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Bert w. o'malley, jr., m.d.: short cv



PERSONAL

Current Position:
Department of Otorhinolaryngology-Head and Neck Surgery Director, Head and Neck Cancer Center and Research Program Co-Director, Head and Neck Cancer Center (Abramson Cancer Center) The University of Pennsylvania School of Medicine and Health System
EDUCATION

University
University of Texas Southwestern Medical School, Medical Degree 1988 General Surgery Residency, UT Southwestern Otolaryngology-Head and Neck Surgery Residency Head and Neck Oncology and Cranial Base Surgery Fellowship University of Pittsburgh, Pittsburgh, PA American Academy of Otolaryngology-Head and Neck Surgery
HONORS and AWARDS

Dean's
UT Southwestern Clinical Rotations' Ranking: First Place Resident Research Award, Texas Association of Otolaryngology 1992 Charles Dickson Resident Research Award for Laboratory Science Resident Research Award-Runner Up, Triological Society Southern Section Second Place Resident Research Award, Texas Association Otolaryngology First Place Resident Research Award, Texas Association of Otolaryngology 1994 The American Cancer Society Clinical Oncology Fellowship Award International College of Surgeons Research Award First Place Scholarship Award Competition, Am. Soc. Head and Neck Surgery First Place Scholarship Award Competition, Am. Soc. Head and Neck Surgery First Place Scholarship Award Competition, Am. Soc. Head and Neck Surgery Honor Award, Am. Academy of Otolaryngology - Head and Neck Surgery
ACADEMIC APPOINTMENTS
University of Pittsburgh Eye and Ear Institute

Fellow and Clinical Instructor, Department

Johns Hopkins University School of Medicine
Assistant Professor, Department of Otolaryngology - Head and Neck Surgery
Faculty Member, Markey Graduate Program in Cellular and Molecular Biology Director, Gene and Molecular Therapy Division, Dept. of Otolaryngology-HNS Associate Professor, Department of Otolaryngology – HNS
University of Maryland School of Medicine
Director, Division of Otolaryngology-Head & Neck Surgery
Director, Residency Program, Otolaryngology-Head & Neck Surgery Director, Head & Neck Oncology Research Program Co-Director, Center for Skull Base Surgery Associate Director, Univ. Maryland Greenebaum Cancer Center Professor and Chairman, New Department Otolaryngology-Head and Neck Surgery (July)
University of Pennsylvania School of Medicine and Health System

Gabriel Tucker Professor and Chairman, Dept.
Director, Residency Program, Dept. Otorhinolaryngology-HNS
Co-Director, Head and Neck Cancer Center
Director, Division of Head and Neck Surgery
ADMINISTRATIVE APPOINTMENTS
Johns Hopkins University

Resident Research Committee, Department
University of Maryland School of Medicine

Faculty
Executive Committee, Department of Surgery Executive Committee, Univ. of MD Surgical Associates, PA Research Subcommittee Group Leader, Univ. of MD Five Year Strategic Plan Co-Chairman, Univ. MD First Annual Research Retreat Research Affairs Advisory Committee to the Dean (RAAC) 2001 Dean's Search Committee, Univ. MD Dental School Univ. MD School of Medicine, Faculty Assembly
University of Pennsylvania School of Medicine and Health System

Clinical Practices University Pennsylvania (CPUP) Board of Directors
Standing Committee of Department Chairs and Center Directors Univ. Pennsylvania Health System OR Committee Chair, Dept. ORLHNS Executive Steering Committee
National


Search Committee for the position of Chief, Oral & Pharyngeal Cancer Branch
Division of Intramural Research, National Institute for Dental Research, NIH Professional Relations & Public Education American Academy Otolaryngology-Head and Neck Surgery Research Committee for the American Head & Neck Society Association for Research in Otolaryngology Physician Research Training Committee Chairman, Otolaryngology Section, International College of Surgeons Board of Trustees, National Advanced Cranio-Maxillofacial AO ASIF North American Cranio-Maxillofacial Education Committee
SOCIETY MEMBERSHIPS

American Academy of Otolaryngology Head and Neck Surgery
Cell Transplant Society, Founding Member American Society for Gravitational and Space American Association for Cancer Research American Association for the Advancement Fellow, American Head and Neck Society 1998 Society of University Otolaryngologists - Head & Neck Surgeons Physician / Scientist Member; Russian-American Cancer Alliance
JOURNAL EDITORIAL POSITIONS

Editor

Editor-in-Chief, ORL, Journal of Oto-Rhino-Laryngology
S.Karger Medical and Scientific Publishers, Basel, Switzerland
Editorial Board

Editorial Board, Skull Base Surgery, Otolaryngology-Head & Neck Surgery
International Editorial Board, Otolaryngology-Head & Neck Surgery
Reviewer

Reviewer, Archives of Otolaryngology-Head & Neck Surgery
Reviewer, Clinical Cancer Research

TEXTBOOK EDITORSHIP

Atlas of Skull Base Surgery

Editors: Donlin M. Long, John K. Niparko, Bert W. O’Malley, Jr., and S. James Zeinrich.
NIH GRANT REVIEW POSITIONS and ADVISORY BOARDS
Ad-Hoc
Ad-Hoc Reviewer National Cancer Institute, Extramural RFA CA-02-009, "Chemoprevention of Tobacco-Related Cancers in Former Smokers" External Advisory Board, The Johns Hopkins University School of Medicine present
Head and Neck Cancer SPORE.

CURRENT
GRANTS
1. *RO1 DE14562 (NIH) Adenovirus Limitations and Tumor Targeted Gene Therapy
$1,225,000 direct costs; total costs $1,782,000. (12/02-11/07) [score 140, percentile 6.2] 2. Combination Adenovirus-Mediated RB-94 and IL-2 Gene Therapy for Head and Neck Cancer; $456,554.00 direct costs; total costs $682,423 (1/00 - 12/03). 3. MRN-Targeted Chemosensitization for Oral Cancer (in vitro) $300,000.00 (direct cost); (7/02-6/05) Sponsor: Flight Attendant Medical Research Institution 4. R01/NIH, Gene Therapy for Laryngeal Paralysis P.I.: Paul W. Flint, M.D. (Johns Hopkins University) GRANTS IN SUBMISSION (PENDING)
1. P01 CA95102-01, "Targeted Molecular Therapy and Intensity Modulated Arc Therapy (IMAT) for
Head & Neck Squamous Cell Cancer. [SCORE 190 12/22/02] *Project 1: Smart Targeting Strategies for Head and Neck Cancer Project 2: Molecular Targeting to the MRN Complex to Achieve Radiosensitization *Project 3: Combination Tumor Targeted Gene Therapy and Radiation for HNSCC Project 4: Broadscope Optimization of IMAT for HNSCC Overall Program: INTEGRATED TO HIGHLY INTEGRATED 2. Molecular/Cellular Responses in Head and Neck Cancer with Xeloda and Radiation $100,000 direct costs; $148,000 total costs (7/03- 6/04) Sponsor: Roche Pharmaceuticals Role: Co-Investigator 3. 1 R01 CA100591 MRN-Targeted Chemosensitization for Head and Neck Cancer (score 180 12/02) $1,250,000 direct cost; $1,862,500 total costs (2003-2008) Sponsor: NIH/NCI Role: Co-Investigator 4. FGF2 Retargeting of Combination B7 Immunotherapy to Head and Neck (Oral) Cancer” $803,916 direct costs; $1,000,000 total costs (2003-2007) 5. STTR Phase I Grant Application; RB94 Gene Therapy of Head and Neck Cancer 6. Polymers for Gene Therapy of Head and Neck Cancer; $250,000 total costs (2003-2005) 7. The Effect of Lactoferrin on Human Squamous Carcinoma Cell Lines, $300,000 total costs (2003-2005) 8. Oral Lactoferrin Therapy, $200,000 total costs (2004-2006) GRANTS IN SUBMISSION (continued)
9. Engineering Polymers for Gene Therapy of Head & Neck Cancer, $1,150,000 total costs
P.I. Hamid Ghandehari, Ph.D. (Submitted 7/2003) 10. Radiosensitization of Head and Neck Squamous Cell Cancer, $1,250,000 total costs (2004-2009) Sponsor: NIH Role: Co-Investigator 1. Genomic Characterization of Head and Neck Cancer, $1,250,000 total costs (2004-2009) Sponsor: NIH Role: Co-Investigator P.I. Marcia Brose, M.D., Ph.D. (submitted 8/2003)
GRANT HISTORY
1. NIH First Award (R29) DE11772 Gene therapy for Oral Cancer
$350,000 direct costs; $583,472 total costs (4/96 – 12/01) [score 123, percentile 2.9]
2. DNA-Mediated Gene Therapy for Head and Neck Cancer
Sponsor: Valentis/GeneMedicine, Inc., The Woodlands, TX
3. Slow Release Polymer Chemotherapy for Head and Neck Cancer

4. The Prognostic/Predictive Value Of Ts, Tp & Dpd In Chemoradiation Strategies For Squamous Cell
Carcinoma Of The Head And Neck. $100,000 direct costs; $50,000 total costs (2000-2001). 5. Gene Transfer to Maintain Muscle Mass in Microgravity. National Space Biomedical Research Institute Grant /Muscle Team $90,000 direct costs; (10/1/97-9/30/2000) 6. Phase II Human Clinical Trial: hIL-2 Plasmid Gene Therapy for Patients with Squamous Cell Carcinoma Sponsor: Valentis, Inc., The Woodlands, TX Role: Principal Investigator

7. Lactoferrin Treatment of Cancer.
$400,000 total costs: (9/1/1997-9/30/1999)
GRANT HISTORY (continued)
8. JHU Clinician Scientist Award: Gene therapy for head and neck cancer
$100,000 total costs / salary support (1995-1997)
9. Endoscopic Surgery of the Pituitary Gland
Sponsor: Johns Hopkins Minimally Invasive Surgery Center Research Grant
10. IGF-1 Gene Therapy for the Treatment of Laryngeal Paralysis
Sponsor: The Cal Ripken /Lou Gehrig Fund for Neuromuscular Research; 11. Human IGF-1 Gene Transfer into the Paralyzed Rat Larynx: single vs. multiple injection. $31,854 direct costs (12/1/98 – 11/30/99) 12. Phase I Human Clinical Trial: hIL-2 Plasmid Gene Therapy for Patients with Squamous Cell Carcinoma of the Head and Neck (IL2-1001) Sponsor: GeneMedicine, Inc., The Woodlands, TX. Role: PrincipaI Investigator (Investigator Initiated)
13. Richard S. Ross Clinician Scientist Award, $32,500 annual direct costs (1995-1997)
Sponsor: Johns Hopkins University/Richard S. Ross Foundation Role: Principal Investigator
14. University of Pittsburgh Cancer Institute, Markey Research Grant. Adenovirus TK and IL-2 Gene

TEACHING RESPONSIBILITIES
Johns Hopkins University
Faculty Preceptor, Physical diagnosis
Johns Hopkins University medical students Faculty Lecturer, Lecture series program for new JHU "Medical and Surgical Management of Sinusitis" JHU Dept. Otolaryngology-HNS resident and faculty grand rounds yearly lectures: "Approaches to the Skull Base" and Faculty Lecturer, ENT course: "Surgical Evaluation of the Sinusitis Patient" for 3rd year students on the general surgical rotation. Faculty Supervisor/Advisor for JHU OHNS residents each year Faculty participant in the American Head and Neck Society Approved Head and Neck Surgical Oncology Fellowship
University of Maryland School of Medicine
Otolaryngology-HNS Resident and Medical Student Rotation Yearly Lectures
"Anterior Skull Base Surgery"; "Evaluation of the Sinus Surgery Patient" "Introduction to Otolaryngology-HNS Physical Exam and Diagnosis" Faculty Preceptor for One Rotating 3rd Year UM Medical Student per week Responsible for teaching ENT patient history and physical exam and introduction to basic ENT surgical techniques Otolaryngology-Head & Neck Surgery Faculty Preceptor for Gross Anatomy Dissection instruction for Infratemporal Fossa and Skull Base Anatomy “Gene Therapy for Cancer “ Lecture and test questions for the M.D./Ph.D. students
INSTRUCTIONAL COURSES
1. Co-Director: Surgical Anatomy of the Head & Neck, The University of Pittsburgh, The Eye & Ear
Institute, June 19-23, 1995, Pittsburgh, PA Instructor: Comprehensive Endoscopic Sinus Surgery, Johns Hopkins Institution, Jan. 23-25,
3. Course Instructor: Comprehensive Endoscopic Sinus Surgery, Johns Hopkins Institutions, Jan. 15-18, 4. Co-Director: Gene Therapy Technology: Clinical Implications in Otolaryngology Head and Neck Surgery. Instructional Course for the American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 7-10, 1997; San Francisco, CA. 5. Co-Director: Gene Therapy Technology: Clinical Implications in Otolaryngology Head and Neck Surgery. Instructional Course for the American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 13-16, 1998; San Antonio, TX. 6. Co-Producer, International College of Surgeons, Annual Meeting Otolaryngology-HNS Program
7. Co-Producer, Endoscopic Laser Resection of Advanced Laryngeal Cancers, International College of
Surgeons Otolaryngology-HNS Program for the 62nd Annual Surgical Update Meeting; 2000, Boston, MA INSTRUCTIONAL COURSES (continued)
8. Co-Chairman and Producer: Interdisciplinary Problem Solving in Cranio-Maxillofacial Surgery.
Advanced Surgical Forum Consortium. Baltimore, MD February 17-18, 2000. 9. Co-Chairman and Producer: Interdisciplinary Problem Solving in Cranio-Maxillofacial and Navigational Surgery Symposium, Vienna, VA, March 9, 2002 10. Co-Chairman, Controversies and Interdisciplinary Problem Solving in Cranio-Maxillofacial and Navigational Surgery, October 19, 2002, Seattle, WA 11. Faculty, The 10th Annual Techniques in Head and Neck Surgery-Otolaryngology Course, May 29th – June 1, 2003, RUSH-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois. 12. Faculty: Interdisciplinary Problem Solving in Cranio-Maxillofacial Surgery, ACMF. October 4-5, 2003, 13. Co-Director: Fourth International Laryngeal Cancer Conference: State-of-the-Art in Surgical and Non- Surgical Organ Preservation for Laryngeal and Pyriform Sinus Carcinoma, Philadelphia, PA, March 11-12, 2004. 14. Faculty: The PENN International Rhinology Course: Advances in Management of Sino-nasal Disease,
MEDICAL STUDENT, RESIDENT, AND FELLOW MENTORSHIP
1. Duane Sewell, M.D.
Focus: Scientific preceptor and laboratory supervisor for "Gene Therapy in Head and Neck Cancer Projects" Sewell DA, Li D, Duan L, O'Malley BW, Jr. Optimizing an adenoviral mediated "suicide gene" strategy for human application in the treatment of head and neck cancer. Laryngoscope 1997;107(11):1490-1495. O'Malley BW, Jr, Sewell DA, Li D, Kosai K, Chen S-H, Woo SLC, Duan L. The Role of Interleukin-2 in Combination Adenovirus Gene Therapy for Head and Neck Cancer Molecular Endocrinology 1997;11(6):667-673. Sewell DA, Li D, Duan L, Westra W, O'Malley BW, Jr. Safety of In Vivo Adenoviral-Mediated Thymidine Kinase Treatment of Oral Cancer. Archives Otolaryngol Head Neck Surg, 1997:123(12) Awards: First Place Scholarship Competition,1997, Am. Society Head & Neck Surgery Academic Appointment: Asst. Professor, University of Pennsylvania Focus: Scientific Preceptor and Laboratory Supervisor for "Combination Adenoviral Gene Therapy for Head and Neck Cancer" O’Malley BW Jr., Li D, Duan L., Buckner, A., Pardoll DM. Limitations of IL-2 Gene Therapy for Oral Cancer. The Gillespie MB, O’Malley BW Jr.(corresponding author), Frances H. An Approach to Fulminant Invasive Fungal Rhinosinusitis in the Immunocompromised Host. Archives Otolaryngol Head Neck Surg 1998;124:1-7. Gillespie MB, O'Malley BW Jr. An Algorithmic Approach to the Diagnosis and Management of Invasive Fungal Rhinosinusitis in the Immunocompromised Patient. Otolaryngologic Clinics of North America. 2000;33(2):323-334. Gillespie MB, Huchton DM, O'Malley BW Jr. The Role of Middle Turbinate Biopsy in the Diagnosis of Fulminant Invasive Fungal Rhinosinusitis. The Laryngoscope 2000 Nov;110(11):1832-6. Academic Appointment: Assistant. Professor, University of South Carolina Focus: Scientific Preceptor and Laboratory Supervisor for "Tumor Suppressor Gene Therapy in Head and Neck Cancer Projects" Rocco J, Li D, Liggett B, Duan L, Saunders JK, Sidransky D, O’Malley BW, Jr. p16 Adenovirus-Mediated Gene Therapy for Human Head and Neck Squamous Cell Cancer. Clinical Cancer Research 1998;4:1697-1704. Couch MC, Saunders JK, O’Malley BW Jr., Jafee E, Pardoll DM. Genetically engineered tumor cell vaccine in a head and neck cancer model. [submitted in revision, The Laryngoscope, 2002] Academic Appointment: Georgetown University School of Medicine Medicine Residency, New York University 2002 - present
MEDICAL STUDENT, RESIDENT, AND FELLOW MENTORSHIP (continued)

5. James Rocco, M.D., Ph.D.
Focus: p16 Tumor Suppressor Gene Therapy in Head and Neck Cancer Rocco J, Li D, Liggett B, Duan L, Saunders JK, Sidransky D, O’Malley BW, Jr. p16 Adenovirus-Mediated Gene Therapy for Human Head and Neck Squamous Cell Cancer. Clinical Cancer Research 1998;4:1697-1704. Awards: First Place Scholarship Competition, Am. Society Head & Neck Surgery, (1998) Academic Appointment: Assistant Professor, Mass Eye and Ear Hospital, Harvard Univ. 4th Year Medical Student, Johns Hopkins Univ. Focus: "Non-Viral Cytokine Gene Therapy for Head and Neck Cancer" Li D, Jiang W, Ralston R, O'Malley BW Jr. Combination Surgery and Non-viral IL-2 Gene Therapy for Head and Neck Cancer. Clinical Cancer Research 1999;5:1551-1556. Academic Appointment: OHNS residency, research track, Washington University, St. Louis 7. Aki Shiotani, M.D. Postdoctoral Fellow, Johns Hopkins Univ. Focus: Non-viral Gene Therapy for Laryngeal Paralysis Flint PW, Shiotani A, O'Malley BW, Jr. (Co-corresponding author) IGF-1 Gene Transfer into Denervated Rat Laryngeal Muscles. Archives of Otolaryngology HNS, 1999;125(3):274-9.] Shiotani A, O'Malley BW,Jr. (Co-corresponding author), Flint PW. Reinnervation of Motor Endplates after IGF-1 Gene Transfer into the Paralyzed Larynx. Human Gene Therapy 1998;9:2039-2047. Shiotani A, O'Malley BW Jr, (Co-corresponding author) Coleman ME, Flint PW. Human insulin-like growth factor 1 gene transfer into paralyzed rat larynx: single vs. multiple injections. Archives of Otolaryngology-HNS 1999;125(5):555-60. Academic Appointment: Assoc. Professor of OHNS, Keio Univ. School of Medicine, Japan. 4th year Medical Student, Univ. Maryland Focus: Non-viral Cytokine Gene Therapy for Head and Neck Cancer Li D, Ronson B, Liu S, Guo M, Bishop J, Van Echo D, Bert W. O’Malley, Jr. Interleukin 2 Gene Transfer Prevents NKG2D Suppression and Enhances Anti-tumor Efficacy in Combination with Cisplatin for Head and Neck Squamous Cell Cancer. Cancer Research 2002;62:4023-4028 Academic Appointment: Residency in Radiation Oncology, University of Southern California Focus: Cytokine and Tumor Suppressor Gene Therapy for Head and Neck Cancer Li D, Day KV, Liu S, Guo M, Sreedharan SP, O’Malley BW Jr: Adenovirus-mediated Rb94 Gene Transfer for Head and Day KV, Li D, Duan L, O'Malley BW Jr. Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer. Laryngoscope. 2001 May;111(5):801-6. Awards: First Place, Maryland Otolaryngology Society Resident Competition, 2001 First Place Scholarship Award Competition, Am. Soc. Head & Neck Surgery, 2001 Focus: Non-viral IL-2, IL-12, and IFNa Gene Therapy for Head and Neck Cancer Publications: Li D, Zeiders JW, Bishop J, Duan L,, O’Malley BW Jr. Comparison of Non-viral IL-2, IL-12, and IFN-α Gene Therapy for Head Academic Appointment: OHNS Residency at the University of South Florida MEDICAL STUDENT, RESIDENT, AND FELLOW MENTORSHIP (continued)
11. Beth Schugert
4th year medical student, Univ. Maryland Focus: Non-viral Cytokine Gene Therapy for Head and Neck Cancer Li D, Shugert E, Jiang W, Bishop J, O’Malley BW Jr. Non-Viral IL-2 and IL-12 combination gene therapy for oral cancer. Archives of Otolaryngology Head & Neck Surgery, 2001. Academic Appointment: OHNS Residency, Baylor College of Medicine, Houston, TX. Focus: Enzymatic Expression Patterns in Head & Neck Cancer and Sensitivity to Chemotherapy TS, TP, and DPD as Predictors for Response to Xeloda Therapy (in preparation) Academic Appointments: Assistant Professor of Medicine of Oncology, Harvard 13. B. Emmerich Yoder 4th year medical student, Univ. Maryland Focus: Image Guided Surgery in Otolaryngology-HNS and Skull Base Surgery H. Staecker, B.W. O'Malley Jr, H. Eisenberg, Yoder BE. Surgical navigation in lateral skull base and temporal bone surgery. Academic Appointment: OHNS Residency, Georgetown University 4th year medical student, Univ. Maryland Focus: Combination Non-viral Gene Therapy and Radiation for HNSCC Li D, Suntharalingam M, Koprowski H, Guo M, Pericle F, O'Malley BW Jr. Combination non-viral IL-2 and radiation therapy for head and neck cancer. [accepted and in press, Archives of OHNS, 2002] Publications: pending: Chemosensitization for Head and Neck Cancer Awards: First Place, American Academy of Otolaryngology-Head and Neck Surgery Resident Research Award for Basic Science, Award and Lecture Presentation at the annual AAOHNS meeting in Orlando, FL, September 2003.
FACULTY MENTORSHIP

1. Daqing Li, M.D., Assistant Professor of Surgery, Otolaryngology-HNS, Univ. MD
Focus: (1) Overall U.S. Career Development from July 1993 to present (2)Molecular biology and See Bert O'Malley "Journal Articles" Section “Adenovirus B7 in Combination Gene Therapy for Head and Neck Squamous Cell Carcinoma” Sponsor: American Cancer Society, $16,000.00, direct cost, (2000-2001) Role: Principal Investigator “The Prognostic/Predictive Value Of Ts, Tp & Dpd In Chemoradiation Strategies for Squamous Cell Carcinoma of the Head and Neck” $100,000 direct costs; $50,000 total costs (2000-2001). “Molecular/cellular Responses in Head and Neck Cancer with Xeloda and Radiation” $150,000.00 direct costs; $225,000.00 total costs (12/02- 11/03) Sponsor: Roche Pharmaceuticals Role: Co-Principal Investigator Grants Submitted: 1 R01 CA100591, "MRN-Targeted Chemosensitization for Head and Neck Cancer" (score 180) $1,250,000 (direct cost); $612,500.00 (indirect cost), (2003-2008) (pending 11/2002 council) FACULTY MENTORSHIP (continued)
Daqing Li, M.D (continued)
“FGF2 Retargeting of Combination B7 Immunotherapy to Head and Neck (Oral) Cancer” $,803,916.00 (direct cost); $196,084.00 (indirect cost), (2003-2007), pending “STTR Phase I Grant Application; RB Gene Therapy of Head and Neck Cancer Academic Appointments : Visiting Clinician, Dept. Otorhinolaryngology, Baylor College of Medicine; Post-Doctoral Fellow, Dept. Cell Biology, Baylor College of Medicine; Neurotology/Skull Base Surgical Fellowship under Professor Ugo Fisch, Univ. Zurich, Switzerland; Research Associate, Johns Hopkins Univ.; Assistant Professor, Johns Hopkins Univ.; Assistant Professor, Univ. of Maryland; Director, Gene and Molecular Therapy Laboratories, Univ. of Maryland
2. Paul F. Castellanos, M.D., Assistant Professor of Surgery, Otolaryngology-HNS, Univ. of Maryland
Focus: (1) Overall Clinical and Scientific Career Development (2) Translational Research on Reflux and its Association with Upper and Lower Respiratory Disease "Critical Care Incidence and Manifestations of Laryngopharyngeal Reflux of Gastric Contents Human Clinical Trial” Clinical Appointments: Medical Director, The UMMS Center for Voice, Swallowing, and Esophageal Disorders 3. Hinrich Staecker, M.D., Ph.D., Assistant Professor of Surgery, Otolaryngology-HNS, Univ. MD Focus: (1) Gene Therapy and Hearing Loss Research (2) Skull Base Surgery and Image Guided Staecker H, Li D, O'Malley BW Jr., Van De Water TR. Gene Expression in the Mammalian Cochlea: A study of multiple vector systems. Acta Otolaryngologica, 2001:121(2):157-63. H. Staecker, B.W. O'Malley Jr, H. Eisenberg, Yoder BE. Surgical navigation in lateral skull base and temporal bone surgery. H. Staecker, J. Berry, B.W. O’Malley Jr. Making Image Guidance Work: Understanding Control of Accuracy. Annals of “Gene Therapy for Inner Ear Disorders” Clinical Appointments: Director, Vestibular Diagnostics Laboratory, Univ. of Maryland OHNS 4. Mohan Sunthalarigam,M.D., Associate Professor and Vice Chairman, Dept. Radiation Oncology, Focus: Molecular and Gene Therapy Strategies for Radiation Sensitization. Rhee JG, Li D, O'Malley BW Jr, Suntharalingam M. Combination radiation and adenovirus mediated p16 (INK4A) and gene therapy for head and neck cancer. ORL J Otorhinolaryngology Relat Spec 2003 June;65(3):144-54. Bray D, Yu SZ, Koprowski H, Rhee J, Kumar S, Pericle F, Suntharalingam M, Van Echo DA, Li D, O'Malley BW Jr. Combination non-viral IL-2 gene therapy and external beam radiation therapy for head and neck cancer. Arch Otolaryngol Head Neck Surg 2003 June;129(6):618-22. O’Malley BWJr, Li D, Carney J, Rhee J, Suntharalingam M. Molecular disruption of the MRN(95) complex induces radiation Li D, Van Echo D, Suntharalingam M, Guo M, O'Malley BW Jr. Combination Xeloda and IL-2 Gene Therapy for Head and Day, K, Li D, Sreedharan S, Suntharalingam M, Guo M, O'Malley BW Jr. RB-94 gene therapy and radiation for Head and FACULTY MENTORSHIP (continued)
Mohan Sunthalarigam,M.D (continued)
Grants: “Molecular/cellular Responses in Head and Neck Cancer with Xeloda and Radiation” $150,000.00 direct costs; $225,000.00 total costs (12/02- 11/03) Sponsor: Roche Pharmaceuticals Role: Co-Principal Investigator with Dr. Daqing Li. P01 CA95102-01, "Targeted Molecular Therapy and Intensity Modulated Arc Therapy (IMAT) for Head & Neck Cancer. Project 4: Broadscope Optimization of IMAT for HNSCC
INVITED LECTURES International

1. "Gene Therapy in Head & Neck Cancer: Today and Tomorrow", International Federation of Head and
Neck Oncologic Societies, Asia-Pacific Congress, Bombay, INDIA, Dec. 11-14, 1997. 2. "Suicide, Cytokine, and Tumor Suppressor Gene Therapy for Head and Neck Cancer"; Key Note Speaker, International Symposium on Metastasis in Head and Neck Cancer, Kiel, Germany, 3. "Gene Therapy for Head and Neck Cancer" Invited Symposium Speaker, 2nd International Symposium on Minimal Residual Cancer, Berlin, Germany, September 20-22, 1998. 4. "Evolution of Skull Base Surgery" Invited Speaker, III International Skull Base Course, Rio de Janeiro, 5. "Role of Combined Therapy for Head and Neck Cancer" Invited Speaker, III International Skull Base Course, Rio de Janeiro, Brazil, April 6-8, 2000. 6. "Approaches to the Anterior Skull Base and the Orbital Apex" Invited Speaker, III International Skull Base Course, Rio de Janeiro, Brazil, April 6-8, 2000. 7. "Approaches to the Anterior Skull Base and Orbital Apex" and "Gene Therapy and Novel Radiofrequency Therapy", First Joint Meeting of the Turkish Otorhinolaryngology - Head & Neck Surgery Society and the American Academy of Otolaryngology - Head & Neck Surgery, Istanbul,Turkey, June 9-12, 2001. 8. "Gene Therapy Technology & Clinical Implications in Head & Neck Surgery"; "The Evolution of Reconstruction in Head & Neck Surgery: Pedicle Flaps to Free Tissue Transfer"; "Extended Pericranial Flap and Graft Reconstruction in Anterior Skull Base Surgery"; and "Maxillectomy and Facial Translocation"; The American Russian Cancer Alliance and the National Head & Neck Cancer Conference of Russia. Participating Institutions: N.N. Blokhin Russian Cancer Research Center RAMS, Fox Chase Cancer Center, Philadelphia, PA, Greenebaum Cancer Center, University of Maryland, Baltimore, MD. Moscow, Russia, June 25-26, 2002. 9. "Practical Laryngoscopy for the Clinician", Puerto Rico Society of Pneumology, San Juan, Puerto 10. "Image Guided Head & Neck and Skull Base Surgery", Annual Congress in Otolaryngology-HNS, San Juan, Puerto Rico, October 10-13, 2002. 11. "Anterior Skull Base Surgery and Novel Techniques in Reconstruction", National Meeting for the Association of Otolaryngologists, Patna, India, January 9-13, 2003. 12. "Combination Gene Therapy and Standard Therapy for HNSCC", 2nd National Meeting for the Foundation for Head & Neck Oncology, Kolkotta, India, January 5-7, 2003. 13. “Evolution of Reconstruction in Head and Neck Surgery”, Visiting Professor and Speaker, Dept. ENT, Cantonal University Hospital, Bern, Switzerland, November 12, 2003. 14. “Gene Therapy for Head and Neck Cancer”, Invited Speaker, Dept. ENT Cantonal University and Novartis Symposium, Geneva Switzerland, November 13, 2004. 15. “Targeted Molecular Therapy for Enhancing Radiation and Chemotherapy”, Keynote Speaker and Dr. Mariano Elia Lecturer, 5th Annual Wharton Day, Princess Margaret Hospital, Toronto, Ontario, Canada. June 12th – 13th, 2004. INVITED LECTURES National
1. "Gene Therapy for Head and Neck Cancer", Dept. of Surgery, Division of Otolaryngology-HNS,
Stanford University, CA, November, 1994. 2. "Adenovirus Mediated Gene Therapy for Head and Neck Cancer", Department of Otolaryngology, Grand Rounds, University of Pittsburgh, PA, October, 1994. 3. "Mediastinal Dissection" and "Management of the N3 Neck", and "Surgical Approaches to the Nasopharynx", Surgical Anatomy of the Head and Neck Course, University of Pittsburgh, PA, April, 1995. 4. “Molecular Vaccines and Gene Therapy for Salivary Neoplasms”, NIDR/NIH Conference on Salivary Gland Biogenesis, Airlington, VA, November 9, 1996. 5. "Gene Therapy for Oral Cancer", National Institutes of Health and the National Institute for Dental 6. "Gene Therapy for Head and Neck Cancer", City of Hope National Medical Center, Duarte, CA., June 7. "Tumor Suppressor Gene Therapy for Oral Cancer", Invited Symposium Speaker, American Association for Dental Research Annual Meeting, Minneapolis, MN, March 4-7, 1998. 8. "Anterior Skull Base Neoplasms", "Gene Therapy for Head and Neck Cancer", "Adenovirus Receptor Influences Gene Therapy Response". Three lectures as visiting professor for the University of Kentucky, Division of Otolaryngology; Grand Rounds, Dept. of Surgery, University of Kentucky, June 19 and 20, 1998. 9. "Viral and Non-Viral Gene Therapy for Head and Neck Cancer", Visiting Professor and lecturer, Memorial Sloan Kettering Cancer Center, New York, NY, October 8, 1998. 10. “Adenovirus-Mediated Suicide and Cytokine Gene Therapy for Oral Cancer”; NIH/NIDCR sponsored Workshop on Oral Cancer. Bethesda, MD, February 21-23, 1999. 11. "Viral and Non-Viral Gene Therapy for Cancer" Visiting Professor; Dept. Cell and Molecular Biology, Baylor College of Medicine, November 15, 1999. 12. "Viral Gene Therapy for Head and Neck Cancer" Gene Therapy Panel Invited Speaker, 5th International Conference on Head & Neck Cancer, July 29-August 4, San Francisco CA, 1999. 13. "Gene and Molecular Manipulations and Therapies" International College of Surgeons 62nd Annual 14. "Combination Radiation and Gene Therapy for Cancer" Visiting Professor; Dept. Cell and Molecular Biology, Baylor College of Medicine, November 13, 2000. 15. “Creation of a Multidisciplinary Research Laboratory”, Invited Speaker, Oregon Health Sciences Center, 16. “Combination Gene Therapy and Radiation for Cancer Therapy”, Visiting Professor, Baylor College of Medicine Center for Gene Therapy, November 13, 2000. 17. “Molecular Therapy and Radiation Sensitization: A Multidisciplinary Research Program”, Visiting professor and Invited Speaker, The Lombardi Cancer Center, Georgetown University, D.C, March 2001. 18. “Combination Molecular Therapy and Radiation for Cancer”, Invited Speaker, Moffit Cancer Center, University of South Florida, April 2001. 19. “Image Guided Surgery: Now and Into the Future”; Visiting Professor, Department of Otolaryngology, 20. “Image Guidance in Skull Base Surgery”, Invited Speaker, University of Pittsburgh, Dept. Otolaryngology, “Skull Base Surgery CME Program, May 2001. 21. "Making Better Medicines: Harnessing the Promise of Biotechnology Research", Virginia Biotechnology Summit, Hilton Alexandria Mark Center, Alexandria, Virginia, October 22-23, 2001. 22. "Pre-Operative Evaluation of Sinus Patients" High Altitude/Masters in Otolaryngology, sponsored by The University of Pittsburgh School of Medicine, Department of Otolaryngology, Park City, Utah, March 11-15, 2002. 23. "Anterior Craniofacial Surgery and Reconstruction of Skull Base Defects", Visiting Professor, 24. "Image Guided Surgery in Head and Neck and Skull Base Surgery", Metro ENT Society, 25. "Targeted Molecular Therapy in Combination with Radiation and Chemotherapy for HNSCC", Symposium on Identifying and Targeting the Diversity of Oral Cancer, AAAS Annual Meeting and Science Innovation Exposition, Denver, CO, February 13-18, 2003. INVITED LECTURES National (continued)
26. “Skull Base Surgery for the Future, University of Miami Dept. OHNS, visiting professor, March 6th,
27. “Targeted Molecular Therapy for HNSCC”, University of Miami Sylvester Comprehensive Cancer Center, Distinguished Speaker Series, March 7th, 2003. 28. AACR Special Session on New Directions in Cancer: Organ Site Research from the Laboratory to the Clinic Session entitled "Cancer of the Aerodigestive Tract". Chairs and Invited Speakers / Organizers: Bert W. O’Malley Jr., M.D. and David Sidransky, M.D. 29. “Molecular Therapy for Oral Cancer”, NIH Workshop, University of Connecticut Cancer Center, June 30. “Image Guided Sinus and Skull Base Surgery”, The 10th Annual Techniques in Head and Neck Surgery-Otolaryngology Course, May 29th – June 1, 2003, RUSH-Presbyterian-St. Luke’s Medical Center, Chicago, Ilinois. 31. “Indications, Contraindications, and Limitations of Skull Base Surgery”, International Symposium, Update in Skull Base Surgery, American Academy of Otolaryngology-Head and Neck Surgery Meeting, 2003, Orlando, FL.

INVITED LECTURES Local
1. "Anterior Cranial Base Surgery", Grand Rounds, Greater Baltimore Medical Center, Baltimore, MD,
2. "Surgical Approaches to the Anterior Skull Base”, Grand Rounds, Johns Hopkins University, Department of Neurosurgery, Baltimore, MD, March 1996. 3. “Cranial Base Surgery: Present and Future”, General Surgery Grand Rounds, Johns Hopkins University, 4. “Cranial Base Surgery”, General Surgery Grand Rounds, St. Joseph’s Hospital, Baltimore, MD, March 5. "Recent Advances in the Surgical Treatment of Oral Cancer", University of Maryland Committee of 6. "Gene Therapy for Head & Neck Cancer" University of Maryland, General Surgery Grand Rounds, 7. "Gene Therapy for Vocal Cord Paralysis" University of Maryland, Department of Neurology Grand 8. 'Head & Neck Cancer: New Developments in Multidisciplinary Management" University of Maryland Outreach CME program, Stone Manor, Frederick MD, March 14, 2000. 9. "Where Genetics and Technology Merge", Committee of 1000 Luncheon, September 22, University of 10. "Merging Gene Therapy and Technology", University of Maryland Baltimore Foundation Inc., Board of Trustees Meeting, National Dental Museum, June 21, 2001. 11. "Paranasal Sinus Decision Making", Update in Internal Medicine, University of Maryland School of Medicine, Hyatt Regency Inner Harbor, Baltimore, Maryland, June 21, 2001. 12. "Targeted Molecular Therapy and Radiation Sensitization for HNSCC", Research Matters: A Conference on the Statewide Academic Health Centers Cancer Initiatives" The University of Maryland Greenebaum Cancer Center and the Johns Hopkins Comprehensive Cancer Center, Johns Hopkins Comprehensive Cancer Center, November 29, 2001. 13. "Gene Therapy", Biochemical Pharmacology Spring Course MPET604/TOX1604, University of Maryland School of Medicine, March 19 and 21, 2002. 14. “Gene Therapy: Clinical Applications in Otolaryngology-Head and Neck Surgery, Department of General Surgery Research Forum, May 2002. 15. “Targeted Molecular Therapy to Enhance Radiation and Chemotherapy”, Glaxo Smith Kline / University of Pennsylvania Medicine Oncology Symposium; February 02, 2004. PROGRAM DEVELOPMENT, UNIVERSITY OF MARYLAND and OTOLARYNGOLOGY-HNS

1. Founded the Head and Neck Oncology Research Program within the Head and Neck Cancer Center
Success: Coordinated and built a collaborative effort in translational laboratory research that brings together
multiple clinical and scientific disciplines. Selected Members: John Sauk, Ph.D., DDS, Professor and Chair, Dept. Oromaxillofacial Pathology and Diagnostic Sciences, Dental School; Robert Ord M.D., DDS, Professor of Oromaxillofacial Surgery, Dental School; David Van Echo, M.D., Professor Dept. Medicine/Oncology; Mohan Suntharalingam, M.D., Dept. Radiation Oncology; James Carney, Ph.D., Dept. Radiation Oncology; William Morgan, Ph.D., Dept. Radiation Oncology; Cedirc Yu, Ph.D., Dept. Radiation Oncology; Joung Rhee, Ph.D., Dept. Radiation Oncology; John Papadimitriou, M.D., Dept. Pathology; Ken Bauer, Ph.D., School of Pharmacy; Daqing Li, MD, Div. Otolaryngology-HNS. Grants: P01 Program Project submitted in revision 2002, "Targeted Molecular Therapy and Intensity Modulated Arc Therapy (IMAT) for HNSCC" 2. Founded Multidisciplinary Head & Neck Cancer Laboratory Success: Created a unique interactive, multidisciplinary research facility for Gene and Molecular research which translates the principle of our Multi-Disciplinary Tumor Board and Clinic to the laboratory setting. A shared laboratory facility was organized in which a selected core of clinicians and scientists from three different schools in the University of Maryland System (Medical School, Dental School, Pharmacy School) come together and work side by side at the bench top on collaborative and unified research projects. Each of the respective departments and their senior researchers have individual projects for which they are taking the lead, but they send a representative scientist or fellow into this shared lab for the day to day experimentation. Overall direction, and data evaluation is done jointly with lab members and technicians that cross these disciplines. This unique laboratory serves as the main hub for the collaborative research that is part of the overall Head and Neck Oncology Research Program. 3. Founded the Center for Voice, Swallowing, and Esophageal Disorders Success: In conjunction with Dr. Paul Castellanos, we envisioned and pioneered the creation of a multidisciplinary clinical center funded by the University of Maryland Medical System that brings together clinicians from the Otolaryngology-HNS, the Div. of GI Medicine, the Div. of General Surgery, and the Div. of Thoracic Surgery for the purpose of diagnosing and treating patients with disorders of the upper aerodigestive tract. The Center opened in July of 2002 and the Otolaryngology-HNS component has brought 351 new outpatient surgical cases to the UMMS in the first quarter (July-September 2002). 4. Founded the Center for Skull Base Surgery Success: Established a multi-disciplinary skull base tumor conference as well as an organized clinical program in conjunction with Dr. Howard Eisenberg, Chairman, Department of Neurosurgery. Incorporated the efforts and collaboration of Interventional Radiology and Radiation Oncology.
PROGRAM DEVELOPMENT AT THE UNIVERSITY OF PENNSYLVANIA
1. Establishing a Multidisciplinary Translational Oral and Head and Neck Cancer Research Program across the School of Medicine and School of Dentistry. (in progress) 2. Establishing a Comprehensive Pre-cancer to Cancer Tissue/Tumor Bank. (in progress) 3. Formalize an Organized and Unified Skull Base Surgical Team in conjunction with the Department of Neurosurgery and Radiation Oncology. (in progress)

ABSTRACTS AND SCIENTIFIC PRESENTATIONS

1.
O'Malley, B.W., Jr., Finegold, M., Ledley, F.D. Orthotopic thyroid follicular cell transplantation: a potential component of somatic gene therapy. Proceedings of the American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, Washington, D.C., September 13-17, 1992. Otolaryngol Head Neck Surg. 1992;107:192. O'Malley, B.W., Jr., Sikes, M.L., Adams, R.M., Finegold, M.J., Ledley, F.D. Somatic Gene Therapy Targeted to the Thyroid: DNA Mediated and Viral Mediated Gene Transfer in Animal Models. First International Congress of the Cell Transplant Society, Pittsburgh, PA, May 31-June 3, 1992. Cell Transplantation. 1992;1(2/3):187. Jr., Sikes, M.L., Adams, R.M., Finegold, M.J., Ledley, F.D. Targeting the thyroid for somatic gene therapy: in vivo studies with DNA mediated gene transfer. APS-SPR Annual Meeting, Baltimore, MD, May 7,1992. Pediatric Research. 1992;34:81a. Sikes, M., O'Malley, B.W., Jr., Finegold, M.J., Ledley, F.D. In vivo and ex situ gene transfer to the thyroid for somatic gene therapy. Proceedings of the American Society for Human Genetics. American J. Human Genetics. 1992;51:A227. O'Malley, B.W., Jr. Award Presentation: Thyroid follicular cell transplantation. Texas Association of Otolaryngology Annual Meeting, San Antonio, TX, May 14-15, 1992. Ledley, F.D., Jovandich, J., O'Malley, B.W., Jr. Gene transfer and expression into synovial cells of rabbit joints by in vivo delivery of DNA vectors: an approach to somatic gene therapy of arthritis. Cold Spring Harbor Symposium on Gene Therapy, September 1992. O'Malley, B.W., Jr., Sikes, M., Adams, R.M., Ledley, F.D. Ex vivo and in vivo gene transfer into the thyroid in animal models: a novel target for somatic gene therapy. Cold Spring Harbor Symposium on Gene Therapy, 1992. Jr., Ledley, F.D. DNA and viral mediated gene transfer in follicular cells in vitro: progress towards gene therapy of the thyroid. Proceedings of the Southern Section Triological Society, Boca Raton, FL, January 14-16,1993. Sikes, M.L., O'Malley, B.W., Jr., Ledley, F.D. In vivo gene transfer into rabbit thyroid by direct DNA injection: A novel strategy for gene therapy. Keystone Symposium on Gene Therapy, 1993. J Cell Biochem. 1993;27E:215. O'Malley, B.W., Jr., Adams, R.M., Ledley, F.D. Gene transfer into human thyroid follicular cells. Proceedings of the Southern Section Triological Society. Marco Island, FL, January 13-15, 1994. Sikes, M.L., O'Malley, B.W., Jr., Ledley, F.D. A rat model for studying DNA uptake and expression by thyroid cells after direct injection. Keystone Symposium on Gene Therapy, 1994. J Cell Biochem. 1994;18A;229. O'Malley, B.W., Jr. Award Presentation: Gene transfer into human thyroid follicular cells. Texas Association of Otolaryngology Annual Meeting, Austin, TX, May 13-14, 1994. Tsai, S.Y., Wang, Y., O'Malley, B.W., Jr., and O'Malley, B.W. A novel inducible system for target gene expression in vivo. Endocrine Society 76th Annual Meeting, June 15-18, 1994. Sikes, M.L., O'Malley, B.W., Jr., Ledley, F.D., and Smith, L.C. Characterization of in vivo gene transfer into rat thyroid follicular cells following intrathyroid DNA injection. Cold Spring Harbor Symposium on Gene Therapy, September 21-25, 1994. Wang, Y., O'Malley, B.W., Jr., Tsai, S.Y., O'Malley, B.W. A gene switch system for target gene expression. Cold Spring Harbor Symposium Gene Therapy, September 21-25, 1994. ABSTRACTS AND SCIENTIFIC PRESENTATIONS (continued)
16.
O'Malley, B.W., Jr., Chen, S.H., Schwartz, M.R., Woo S.L.C. Adenovirus-Mediated Gene Therapy for Head and Neck Cancer. 16th Annual Meeting for the Ohio Valley - Lake Erie Association of Cancer Centers in association with the Pittsburgh Cancer Institute. Poster and selected abstract presentation, October 14-15, 1994. O'Malley, B.W., Jr., Chen, S.H., Schwartz, M.R., Woo S.L.C. Adenovirus-mediated gene therapy for human squamous cell cancer in a nude mouse model. American Association for Cancer Research 86th Annual Meeting, Toronto, Canada, March 18-22,1995. Proceedings of the American Association for Cancer Research 1995;36:424. Ledley, FD, O’Malley, BW, Jr., Borchardt, J, Roop, D., Rolland, A., Tomlinson, E. Novel Methods for delivery of gene medicines to the epidermis - Hypospray method for transfection in gene therapy. J Cell Biochem 18A (1994) 226. O'Malley, B.W., Jr. Gene therapy for the treatment of human head and neck cancer. Award presentation. 57th Annual Meeting of the International College of Surgeons. San Diego, California, March 30-April 2, 1995. Wang, Y., O'Malley, B.W., Jr., Tsai, S.Y., O'Malley, B.W. Gene switch via progesterone antagonist RU486. Keystone Symposium on Gene Therapy. J Cell Biochem 1995;21A:387. O'Malley, B.W., Jr. and Tamargo, R. Anterior Cranial Base reconstruction using a split calvarial bone graft. Second International Skull Base Congress, Seventh Annual Meeting of the North American Skull Base Society. June 29-July 4, 1996, San Diego, CA. O'Malley, B.W., Jr., Cope, K.A., Schwartz, M.R., Johnson, C.S., Li, D. Combination Gene Therapy for Oral Cancer. Fourth International Conference on Head and Neck Cancer. Toronto, Canada. July 28 - August 1, 1996. O'Malley, B.W., Jr., Cope, K.A., Chen, S-H., Schwartz, M.R., Woo, S.L.C., and Li., D. Combination Gene Therapy for Head and Neck Cancer in a Murine Model. 87th Annual Meeting of the American Association for Cancer Research. Washington, D.C., April 20-24, 1996. Sewell DA, Li D, O'Malley BW, Jr. Optimizing an adenoviral mediated "suicide gene" strategy for the treatment of head and neck cancer. The American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, Washington, D.C., September 1996. Li D, Henley C, O'Malley BW, Jr. Distortion-product otoacoustic emissions and cochlear morphology in the congenital hypothyroid (hyt/hyt) mouse. The American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, Washington, D.C., September 1996. O'Malley BW, Jr. and Cope KA. Combination thymidine kinase and interleukin-2 gene therapy for head and neck cancer in a murine model. The American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, Washington, D.C., September 1996. Jr. Molecular Vaccines and Gene Therapy for Salivary Neoplasms. Proceedings from the Conference on Salivary Gland Biogenesis and Function; 1996. Sewell DA, Li D, Duan L, Westra W, O'Malley BW, Jr. Safety of In Vivo Adenoviral-Mediated Thymidine Kinase Treatment of Oral Cancer. First Prize, Research Competition, Society of Head and Neck Surgeons, COSM Meeting, Scottsdale, AZ, May 10-13, 1997. Xiang M, Gan L, Li D, Zhou L, Chen Z, Wagner D, O'Malley BW, Jr., Klein W, Nathans J. Brn-3 family POU-domain genes in the development of auditory/vestibular, somatosensory, and visual systems. Cold Spring Harbor Symposium on Quantitative Biology, 1997. Gillespie MB, O'Malley BW Jr, Francis H. New Concepts in Invasive Fungal Rhinosinusitis. The American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 7-10, 1997; San Francisco, CA. Rocco J, Liggett B, Li D, Duan L, Saunders JK, Sidransky D, O’Malley BW, Jr. Adenoviral-Mediated p16 Therapy for Head and Neck Cancer. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 7-10, 1997; San Francisco, CA. O’Malley BW, Jr., Li D, Duan L., Pardoll DM. Interleukin-2 Gene Therapy for Established Oral Tumors: Limitations in a Murine Model. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 7-10, 1997; San Francisco, CA. ABSTRACTS AND SCIENTIFIC PRESENTATIONS (continued)
33.
Li D, O'Malley BW, Jr., Xiang M, Gan L, Zhou L, Klein W, Nathans J. Role of Brn-3c in Auditory and Vestibular Hair Cell Development. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 7-10, 1997; San Francisco, CA. Flint PW, Shiotani A, O'Malley BW, Jr. Gene Transfer into Laryngeal Muscles. American Academy of Otolaryngology Head and Neck Surgery Annual Meeting; September 7-10, 1997; San Francisco, CA. Ralston R, Munger WE, Li D, Bishop J, Thull N, Bruno M, Simon A, Kao G, Muller S, Levin J, O'Malley BW Jr. Combination Cytokine Therapy Using IL-2 Gene Delivery with Adjuvant Induction of IL-12 and IFN-alpha. Selected for Presidential Section Presentation. Society for Biological Therapy Annual Meeting, Oct. 23-25, Pasadena, CA. Ralston R, Munger WE, Li D, Bishop J, Thull N, Bruno M, Simon A, Kao G, Muller S, Levin J, O'Malley BW Jr Combination Cytokine Therapy for Head and Neck Cancer Using IL-2 Gene Delivery and Adjuvant Induction of IL-12 and IFN-alpha. Keystone Symposium on Molecular and Cellular Biology of Gene Therapy. January 19-25, 1998, Keystone, CO. Simon C, Hicks J, Nemechek A, Mehta R, O'Malley BW, Jr., Flaitz C., Goepfert H, Boyd D. A Novel ERK-Pathway Inhibitor (PD098059) Arrests Invasion and Growth of HNSCC in a Murine Model. International Symposium on Metastases in Head and Neck Cancer. January 15-18, 1998, Kiel, Germany. O'Malley BW Jr., Liggett WH, Freimuth P, Duan L, Li D. Human Cancer Cell Susceptibility to Suicide Gene" Therapy is Dependent on Adenovirus Receptor Status. 89th Annual Meeting American Assoc. for Cancer Research, March 28-April 1, 1998, New Orleans, LA. Rocco JW, Li D, Liggett MW Jr, Duan L, Saunders JK, Sidransky D, O'Malley BW Jr. p16INK4A Adenovirus-Mediated Gene Therapy of Human Head and Neck Squamous Cell Cancer. Combined Otolaryngology Spring Meeting and American Society Head and Neck Surgery and Society of Head and Neck Surgeons. Palm Beach, FL, May 14-16, 1998. Couch M, Saunders JK, O'Malley BW Jr., Jaffee E, Pardoll D. Tumor Vaccination Stimulates Anti-Tumor Immunity in a Head and Neck Squamous Cell Carcinoma Model. Combined Otolaryngology Spring Meeting and Joint Program American Society Head and Neck Surgery and Society of Head and Neck Surgeons. Palm Beach, FL, May 14-16, 1998. Jr., Ralston R, Li D, Duan L, Munger WE, Schaumberg JP, McQuone S. Non-viral Plasmid IL-2 Gene Transfer with Resulting Local Induction of IL-12 and IFN-g as a Primary and Combination Therapy with Surgery for Oral Cancer. 102nd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 13-16, 1998, San Antonio, TX. Li D, Duan B, Duan L, Freimuth P, O'Malley BW Jr. The Role of the Adenovirus Receptor in Adenovirus-Mediated Head and Neck Cancer Gene Therapy. 102nd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 13-16, 1998, San Antonio, TX. Rocco JW, Sidransky D, O'Malley BW Jr. p16INK4A Adenovirus-Mediated Gene Therapy of Human Head and Neck Squamous Cell Cancer Induces Cell Cycle Arrest and a Loss of Telomerase Activity. 102nd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 13-16, 1998, San Antonio, TX. Buckner A, O'Malley BW Jr., Li D, Duan L. Combination gene therapy in a murine model for head and neck cancer. 102nd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 13-16, 1998, San Antonio, TX. Shiotani A, O'Malley BW Jr., Flint PW. Reinnervation of Motor Endplates and Increased Muscle Fiber size after IGF-1 Gene Transfer into the Paralyzed Larynx. 102nd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 13-16, 1998, San Antonio, TX. O’Malley BW Jr., Li D, Duan L, Wang J, Bishop JS, Ralston R. Non-Viral Gene Therapy for Head & Neck Cancer. Otolaryngology Combined Spring Meeting and American Head and Neck Society. Palm Desert, CA, April 24-27, 1999. ABSTRACTS AND SCIENTIFIC PRESENTATIONS (continued)
48.
O’Malley BW Jr., Li D, Duan L, Wang J, Bishop JS, Ralston R. Combination Non-Viral IL-2 and IL-12 Gene Therapy for Head & Neck Cancer. 90th Annual Meeting of the American Association for Cancer Research, Philadelphia, PA , April 10-14, 1999. Li D, Duan L, and O’Malley BW Jr. Upregulation of Adenovirus Receptor Increases Gene Transfer Efficiency in HNSCC. 103rd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, New Orleans, LA, September 26-29, 1999 O’Malley BW Jr., Li D, Bishop J, Ralston R. Combination Non-Viral Gene Therapy for HNSCC. 103rd Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation, New Orleans, LA, September 26-29, 1999 O'Malley BW Jr., Li D., Duan L. Variability of adenovirus receptor density influences gene transfer efficiency and therapeutic response in head and neck cancer. 2nd Annual Meeting of The American Society of Gene Therapy, Washington, DC, June 9-13, 1999. Flint PW, Nakagawa H, Shiotani A, O'Malley BW Jr. Myosin Changes after IGF-1 Gene Transfer for Laryngeal Paralysis. 103rd Annual Meeting American Academy of Otolaryngology-Head & Neck Surgery, New Orleans, LA, September 26-29, 1999 M. B. Gillespie, D.M. Huchton, B.W. O'Malley Jr. The role of middle turbinate biopsy in the diagnosis of fulminant invasive fungal rhinosinusitis. Otolaryngology Combined Spring Meeting and American Head and Neck Society. Orlando, Florida, May 13-18, 2000. D.M. Huchton, M.T. Brown, B.W. O'Malley Jr., P.A. Pollice. Microvascular reconstruction of cranial base defects. Otolaryngology Combined Spring Meeting and American Head and Neck Society, Orlando, FL, May 13-18, 2000. H. Staecker, H. Eisenberg, B.W. O'Malley Jr. Use of LandmarXTM surgical navigation system in lateral skull base and temporal bone surgery. North American Skull Base Society Annual Meeting, Scottsdale, AZ, May 16-21, 2000. B. W. O’Mal ey Jr., D Li, B Ronson, J Bishop: Combination Cisplatin and Non-viral Interleukin-2 Gene Therapy for Head and Neck Cancer. American Association for Cancer Research 91st Annual Meeting, 2000, San Francisco, CA. KV Day, D Li, S Liu, M Guo, SP Sreedharan, BW O’Malley Jr. Adenovirus-mediated Rb Gene Transfer for Head and Neck Cancer. Oral presentation, American Academy of Otolaryngology-Head and Neck Surgery Meeting, 2000, Washington DC. Daqing Li, Brian Ronson, Shixi Liu, Ming Guo, Jeffrey Bishop, and Bert W. O’Malley, Jr.:Combined Cisplatin and Non-viral IL-2 Gene Therapy for HNSCC. Poster presentation, American Acad of Otolaryngology-Head and Neck Surgery Meeting, 2000, Washington DC. Daqing Li, Jacob W. Zeiders, Shixi Liu, Ming Guo, Jeffrey S. Bishop, and Bert W. O’Malley, Jr. Combination non-viral gene therapy for head and neck squamous cell carcinoma. Poster presentation, American Academy of Otolaryngology-Head and Neck Surgery Meeting, 2000, Washington DC. Chan DY, O'Malley BW Jr., Li D, Nicol TL, Kavoussi LR, Solomon SB. High Intensity Focused Ultrasound Increases Gene Delivery to Targeted Tissue. Annual Academy Radiology Meeting, 2000. Chan DY, O'Malley BW Jr, Nicol TL, Kavoussi LR, Solomon SB. Gene Therapy Targeted to the Renal Tubules Using a Liposomal Vector. Annual Academy of Urology Meeting 2000. O'Malley BW Jr, Li D, Ronson D, Guo M. Combination Cisplatin and Non-Viral IL-2 Gene Therapy for head and neck cancer. 5th International Conference on Head & Neck Cancer, July 29-August 4, San Francisco CA, 2000. Rhee JG, LI D, Guo M, Liu S, Duan L, O'Malley BW Jr, Suntharalingam M. Combination adenovirus mediated p16(INK4A) and radiation therapy for head and neck cancer. Annual Radiation Oncology Meeting, 2000. Qin H, Valentino J, Chatterjee M, Foon KA, O'Malley BW Jr., Chatterjee SK. Therapy of head and neck cancer by recombinant vaccinia virus expressing IL-2 in a murine model and evidence of immune suppression. American Assoc. Cancer Res. Ann. Meeting, New Orleans, LA 2000. ABSTRACTS AND SCIENTIFIC PRESENTATIONS (continued)
66.
Li D, Bishop J, O'Malley BW Jr. Synergistic Effect of Combined Xeloda and IL-2 Gene Therapy for Head and Neck Cancer. American Assoc. Cancer Research Annual Meeting, New Orleans, LA 2000. Day KV, Li D, Liu S, Guo M, O’Malley BW Jr. The Role of GM-CSF in Combination Gene Therapy Strategies against Head and Neck Cancer. Southern Section Triological Meeting, Marco Island, FL, January 2000. Li D, Day KV, Sreedharan S, O’Malley BW Jr. Combination RB94 and XRT for Head & Neck Cancer. American Society for Gene Therapy Annual Meeting, Seattle, WA, 2001. Day KV, Li D, O'Malley BW Jr. The Role of Adenovirus-Mediated RB94 in the Treatment of Head and Neck Cancer. American Head and Neck Society, Combined Otolaryngology Spring Meeting (COSM), Palm Desert, CA, May 14-16, 2001. Day KV, O'Malley BW Jr., Li D., Sreedharan, SX. Radiation and RB94 Gene Therapy: An Effective Combination against Head and Neck Cancer. Annual Meeting of the American Academy of Otolaryngology - Head & Neck Surgery, Denver, Colorado, September 9-12, 2001. O'Malley BW Jr., Li D., Pericle F. Combination of Non-viral IL-2 Gene Transfer and Radiotherapy in Treatment. Annual Meeting of the American Academy of Otolaryngology - Head & Neck Surgery, Denver, Colorado, September 9-12, 2001. Li D., Bishop JS, O'Malley BW Jr. IL-2 Synergistically Enhances the Efficacy of Xeloda against Head and Neck Cancer. Annual Meeting of the American Academy of Otolaryngology - Head & Neck Surgery, Denver, Colorado, September 9-12, 2001. Carney JP, Rhee JG, Li D, Chen TT, Suntharalingam M, O'Malley BW. Radiosensitization of head/neck squamous cell carcinoma by adenovirus-mediated expression of dominant negative constructs of the Nbs1 protein. American Society for Therapeutic Radiology & Oncology (ASTRO), November, 2001. Rena G. Lapidus, Daqing Li, Wenbin Dang, and Bert W. O’Malley Jr. Radiation Combined with PACLIMER Microspheres is Superior to Single Modality Treatment in a Human Orthotopic Head and Neck Cancer Model, American Association of Cancer Research, 2002, San Francisco. Shu-Zhen Yu, Steve Ronson, Joung Rhee, Gouyan Li, David Van Echo, John Sauk, Bert W. O’Malley, Jr., Mohan Suntharalingam, and Daqing Li. The Predictive Value of TP, TS and DPD in Xeloda-based Chemotherapy Strategy for Head and Neck Cancer American Association of Cancer Research, 2002, San Francisco. David A Bray, Jr, Shu-Zhen Yu, David A. Van Echo, Sunil Sreedharan, Daqing Li and Bert W. O’Malley, Jr. Combination Adenovirus-mediated Retinoblastoma 94 Gene Therapy and Cisplatin for Head and Neck Squamous Cell Carcinoma, American Association of Cancer Research, 2002, San Francisco. Daqing Li, Shu-Zhen Yu, David A Bray, Jr, David A. Van Echo, Sunil Sreedharan and Bert W. O’Malley. Adenovirus-mediated Retinoblastoma 94 Gene Therapy Enhances Cisplatin- Based Chemotherapy for the Treatment of Head and Neck Cancer. American Society of Gene Therapy, 2002, Boston, MA. Li, Rena G. Lapidus, Wenbin Dang, and Bert W. O’Malley Jr. PACLIMER Microspheres Enhances the Efficacy of Radiotherapy against Head and Neck Cancer. American Academy of Otolaryngology-Head and Neck Surgery Meeting, 2002, San Diego, CA. David A Bray, Daqing Li, Shu-Zhen Yu, Jr, David A. Van Echo, Sunil Sreedharan and Bert W. O’Malley. Combination Adenovirus-mediated Retinoblastoma 94 Gene Therapy and Cisplatin for Head and Neck Squamous Cell Carcinoma. American Academy of Otolaryngology-Head and Neck Surgery Meeting, September 2002, San Diego, CA. Daqing Li, Shu-Zhen Yu, and Bert W. O’Malley, Jr. Chemotherapy Outcome and Molecular Makers of TP, TS and DPD in the Treatment of Head and Neck Cancer, American Academy of Otolaryngology-Head and Neck Surgery Meeting, September 2002, San Diego, CA. ABSTRACTS AND SCIENTIFIC PRESENTATIONS (continued)
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Daqing Li, Shu-Zhen Yu, David Bray, Uwe Wirtz, Sunil Sreedharan, Bert W. O’Malley Jr. Down-regulation of telomerase activity and shortening of telomere by combined Rb94 gene therapy and cisplatin in human head and neck squamous cell cancer. American Association for Cancer Research, Special Meeting on Telomere activity, San Francisco, CA, Dec. 2002. Santanu Dasgupta, P.K. Tripathi, Malaya Bhattacharya-Chatterjee, Bert W. O’Malley, Jr., and Sunil K.Chatterjee. Immunotherapy using recombinant vaccinia virus expressing IL-2 generates effective anti-tumor responses in a murine model of head and neck squamous cell carcinoma. American Association of Cancer Research, 2003, Toronto, Canada. Rescheduled. Daqing Li, Guoyan Li, David A. Van Echo, Uwe Wirtz, Sunil Sreedharan, Bert W. O'Malley Jr. FGF2-targeted adenovirus-mediated retinoblastoma 94 (RB94) gene therapy in combination with cisplatin for head and neck squamous cell carcinoma. American Association of Cancer Research, 2003, Toronto, Canada. Rescheduled Washington, D.C., 2003. Mimi Tran, Daqing Li, Shu-Zhen Yu, Jr, and Bert W. O’Malley Jr. Adenovirus mediated p95 mutant gene therapy inhibits DNA repair and augments anti-tumor response to Cisplatin therapy for head and neck cancer. American Association of Cancer Research, 2003, Toronto, Canada, Rescheduled Washington, D.C., July, 2003. Bert W. O’Malley, Jr., Daqing Li, James Carney, Joug Rhee, and Mohan Suntharalingam. Targeted Molecular Disruption of the MRN Complex Induces Radiation Sensitization in HNSCC. Triological Society Annual Meeting (COSM), 2003, Memphis, TN. Daqing Li, G Li, DA Van Echo, U Wirtz, S Sreedharan, BW O’Malley Jr. Targeted Adenovirus-mediated Rb 94 and Cisplatin Approach for Head and Neck Cancer. American Academy of Otolaryngology-Head and Neck Surgery Meeting, 2003, Orlando, FL. Hao Mimi Tran, G Shi, G Li, JP Carney, BW O’Malley Jr., D Li. Mutant Nbs1 Enhances Cisplatin-Induced DNA Damage and Cytotoxicity in Head and Neck Cancer. American Academy of Otolaryngology-Head and Neck Surgery Meeting, 2003, Orlando, FL. H. Chanderhari, Z. Megeed, M. Haider, D. Li, B.W. O’Malley Jr, and J. Cappello. Recombinant polymers for gene delivery. Symposium on Recent Advances in Gene and Drug Deilivery, 2003 Regional Meeting of the American Chemical Society, Pittsburgh, PA October 20, 2003. S.K. Chatterjee, S. Dasgupta, P.K. Tripathi, M B-Chatterjee, B.W. O’Malley Jr. Induction of cellular immunity in an orthotopic murine model of head neck squamous cell carcinoma following vaccination with vaccinia virus expressing IL-2. 12th International Conference on Gene Therapy for Cancer, San Diego, CA, December 11-13, 2003. H. Ghandehari, Z. Megeed, M. Haider, R. Dandu, D. Li, B. W. O'Malley Jr., and J. Cappello. Localized Delivery of Plasmid DNA and Adenoviral Vectors For Cancer Gene Therapy By Recombinant Silk-Elastinlike Polymers, Sixth International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Welsh School of Pharmacy, Cardiff University, Cardiff, United Kingdom, January 7-9, 2004. Z. Megeed, J. Cappello, D. Li, B. W. O'Malley,Jr., H. Ghandehari, Genetically Engineered Biomaterials for Viral & Nonviral Cancer Gene Therapy, 31st International Symposium on Controlled Release of Bioactive Materials, Honolulu, Hawaii, June 13-16, 2004. R. Dandu, D. Li, B. W. O'Malley Jr., J. Cappello, and H. Ghandehari, Matrix-Mediated Adenoviral Gene Delivery with Recombinant Silk-Elastinlike Hydrogels, 31st International Symposium on Controlled Release of Bioactive Materials, Honolulu, Hawaii, June 13-16, 2004. H. Ghandehari, Z. Megeed, M. Haider, R. Dandu, D. Li, B. W. O’Malley, Jr. and J. Cappello. Matrix-Mediated Gene Delivery from Recombinant Polymers, AAPS Conference on Pharmaceutics and Drug Delivery, Philadelphia, PA, June 7-9, 2004. JOURNAL ARTICLES
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O'Malley, B.W., Jr., Sikes, M.L., Adams, R.M., Finegold, M.J., Ledley, F.D. Somatic gene therapy targeted to the thyroid: viral mediated gene transfer in animal models. Transplantation Proceedings. 1992;24/6:2973-2974. Ledley, F.D., Soriano, H.E., O'Malley, B.W., Jr., Lewis D., Darlington, G.J., Finegold, M.J. DiI as a marker for cellular transplantation into solid organs. Biotechniques. 1992;13:580-85. O'Malley, B.W., Jr. Resident's Page (Pathology): Basaloid-Squamous Carcinoma. Archives of Otolaryngology-Head and Neck Surgery. 1992;118:212-215. O'Malley, B.W., Jr., Finegold, M., Ledley, F.D. Autologous, Orthotopic Follicular Cell Transplantation: A Surgical Component of ex vivo Somatic Gene Therapy. Otolaryngology-Head and Neck Surgery. 1993;108(1):51-62. O'Malley, B.W., Jr., Adams, R.M., Sikes, M.L., Ledley, F.D. Retroviral-mediated gene transfer into canine thyroid using an ex vivo strategy. Human Gene Therapy. 1993;4:171-177. O'Malley, B.W., Jr. and Ledley, F.D. DNA and retroviral mediated gene transfer into follicular cells in vitro: progress towards gene therapy of the thyroid. The Laryngoscope. 1993;103(10): 1084-1092. Jr., Ledley, F.D. Somatic gene therapy in Otolaryngology-Head and Neck Surgery. Archives of Otolaryngology-Head and Neck Surgery. 1993;119(11):1191-1197. Jr., Ledley, F.D. Somatic Gene Therapy: Methods for the Present and Future. Archives of Otolaryngology-Head and Neck Surgery. 1993;119(10):1100-1107. O'Malley, B.W., Jr., Adams, R.M., Ledley, F.D. Gene Transfer into Human Thyroid Follicular Cells. The Laryngoscope. 1994;104:1330-1336. Sikes, M.L., O'Malley, B.W., Jr., Finegold M.J., Ledley F.D. In Vivo Gene Transfer into Rabbit Thyroid Follicular Cells by Direct DNA Injection. Human Gene Therapy 1994;5:837-844. Wang, Y.L., O'Malley, B.W., Jr., Tsai, S., Tsai, M., O'Malley, B.W. A Novel Regulatory Switch Designed for Gene Therapy. Proceedings Nationalof the National Academy Science 1994;91:8180-8184. O'Malley, B.W., Jr., Janecka, I.P. Evolution of Outcomes in Cranial Base Surgery. Seminars in Surgical Oncology 1995;11:1-7. O'Malley, B.W., Jr., Li, D., Turner, D. Hearing Loss and Cochlear Abnormalities in the Congenital Hypothyroid (hyt/hyt) Mouse. Hearing Research 1995;88:181-189. Yovandich, J., O'Malley, B.W., Jr., Sikes, M.L., Ledley, F.D. Gene Transfer to Synovial Cells by Intra-Articular Administration of Plasmid DNA Human Gene Therapy 1995;6:603-10. O'Malley, B.W. Jr., Chen, S.H., Schwartz, M.R., Woo, S.L.C. Adenovirus-Mediated Gene Therapy for Head and Neck Cancer in a Nude Mouse Model. Cancer Research 1995;55:1080-1085. Prichett, D.D., O’Malley, B.W., Westra W.H. Sinonasal mucosal melanoma: pathology case. Archives Otolaryngol Head Neck Surg. 1996;122(4):441, 443-4. O'Malley, B.W., Jr., Cope, K.A., Chen, S-H., Schwartz, M.R., Woo, S.L.C. Combination Gene Therapy for Oral Cancer in a Murine Model. Cancer Research 1996;56:1737-1741. O'Malley, B.W., Jr., Cope, K.A., Johnson, C.S., Schwartz, M.R. A New Immunocompetent Murine Model for Oral Squamous Cell Carcinoma. Archives Otolaryngol Head Neck Surg. 1997;123:20-24. Sewell DA, Li D, Duan L, O'Malley BW, Jr. Optimizing an adenoviral mediated "suicide gene" strategy for human application in the treatment of head and neck cancer. The Laryngoscope 1997;107(11):1490-1495. O'Malley BW, Jr, Sewell DA, Li D, Kosai K, Chen S-H, Woo SLC, Duan L. The Role of Interleukin-2 in Combination Adenovirus Gene Therapy for Head and Neck Cancer Molecular Endocrinology 1997;11(6):667-673. Sewell DA, Li D, Duan L, Westra W, O'Malley BW, Jr. Safety of In Vivo Adenoviral-Mediated Thymidine Kinase Treatment of Oral Cancer. Archives Otolaryngol Head Neck Surgery, 1997:123(12) BW, Jr. And Li D. Combination Gene Therapy for Salivary Gland Cancer. Ann New York Xiang M, Gan L, Li D (equal first authors), Chen Z, Zhou L, O’Malley BW, Jr., Klein W, Nathans J. Essential Role of POU-Domain Factor Brn-3c in Auditory and Vestibular Hair Cell Development. Proceedings of the National Academy of Sciences 1997;94:9445-9450. JOURNAL ARTICLES (continued)
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Xiang M, Gan L, Li D, Zhou L, Chen Z, Wagner D, O'Malley BW, Jr., Klein W, Nathans J. Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harbor Quant. Biology 1997;62:325-336. Gillespie MD, O’Malley BW Jr.(corresponding author), Frances H. An Approach to Fulminant Invasive Fungal Rhinosinusitis in the Immunocompromised Host. Archives Otolaryngology Head Neck Surgery 1998;124:1-7. Jr., Li D, Duan L., Buckner, A., Pardoll DM. Limitations of IL-2 Gene Therapy for Oral Cancer. The Laryngoscope 1999:109(3):389-95. Rocco J, Li D, Liggett B, Duan L, Saunders JK, Sidransky D, O’Malley BW, Jr. p16 Adenovirus-Mediated Gene Therapy for Human Head and Neck Squamous Cell Cancer. Clinical Cancer Research 1998;4:1697-1704. Flint PW, Shiotani A, O'Malley BW, Jr. (Co-corresponding author) IGF-1 Gene Transfer into Denervated Rat Laryngeal Muscles. Archives of Otolaryngology HNS, 1999;125(3):274-9. Shiotani A, O'Malley BW,Jr. (Co-corresponding author), Flint PW. Reinnervation of Motor Endplates after IGF-1 Gene Transfer into the Paralyzed Larynx. Human Gene Therapy 1998;9:2039-2047. Simon C, Nemechek AJ, Boyd D, O'Malley BW, Jr., Goepfert H, Flaitz CM, Hicks MJ. An Orthotopic Floor-of-Mouth Cancer Model Allows Quantification of Tumor Invasion. The Laryngoscope 1998;108(11Pt1):1686-91. Simon C, Hicks MJ, Nemechek AJ, Mheta R, O'Malley BW, Jr.,Goepfert H, Flaitz CM, Boyd D. Attenuated In Vivo Invasiveness of Head and Neck Squamous Cell Carcinoma Treated with PD098059 and Inhibitor of ERK1 Activation. British Journal of Cancer, 1999;80(9):1412-9. Shiotani A, O'Malley BW Jr (Co-corresponding author), Coleman ME, Flint PW. Human insulinlike growth factor 1 gene transfer into paralyzed rat larynx: single vs. multiple injections. Archives of Otolaryngology Head Neck Surgery 1999;125(5):555-60. Li D., Henley C., O'Malley, B.W., Jr. Otoacoustic Emissions and Auditory Pathway Function in the hyt/hyt Congenital Hypothyroid Mouse. Hearing Research, 138:65-72, 1999. Li D, Jiang W, Ralston R, O'Malley BW Jr. Combination Surgery and Non-viral IL-2 Gene Therapy for Head and Neck Cancer. Clinical Cancer Research 1999;5:1551-1556. Li D, Duan L, Freimuth P, O’Malley BW, Jr. Variability of Adenovirus Receptor Density Influences Gene Transfer Efficiency and Therapeutic Response in Head and Neck Cancer. Clinical Cancer Research 1999;4:4175-4181. Gillespie MB, O'Malley BW Jr. An Algorithmic Approach to the Diagnosis and Management of Invasive Fungal Rhinosinusitis in the Immunocompromised Patient. Otolaryngologic Clinics of North America. 2000;33(2):323-334. Gillespie MB, Huchton DM, O'Malley BW Jr. The Role of Middle Turbinate Biopsy in the Diagnosis of Fulminant Invasive Fungal Rhinosinusitis. The Laryngoscope 2000 Nov;110(11):1832-6. O’Malley BW Jr., Couch ME. Gene Therapy Principles and Strategies for Head and Neck Cancer. Adv Otorhinolaryngology 2000;56:279-88. H. Staecker, B.W. O'Malley Jr, H. Eisenberg, B. Yoder. Use of the LandmarX Surgical Navigation System in Lateral Skull Base and Temporal Bone Surgery. Skull Base Surgery, 2001: 11(No.4);245-255. Li D, Zeiders JW, Liu S, Guo M, Xu Y, Bishop JS, O'Malley BW Jr. Combination nonviral cytokine gene therapy for head and neck cancer. The Laryngoscope. 2001;111(5):815-2. Khurana D, Martin EA, Kasperbauer JL, O'Malley BWJr, Salomao DR, Chen L, Strome SE. Characterization of spontaneously arising murine squamous cell carcinoma (SCCVII) as a prerequisite for head and neck cancer immunotherapy. Head Neck 2001 Oct.23(10):899-906. Staecker H, Li D, O'Malley BW Jr., Van De Water TR. Gene Expression in the Mammalian Cochlea: A study of multiple vector systems. Acta Otolaryngologica, 2001:121(2):157-63. Li D, Shugert E, Guo M, Bishop J, O’Malley BW Jr. Combination Non-Viral Interleukin 2 and Interleukin 12 Gene Therapy for Head and Neck Squamous Cell Carcinoma. Archives of Otolaryngology Head Neck Surgery 2001 Nov:127(11):1319-1324. JOURNAL ARTICLES (continued)
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Qin H, Valentino J, Manna S, Tripathi PK, Bhattacharya-Chatterjee M, Foon KA, O'Malley BW Jr., Chatterjee SK. Gene Therapy for Head and Neck Cancer Using Vaccinia Virus Expressing IL-2 in a Murine Model, Evidence of Immune Suppression. Molecular Therapy, 2001 Dec:4, (No.6); 551-558. Day K, Li D, Duan L, O'Malley BW Jr. Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer. The Laryngoscope. 2001 May;111(5):801-6. Monitto CL, Berkowitz D, Lee KM, Pin S, Li D, Breslow M, O'Malley BW Jr, Schiller, M. Differential gene expression in a murine model of cancer cachexia. Am J Physiol Endocrinol Metab, 2001:281(2): E289-97. Constance L. Monitto, Dan Berkowitz, Kyoung Min Lee, Sokhon Pin, Daqing Li, Michael Breslow, O’Malley, Bert W. Jr. Martin Schiller. Differential Gene Expression in a Murine Model of Cancer Cachexia. Am J Physiol 2001;28:E289-97 Wolf JS, Malekzadeh S, Berry JA, O'Malley BW Jr. Informed Consent in Functional Endoscopic Sinus Surgery. The Laryngoscope 2002 May;112(5):774-778. Li D, Day KV, Liu S, Guo M, Sreedharan SP, O’Malley BW Jr: The Role of Adenovirus-Mediated Retinoblastoma 94 in the Treatment of Head and Neck Cancer. Cancer Research 2002 August 15;62(16):4637-4644. Li D, Ronson D, Liu S, Guo M, Bishop J, Van Echo D, Bert W. O’Malley, Jr.: Interleukin 2 Gene Transfer Prevents NKG2D Suppression and Enhances Anti-tumor Efficacy in Combination with Cisplatin for Head and Neck Squamous Cell Cancer. Cancer Research 2002 July 15;62(14):4023-4028. Couch MC, Saunders JK, O’Malley BW Jr., Jafee E, Pardoll DM. Genetically engineered tumor cell vaccine in a head and neck cancer model. The Laryngoscope, 2003 March 113(3):552-6. Bray D, Yu SZ, Koprowski H, Rhee J, Kumar S, Pericle F, Suntharalingam M, Van Echo DA, Li D, O'Malley BW Jr. Combination non-viral interleukin-2 gene therapy and external beam radiation therapy for head and neck cancer. Archives of Otolaryngol Head Neck, 2003 June;129(6)618-22. Nikitakis NG, Salama AR, O’Malley BW Jr., Ord RA, Papadimitriou JC. Malignant Peripheral Primitive Neuroectodermal Tumor-Peripheral Neuroepithelioma of the Head and Neck; A Clinicopathologic Study of Five Cases and Review of the Literature. Head & Neck, 2003 June:25(6):488-98. Berry J, O'Malley BW Jr, Humphries S, Staecker H. Making Image-Guidance Work: Understanding Control of Accuracy. Annals of Otol Rhinol Laryngol, 2003;112:689-692. Dasgupta S, Tripathi P, Bhattacharya-Chatterjee M, O’Malley B Jr., Chatterjee S. Recombinant Vaccinia Virus Expressng IL-2 Generates Effective Anti-tumor Responses in an Orthotopic Murine Model of Head and Neck Carcinoma. Molecular Therapy, Vol. 8, No. 2, August 2003, 238-246 Rhee JG, Li D, Guo M, O'Malley BW Jr., Suntharalingam M. Combination radiation and adenovirus mediated p16 (INK4A) gene therapy in a murine model for head and neck cancer. ORL J Otorhinolaryngol 2003 June;65(3);144-154. O’Malley BW Jr., Li D., Carney J., Rhee J., Suntharalingam M. Molecular Disruption Of The MRN(95) Complex Induces Radiation Sensitivity in Head And Neck Cancer. The Laryngoscope, 2003 Sep;113(9)1588-94. Couch MC, Saunders JK, O’Malley BW Jr., Pardoll DM, Jafee E. Spatial Distribution of Tumor Vaccine Improves Efficacy. Laryngoscope 2003 Aug;113(8):1401-5. Wolf J, Li D, Taylor R, O’Malley BW Jr. Lactoferrin inhibits growth of malignant tumors of the head and neck. ORL J Otorhinolaryngol, 2003 O’Malley BW Jr., Rodrigues M., Tomargo R. Split Calvarial Bone Grafts and Extended Pericranial Flap Reconstruction of Anterior Cranial Base Defects [accepted, Otolaryngol Head Neck Surg, in press 2004] Flint PW, Nakagawa H, Shiotani A, Coleman ME, and O’Malley BW Jr. Effects of insulin-like growth factor-1 gene transfer on Myosin heavy chains in denervated rat laryngeal muscle. Laryngoscope. 2004 Feb;114(2):368-71. Megeed Z, Haider M, Li D, O'Malley BW Jr, Cappello J, Ghandehari H. In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy. J Control Release. 2004 Feb 10;94(2-3):433-45. JOURNAL ARTICLES (continued)
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O’Malley BW, Jr, Do K, Huchton DM, Brown M. Microvascular Reconstruction of Cranial Base Defects. [submitted Journal of ORL, 2004] Bray DA, Li D, Yu S-Z, Van Echo DA, Sreedharan S, O’Malley. BW Jr. Combination Adenovirus-mediated Retinoblastoma 94 Gene Therapy and Cisplatin for Head and Neck Squamous Cell Carcinoma [submitted, Cancer Research 2004]. O'Malley BW, Jr. Combination Non-viral IL-2 Gene Immunotherapy for Head and Neck Cancer: From Bench Top to Bedside. [Triolgical Society Thesis, in press 2004]
MANUSCRIPTS IN PREPARATION (Research Completed):
1.
Sikes, M.L., O'Malley, B.W., Jr., Yovandich, J.L., Smith, L.C., Ledley, F.D. Direct Gene Transfer in the Rat Thyroid. [in preparation] Sikes, M.L., O'Malley, B.W., Jr., Yovandich, J.L., Smith, L.C., Ledley, F.D. Intracellular processing of plasmid DNA in an in vivo epithelial model. [in preparation] Li D, Van Echo D, Suntharalingam M, Guo M, O'Malley BW Jr. Combination Xeloda and IL-2 Gene Therapy for Head and Neck Cancer. [in preparation for 2004 submission]. Li D, Day KV, Sreedharan S, Suntharalingam M, Guo M, O'Malley BW Jr. RB-94 gene therapy and radiation for HNSCC [in preparation for 2004 submission] Carney JP, Rhee JG, Li D, Chen TT, Suntharalingam M, O'Malley BW Jr. Radiosensitization of head/neck squamous cell carcinoma by adenovirus-mediated expression of dominant negative constructs of the Nbs1 protein. [2004]
TEXTBOOK CHAPTERS

1.
Bert W. O’Malley, Jr., M.D. Fundamentals of Molecular Biology and Gene Therapy. In Cummings, et al. Otolaryngology Head & Neck Surgery. Third Edition, Mosby Publishing 1998. Bert W. O’Malley, Jr., M.D., Dan Nuss, MD. and Ivo P. Janecka, MD. Surgery of the Anterior and Middle Cranial Base. In Cummings, et al. Otolaryngology-Head & Neck Surgery. Third Edition, Mosby Publishing 1998. Bert W. O’Malley, Jr., M.D. Paranasal Sinus Emergencies. In Eisele et al. Emergencies in Otolaryngology, Mosby Publishing Bert W. O'Malley, Jr., MD and Marion Couch MD. Gene Therapy for Cancer: Approaches and Clinical Trials. In Rolland ed: Advanced Gene Delivery: from Concepts to Pharmaceutical Products, Harwood Academic Publishers, Switzerland, 1999. Bert W. O'Malley, Jr., M.D. Suicide Gene Therapy for Cancer. In Templeton and Lasic eds: Gene Therapy: Therapeutic Mechanisms and Strategies; Marcel Dekker, Inc., June 2000. Marion Couch MD and Bert W. O'Malley, Jr., MD. Gene Therapy for Oral Cancer, Oxford University Press, New Dehli, 2000. William Gray MD and Bert W. O'Malley Jr. MD. Neoplasms of the Hypopharynx. In Alper, Myers, Eibling eds: Decision Making in Ear, Nose and Throat Disorders. W.B. Saunders Company, Philadelphia, PA, 2001. Bizahn Aarabi and Bert W. O'Malley Jr. Repair of Cerebrospinal Fluid leaks in the Paranasal Sinuses and Temporal Bone. In Sekhar and Fessler, eds: Atlas of Neurosurgical Techniques. Bert W. O'Malley, Jr., M.D. Anterior Craniofacial Resection. In Niparko, Long, and O’Malley eds: Atlas of Skull Base Surgery, Parthenon Publishing , London, UK 2002 (in press) Bert W. O'Mal ey, Jr., MD. Transfacial Approaches to the Skul Base. In Niparko, Long, and O’Malley eds: Atlas of Skull Base Surgery, Parthenon Publishing, London, UK 2002 (in press) Bert W. O'Mal ey, Jr., M.D. Transoral Approaches to the Midline Skul Base. In Niparko, Long, and O’Malley eds: Atlas of Skull Base Surgery, Parthenon Publishing, London, UK 2002 (in press) Bert W. O'Malley, Jr., M.D. Transphenoid Approaches to the Skull Base. In Niparko, Long, and O’Malley eds: Atlas of Skull Base Surgery, Parthenon Publishing, London, UK 2002 (in press) Dan Nuss, MD, Bert W. O’Malley, Jr., M.D and Ivo P. Janecka, MD. Surgery of the Anterior and Middle Cranial Base. In Cummings, et al. Otolaryngology-Head & Neck Surgery. Fourth Edition, Springer Verlager Publishing, in revision for 2003. TEXTBOOK CHAPTERS (continued)
18.
Bert W. O’Malley, Jr., M.D., Daqing Li, M.D., and Hinrich Staecker, M.D., Ph.D. Fundamentals of Molecular Biology and Gene Therapy. In Cummings, et al. Otolaryngology Head & Neck Surgery. Fourth Edition, Springer Verlager Publishing, in revision for 2003 Bert W. O'Malley, Jr., M.D. Suicide Gene Therapy for Cancer. In Templeton and Lasic eds: Gene Therapy: Therapeutic Mechanisms and Strategies; Second Edition; Marcel Dekker, Inc., November 2002. M. Lango, B. W. O’Malley Jr., Ara Chalian. Neck Dissection 2004

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Material safety data sheet

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