Overactive bladder

Overactive Bladder (OAB) and Urge Urinary Incontinence

Very often we do not know the exact cause of bladder dysfunction. Urinary tract
infections, hormone changes, vaginal births, muscular relaxation, fascial nerve damage,
radiation treatment, pelvic surgery, and trauma, for instance, may be causes of voiding
dysfunction. Voiding dysfunction includes symptoms such as frequency, and urinary
incontinence.
An overactive bladder occurs when the parasympathetic nervous system may be
dysfunctional at the pelvic level and cause irregular bladder contractions. The bladder
starts to contract uncontrollably often leading to leakage of urine called urge
incontinence.
Direction and Diagnosis
Testing can be done to determine the type of voiding dysfunctions you are experiencing.
Urinalysis
Urine samples may detect infection, blood, and cancer cells.
Cystoscopy
Cystoscopy is a test in order to visualize the urethra and bladder for irregular anatomy,
including urethral narrowing, foreign bodies, or cancer. The procedure is simply done in
the office and may be comparable to a Pap smear in terms of pain.
Urodynamic Study
A urodynamic study utilizes small cables and a sophisticated computer system designed
to identify the delicate pressures within your bladder. It is a 20-minute test that requires
approximately a one-hour office visit. A small catheter, like the inside of a pen, is placed
through the urethra into the bladder, and another catheter, the same size, is carefully
placed within the rectum. Through the rectal catheter, abdominal pressures are subtracted
out to give the actual bladder pressure.
The catheters and electromyogram patches are attached to a state-of-the art computer
system as you sit on an electronic, neurologically-safe chair. Your bladder is slowly
filled with water and monitored for abnormal contractions, leakage, abnormal
urination/voiding and obstruction, as well as abnormal bladder pressures. This is like and
“EKG” of the bladder. It is an objective way to determine the function of the bladder.
Treatment Options
Overactive bladder (OAB) and urinary incontinence have significant improvement rates
when therapy is initiated. Following the urodynamics study, options for therapy are
available depending on the diagnosis.
Medications
Medical therapies for overactive bladder (frequency, urgency, urge incontinence, and
nocturia) include medications that relax the bladder. These are called anticholinergic
medications, which may include medications such as Detrol LA, Enables, VESIcare,
Sanctura XR, Ditropan XL, and Oxytrol patches. Side-effects typically include dry
mouth and mild constipation, but may not occur. Increased fluid intake will help improve
tolerance until the side-effects decrease.
Pelvic Floor Therapy
If medical therapy does not help, Pelvic Floor Therapy is an option that can improve
symptoms up to 75% for OAB, urge incontinence, stress incontinence, or pelvic pain. It
includes placing a probe vaginally which sends off pulse waves to “reset” the pelvic
nerves and muscles via computer assistance and applying biofeedback-type information
to determine the degree of tension within the pelvis. Whether hyper- or hypotonic pelvic
muscles are identified, the therapy is initiated typically one time a week for six weeks to
improve pelvic function. This from of therapy is highly successful. It can compliment
medical therapy or be given as a single source of therapy.
Minimally Invasive Treatments
If these therapies fail, then the next step is to consider minimally invasive therapies.
For an overactive bladder with or without incontinence, percutaneous needle placement,
like acupuncture, may be place into the perineal nerve at lower aspects of the patient.
This therapy is offered in sessions, and has a success rate of 58-70%. Botox is available,
but not FDA approved and unfortunately involves a high cost, and repeat injections
include success rates on average of 60-70% with minimal side-effects. Long-term
success is equivocal.
A very successful form of therapy which is FDA approved for OAB/incontinence and
urinary retention or interstitial cystitis is called sacral neuromodulation. Medtronic
Corporation has developed InterStim which offers sacral neuromodulation. It can be up
to 95% successful. It is like a pacemaker for the bladder. Under light anesthesia the
devise is placed at the back hip under the skin. A wire is placed above the coccyx bone
well below the spinal cord. Typical risks include, but are not limited to, bleeding,
infection, or failure of the procedure.
An ultimate form of therapy may be applied if the patient’s bladder is completely
noncompliant after the above stated therapy, and after years of symptoms that
significantly affect a patient’s quality of life. Augmentation enterocystoplaty is a
procedure whereby the bladder is enlarged with a piece of bowel. This may also be an
option which is quite successful but rarely indicated.

Source: http://www.manchesterurology.com/Overactive%20Bladder.pdf