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Proposition 65 status report: safe harbor levels: no significant risk levels and maximum allowable dose levels

PROPOSITION 65
STATUS REPORT
SAFE HARBOR LEVELS:
January 2005
Office of Environmental Health Hazard Assessment California Environmental Protection Agency The energy challenge facing California is real. Every Californian needs to take immediate action to reduce energy consumption. TABLE OF CONTENTS

Proposition 65 Safe Harbor Levels Development
…………………… 1

A. No Significant Risk Levels (NSRLs) Adopted

in Regulation for Carcinogens……………………………………. 2

B. Maximum Allowable Dose Levels (MADLs) Adopted

in Regulation for Chemicals Causing Reproductive Toxicity…… 9

C. Priority List for the Development of NSRLs for Carcinogens
…. 10
D. Priority List for the Development of MADLs for Chemicals

Causing Reproductive Toxicity…………………………………… 16

Proposition 65 Safe Harbor Levels Development

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). In that role, OEHHA has developed Proposition 65 safe harbor levels -- no significant risk levels (NSRLs) for carcinogens and maximum allowable dose levels (MADLs) for chemicals that cause reproductive toxicity. The NSRL is the daily intake level calculated to result in one excess case of cancer in an exposed population of 100,000, assuming lifetime (70-year) exposure at the level in question. The MADL is the level at which the chemical would have no observable adverse reproductive effect assuming exposure at 1,000 times that level. The NSRLs and MADLs are promulgated in Title 22, California Code of Regulations, (CCR) Sections 12705 and 12805 respectively to assist interested parties in determining whether warnings are required for exposures to listed chemicals, and whether discharges to sources of drinking water are prohibited. Safe harbor levels may be based on risk assessments conducted outside OEHHA, as provided for in 22 CCR 12705(b), 12705(c), and 12805. In some cases, this can expedite safe harbor development. However, it should be noted that the process of review and consideration of existing risk assessments can be a lengthy one, and will depend on the complexity of the scientific information underlying the assessment, as well as on available resources. This document provides the status of the development and adoption of intake levels calculated for all chemicals on the Proposition 65 list. In units of micrograms per day (µg/day), Part A reports NSRLs adopted in regulation for carcinogens and Part B reports MADLs adopted in regulation for chemicals that cause reproductive toxicity. Parts C and D of this document give priority levels for development of dose response assessments for chemicals that cause cancer and reproductive toxicity, respectively. Interested parties are invited to recommend changes in priority levels. OEHHA retains the right to change priorities in response to the nature and availability of scientific information, and resources available, and requests from the public and the Attorney General’s office. Parts C and D also give draft levels, some of which have been available since the early 1990’s and others of which have been updated recently. OEHHA will continue to review the basis for draft numbers and update analyses as needed, before proposing or finalizing levels for formal adoption in regulation. This status report will be updated on a regular basis. A. No Significant Risk Levels (NSRLs) Adopted in Regulation
for Carcinogens
The table below lists NSRLs for Proposition 65 carcinogens in regulation (22 CCR §12705 and §12709). These levels are intended to provide “safe harbors” for persons subject to the Act, and do not preclude the use of alternative levels that can be demonstrated by their users as being scientifically valid. A three-tiered procedure for development of NSRLs is currently in place. NSRLs may be based on a de novo dose response assessment conducted or reviewed by OEHHA (22 CCR §12705(b)), an assessment conducted by another state or federal agency (22 CCR §12705(c)), or an expedited process conducted by OEHHA (22 CCR §12705(d)). The last column of the table below indicates which of these processes was used to develop the NSRL for each chemical. NSRLs represent the daily intake level calculated to result in a cancer risk of one excess case of cancer in 100,000 individuals exposed over a 70-year lifetime. NSRLs for chemicals in bold have been adopted since the last Status Report. As chemicals are removed from the Proposition 65 list, the regulatory process to remove the safe harbor level from regulation will be initiated. Carcinogen A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) AF-2; [2-(2-furyl)-3(5-nitro-2-furyl)acrylamide] 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 0.04 NSRL for fibers > 5 micrometers (mm) long and 0.3 wide, with a length/width ratio > 3:1 as measured by phase contrast microscopy. Status Report
Proposition 65 Safe Harbor Levels
January 2005
Chlorinated paraffins (Ave. chain length C12; Chloromethyl methyl ether (technical grade) p-Chloro-o-toluidine, hydrochloride Status Report
Proposition 65 Safe Harbor Levels
January 2005
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) 4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) 1,2-Dichloroethane (Ethylene dichloride) 1,2-Dichloropropane 9.7
12705(b)
3,3'-Dimethoxybenzidine (o-Dianisidine) 0.15 [2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole 3,3'-Dimethylbenzidine (o-Toluidine) 0.044 Status Report
Proposition 65 Safe Harbor Levels
January 2005
Ethyl-4,4'-dichlorobenzilate (Chlorobenzilate) 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole 0.3 Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole) Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]-imidazole) Gyromitrin (Acetaldehyde methylformylhydrazone) IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) MeIQ (2-amino-3,4-dimethylimidazo-[4,5-f]quinoline) 0.46 MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) 0.41 Status Report
Proposition 65 Safe Harbor Levels
January 2005
4,4'-Methylene bis(N,N-dimethyl)benzeneamine 2-Methyl-1-nitroanthraquinone (of uncertain purity) N-Methyl-N'-nitro-N-nitrosoguanidine 0.08 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino] -2-oxazolidinone MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) 0.11 Nitrilotriacetic acid, trisodium salt monohydrate 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone 0.4 N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide 0.5 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone 0.014 Status Report
Proposition 65 Safe Harbor Levels
January 2005
o-Phenylenediamine dihydrochloride 2,3,7,8-Tetrachlorodibenzo-p-dioxin 0.000005 Status Report
Proposition 65 Safe Harbor Levels
January 2005
Tris(1-aziridinyl)phosphine sulfide (Thiotepa) Vinyl trichloride (1,1,2-Trichloroethane) Status Report
Proposition 65 Safe Harbor Levels
January 2005
B. Maximum Allowable Dose Levels (MADLs) Adopted in Regulation
for Chemicals Causing Reproductive Toxicity
The following table is a compilation of MADLs in regulation (22 CCR §12805) for Proposition 65 chemicals that cause reproductive toxicity. These levels represent the no observable effect level (NOEL) for the chemical, divided by 1,000. NOELs are set in accordance with procedures specified in 22 CCR §12803. MADLs for chemicals in bold have been adopted since the last Status Report. Chemical Listed as Causing Reproductive Toxicity 2,4-DB (2,4-dichlorophenoxybutyric acid) 1,2-Dibromo-3-chloropropane (DBCP)
3.1 (oral)
(inhalation)
m-Dinitrobenzene 38
Disodium cyanodithiomidocarbonate
56 (oral)
[170 (oral) for a 32% pesticidal formulation]
Ethyl dipropylthiocarbamate
700 (oral and inhalation)
(dermal)
Ethylene glycol monomethyl ether
63 (oral)
Ethylene glycol monomethyl ether acetate
98 (oral)
Methyl bromide as a structural fumigant
810 (inhalation)
Quizalofop-ethyl 590
Thiophanate-methyl 600
aWhere a source or product results in exposures by multiple routes, the total exposure must be considered. For example, the MADL for benzene is exceeded when the absorbed dose exceeds 24 µg/day. If only inhalation and oral exposure occurs, the benzene MADL is exceeded when: (oral dose ÷ 24 µg/day) + (inhalation dose ÷ 24 µg/day) > 1.0 b Level represents absorbed dose (rounded from 6,525 µg/day). Since 100% of ingested toluene is absorbed, oral dose is equivalent to administered dose. It is assumed that roughly 50% of the dose administered by the inhalation route is absorbed. Therefore the MADL for inhaled toluene is 13,000 µg/day (rounded from 13,050 µg/day), corresponding to an absorbed dose of 6,525 µg/day.
Status Report
Proposition 65 Safe Harbor Levels
January 2004
C. Priority List for the Development of NSRLs for Proposition 65
Carcinogens

OEHHA has developed the following priority list, which classifies into four priorities carcinogens for
which dose-response assessments have not been completed. Priority levels reflect the availability and
quality of scientific data for dose-response assessments, potential for exposure, resources available to
perform the assessment, commitments made in settlement of the case of AFL-CIO v. Deukmejian
(Sacramento Superior Court No. 3481295) and input from the public and Attorney General’s office.
OEHHA anticipates proposing NSRLs for the majority of chemicals in the first priority group within the
next two years, and for second priority chemicals within the next two to four years. It is unlikely that
NSRLs for third and fourth priority chemicals would be released within the next three years.
Any interested party may submit recommendations to OEHHA for revising the priority assignment for any
of the chemicals listed. Recommendations should be accompanied by appropriate documentation
supporting the alternative priority assignment suggested. OEHHA expects changes in priorities resulting
from the availability of scientific information and resources, and requests from the public and Attorney
General’s office.
A three-tiered procedure for development of NSRLs is currently in place. NSRLs may be based on a
de novo dose response assessment conducted or reviewed by OEHHA (22 CCR §12705(b)), an assessment
conducted by another state or federal agency (22 CCR §12705(c)), or an expedited process conducted by
OEHHA (22 CCR §12705(d)). The table below lists draft NSRLs and their year of release, along with the
subsection of 12705 indicating the procedure used to develop the value. OEHHA will review the basis for
draft numbers and update analyses as needed, before proposing or finalizing levels for formal adoption in
regulation. Chemicals in bold font have been added to the Proposition 65 list or changed in priority status
since the last Status Report.
First Priority for NSRL Development Acetochlor 1-Amino-2,4-dibromoanthraquinone Aniline hydrochloride Antimony oxide Azacitidine Benzo[k]fluoranthene Benzotrichloride (1993 draft inhalation NSRL: 0.0002 µg/day [12705(d)]) 2,2-Bis(bromomethyl)-1,3-propanediol Bromate Chlordimeform p-Chloroaniline p-Chloroaniline hydrochloride C. I. Acid Red 114 C.I. Direct Blue 15 C.I. Direct Blue 218 C.I. Solvent Yellow 14 Status Report
Proposition 65 Safe Harbor Levels
January 2005
Dibenz[a,h]acridine Dibenz[a,j]acridine Dibenzo[a,e]pyrene Dibenzo[a,l]pyrene 3,3'-Dichlorobenzidine dihydrochloride 1,3-Dichloropropene (1992 draft NSRL: 0.3 µg/day [12705(b)]) 2,6-Dinitrotoluene Estragole Ethylbenzene Ethinylestradiol Furan Glycidol (1992 draft NSRL: 0.01 µg/day [12705(b)]) Indeno[1,2,3-cd]pyrene Isoprene Lactofen Methylmercury compounds N-Methylolacrylamide Nickel carbonyl o-Nitroanisole Nitrobenzene 4-Nitrobiphenyl 6-Nitrochrysene (1993 draft NSRL: 0.004 µg/day [12705(b)]) ∗ For explanation of priority levels see discussion above. Status Report
Proposition 65 Safe Harbor Levels
January 2005
o-Phenylphenol PhiP Progesterone Propylene glycol mono-t-butyl ether Pronamide Pyridine Selenium sulfide 1,2,3-Trichloropropane Tris(2-chloroethyl)phosphate Vinyl First priority for changes to NSRLs currently in regulation: o-Phenylphenate, sodium Pentachlorophenol Safrole p-Aminoazobenzene Bis(2-chloro-1-methylethyl)ether, technical grade Bromoethane Cacodylic acid Catechol Ceramic fibers (airborne particles of respirable size) 1-Chloro-4-nitrobenzene Chloroprene 5-Chloro-o-toluidine and its strong acid salts Cobalt metal powder Cobalt [II] oxide Cobalt sulfate heptahydrate Diaminotoluene (mixed) 2,3-Dibromo-1-propanol Dichloroacetic acid 1,4-Dichloro-2-butene Diesel engine exhaust Di-n-propyl isocinchomeronate (MGK Repellent 326) Diuron Ethoprop Fenoxycarb Fumonisin B1 Indium phosphide Iprodione Isoxaflutole Status Report
Proposition 65 Safe Harbor Levels
January 2005
Isosafrole Metham sodium Methyl iodide 1-Naphthylamine Nickel and nickel compounds Nitromethane o-Nitrotoluene Oxadiazon Oxythioquinox Polychlorinated dibenzo-p-dioxins Primidone Propachlor Quinoline and its strong acid salts Radionuclides Salicylazosulfapyridine Silica, crystalline (airborne particles of respirable size) Testosterone and its esters p-a,a,a-Tetrachlorotoluene Tetrafluoroethylene Thiouracil 2,4,5-Trimethylaniline and its strong acid salts Triphenyltin hydroxide Trypan blue (commercial grade) 4-Vinyl-1-cyclohexene diepoxide Third Priority for NSRL Development Adriamycin (Doxorubicin hydrochloride) Benzidine-based dyes N,N-Bis(2-chloroethyl)-2-naphthylamine Bischloroethyl nitrosourea (BCNU) (Carmustine) 1,4-Butanediol dimethanesulfonate (Busulfan) Carbon black (airborne, unbound particles of respirable size) Chloramphenicol 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea Chlorotrianisene Ciclosporin (Cyclosporin A; Cyclosporine) Cidofovir Cisplatin Clofibrate Daunomycin N,N'-Diacetylbenzidine 3,3'-Dichloro-4,4'-diaminodiphenyl ether Dienestrol 1,2-Diethylhydrazine Diisopropyl sulfate 2,4-/2,6-Dinitrotoluene mixture Diphenylhydantoin (Phenytoin) Diphenylhydantoin (Phenytoin), sodium salt 3,3’-Dimethoxybenzidine-based dyes metabolized to 3,3’-dimethoxybenzidine 3,3’-Dimethylbenzidine-based dyes metabolized to 3,3’-dimethylbenzidine Estrone Estropipate Status Report
Proposition 65 Safe Harbor Levels
January 2005
Ethyl acrylate Furazolidone Fusarin C Ganciclovir sodium Gasoline engine exhaust (condensates/extracts) Gemfibrozil Glasswool fibers (airborne particles of respirable size) Glycidaldehyde Mancozeb Maneb Medroxyprogesterone acetate Merphalan Mestranol Metiram Mustard Gas Niridazole Nitrogen mustard (Mechlorethamine) Nitrogen mustard hydrochloride (Mechlorethamine HC1) Norethisterone (Norethindrone) Oxymetholone Panfuran S Polychlorinated dibenzofurans Procymidone Propargite Propylene Spironolactone Stanozolol Strong inorganic acid mists containing sulfuric acid Tamoxifen and its salts Terrazole Thiodicarb Thorium dioxide Treosulfan Trichlormethine (Trimustine hydrochloride) Uracil mustard Vinclozolin Vinyl fluoride Zileuton Alcoholic beverages
2-Aminofluorene
4-Amino-2-nitrophenol
Analgesic mixtures containing phenacetin
Aristolochic acid
Betel quid with tobacco
Bitumens, extracts of steam-refined
Bracken fern
Caffeic acid
Carbon-black extracts
Certain combined chemotherapy for lymphomas
Citrus Red No. 2
Status Report
Proposition 65 Safe Harbor Levels
January 2005
Conjugated estrogens
Creosotes
Cycasin
Cytembena
D&C Orange No. 17
D&C Red No. 8
D&C Red No. 19
3,7-Dinitrofluoranthene
3,9-Dinitrofluoranthene
Erionite
Ethyl methanesulfonate
Herbal remedies containing plant species of the genus Aristolochia
Iron dextran complex
Lynestrenol
8-Methoxypsoralen with ultraviolet A therapy
5-Methoxypsoralen with ultraviolet A therapy
Methylazoxymethanol
Methylazoxymethanol acetate
Nitrogen mustard N-oxide
Nitrogen mustard N-oxide hydrochloride
3-(N-Nitrosomethylamino)propionitrile
Norethynodrel
Oil Orange SS
Oral contraceptives, combined
Oral contraceptives, sequential
Palygorskite fibers
Phenolphthalein
Residual (heavy) fuel oils
Riddelliine
Shale-oils
Soots, tars, and mineral oils
Talc containing asbestiform fibers
Tobacco, oral use of smokeless products
Tobacco smoke
Tris(aziridinyl)-para-benzoquinone (Triaziquone)
Unleaded gasoline (wholly vaporized)
Status Report
Proposition 65 Safe Harbor Levels
January 2005
D. Priority List for the Development of MADLs for Chemicals Causing
Reproductive Toxicity
OEHHA has developed the following priority list, which divides chemicals causing reproductive toxicity for which dose-response assessments have not been completed into three priorities. Priority levels reflect the availability and quality of scientific data for dose-response assessments, potential for exposure, resources available to perform the assessment, and input from the public and the Attorney General’s office. OEHHA anticipates proposing MADLs for the majority of chemicals in the first priority group within the next two years, and for several chemicals in the second priority within the next two to four years. It is unlikely that MADLs for chemicals in the third priority group would be released within the next three years. Any interested party may submit recommendations to OEHHA on revising the priority assignment for any of the chemicals listed. Recommendations should be accompanied by appropriate documentation supporting the alternative priority assignment suggested. OEHHA expects changes in priorities resulting from the availability of scientific information and resources and requests from the public and Attorney General’s office. Also given below are draft levels available and year of release. OEHHA will review the basis for draft numbers and update analyses as needed, before proposing or finalizing levels for formal adoption in regulation. Chemicals in bold font have been added to the Proposition 65 list or changed in priority status since the last Status Report. 1. 1-Bromopropane
Carbon
Di (2-ethylhexyl) phthalate
(2004 draft iv MADL: 4200 µg/day)
Ethylene glycol monoethyl ether Ethylene glycol monoethyl ether acetate Mercury and mercury compounds* Nicotine Triphenyl tin hydroxide Vinclozolin Amitraz Bromacil lithium salt Bromoxynil Bromoxynil octanoate 1,3-Butadiene Chinomethionat (Oxythioquinox) Chlorsulfuron Cocaine Cycloate Dichlorophene * For explanation of priority levels see discussion above. Status Report
Proposition 65 Safe Harbor Levels
January 2005
Diclofop methyl
Ethylene thiourea
Fenoxaprop ethyl
Fluazifop butyl
Fluvalinate
Methazole
Metiram
Myclobutanil
Nabam
Nitrapyrin
Oxadiazon
Oxydemeton methyl
Potassium dimethyldithiocarbamate
Propargite
Resmethrin
Sodium dimethyldithiocarbamate
(2004 draft oral MADL: 23 µg/day [58 µg/day for a 40% pesticidal formulation]) Sodium fluoroacetate Terbacil 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) Triadimefon Tributyltin methacrylate Triforine Acetazolamide Acetohydroxamic acid Actinomycin D All-trans retinoic acid Alprazolam Altretamine Amantadine hydrochloride Amikacin sulfate Aminoglutethimide Aminoglycosides Aminopterin Amiodarone hydrochloride Amoxapine Anabolic steroids Angiotensin converting enzyme (ACE) inhibitors Anisindione Aspirin Atenolol Auranofin Azathioprine Barbiturates Beclomethasone dipropionate Benomyl Benzphetamine hydrochloride Benzodiazepines Bischloroethyl nitrosourea (BCNU) (Carmustine) Butabarbital sodium 1,4-Butanediol dimethanesulfonate (Busulfan) Status Report
Proposition 65 Safe Harbor Levels
January 2005
Carbamazepine Carbon monoxide Carboplatin Chenodiol Chlorambucil Chlorcyclizine hydrochloride Chlordecone (Kepone) Chlordiazepoxide Chlordiazepoxide hydrochloride 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Cidofovir Cladribine Clarithromycin Clobetasol propionate Clomiphene citrate Clorazepate dipotassium Codeine phosphate Colchicine Conjugated estrogens Cyanazine Cycloheximide Cyclophosphamide (anhydrous) Cyclophosphamide (hydrated) Cyhexatin Cytarabine Dacarbazine Danazol Daunorubicin hydrochloride o,p'-DDT p,p'-DDT Demeclocycline hydrochloride (internal use) Diazepam Diazoxide Dichlophenamide Dicumarol Diethylstilbestrol (DES) Diflunisal Dihydroergotamine mesylate Diltiazem hydrochloride o-Dinitrobenzene p-Dinitrobenzene 2,4-Dinitrotoluene 2,6-Dinitrotoluene Dinitrotoluene (technical grade) Dinocap Dinoseb Diphenylhydantoin (Phenytoin) Doxorubicin hydrochloride Doxycycline (internal use) Doxycycline calcium (internal use) Doxycycline hyclate (internal use) Doxycycline monohydrate (internal use) Endrin Epichlorohydrin Status Report
Proposition 65 Safe Harbor Levels
January 2005
Ergotamine tartrate Estropipate Ethionamide Ethyl alcohol in alcoholic beverages Ethylene dibromide Etodolac Etoposide Etretinate Filgrastim Flunisolide Fluorouracil Fluoxymesterone Flurazepam hydrochloride Flurbiprofen Flutamide Fluticasone propionate Ganciclovir sodium Gemfibrozil Goserelin acetate Halazepam Halobetasol propionate Haloperidol Halothane Heptachlor Hexachlorobenzene Hexamethylphosphoramide Histrelin acetate Hydroxyurea Idarubicin hydrochloride Ifosfamide Iodine-131 Isotretinoin Leuprolide acetate Levodopa Levonorgestrel implants Lithium carbonate Lithium citrate Lorazepam Lovastatin Mebendazole Medroxyprogesterone acetate Megestrol acetate Melphalan Menotropins Meprobamate Mercaptopurine Methacycline hydrochloride Methimazole Methotrexate Methotrexate sodium Methyl chloride Methyltestosterone Midazolam hydrochloride Minocycline hydrochloride (internal use) Status Report
Proposition 65 Safe Harbor Levels
January 2005
Misoprostol Mitoxantrone hydrochloride Nafarelin acetate Neomycin sulfate (internal use) Netilmicin sulfate Nickel carbonyl Nifedipine Nimodipine Nitrofurantoin Nitrogen mustard (Mechlorethamine) Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) Norethisterone (Norethindrone) Norethisterone acetate (Norethindrone acetate) Norethisterone (Norethindrone)/Ethinyl estradiol Norethisterone (Norethindrone)/Mestranol Norgestrel Oxazepam Oxymetholone Oxytetracycline (internal use) Oxytetracycline hydrochloride (internal use) Paclitaxel Paramethadione Penicillamine Pentobarbital sodium Pentostatin Phenacemide Phenprocoumon Pimozide Pipobroman Plicamycin Polybrominated biphenyls Polychlorinated biphenyls Pravastatin sodium Prednisolone sodium phosphate Procarbazine hydrochloride Propylthiouracil Pyrimethamine Quazepam Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. Ribavirin Rifampin Secobarbital sodium Sermorelin acetate Streptomycin sulfate Streptozocin (streptozotocin) Sulfasalazine Sulindac Tamoxifen citrate Temazepam Teniposide Testosterone cypionate Testosterone enanthate Tetracycline (internal use) Status Report
Proposition 65 Safe Harbor Levels
January 2005
Tetracyclines (internal use) Tetracycline hydrochloride (internal use) Thalidomide Thioguanine Tobacco smoke (primary) Tobramycin sulfate Triazolam Trientine hydrochloride Trilostane Trimethadione Trimetrexate glucuronate Uracil mustard Urethane Urofollitropin Valproate (Valproic acid) Vinblastine sulfate Vincristine sulfate Warfarin Zileuton Status Report
Proposition 65 Safe Harbor Levels
January 2005

Source: http://www.appliedspeciation.com/Jan2005StatusReport.pdf

margifox.com.au

In the 1930s it was postulated that skin exposed to normally found in skin in fairly high concentrations. In people sunlight aged faster than skin that was protected from of Asian descent the beta-carotene levels are higher than sunlight. By 1955 it was discovered that the application of in Westerners. Beta-carotene has the ability to be cleaved vitamin A as retinyl palmitate to aged ski

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