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Kristen Riddle, PharmD • Julie Jones, PharmD • Becca Mitchel , PharmD
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Compounded Bioidentical Hormone Replacement
Compounded bioidentical hormones are chemical y processed from
precursors found in yam or soy plants to have exactly the same chemical
structure as hormones produced by the human body. The benefits of bioidentical
hormones include fewer side effects versus synthetic derivatives, individualized
therapy, and positive benefits of estrogen, testosterone, and progesterone
balance. Bioidentical hormones can be compounded in various dosage forms,
including creams, capsules, and lozenges.
Symptoms of hormone imbalance can include abdominal weight gain, hot
flashes, night sweats, irritability, decreased sex drive, fatigue, dry skin or hair,
heavy or irregular menses, difficulty sleeping, and MANY more.
therapy has both benefits and risks. Some of the documented
benefits of adequate estrogen levels include increased metabolism, increased
insulin sensitivity, improved sleep quality, reduction of overal heart disease risk
by 40-50%, decreased blood pressure, improved concentration, maintenance of
good bone density, and increased energy and sexual interest. However, excess
estrogen levels can cause depression, fluid retention, headaches, poor sleep,
irritability, mood swings, fatigue, increased risk of auto-immune diseases, weight
gain, and increased risk of breast and uterine cancer.
The human female body makes three primary estrogens: estrone,
estradiol, and estriol, abbreviated E1, E2, and E3. Estrone (E1) is a very strong
estrogen that has been linked to breast and uterine cancer in some women. US
Compounding prefers not to give estrone, but some patients require it temporarily
to achieve symptom relief. Estradiol (E2) is the estrogen that our bodies produce
in the highest amount, and it is crucial for proper estrogen balance. Estradiol has
also been linked to some breast cancers. Estriol (E3) is the weakest estrogen in
our bodies, and is produced as a breakdown product of estrone and estradiol. It
is thought to have protective effects against many of the health problems that
excess levels of estrone and estradiol may cause. Symptoms of too much
estrogen can include breast tenderness, headache, irritability, and hot flashes.
US Compounding advocates conservative, customized dosing to maintain
proper hormone balance and promote healthy estrogen levels. Estrogen levels
are improved with a diet high in grains and fiber, moderate exercise, stress
reduction, certain B vitamins, omega-3 fatty acids (fish oil), and maintaining a
healthy body mass index (BMI). Just as important as maintaining a healthy
estrogen level is ensuring its proper balance with other hormones in the body,
including progesterone, testosterone, and cortisol.
is a hormone produced by the ovaries and adrenal glands
that helps to balance estrogen. Natural progesterone, which is very different
from the synthetic progestins found in many non-compounded hormones, has
many benefits. Progesterone improves sleep, has a natural calming effect,
lowers high blood pressure, helps the body use and eliminate fats, lowers
cholesterol, has anti-inflammatory properties, and is both a natural diuretic and a
natural antidepressant. Too much progesterone upsets the natural
progesterone/estrogen balance, and can cause hot flashes and fluid retention.
is important in both males and females for proper body
function. Testosterone increases sexual interest and sense of emotional wel -
being, increases muscle mass and strength, helps maintain memory and keep
skin from sagging, helps maintain bone density, and decreases excess body fat.
Some ways to natural y improve libido, without supplementing testosterone,
include decreasing calorie and increasing protein intake, exercising properly,
getting adequate sleep, losing weight, and reducing stress levels. Too much
testosterone can cause acne, irritability, and (in extreme cases) facial hair growth
is a stress hormone secreted by the adrenal glands to help the
body cope with day-to-day stresses. It should start highest in the morning and
gradual y fal throughout the day. Cortisol functions to aid in blood sugar
balance, weight control, immune system responses, reaction to stress, and
sleep. Elevated cortisol can cause fatigue, irritability, insomnia, decreased
immunity, insulin resistance, elevated cholesterol, increased risk for
osteoporosis, muscle weakness, easy bruising, and weight gain (especial y
around the “middle”). Low cortisol, characterized as adrenal fatigue, can cause
fatigue, insomnia, decreased sexual interest, decreased immunity, al ergies,
unresponsive hypothyroidism (does not respond to treatment), emotional
imbalances, lack of motivation, and digestive problems. Cortisol imbalances are
corrected with over-the-counter supplements. For more information on cortisol,
please visit www.adrenalfatigue.org.
The first step on the road to hormone balance is setting up an
appointment to review your medical history and symptoms. A simple saliva test
you do at home gives us a picture of your hormone levels and how your body
metabolizes these hormones. Based on these results, we work with your
physician to provide you with customized hormone prescriptions. Most women
see symptom improvement the first month, though a ful two months is
sometimes required to see the maximum effect of a new regimen or a dosage
change. At US Compounding, we treat the whole person, with the ultimate goal
of improved overal health and wel -being. For many patients, hormone balance
is just the first step towards a whole new life.
CAMP SMITH POLICIES AND PROCEDURES CHAPTER 6 – ENVIRONMENTAL CONSIDERATIONS JULY 2009 6-1 Camp Smith follows the principles of Integrated Training Area Management (ITAM). ITAM is a trainer run environmental protection program implemented to insure that our training areas will be usable for centuries to come and that our war fighting training will not negatively affect the training areas and th
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