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Microsoft word - cv-1.doc

Srinivas Deekonda, Ph. D.
Department of Chemistry and Biochemistry
Objective:
To obtain a position in the area of Synthetic Organic /Medicinal Chemistry
Highlights:
Over fifteen years of research experience in synthetic organic, peptide and medicinal chemistry Strong background in medicinal chemistry, thorough knowledge of organic reaction mechanisms and contemporary synthetic methods Experienced in designing and executing multi step synthesis of various bio-active molecules Experience in derive and utilize structure activity relationships (SAR) to improve the efficacy of drug candidates Experience in solution, solid-phase synthesis of peptide chemistry Expertise in chromatographic purification, spectral characterization, process research and scale-up operations Working knowledge of most of the chemical databases and basics in computers Experience in writing scientific manuscripts, mentoring graduate and undergraduate students Research Experience:
Post Doctoral Research Associate:
08/2009 – Present
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA
(Research Advisor: Prof. Victor J Hruby)
Design and synthesis of novel bifunctional ligands for treatment of chronic and neuropathic pain Successfully designed and synthesized novel bivalent ligands in single structures mu/delta opioid agonists and bradykinin receptor antagonists Senior Research Scientist: 02/2009 – 07/2009
Jubilant Biosys, Bangalore, India

Designed and synthesized novel small molecules for Bradykinin Receptor l antagonists Mentoring group of masters and lead the BK 1 project
Senior Research Scientist: 04/2008 – 12/2008
Sai Adventium Pharma Ltd., Pune, India

Designed and synthesized novel small molecules Mentoring group of masters and lead the project Graduate Research Fellow: 02/2003 – 04/2008
National Chemical laboratory, Pune, India
Design, synthesis and structural investigations of novel foldamers (conformationally ordered synthetic oligomers) derived from alpha amino acid and aromatic amino acid conjugates Design, synthesis, and structural studies of novel hybrid foldamers, derived from Aib-Pro-Adb building block that displays repeat β-bend ribbon spiral motif Account of synthesis and secondary structural investigations of hybrid foldamers containing Adb-Aib and Spirobiindane building blocks A semi synthetic peptide motif that concurrently displays both α- and β-turns, as evidenced from extensive structural investigations by single crystal X-ray crystallography and solution-state NMR studies The serendipitous discovery of an efficient synthetic route to BINOL-m-phenylenediamine-derived macrocycles
Senior Chemist-Research Associate:
05/1995 – 01/2003
Dr. Reddy’s Research Foundation, Hyderabad, India.

During this period, I actively involved in design and synthesis of novel small molecules for various therapeutic areas like antidiabatic, antiulcer and antibacterial Education:
National Chemical Laboratory / Pune University, India, April 2008 Supervisor: Dr. Gangadhar J Sanjayan; Title: “De Novo Designed Foldamers based on Biotic and Abiotic
Building Blocks”
M.Sc: Organic Chemistry, Kakatiya University, Warangal, India, 1994
Awards/Fellowships/Affiliations:
Postdoctoral Fellowship,(NIDA) (National Institute of Drug Abuse) Awarded Senior Research Fellowship (SRF) from Council of Scientific and Industrial Research (CSIR), New Delhi, 2004-2007 Member of American Chemical Society (ACS, Medicinal Chemistry Division) Research Publications
1. A hybrid foldamer with unique architetechture from conformationally constrained aliphatic-aromatic amino
acid conjugate
Deekonda Srinivas, Gonnade, R; Ravindranathan, S.; Sanjayan, G. J. Tetrahedron. 2006, 62, 10141-1-146.
2. Constrained Aliphatic-Aromatic Aminoacid-Conjugated Hybrid Foldamers With Periodic β-turn motifs Deekonda Srinivas, Gonnade, R; Ravindranathan, S.; Sanjayan, G. J. J. Org. Chem. 2007, 72, 7022-7025.
3. Pre-organization-Mediated Macrocyclization: Synthesis and structural investigations of BINOL-m-Phenylene diamine-derived Macrocycles Deekonda Srinivas, Gonnade, R.; Rajmohanan, P.R., Sanjayan, G. J. Tetrahedron Letters 2008, 49, 2139–
2142.
4. Concurrent Display of Both α-and β-Turns in a Semi synthetic Peptide
Deekonda Srinivas, Gonnade, R.; Phalgune, U.; Rajmohanan, P.R., G. J. Sanjayan, G. J. (Recently Accepted
in Org. Biomol.Chem.,)
5. Synthesis of Conformationally Constrained Analogues of Linezolid: Structure-Activity Relationship (SAR)
Studies on Selected Novel tricyclic Oxazolidinones
Selvakumar, N.; Deekonda Srinivas, Khera, M. K.; Sitaram Kumar, M.; Srinivas Rao, N. V. S. M.; Sarnaik, H.;
Charayaryamath, C.; Srinivas Rao, B.; Raheeem, M. A.; Das, J.; Javed Iqbal, Rajagopalan, R. J. Med. Chem.
2002, 45, 3953-3962.
6. Observation of O→N Type Smiles Rearrangement in Certain Alkyl Aryl Nitro Compounds
Selvakumar, N.; Deekonda Srinivas, Azhagan, M. A. Synthesis. 2002, 16, 2421-2425.
7. Synthesis of novel tricycle oxazolidinones by a tandem SN2 and SNAr reaction SAR Studies conformationally constrained analogues of linezolide Selvakumar, N.; D. Srinivas,.; Yadireddy, B.; Sunil kumar,G.; Khera, M. K.; Sitaram Kumar, M.; Das, J.;
Iqbal,J.; Trehan.S. Bioorg. Med. Chem. Lett. 2006, 16, 4416–4419
8. A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)- coerulescine and (±)-horsfiline Selvakumar, N.; Azhagan, M. A.; D. Srinivas, Krishna, G. G. Tetrahedron Lett.. 2002, 43, 9175-9178.
9. Highly Efficient CuI-Catalyzed Coupling of Aryl Bromides with Oxazolidinones Using Buchwald's Protocol: A
Short Route to Linezolid and Toloxatone.
Mallesham, B.; D. Srinivas Rajesh, B. M.; Reddy, P.R.;Org. Lett. 2003, 5, 963-965.
10. An efficient total synthesis of 9-methoxycarbazole-3-carbaldehyde based on a novel methodology for the
preparation of methoxyindoles
Selvakumar, N.; Khera, M. K.; Yadireddy, B.; D. Srinivas.; Azhagan, A. M.; Iqbal. J. Tetrahedron Lett. 2003, 44,
7071-7074.
Poster Presentations:
1. A hybrid foldamer with unique architetechture from conformationally constrained aliphatic-aromatic aminoacid
conjugate National Science Day at National Chemical Labortatory Pune. Deekonda Srinivas, Gonnade, R;
Ravindranathan, S.; Sanjayan, G. J. National Science Day-2006.
2. Structure Activity Relationship Studies on Certain Conformationally Constrained Oxazolidinones. N.
Selvakumar, B. Yadireddy. D.Srinivas, Javed Iqbal. 42nd Interscience Conference on Antimicrobial Agents and
Chemotherapy. Abstract # F-1324.September 27-30, 2002, CANADA.

Source: http://www.cbc.arizona.edu/sites/default/files/researchgroups/blank/CVSrinivas_Deekonda.pdf

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