £10.73
Sinemet CR 50mg/200 mg Prolonged–Release Tablets - All aluminium blister packs of 90
Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets - All aluminium blister packs of
Marketing Authorisation Numbers
PL 00025/0226 Sinemet 12.5 mg/50 mg Tablets
PL 00025/0084 Sinemet 10 mg/100 mg Tablets
PL 00025/0150 Sinemet Plus 25 mg/100 mg Tablets
PL 00025/0085 Sinemet 25 mg /250 mg Tablets
PL 00025/0269 Sinemet CR 50mg/200 mg Prolonged–Release Tablets
PL 00025/0287 Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets
Marketing Authorisation Holder
Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, UK
POM Date of review of prescribing information: July 2012
Merck Sharp & Dohme Limited, 2012. All rights reserved.
Easy-to-install wireless liquid level alarm system with auto-reset and battery backup features. The Tank Alert® ABW alarm system features a battery operated wireless transmitter that is placed in a tank (up to 150 feet away from the indoor alarm). When the high water alarm float switch activates, the transmitter sends a signal and sounds the indoor alarm warning of a potentially thre
Abstract In this paper, I call for a re-consideration of anarchism and its alternative ways of conceptualising spaces for radical politics. Here I apply a Lacanian analysis of the social imaginary to explore the utopian fantasies and desires that underpin social spaces, discourses and practices – including planning, and revolutionary politics. I will go on to develop – via Castoriadis and